28 research outputs found
Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 11/11/2016
- Field of study
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor progression on therapy. Here, we characterized a novel non-mutational early adaptive drug-escape in EGFR-mutant lung tumor cells only days after therapy initiation, that is MET-independent. The drug-escape cell states were analyzed by integrated transcriptomic and metabolomics profiling uncovering a central role for autocrine TGFβ2 in mediating cellular plasticity through profound cellular adaptive Omics reprogramming, with common mechanistic link to prosurvival mitochondrial priming. Cells undergoing early adaptive drug escape are in proliferative-metabolic quiescent, with enhanced EMT-ness and stem cell signaling, exhibiting global bioenergetics suppression including reverse Warburg, and are susceptible to glutamine deprivation and TGFβ2 inhibition. Our study further supports a preemptive therapeutic targeting of bioenergetics and mitochondrial priming to impact early drug-escape emergence using EGFR precision inhibitor combined with broad BH3-mimetic to interrupt BCL-2/BCL-xL together, but not BCL-2 alone
Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a TAP1- and proteasome-dependent pathway.
- Author
- Publication venue
- LVHN Scholarly Works
- Publication date
- 15/06/2005
- Field of study
In vivo studies suggest that vascular endothelial cells (ECs) can acquire and cross-present exogenous Ag on MHC-I but the cellular mechanisms underlying this observation remain unknown. We tested whether primary female mouse aortic ECs could cross-present exogenous male Ag to the T cell hybridoma, MHH, specific for HYUty plus D(b). MHC-I-deficient male spleen cells provided a source of male Ag that could not directly stimulate the MHH cells. Addition of male but not female MHC-I-deficient spleen cells to wild-type syngeneic female EC induced MHH stimulation, demonstrating EC cross-presentation. Lactacystin treatment of the donor male MHC-I-deficient spleen cells, to inhibit proteasome function, markedly enhanced EC cross-presentation showing that the process is most efficient for intact proteins rather than degraded peptide fragments. Additional experiments revealed that this EC Ag-processing pathway is both proteasome and TAP1 dependent. These studies demonstrate that cultured murine aortic ECs can process and present MHC-I-restricted Ag derived from a separate, live cell, and they offer insight into the molecular requirements involved in this EC Ag presentation process. Through this pathway, ECs expressing cross-presented peptides can participate in the effector phase of T cell-mediated inflammatory responses such as autoimmunity, anti-tumor immunity, and transplant rejection
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Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 01/12/2016
- Field of study
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor progression on therapy. Here, we characterized a novel non-mutational early adaptive drug-escape in EGFR-mutant lung tumor cells only days after therapy initiation, that is MET-independent. The drug-escape cell states were analyzed by integrated transcriptomic and metabolomics profiling uncovering a central role for autocrine TGFβ2 in mediating cellular plasticity through profound cellular adaptive Omics reprogramming, with common mechanistic link to prosurvival mitochondrial priming. Cells undergoing early adaptive drug escape are in proliferative-metabolic quiescent, with enhanced EMT-ness and stem cell signaling, exhibiting global bioenergetics suppression including reverse Warburg, and are susceptible to glutamine deprivation and TGFβ2 inhibition. Our study further supports a preemptive therapeutic targeting of bioenergetics and mitochondrial priming to impact early drug-escape emergence using EGFR precision inhibitor combined with broad BH3-mimetic to interrupt BCL-2/BCL-xL together, but not BCL-2 alone
MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
- Author
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- Field of study
Escape of EML4-ALK
- Author
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- Field of study
Actividades preventivas en los mayores. Actualización PAPPS 2018
- Author
- Almeida
- Apostolo
- Bagai
- Bischoff-Ferrari
- Clarke
- Clegg
- Clyne
- Cooper
- De Coninck
- De Labra
- Dedeyne
- Esteban
- Flodgren
- Garfinkel
- Gillespie
- Herreros Herreros
- Hilmer
- Huiskes
- Jacobs
- Kane
- Kiel
- Larson
- Lavan
- Livingston
- López Trigo
- López-Torres Hidalgo
- López-Torres Hidalgo
- Martin-Lesende
- Masnoon
- Morey
- Moyer
- Muhlack
- Olazarán
- O’Mahony
- Potter
- Pottie
- Qato
- Rakesh
- Saum
- Schubert
- Tarazona-Santabalbina
- Yueh
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The Role of the Insulin-like Growth Factor-1 Receptor (IGF-1R), Phosphatase and Tensin Homolog (PTEN), c-Met, and the PI3-Kinase Pathway in Colorectal Cancer
- Author
- A Bardelli
- A Inno
- A Jemal
- A Lievre
- A Sood
- AB Sparks
- AF Sobrero
- AS Wong
- B Lutterbach
- BD Manning
- C Birchmeier
- C Birchmeier
- C Bokemeyer
- C Migliore
- C Migliore
- C Ponzetto
- CF Gao
- CJ Allegra
- CS Karapetis
- D Coppola
- D Liaw
- D Matsubara
- D Sachdev
- DJ Jonker
- DJ Marsh
- DW Parsons
- E Cutsem Van
- E Cutsem Van
- F Loupakis
- G Dicuonzo
- G Manning
- GA Smolen
- GJ Poston
- H Prenen
- H Rajagopalan
- H Takeuchi
- HE Feilotter
- I Vivanco
- IS Long
- J Abubaker
- J Li
- J Roper
- J Zha
- JA Engelman
- JM Bhatavdekar
- K Fazekas
- K Nosho
- K Okamoto
- K Sawada
- L Barault
- LD Wood
- LV Sequist
- M Keniry
- M Miyaki
- M Ollikainen
- M Pollak
- M Scartozzi
- MF Renzo Di
- MM Georgescu
- N Reinmuth
- Network TCGA
- P Laurent-Puig
- PA Steck
- Patrick C. Ma
- PC Ma
- PC Ma
- PC Ma
- PC Ma
- PC Ma
- Q Xie
- R Parsons
- Rakesh Bagai
- RG Amado
- S Bose
- S Garcia
- S Kato
- S Ogino
- S Velho
- S Wee
- T Sjoblom
- T Watanabe
- U Asghar
- U Stein
- US Kammula
- W Roock De
- WM Lin
- X Zhou
- XH Li
- XP Zhou
- Y Feng
- Y Samuels
- Y Samuels
- Y Samuels
- Y Yu
- YP Hu
- Z Wang
- Z Wang
- Z Zeng
- ZS Zeng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Management of coronary disease in patients with advanced kidney disease
- Author
