Mode visibilities in radial velocity and intensity Sun-as-a-star helioseismic measurements

We analyze more than 5000 days of Sun-as-a-star radial velocity GOLF and intensity VIRGO observations to measure the visibilities of the l=0, 1, 2, and 3 modes and the m-amplitude ratios of the l=2 and 3 modes in the solar acoustic spectrum. We provide observational values that we compare to theoretical predictions.Comment: SOHO 24 / GONG 2010 conference, to be published in JPC

CoRoT reveals a magnetic activity cycle in a Sun-like star

The 11-year activity cycle of the Sun is a consequence of a dynamo process occurring beneath its surface. We analyzed photometric data obtained by the CoRoT space mission, showing solar-like oscillations in the star HD49933, for signatures of stellar magnetic activity. Asteroseismic measurements of global changes in the oscillation frequencies and mode amplitudes reveal a modulation of at least 120 days, with the minimum frequency shift corresponding to maximum amplitude as in the Sun. These observations are evidence of a stellar magnetic activity cycle taking place beneath the surface of HD49933 and provide constraints for stellar dynamo models under conditions different from those of the Sun.Comment: Brevia text and supporting online material, published in Scienc

Simulations of turbulent convection in rotating young solar-like stars: Differential rotation and meridional circulation

We present the results of three-dimensional simulations of the deep convective envelope of a young (10 Myr) one-solar-mass star, obtained with the Anelastic Spherical Harmonic code. Since young stars are known to be faster rotators than their main sequence counterparts, we have systematically studied the impact of the stellar rotation speed, by considering stars spinning up to five times as fast as the Sun. The aim of these nonlinear models is to understand the complex interactions between convection and rotation. We discuss the influence of the turbulence level and of the rotation rate on the intensity and the topology of the mean flows. For all of the computed models, we find a solar-type superficial differential rotation, with an equatorial acceleration, and meridional circulation that exhibits a multicellular structure. Even if the differential rotation contrast decreases only marginally for high rotation rates, the meridional circulation intensity clearly weakens according to our simulations. We have also shown that, for Taylor numbers above a certain threshold (Ta>10^9), the convection can develop a vacillating behavior. Since simulations with high turbulence levels and rotation rates exhibit strongly cylindrical internal rotation profiles, we have considered the influence of baroclinic effects at the base of the convective envelope of these young Suns, to see whether such effect can modify the otherwise near cylindrical profiles to produce more conical, solar-like profiles.Comment: 32 pages, 18 figures, 2 tables, to appear in Ap

Detection of solar-like oscillations from Kepler photometry of the open cluster NGC 6819

Asteroseismology of stars in clusters has been a long-sought goal because the assumption of a common age, distance and initial chemical composition allows strong tests of the theory of stellar evolution. We report results from the first 34 days of science data from the Kepler Mission for the open cluster NGC 6819 -- one of four clusters in the field of view. We obtain the first clear detections of solar-like oscillations in the cluster red giants and are able to measure the large frequency separation and the frequency of maximum oscillation power. We find that the asteroseismic parameters allow us to test cluster-membership of the stars, and even with the limited seismic data in hand, we can already identify four possible non-members despite their having a better than 80% membership probability from radial velocity measurements. We are also able to determine the oscillation amplitudes for stars that span about two orders of magnitude in luminosity and find good agreement with the prediction that oscillation amplitudes scale as the luminosity to the power of 0.7. These early results demonstrate the unique potential of asteroseismology of the stellar clusters observed by Kepler.Comment: 5 pages, 4 figures, accepted by ApJ (Lett.

Prérequis nécessaires pour la mise en place de protocoles de recherche clinique évaluant des thérapies cellulaires et géniques par lymphocytes T dotés de récepteur chimérique à l’antigène (CAR T-cells) : recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC)

International audienc

Pediatr Nephrol

BACKGROUND: Pediatric ANCA vasculitis is a rare group of diseases with a scarcity of data in children. Annual incidence appeared to increase in the last several years, placing higher interest in the clinical and therapeutical outcomes of the disorder. Also, the growing use of rituximab questions the latest outcomes in these diseases. We therefore conducted a retrospective study to better understand the current characteristics, management, and the latest outcomes of the disorder. METHODS: We conducted a 9-year retrospective study of 46 children in 14 different centers across France to describe their clinical and laboratory presentations, therapeutic regimens, and kidney outcome. RESULTS: P-ANCA appeared to be a potential marker for higher relapse risk. Compared to adults, we found that ear-nose-throat presentations were frequent (45.7%) and more severe. Despite an evolution in the treatment management, kidney outcome remained poor with a substantial proportion of chronic kidney disease (54.8% at 1 year). Mortality stays low with 3 patients (6.5%) deceased at the end of our study. CONCLUSION: Clinical presentation was as previously described and time to diagnosis remains long. P-ANCA is a statistically significant marker for increased relapse risk. We observed a modification in the treatment regimens over the past several years with a growing use of rituximab and a decreasing use of cyclophosphamide. Despite these changes, kidney outcome remains poor and prospective studies should be conducted to assess the most appropriate therapeutic modality for each patient. A higher resolution version of the Graphical abstract is available as Supplementary information