Proposal for a DoD Combined Battlefield Electromagnetic Environmental Effects (E3) Initiative

The presentation emphasizes the growing importance of electromagnetic survivability and compatibility. Operation Desert Storm demonstrated the clear military advantage provided by sophisticated electronic weapon and communication systems. In addition, the offensive tactic of taking out the enemy\u27s eyes and ears during the air war paid off, giving our military decisive air superiority. The lessons for the future are clear. High-tech electronics now so dominates the battlefield that the outcome of future conflicts could well be decided by electronics attrition rather than human casualties. Our Desert Storm experience thus accentuates the importance of guaranteeing that our electronic systems will not be disabled either deliberately or accidentally by electromagnetic environmental effects. Factors which pose implementation challenges and problems are addressed. The increasing use of commercial equipment in military applications will require that commercial and military standards be integrated to some degree. While many technical questions will need to be resolved, the major challenges are associated with organization and process given the large number of technical disciplines and organizations involved in electromagnetic effects issues. The presentation concludes by proposing a top-level solution path. Recognizing the growing importance of electronics survivability, the Joint Chiefs of Staff (J6) has requested and the Under Secretary of Defense for Acquisition has tasked the development of Combined Battlefield Environmental Effects (CBEE)

Evolution and Rationale for United States Department of Defense Electromagnetic Pulse Protection Standard

The United States (US) Department of Defense (DoD) Electromagnetic Pulse (EMP) protection standard offers a solid basis for protecting commercial communication, data, and control facilities. Because of the standard’s shielded barrier and test requirements, it is not surprising that there is a strong temptation within industry and government to dismiss the MIL-STD 188-125 approach in favor of less rigorous protection methods. It is important to understand that US DoD EMP protection standard for fixed facilities, MIL-STD-188-125, reflects an evolution by trial and error that spanned a period of decades beginning with the acquisition of the Minuteman Missile System in the 1960s. In fact, one of the main motivating factors for developing the standard was that system developers in the Air Force, Army, Navy, and Defense Communications Agency (now Defense Information Systems Agency) and the Federal Emergency Management Agency tried less technically-sound approaches that failed in their effectiveness, testability, and maintainability. This paper revisits the development of the US DoD standard and explains its provisions and underlying technical rationale. The paper’s objective is to enable the public officials and engineers involved in planning and implementing EMP protection for critical infrastructure facilities to avoid the pitfalls encountered in the past and use the best practices available to achieve low risk protection designs that can be maintained over the entire lifecycle of critical infrastructure systems

Testimony of Dr. George H. Baker, Senior Advisor to the Congressional EMP Commission

This is the script of testimony before the Federal Energy Regulatory Commission. It offers a vision for a future in which our electric power systems will be able to operate through or quickly recover from catastrophic failure due to electromagnetic pulse (EMP), cyber, and physical attacks. The scope of the term ‘EMP’ used in this testimony includes both naturally occurring solar storms and the more energetic man-made EMP hazards. The vision has been discussed with members of the electric power industry, and prominent EMP/cyber/physical protection advocates who find it to be supportable and actionable. The nature of EMP, cyber, and physical threats to the United States’ electric power grid are severe, to be sure. Bounding consequences could include risk measurement units of millions of casualties (EMP Commission), trillions of dollars (Lloyds of London), and, dents in the history of civilization (Center for Policy on Emerging Technology). The good news is that well-known engineering solutions are available to counter these threats

Damage Analysis Modified TRAC Computer Program (DAMTRAC)

A computer program tailored for EMP damage analysis of solid-state circuitry has been developed by modifying the existing TRAC network analysis program. Modification of the TRAC diode and transistor models to include breakdown parameters and the addition of a semiconductor device parameter library have greatly simplified the analyst\u27s task. An added feature is a subroutine that automatically calculates the amplitude and duration of transient power dissipated in electronic circuit components

High Consequence Scenarios for North Korean Atmospheric Nuclear Tests with Policy Recommendations for the U.S. Government