- Abdallah M Abdallah Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew Starovoytov, Andrzej \u141abyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-\uc9ric Gagn\ue9, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Bj\uf6rklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Daugas, Erick Alex\ue1nderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Fl\ue1via Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, Fran\ue7ois Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jes\ufas Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaqu\uedn V Pe\uf1afiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-I\uf1iguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Costa Vieira, Jos\ue9 M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, Jos\ue9 Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel L\uf3pez Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio C\ue9sar Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Shinseki, Matthew Weir, Maura Carina N\ue9dio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdo\u144czyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula Garc\ueda-Gonz\ue1lez, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto Ren\ue9 Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth P\ue9rez-Fern\ue1ndez, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, S\ue9rgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, S\uedlvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, T\ue9odora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fern\ue1ndez-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-R\uedos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek P\ue9pin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
- Alexander K.P.
- Ali Z.A.
- Bangalore S.
- Berger J.S.
- Bockeria O.
- Boden W.E.
- Briguori C.
- Broderick S.
- Chaitman B.R.
- Chertow G.M.
- Fleg J.L.
- Herzog C.A.
- Hochman J.S.
- Huang Z.
- Kaul U.
- Kretov E.I.
- Mark D.B.
- Maron D.J.
- Mathew R.O.
- Mazurek T.
- Newman J.D.
- O'Brien S.M.
- Pracon R.
- Reynolds H.R.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization (if appropriate) added to medical therapy or an initial conservative strategy consisting of medical therapy alone and angiography reserved for those in whom medical therapy had failed. The primary outcome was a composite of death or nonfatal myocardial infarction. A key secondary outcome was a composite of death, nonfatal myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. RESULTS At a median follow-up of 2.2 years, a primary outcome event had occurred in 123 patients in the invasive-strategy group and in 129 patients in the conservative-strategy group (estimated 3-year event rate, 36.4% vs. 36.7%; adjusted hazard ratio, 1.01; 95% confidence interval [CI], 0.79 to 1.29; P=0.95). Results for the key secondary outcome were similar (38.5% vs. 39.7%; hazard ratio, 1.01; 95% CI, 0.79 to 1.29). The invasive strategy was associated with a higher incidence of stroke than the conservative strategy (hazard ratio, 3.76; 95% CI, 1.52 to 9.32; P=0.004) and with a higher incidence of death or initiation of dialysis (hazard ratio, 1.48; 95% CI, 1.04 to 2.11; P=0.03). CONCLUSIONS Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction
Health status after invasive or conservative care in coronary and advanced kidney disease
- Author
- Bangalore S
- Chaitman B.R.
- Chertow G.M.
- Fleg J.L.
- Hochman J.S.
- ISCHEMIA-CKD Research Group: Abdallah M Abdallah Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew Starovoytov, Andrzej \u141abyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-\uc9ric Gagn\ue9, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Bj\uf6rklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Daugas, Erick Alex\ue1nderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Fl\ue1via Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, Fran\ue7ois Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jes\ufas Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaqu\uedn V Pe\uf1afiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-I\uf1iguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Costa Vieira, Jos\ue9 M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, Jos\ue9 Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel L\uf3pez Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio C\ue9sar Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Shinseki, Matthew Weir, Maura Carina N\ue9dio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdo\u144czyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula Garc\ueda-Gonz\ue1lez, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto Ren\ue9 Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth P\ue9rez-Fern\ue1ndez, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, S\ue9rgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, S\uedlvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, T\ue9odora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fern\ue1ndez-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-R\uedos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek P\ue9pin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
- Jones P.G.
- Mark D.B.
- Maron D.J.
- O'Brien S.M.
- Reynolds H.R.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of <30 ml per minute per 1.73 m2 or receipt of dialysis). A secondary objective of the trial was to assess angina-related health status. METHODS We assessed health status with the Seattle Angina Questionnaire (SAQ) before randomization and at 1.5, 3, and 6 months and every 6 months thereafter. The primary outcome of this analysis was the SAQ Summary score (ranging from 0 to 100, with higher scores indicating less frequent angina and better function and quality of life). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate the treatment effect with the invasive strategy. RESULTS Health status was assessed in 705 of 777 participants. Nearly half the participants (49%) had had no angina during the month before randomization. At 3 months, the estimated mean difference between the invasive-strategy group and the conservative-strategy group in the SAQ Summary score was 2.1 points (95% credible interval, 120.4 to 4.6), a result that favored the invasive strategy. The mean difference in score at 3 months was largest among participants with daily or weekly angina at baseline (10.1 points; 95% credible interval, 0.0 to 19.9), smaller among those with monthly angina at baseline (2.2 points; 95% credible interval, 122.0 to 6.2), and nearly absent among those without angina at baseline (0.6 points; 95% credible interval, 121.9 to 3.3). By 6 months, the between-group difference in the overall trial population was attenuated (0.5 points; 95% credible interval, 122.2 to 3.4). CONCLUSIONS Participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease did not have substantial or sustained benefits with regard to angina-related health status with an initially invasive strategy as compared with a conservative strategy
Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
- Author
- Abbas Jalal
- Abbate Antonio
- Abdullakutty Jabir
- Abhyanakar Atul D.
