Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats: Survival rate in tilmicosin toxicity

Tilmicosin shows different degrees of cardiotoxic effect in various animal species depending on the route of administration and dose. We aimed to determine the effects of amiodarone and amiodarone+dobutamine treatments on tilmicosin cardiotoxicity and survival time. 18 healthy goats were divided into tilmicosin, tilmicosin+amiodarone and tilmicosin+amiodarone+dobutamine groups. After drug administrations, the survival times of the animals in all groups were recorded. In addition, blood was drawn from the animals just before they died. Haemogram, troponin I, CK-MB and other biochemical parameters were measured in all blood samples. Prolonged survival was observed in the treatment groups compared to the tilmicosin group. In the treatment groups, decreases in haemogram parameters, albumin, total protein and cholesterol levels caused by tilmicosin could not be prevented, while the increase in troponin I level was prevented. In conclusion, while cardiotoxicity due to high troponin from tilmicosin was prevented, the survival rate was not affected in both treatment groups, and the survival time was extended at differing rates. In case of accidental or deliberate overdose of tilmicosin in animals, in addition to the use of amiodarone+dobutamine, the survival time may be prolonged, and the success may increase if the necessary symptomatic treatments and equipment support are available.Tilmicosin shows different degrees of cardiotoxic effect in various animal species depending on the route of administration and dose. We aimed to determine the effects of amiodarone and amiodarone+dobutamine treatments on tilmicosin cardiotoxicity and survival time. 18 healthy goats were divided into tilmicosin, tilmicosin+amiodarone and tilmicosin+amiodarone+dobutamine groups. After drug administrations, the survival times of the animals in all groups were recorded. In addition, blood was drawn from the animals just before they died. Haemogram, troponin I, CK-MB and other biochemical parameters were measured in all blood samples. Prolonged survival was observed in the treatment groups compared to the tilmicosin group. In the treatment groups, decreases in haemogram parameters, albumin, total protein and cholesterol levels caused by tilmicosin could not be prevented, while the increase in troponin I level was prevented. In conclusion, while cardiotoxicity due to high troponin from tilmicosin was prevented, the survival rate was not affected in both treatment groups, and the survival time was extended at differing rates. In case of accidental or deliberate overdose of tilmicosin in animals, in addition to the use of amiodarone+dobutamine, the survival time may be prolonged, and the success may increase if the necessary symptomatic treatments and equipment support are available

Aspect angle dependence of the E region irregularity velocity at large flow angles

We present the Doppler velocity observations of 1-m plasma waves in the auroral E region by the Scandinavian Twin Auroral Radar Experiment (STARE) Norway VHF coherent radar in the context of simultaneous and coincident measurements of electron and ion drift velocities determined by the European Incoherent Scatter (EISCAT) tristatic radar facility. The measurements were performed in the afternoon sector (1500–2000 MLT) at seven locations along the STARE radar beam 2 with different values of the magnetic off-perpendicular (aspect) angle α between 0.48° and 2.63° and at large angles with respect to the electron background drift ( = 55°–90°). It is demonstrated that the STARE line-of-sight velocity, normalized to the EISCAT-derived electron drift speed at large flow angles, exhibits a decrease with increasing aspect angle, and the rate of decrease is investigated as a function of the flow angle. We also compare the STARE velocity with the electron and ion drift velocity components along the STARE radar beam look direction and show that, at large aspect angles, the E region velocity is correlated (anticorrelated) with the ion (electron) drift velocity component. The results are discussed in the contexts of the linear fluid theory of the modified two-stream plasma instability and the theory of anomalous collisions

Evaluation of the effects of amiodarone and amiodarone+dobutamine on survival in tilmicosin-induced toxicity by electrocardiography and biochemical parameters in goats

Tilmicosin shows different degrees of cardiotoxic effect in various animal species depending on the route of administration and dose. We aimed to determine the effects of amiodarone and amiodarone+dobutamine treatments on tilmicosincardiotoxicity and survival time. 18 healthy goats were divided into tilmicosin, tilmicosin+amiodarone and tilmicosin+amiodarone+dobutamine groups. After drug administrations, the survival times of the animals in all groups were recorded. In addition, blood was drawn from the animals just before they died. Haemogram, troponin I, CK-MB, and other biochemical parameters were measured in all blood samples. Prolonged survival was observed in the treatment groups compared to the tilmicosin group. In the treatment groups, decreases in haemogram parameters, albumin, and total protein levels caused by tilmicosin could not be prevented, while the increase in troponin I level was prevented. In conclusion, while cardiotoxicity due to high troponin from tilmicosin was prevented, the survival rate was not affected in both treatment groups, and the survival time was extended at differing rates. In case of accidental or deliberate overdose of tilmicosin in animals, in addition to the use of amiodarone+dobutamine, the survival time may be prolonged, and the success may increase if the necessary symptomatic treatments and equipment support are available. © 2024, D Coskun, M ider, A naseri, B Dik, E Bahcivan, B Tras, ayse ERSUPABK, (20401008

Effects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon cancer

The aim of this research was to determine the effects of Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillation (NOD) on the colon aberrant cryptal foci (ACF) score, serum cytokines [Tumour necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-6, IL-10], prostaglandin E2, and oxidative status parameters (malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase) in an experimentally induced colon cancer model in rats. Male rats (38 in total) were divided into 4 groups: Control group (n = 8), Colon Cancer group (CC, n = 10), CC+TCAE group (n = 10), and CC i NOD group (n = 10). Except for the Control group, the rest of rats received azoxymethane (15 mg/kg, SC) once a week for two weeks to induce colon cancer. TCAE was administered once a week at 0.2 mL/kg (SC) and NOD was administered in water to CC+TCAE and CC+NOD groups for 18 weeks. After blood samples were collected, the rats were euthanized, colons were removed, washed with saline, then fixed with 10% formaldehyde, and stained with 0.2% methylene blue. ACFs were scored by light microscopy. Serum levels of cytokines, prostaglandin E2, and oxidative status parameters were determined with ELISA. ACF score of the CC group was higher than CC+TCAE and CC+NOD groups. The prostaglandin E2 level of the Control group was lower than the CC i TCAE group, while IL-2 and IL-10 levels of the Control group were lower than all other groups. In conclusion, it can be stated that TCAE and NOD applications may be beneficial in the treatment of colon cancer.SUBAPK [17401073]This study was financed by SUBAPK (17401073). Study abstract was present as oral presentation in the International Conference on Veterinary, Agriculture and Life Sciences (ICVALS), October 26-29, 2018, Antalya, Turke