The government of North Korea has declared high-altitude EMP-capability to be a “strategic goal” and has also threatened an atmospheric test of a hydrogen bomb. Atmospheric nuclear tests have the potential to cripple satellites and the undersea cable networks critical to communication, and navigation necessary for trans-Pacific trade among the U.S., China, and other nations. When a nuclear warhead is detonated at high altitude, a series of electromagnetic pulses radiate downward within the line of sight of the blast. These pulses can disable equipment with miniature electronics and long conductors. Electric grid controls and transmission systems are especially vulnerable. Intense X-rays and free electrons caused by high-altitude nuclear tests can also disable satellites over large regions of space. After the 1962 Starfish Prime test of EMP effects by the U.S, numerous satellites failed. Based on past missile tests, calculated delivery ranges, EMP coverage areas, and geography, Resilient Societies developed five scenarios for North Korean atmospheric tests. Possible sites for EMP tests include the South Pacific Ocean northeast of French Polynesia, Johnson Atoll southwest of Hawaii, and vicinity of the U.S. territory of Guam. Missile trajectories for all three of these EMP test scenarios overfly populated areas. Missile navigation or nuclear device fuzing errors could place the populations of Japan, Guam, and Hawaii are at risk. All potential EMP test locations could cause disruption to international satellite and undersea cable communications networks. North Korea should not be permitted to conduct an atmospheric nuclear tests since EMP effects on large networks necessary for electric power and international data sharing could have serious worldwide consequences due to the importance of Asia and the Pacific region to the global economy. In the regrettable event that North Korea chooses to conduct atmospheric nuclear tests, U.S. and allied monitoring of EMP effects will be helpful

First radial velocity results from the MINiature Exoplanet Radial Velocity Array (MINERVA)

The MINiature Exoplanet Radial Velocity Array (MINERVA) is a dedicated observatory of four 0.7m robotic telescopes fiber-fed to a KiwiSpec spectrograph. The MINERVA mission is to discover super-Earths in the habitable zones of nearby stars. This can be accomplished with MINERVA's unique combination of high precision and high cadence over long time periods. In this work, we detail changes to the MINERVA facility that have occurred since our previous paper. We then describe MINERVA's robotic control software, the process by which we perform 1D spectral extraction, and our forward modeling Doppler pipeline. In the process of improving our forward modeling procedure, we found that our spectrograph's intrinsic instrumental profile is stable for at least nine months. Because of that, we characterized our instrumental profile with a time-independent, cubic spline function based on the profile in the cross dispersion direction, with which we achieved a radial velocity precision similar to using a conventional "sum-of-Gaussians" instrumental profile: 1.8 m s$^{-1}$ over 1.5 months on the RV standard star HD 122064. Therefore, we conclude that the instrumental profile need not be perfectly accurate as long as it is stable. In addition, we observed 51 Peg and our results are consistent with the literature, confirming our spectrograph and Doppler pipeline are producing accurate and precise radial velocities.Comment: 22 pages, 9 figures, submitted to PASP, Peer-Reviewed and Accepte

Investigating the Structural Impacts of I64T and P311S Mutations in APE1-DNA Complex: A Molecular Dynamics Approach

Elucidating the molecular dynamic behavior of Protein-DNA complex upon mutation is crucial in current genomics. Molecular dynamics approach reveals the changes on incorporation of variants that dictate the structure and function of Protein-DNA complexes. Deleterious mutations in APE1 protein modify the physicochemical property of amino acids that affect the protein stability and dynamic behavior. Further, these mutations disrupt the binding sites and prohibit the protein to form complexes with its interacting DNA.In this study, we developed a rapid and cost-effective method to analyze variants in APE1 gene that are associated with disease susceptibility and evaluated their impacts on APE1-DNA complex dynamic behavior. Initially, two different in silico approaches were used to identify deleterious variants in APE1 gene. Deleterious scores that overlap in these approaches were taken in concern and based on it, two nsSNPs with IDs rs61730854 (I64T) and rs1803120 (P311S) were taken further for structural analysis.Different parameters such as RMSD, RMSF, salt bridge, H-bonds and SASA applied in Molecular dynamic study reveals that predicted deleterious variants I64T and P311S alters the structure as well as affect the stability of APE1-DNA interacting functions. This study addresses such new methods for validating functional polymorphisms of human APE1 which is critically involved in causing deficit in repair capacity, which in turn leads to genetic instability and carcinogenesis

The Effect of Inappropriate Calibration: Three Case Studies in Molecular Ecology

Time-scales estimated from sequence data play an important role in molecular ecology. They can be used to draw correlations between evolutionary and palaeoclimatic events, to measure the tempo of speciation, and to study the demographic history of an endangered species. In all of these studies, it is paramount to have accurate estimates of time-scales and substitution rates. Molecular ecological studies typically focus on intraspecific data that have evolved on genealogical scales, but often these studies inappropriately employ deep fossil calibrations or canonical substitution rates (e.g., 1% per million years for birds and mammals) for calibrating estimates of divergence times. These approaches can yield misleading estimates of molecular time-scales, with significant impacts on subsequent evolutionary and ecological inferences. We illustrate this calibration problem using three case studies: avian speciation in the late Pleistocene, the demographic history of bowhead whales, and the Pleistocene biogeography of brown bears. For each data set, we compare the date estimates that are obtained using internal and external calibration points. In all three cases, the conclusions are significantly altered by the application of revised, internally-calibrated substitution rates. Collectively, the results emphasise the importance of judicious selection of calibrations for analyses of recent evolutionary events

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.