- Aboyans Victor
- Abrantes Jose Antonio M.
- Abu-Fadel Mazen
- Acevedo Monica
- Adamkova Vera
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K.
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Aidar Ayoub Jose Carlos
- Airaksinen Juhani K.
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea Y. Y.
- Alan David
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M.
- Alings Marco
- Alonso Martin Joaquin J.
- Alvarisqueta Andres F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Angel Hominal Miguel
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L.
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Arroyo Julian A. Coronel
- Arstall Margaret A.
- Asanin Milika R.
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayala Carlos A. Chavez
- Aylward Philip E.
- Azizad Masoud M.
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Bang Lia E.
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L.
- Barbato Emanuele
- Barna Olga M.
- Barone-Rochette Gilles
- Barr Craig
- Barrucco Robert
- Bartels Gerard L.
- Bashir Riyaz
- Bastos Jose Mesquita
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Belhassane Abdelkader
- Benedicto Amparo
- Bengus Cristina M.
- Benov Haralambi O.
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
- Berli Mario A.
- Berlowitz Michael
- Berman Brett
- Bernan Alisa
- Berti Sergio
- Bhagwat Ajit
- Bhagwat Ravi
- Bhansali Prasant
- Bhatt Deepak L.
- Binder Ronald
- Birchem Jessica
- Bittner Vera A.
- Blicharski Tomasz
- Blok Thomas
- Blumberg Eduardo D. S.
- Boccara Franck
- Bodanese Luiz C.
- Bodi Peris Vicente
- Boecker Dirk
- Bojovski Stojko
- Bokarev Igor
- Bokern Marcel J. J. A.
- Bonfanti Alberto J. Cadena
- Bono Julio O. E.
- Bordonava Anselmo P.
- Borse Rohidas
- Bortnick Anna
- Bos Robert J.
- Botas Rodriguez Javier
- Botelho Ana
- Botelho Roberto V.
- Botia Diana C. Luna
- Bottcher Morten
- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun-Dullaeus Ruediger
- Breedveld Robert W.
- Brennan J. Matthew
- Brodison Adrian
- Bronzwaer Patrick N. A.
- Brueren Bart R. G.
- Bruguera Cortada Jordi
- Budaj Andrzej
- Bugan Viliam
- Busmane Arija
- Bustamante Labarta Miguel H.
- Busz-Papiez Benita
- Butler Rob
- Bystryk Leszek
- Caccavo Alberto
- Caime Guillermo D.
- Calabro Paolo
- Camprubi Potau Mercedes
- Camsari Ahmet
- Caraco Yoseph
- Carey Charles
- Carlson Eric
- Carnero Gabriela S.
- Carranza Madrigal Jaime
- Carrillo Calvillo Jorge
- Carroll Patrick A.
- Cartasegna Luis R.
- Carter Luther
- Caruso Orlando C.
- Cassimjee Soraya
- Castadot Marc
- Cavallini Claudio
- Cequier Fillat Angel R.
- Cerqueira Maria Jose A. G.
- Cestari Horacio G.
- Cevc Matija
- Cha James
- Chae In-Ho
- Chaitman Bernard
- Chalavarya Gopal
- Chaleff Fred
- Chambilla Jesus M. Carrion
- Chandna Harish
- Chane Majed
- Chang Mark
- Chaudhary Sanjeev
- Chavez V-ctor E. Rodriguez
- Chen Dandan
- Chen Jiyan
- Chen Yundai
- Cheng Shi-Chi
- Cheng Xiaoshu
- Chiang Chern-En
- Chizhov Petr
- Chopda Manoj
- Chopra Vijay K.
- Christenson Stuart
- Chu Alan
- Chua Terrance
- Chumakova Galina
- Chumburidze Vakhtang
- Civeira Murillo Fernando
- Claeys Marc
- Claxton Edmund, Jr.
- Clemmensen Peter
- Clerc Jerome
- Cleveland David
- Clifford Piers
- Clifton Shaun
- Coching Raul Martin
- Codutti Oscar R.
- Cohen Steven
- Collins Nicholas
- Colombo Hugo R.
- Colquhoun David
- Commerford Patrick J.
- Concha Yudy M. Roldan
- Conrad Gary
- Constantine Godwin
- Constantinescu Mircea C. A.
- Convens Carl
- Cools Frank
- Corbett Clive
- Cornel Jan H.
- Correa Flores Roger M.
- Cosavalente Luis A. Camacho
- Cosin Sales Juan
- Costa Fernando
- Coste Pierre
- Cottin Yves
- Coufal Zdenek
- Coverdale Steven G. M.
- Cristian Gabriel
- Cruz Fernandez Jose M.
- Cuccia Claudio
- Cui Lan
- Cyster Henry P.
- Czerski Tomasz
- D'Urso Michael
- Daboul Nizar
- Dagher Georges
- Dahl Charles
- Dai Kazuoki
- Dalby Anthony J.
- Danchin Nicolas
- Dandillaya Ramprasad
- Daniels Christopher
- Das Srihari
- Davidovic Goran
- Davidsen Flemming
- Davies Richard
- Davis William
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- De Berrazueta Fernandez Jose R.
- De Cesare Nicoletta B.
