INTERPLAY BETWEEN THE NOTCH AND p53 PROMOTES NEURONAL CELL DEATH IN ISCHEMIC STROKE

Ph.DDOCTOR OF PHILOSOPH

Lactational Exposure to Di-2-ethyl Hexyl Phthalate (Dehp) Induces Oxidative Stress and Causes Neurodegeneration in Hippocampus of Offspring Female Albino Rats

The purpose of this study was to determine the effect of DEHP on the hippocampus of F1 progeny female albino rats. Healthy mother rats were divided into four groups. The first group (control) was orally fed with olive oil–vehicle and the other three groups were treated with DEHP 1, 10 and 100 mg /kg bw/day via oral gavage from PND (Post natal day) 1 till 21. On PND 60 the offspring female rats were sacrificed, their hippocampus dissected and processed for biochemical analysis. Results showed that DEHP induced oxidative stress in hippocampus by increasing reactive oxygen species and decreasing antioxidant enzymes. Further, DEHP reduced the mRNA expression of ER?, ? and decreased that of Bcl2. Construction of a protein-protein interaction map with ER?, ?, Bcl2 and their downstream interacting partners confirmed the existence of a network, enriched for molecular functions. To conclude, lactational exposure to DEHP causes hippocampal neurotoxicity.&nbsp

Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke

10.1016/j.bbi.2018.09.001BRAIN BEHAVIOR AND IMMUNITY7534-47BBIM