- De Leo Alessandro
- De Luca Giuseppe
- De Mora Martin Manuel
- De Pellegrin Annamaria
- De Salazar Dora I. Molina
- de Santos Mayler O. N.
- de Silva H. Asita
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- de Souza Juliana A.
- De Wolf Luc
- Delarche Nicolas
- Deloatch Shalonda
- Demirtas Mustafa
- Denham Douglas
- Devarapalli Sai K.
- DeVore Adam D.
- Diamantis Steve
- Diaz Fernandez Jose Francisco
- Diaz Ariel
- Diaz Rafael
- Dickey Sheila
- Dilic Mirza
- Dimkovic Sinisa
- Dimov Bojidar I.
- Dincic Dragan V.
- Ding Chunhua
- Dion Danielle
- Dodds George, III
- Dodic Slobodan
- Dombrowski Keith
- Doncovska Snezana
- Dong Shaohong
- Dong Yugang
- Dorobantu Maria
- Dorsel Thomas
- Dran Ricardo D.
- Drexel Heinz
- Drzewiecka Anna
- Ducas John
- Ducrocq Gregory
- Duda Norberto
- Dujardin Karl
- Dukat Andrej
- Dulak Elzbieta
- Dupuis Robert
- Durak-Nalbantic Azra
- Duronto Ernesto A.
- Dzupina Andrej
- Dzyak Georgiy
- Eagerton Donald
- Eapen Zubin
- East Cara
- Eaton Charles
- Ebrahim Iftikhar O.
- Edelberg Jay M.
- Edes Istvan
- Egorova Liudmila
- Eisenberg Steven
- Ekanayaka Ruvan
- El Shahawy Mahfouz
- El-Ahdab Fadi
- Elias Mazen
- Eliaschewitz Freddy G.
- Elliott John
- Endsley Patricia
- Eppinger Arleen
- Erglis Andrejs
- Ersanli Murat
- Fadlallah Hussein
- Faes Dirk
- Faggiano Pompilio
- Fairlamb James
- Fajardo Campos Pedro
- Falukozy Jozsef
- Fang Chih-Yuan
- Fang Weiyi
- Fanghanel Salmon Guillermo
- Farhat Naim
- Farrar Michael
- Fausto Ovando Sergio R.
- Fazekas Frantisek
- Fazlibegovic Emir
- Feitosa Gilson S.
- Fell David
- Feng Yi
- Fernandes Manenti Euler Roberto F.
- Fernandez Portales Javier
- Fernandez Angela M.
- Fernandez Mauricio
- Fernando Nimali
- Ferrari Emile
- Ferratini Maurizio
- Ferrolino Arthur
- Filardi Pasquale Perrone
- Fischer Stuart
- Fishberg Robert
- Fisher Daniel
- Fisher Nicholas
- Fisher Raewyn
- Florenzano Fernando
- Flores Enrique
- Flores Romulo E. Oqueli
- Fong Peter
- Forgosh Les
- Foster Malcolm
- Foster Robert
- Francis Adi
- Franek Edward
- Fras Zlatko
- French William J.
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- Frost Lars
- Fu Guosheng
- Fuchs Shmuel
- Fuentes Jimenez Francisco
- Fujii Kenshi
- Fujimoto Kazuteru
- Fujinaga Hiroyuki
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- Fulwani Mahesh C.
- Furukawa Yutaka
- Galski Thomas
- Galvani Marcello
- Gapon Liudmila
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- Garcia Castillo Armando
- Garcia Duran Ruben O.
- Garcia Lledo Jose Alberto
- Garcia-Dorado David
- Gardner Geraldine
- Garrahy Paul J.
- Garrido Marcelo
- Garza Ruiz Jose Angel
- Gavish Dov
- Ge Junbo
- Gelormini Joseph
- Gerber Jaime
- Gerber Robert
- Ghitis Arnold
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- Gibson Paul
- Gielen Stephan
- Giesler Gregory
- Gil-Extremera Blas
- Gilbert John M.
- Gillespie Eve
- Gilmore Richard
- Gimple Lawrence
- Giordano Jorge A.
- Giorgeto Flavio E.
- Gislason Gunnar
- Giuliano Maria E.
- Gniot Jacek
- Goch Aleksander
- Goloborodko Borys
- Gomez Vilamajo Oscar A.
- Gonsorcik Jozef
- Gonzales Rolando J. Vargas
- Gonzalez Diaz Belinda
- Gonzalez Salas Luis Gerardo
- Gonzalez-Juanatey Carlos
- Gonzalez-Juanatey Jose R.
- Goodman Shaun G.
- Gordeev Ivan
- Gordienko Alexander
- Gorny Jerzy
- Gosselin Gilbert
- Gosselink Antonius T. M.
- Gotcheva Nina N.
- Govinda Ravishankar A.
- Goyal Naresh K.
- Gremmler Uwe
- Grewal Jasprakash Singh
- Griffiths Huw
- Gring Christian
- Groenemeijer Bjorn E.
- Groutars Reginald G. E. J.
- Guardigli Gabriele
- Guerrero De Leon Maria
- Guha Santanu
- Gullestad Lars
- Guneri Sema
- Guo Ying
- Gurevich Victor
- Gusi Tragant Gabriel
- Guzman Pablo N.
- Haddad Tariq
- Hagstrom Emil
- Hahalis P. I. Georgios
- Halabi Majdi
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- Hald Flemming
- Haldis Thomas
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- Hameed Adnan
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- Hanotin Corinne
- Hansen Ole
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- Harding Scott
- Harkut Pankaj
- Harrington Robert A.
- Harris Barry
- Harris Bill
- Hart Hamish
- Hata Yoshiki
- Hattler Brack
- Hedman Anu
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- Heinc Petr
- Heitzer Thomas
- Hemetsberger Rayyan
- Henderson David
- Henkin Yaakov
- Herath Jagath I.
- Herazo Aristides Sotomayor
- Hermans Kurt
- Hermans Walter R. M.
- Hernandez Henry A. Anchante
- Herrman Johannes P. R.
- Hersbach Ferry M. R. J.
- Herzog William, Jr.
- Hess Connie Ng
- Higashikata Toshinori
- Higuera Juan Diego
- Hii Chris L. S.
- Hirayama Atsushi
- Hirooka Keiji
- Hlatky Mark A.
- Hoag Gordon
- Hodes Zachary
- Hoffer Etienne
- Hoffman David
- Hong Taekjong
- Hoogslag Pieter A. M.
- Hoppe Uta
- Horak David
- Horowitz John
- Horvath Ivan
- Horwitz Phillip
- Hove Jens D.
- Hrabar Adrian D.
- Hranai Marian
- Hsieh I-Chang
- Huang Lan
- Huang Shi'An
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- Huang Weijian
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- Huikuri Heikki
- Hunter John
- Hurtig Ulf
- Hussein Osamah
- Huynh Thao
- Hwang Juey-Jen
- Ilic Stevan
- Ilieva-Pandeva Katya A.
- Ince Carlos
- Iniguez Andres
- Iqbal Syed M. R.
- Irimpen Anand
- Istratoaie Octavian
- Ito Kashima
- Ivanov Igor G.
- Ivanova Raya
- Ivanovic Nikola
- Iyengar Shamanna S.
- Izzo Mark
- Jacoby Douglas
- Jafar Zubair
- Jaffrani Naseem
- Jain Diwakar
- Janik Matthew
- Janosik Denise
- Jaramillo Nicolas
- Jatin Fernando G. Manzur
- Jaworska Krystyna
- Jayawardena Jayanthimala
- Jensen Steen Agergaard
- Jeong Myung Ho
- Jeppesen Jorgen
- Jeserich Michael
- Jiang Weihong
- Jintapakorn Woravut
- Johansen Peter Betton
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- Jones William Schuyler
- Jordan Joseph Dedrick
- Jortveit Jarle
- Joshi Abhijeet B.
- Joshi Parag
- Jovin Ion
- Jujjuru Srimannarayana
- Jukema J. Wouter
- Juonala Markus
- Jure Horacio O.
- Jurgaitiene Ruta
- Kadr Honer
- Kaewsuwanna Pinij
- Kahali Dhiman
- Kaikkonen Kari
- Kaiser Sergio
- Kalashetti Suhas
- Kalil Renato
- Kamensky Gabriel
- Kamiya Haruo
- Kandasamy Balachandran
- Kapin Tibor
- Kaplan Refik
- Kapp Ilse E.
- Karalis Ioannis
- Karlsberg Ronald
- Karna Sunil
- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Katona Andras
- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
- Kedev Sasko
- Keen William
- Kehasukcharoen Wirash
- Kelsey Sheryl F.
- Kerkar Prafulla
- Khabeishvili George
- Khaira Ajit S.
- Khaisheva Larisa
- Khan Abul
- Khan Aziz
- Khan Misal
- Khasanov Niiaz
- Khintibidze Irakli
- Khurana Sandeep
- Kibarskis Aleksandras
- Kichukov Kostadin N.
- Killat Holger
- Kim Chongjin
- Kim Hyo Soo
- Kim Moo Hyun
- Kim Sang-Hyun
- Kimmelstiel Carey
- Kimura Kazuo
- Kimura Takeshi
- King Marilyn
- Kinzfogl George, III
- Kirma Cevat
- Kishi Koichi
- Kiss Robert Gabor
- Kiviniemi Tuomas
- Kjovkaroski Aleksandar
- Klancke Kim
- Klantsa Andriy
- Klausen Ib C.
- Kline Geoffrey
- Klutstein Marc
- Knickelbine Thomas
- Knowles Joshua W.
- Knutson Thomas
- Koba Shinji
- Kobalava Zhanna
- Kobayashi John
- Koike Akihiro
- Koldas Lale
- Kolls Bradley J.
- Kondo Nicholas I.
- Kong David F.
- Kopytsya Mykola
- Koren Michael
- Kormann Adrian
- Kornder Jan
- Kornowski Ran
- Korol Marek
- Kosinski Edward
- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
- Kouz Simon
- Kovalskyi Ihor
- Kozuma Ken
- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S.
- Kubica Jacek
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- Kultursay Hakan
- Kumar Anil
- Kumar Priya
- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
- Kurian John
- Kushnir Mykola
- Kutniy Oles
- Kyiak Yulian
- Labroo Ajay
- Lai Christopher
- Lai Wen-Ter
- Lambert Charles, Jr.
- Landzberg Joel
- Larry John
- Larsen John
- Laucevicius Aleksandras
- Laufs Ulrich
- Laxson David
- Lazov Petar V.
- Leaes Paulo E.
- Leclercq Florence
- Lee Kaeng
- Lee Kwan
- Lefevre Thierry
- Leggewie Stefan
- Lehman Sam J.
- Leimbach Wayne
- Lekakis John
- Leon Reynaldo P. Castillo
- Leonardi Sergio
- Leone Attilio
- Lepage Serge
- Lepor Norman
- Leshchuk Oleh
- Lester F. Martin
- Leung Raymond
- Levy Terry
- Li Huanming
- Li Jianping
- Li Xiaodong
- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
- Libov Igor
- Licciardello Giovanni
- Lieber Ira
- Liem Anho A. H.
- Liew Houng B.
- Lillis Linda
- Lin Jinxiu
- Lin Wei Hsiang
- Lin Wenhua
- Lin Xuefeng
- Lindsey Jason
- Linhart Ales
- Link Chad
- Lip Gregory Y. H.
- Lipar Luka
- Lipko Jan Andrzej
- Liu Ming-En
- Liu Shaowen
- Llamas Esperon Guillermo Antonio
- Loizeau Virginie
- Loma-Osorio Rincon Pablo
- Lomakin Nikita V.
- Lomholdt Jens D.
- Lominadze Zaza
- Lopes Renato D.
- Lopez Rosas Enrique
- Lopez Rodrigo Botero
- Lopez-Jaramillo Patricio
- Lorenzatti Alberto J.
- Lotan Chaim
- Lottering Hanlie
- Lotun Kapildeo
- Loussararian Arthur
- Love Michael
- Lozada Henry J. Garcia
- Lozance Nensi
- Lubinski Andrzej
- Luciardi Hector L.
- Lui Henry
- Luis Zamorano Jose
- Luo Zhurong
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo A.
- Lyamina Nadezhda
- Lysek Roman
- M Escudier Juan
- MacDonald Paul
- Macdonell Alexander
- Mach Francois
- Machado Leandro
- Machova Vilma
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- Mahajan Ajaykumar
- Mahal Sharan
- Maia Lilia Nigro
- Majercak Ivan
- Makotoko Ellen Makoali
- Malhotra Vinay
- Malik Amir
- Malozzi Christopher
- Malynovsky Yaroslav
- Manakshe Gajendra V.
- Mannucci Jorge E. Bravo
- Mano Toshiaki
- Manolis Athanassios
- Mansourati Jacques
- Marais H. John
- Marcus Jill
- Marin Neto Jose A.
- Marin Francisco
- Markov Dimitar T.
- Markov Valentin
- Maron David J.
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- Martins Dinis
- Martsin Kaja
- Marusincova Ivana
- Marx Nikolaus
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- Maskon Oteh
- Matas Pericas Laia
- Matei Adrian V.
- Mathews Robin
- Mathur Anthony
- Mathur Rishabh
- Matiga Generoso
- May Ole
- May Wade
- Mayurathan Gnanamoorthy
- Mazur Juraj
- Mcclure Sam
- Mcgarvey Joseph, Jr.
- Mcgough Martin
- Mclaurin Brent
- Medrano Allende Juan C.
- Mehta Rajendra H.
- Mehta Shamir
- Meloni Chiara
- Mendis Sepalika
- Mendonca Carlos
- Mendoza Jose L. Accini
- Mentz Robert J.
- Merkely Bela
- Michalaros Yorghos L.
- Michaud Nicolas
- Michishita Ichiro
- Micko Karol
- Midzic Zlatko
- Miguel Sandra A. Negron
- Miklaszewicz Beata
- Militaru Constantin
- Mincheva Valentina M.
- Minescu Bogdan
- Mintale Iveta
- Mirek-Bryniarska Ewa
- Misonis Nerijus
- Moccetti Tiziano
- Mody Freny
- Mohamed Wan Mohd Izani Wan
- Mohart Ann Elizabeth
- Molchanova Olga
- Mollov Mihail N.
- Montalescot Gilles
- Montana Oscar R.
- Monteiro Minguel R.
- Monteiro Pedro
- Montenegro Valdovinos Pablo Carlos
- Moodley Rajendran
- Morais Joao
- Morales Dante D.
- Moran Joseph
- Moreira Humberto Graner
- Morel Olivier
- Moriarty Andrew
- Moriarty Patrick M.
- Morino Yoshihiro
- Moris De La Tassa Cesar
- Morisset Anne
- Moryusef Angele
- Mosseri Morris
- Mostovoy Yuriy
- Motovska Zuzana
- Moura Jorge Jose C.
- Mourtzinis Georgios
- Mudawi Telal
- Mueller Christian
- Muenzel Thomas
- Mulkay Angel
- Muller Christian
- Muller Gabor
- Munk Peter S.
- Munusamy Vengatesh
- Murin Jan
- Muslibegovic Adis
- Musumeci Giuseppe
- Muthusamy Rangasamy
- Mutlu Bulent
- Mynhardt Joseph H.
- Myshanych Halyna
- Nacoud Ackar Alfredo
- Nager Paul
- Nagy Lajos
- Nahhas Ahed
- Nani Sebastian
- Naplava Robert
- Natour Mohammed
- Navarro Nassip C. Llerena
- Nelson William
- Neuenschwander Fernando
- Nicol Peter
- Nicolau Jose C.
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- Nielsen Tonny
- Nieminen Markku S.
- Nigro Frank
- Nijmeijer Remco
- Nikolaev Konstantin
- Nikolov Fedya P.
- Nikolsky Eugenia
- Nishibe Akira
- Nociar Jan
- Nogareda Gustavo
- Norkiene Sigute
- Novaretto Leonardo P.
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nowins Rosemary
- Nunez Fragoso Juan Carlos
- Nunez Carlos A. Zea
- Nygard Ottar
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- Oklukar Janez
- Olivares Claudia
- Oliver Richard
- Olsson Anders G.
- Omran Heyder
- Ong Hean Yee
- Ong Tiong Kiam
- Ono Yujiro
- Oomen Antonius
- Oomman Abraham
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- Palka Juraj
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- Palvarini Michela
- Panchal Vipul
- Pancholy Samir
- Pandey Amritanshu
- Pandurangi Ulhas
- Parada Jeffrey Castellanos
- Parepa Irinel R.
- Park Hun Sik
- Park Hyeun (Tom)
- Parkhomenko Alexander
- Parthenakis P. I. Frangkiskos
- Pasquini John
- Patange Aparna
- Patel Chetan B.
- Paterlini Gustavo A.
- Patil Sachin N.
- Patki Nitin
- Patocchi Cristian A.
- Patsilinakos Sotiris
- Pawlowicz Lidia
- Pearce Stephen
- Pecin Ivan
- Pella Daniel
- Peng Daoquan
- Penny William, Jr.
- Pepine Carl
- Pereira Edward
- Pereira Helder H.
- Pereira Sabrina Bernardez
- Perez Rios Jesus Antonio
- Perez Enrique S. Sanabria
- Perez Luis
- Perkins Lynn
- Perlmutter Neal
- Pesant Yves
- Petranov Stanislav L.
- Petrulioniene Zaneta
- Piatti Piermarco
- Picone Mark
- Piepiorka Marek
- Pillay Thayabran
- Pimentel Filho Pedro
- Pincetti Cristian
- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
- Plaza Perez Ignacio
- Podoleanu Cristian G. C.
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
- Pollock Stewart
- Pontaga Natalija
- Pope Theodore
- Pordy Robert
- Porthan Kimmo
- Porwal Sanjay
- Posio Pirjo
- Pothineni Ramesh B.
- Potthoff Sergio
- Poulsen Steen Hvitfeldt
- Povolny Petr
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- Povzun Anton
- Precoma Dalton B.
- Premchand Rajendra K.
- Prieto Juan-Carlos
- Probst Vincent
- Proddutur Naveen Reddy
- Prokhorov Alexander
- Puccioni Enrico
- Puri Sanjeev
- Purow Joshua
- Putnikovic Biljana
- Puymirat Etienne
- Qu Baiming
- Radin Michael
- Radovanovic Slavica
- Raev Dimitar H.
- Raffel Owen
- Raffo Carlos A.
- Raghuraman Bagirath
- Rahman Aref
- Raisinghani Ajit
- Rajapaksha Ajantha
- Ramos Lopez Gabriel Arturo
- Ranadive Nandkishore
- Ranjith Naresh
- Rao Sunder
- Rasmanis Gundars
- Rauch-Kroehnert Ursula
- Raungaard Bent
- Ray Kausik K.
- Ray Michael
- Rech Rafael
- Reiner Zeljko
- Reis Gilmar
- Reis Helder J. L.
- Rensing Bernard J. W. M.
- Reshetko Olga
- Reshotko Dmytro
- Reuter Helmuth
- Reynolds Timothy
- Rha Seungwoon
- Rider James
- Rishko Mykola
- Ristic Arsen D.
- Ritt Luiz Eduardo F.
- Roberts-Thomson Philip
- Robinson Simon
- Rodes-Cabau Josep
- Rodriguez De Leon Edgar R.
- Roe Matthew T.
- Rogelio Gregorio
- Rogers James F.
- Rogers William, Jr.
- Rokyta Richard
- Romeo Stefano
- Ronner Eelko
- Roosen John
- Rosenberg Michael
- Rosenschein Uri
- Rosenson Robert
- Rossi Paulo R. F.
- Rossi Peter
- Rosu Doina
- Rouleau Jean-Lucien
- Rozenman Yoseph
- Rubenstein Howard
- Rudenko Anatolii
- Rudenko Leonid
- Ruiz Ricardo L. Fernandez
- Saaiman Jan A.
- Saathe Shireesh
- Saavedra Silvia S.
- Sabatino Kenneth
- Sabbah Eric
- Sader Mark
- Sakagami Satoru
- Sakalyte Gintare
- Sakamoto Tomohiro
- Salcido Vazquez Eduardo
- Salvioni Alessandro
- Saminski Krzysztof
- Sandhu Manjinder
- Sansanayudh Nakarin
- Santharaj Wijeyasingam
- Saporito Wladimir
- Sarkar David
- Sarvan Mahomed
- Sassone Sonia A.
- Sastravaha Krisada
- Savard Daniel
- Sawhney Jitendra
- Schaeufele Tim
- Schellenberg Detlev
- Schiavi Lilia B.
- Schiele Francois
- Schifferdecker Branislav
- Schmalfuss Carsten
- Schmedtje John F., Jr.
- Schmidberg Jorge M.
- Schmidt Ekkehard
- Schuchard Timothy
- Schwartz Gregory G.
- Schwartz Michael
- Schwartz Steven
- Sciborski Ryszard
- Scott Douglas
- Sebastian Peter J.
- Seferovic Petar
- Seixo Filipe
- Selecky Juraj
- Senaratne Manohara
- Senaratne Vajira
- Sethi Sumeet
- Shaburishvili Tamaz
- Shah Anil V.
- Shah Bimal R.
- Shah Vipul
- Shalaev Sergey
- Sharman David
- Shaw James
- Shechter Michael
- Shehova-Yankova Nina S.
- Sheldon William
- Sherwood Matthew W.
- Shetty Sanjay
- Shi Xubo
- Shimizu Masatoshi
- Shinde Rituparna
- Shinke Toshiro
- Shogenov Zaur
- Shou Xiling
- Shoukfeh Mohammad
- Shustov Sergey
- Shvarts Yury
- Sijbrands Eric J. G.
- Silva Ricardo P.
- Silva Sandra I. Barrera
- Silveira Jose A.
- Silver Kevin
- Simaitis Audrius
- Sime Iveta
- Simic Dragan
- Simonis Gregor
- Simoons Maarten L.
- Singal Dinesh
- Singh Narendra
- Sinha Dhurjati
- Sinnaeve Peter
- Sionis Dimitrios
- Sirisena Thilak
- Siu David C. W.
- Skonieczny Grzegorz
- Skorski Marcin
- Skoumas Ioannis
- Slapikas Rimvydas
- Smik Rudolf
- Soggia Ana Priscila
- Soonfuang Wasant
- Soopold sllar
- Soots Mai
- Soran Handrean
- Soroka Eugene
- Sotnikova Tatiana
- Sousa Luciano
- Souza Weimar K. S. B.
- Soward Allan
- Sparby Jon Arne
- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
- Sritara Piyamitr
- Staneta Pawel
- Stanislavchuk Mykola
- Stankovic Aleksandar
- Starmer Gregory
- Stasek Josef
- Stasiewski Arkadiusz
- Steg Gabriel
- Steg Philippe Gabriel
- Steiner Stephan
- Stellbrink Christoph
- Stewart Ralph
- Stojic Stevo
- Stone James
- Storey Robert
- Strader James, Jr.
- Strain Janet
- Stratmann Matthias
- Strbova Jaroslava
- Strelnieks Aldis
- Striekwold Harry
- Stringfellow Kenya
- Stryuk Raisa
- Su Guohai
- Su Xi
- Suarez Otero Rodrigo
- Subkovas Eduardas
- Sudnik Wanda
- Sugino Hiroshi
- Suh David
- Sujjavanich Darin
- Sukonthasarn Apichard
- Suligoj Natasa Cernic
- Sumner Andrew
- Sun Yuemin
- Sundelin Torbjorn
- Sundram P. Sandy
- Suryapranata Harry
- Sussex Bruce
- Svab Premysl
- Sy Rody G.
- Sy Rosa Allyn G.
- Sydow Karsten
- Szarek Michael
- Szpajer Michal
- Taguchi Shuichi
- Takahashi Toshiyuki
- Takata Theodore
- Takeda Yoshihiro
- Tan Edgar
- Tashchuk Viktor
- Tasic Nebojsa
- Taskinen Marja-Riitta
- Taurio Jyrki
- Ternouth Ian
- Terzic Ibrahim
- Tesloianu Dan N.
- Tespili Maurizio
- Teufel Edward
- Thakkar Maitreya
- Thew Stephen
- Ticona Jorge R. Calderon
- Tirador Louie
- Tissera Nirmali
- Todorov Georgi V.
- Toma Mustafa
- Tomala Tadeusz
- Tonnessen Glen
- Torstensson Ingemar
- Toursarkissian Nicole
- Tov Naveh
- Treasure Charles, II
- Tretyakova Tatyana V.
- Trevelyan Jasper
- Triana Miguel A. Urina
- Troquay Roland P. Th
- Trotter Charlene
- Tsai Wei-Chuan
- Tse Hung-Fat
- Tseluyko Vira
- Tsimikas Sotirios
- Tumbev Haralin S.
- Tunon Fernandez Jose
- Tunon Jose
- Turgeman Yoav
- Turi Tibor
- Turk Samir
- Tyrenko Vadim V.
- Tzekova Maria L.
- Ueda Yasunori
- Uehara Hiroki
- Ueng Kwo-Chang
- Ungi Imre
- Ural Ertan
- Ushakov Olexiy
- Utsu Noriaki
- Vahula Veiko
- Vakaluyk Ihor
- Valgimigli Marco
- Vallejo Gregorio Sanchez
- Vallejos Julio A.
- Van Der Wal Ruud M. A.
- Van Der Zwaan Coenraad C.
- van Diepen Sean F. P.
- Van Huysduynen-Monraats Pascalle S. Hooft
- Van Zyl Louis J.
- Vardi Gil
- Varleta Paola
- Vatutin Mykola
- Vedere Amarnath
- Vejar Margarita
- Velasquez Julio R. Durand
- Velcheva Elena S.
- Verdel Gerardus J. E.
- Vered Zvi
- Vervoort Geert
- Vico Marisa L.
- Vida Manuel
- Videbaek Lars
- Vidotti Maria H.
- Vidovich Mladen
- Viergever Eric P.
- Viigimaa Margus
- Vijay Nampalli
- Vijayaraghavan Ram
- Vikman Saila
- Viktorova Inna
- Violini Roberto
- Vishnevsky Alexander Y.
- Vizel Saul
- Vo Anthony
- Voeller Heinz
- Voevoda Mikhail I.
- Vogel Robert
- Vohra Rakesh
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias C. M.
- Vulic Dusko
- Vuurmans Tycho
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D.
- Waites Jonathon H.
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wang Jian'An
- Wang Jianzhong
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weissbrodt Matthias
- Welka Stephen
- Welker James
- Wells Terry
- Werner Nikos
- Westerhausen Donald, Jr.
- Whitaker Jack
- White Harvey D.
- White Lindsey
- White Matthew
- Wiersma Jacobijne J.
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F.
- Wilson Matthew D.
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewoda Pawel
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wright Scott
- Xatzitolios Apostolos
- Xavier Denis
- Xenakis Mark
- Xu Biao
- Xu Dingli
- Xu Xiping
- Yagensky Andriy
- Yakushin Sergey
- Yan Andrew Tze-Kay
- Yan Bryan P. Y.
- Yanez Mario
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
- Zaidman Cesar J.
- Zainea Mark
- Zaman Azfar
- Zeiher Andreas M.
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Xingsheng
- Zheng Yang
- Zheng Zeqi
- Zhou Yujie
- Zhu Hong
- Zirlik Andreas
- Zizka Jiri
- Zong Wenxia
- Zrazhevsky Konstantin
- Zuniga Jose D. Hernandez
- Zurakowski Aleksander
- Zuran Ivan
- Zweiker Robert
- Publication venue
- Publication date
- 01/01/2020
- Field of study