Cortisol Reactivity Across the Day at Child Care: Examining the Contributions of Child Temperament and Attachment to Mother and Lead Teacher

Previous work has shown that full-day center-based child care is associated with increased physiologic stress for many young children (e.g., Tout, de Haan, Campbell, & Gunnar, 1998; Watamura, Sebanc, & Gunnar, 2002). Specifically, increasing cortisol from morning to afternoon at full-day child care in contrast to decreasing cortisol across the day for these same children at home has been repeatedly demonstrated for toddlers and preschoolers. Factors that have been related to rising cortisol across the day at child care include the child\u27s age (rising cortisol at child care between 2 and 5 years, but not for infants or older children, Dettling, Parker, Lane, Sebanc, & Gunnar, 2000; Watamura, Donzella, Alwin, & Gunnar, 2003), and global classroom quality (higher quality classrooms having fewer children showing rising cortisol across the day, e.g., Sims, Guilfoyle, & Parry, 2006). Some studies have also identified relations with particular temperaments (e.g., Watamura, et al., 2002). Furthermore, recent work suggests that rising cortisol at child care may be associated with health risk in the form of lower antibody levels (Watamura, Coe, Laudenslager, & Robertson, 2009) and that early child care may be associated with attenuated cortisol in adolescence (Roisman, et al., 2009). This study extended the previous work on stress reactivity at child care by addressing: 1) whether children\u27s attachment to their primary caregiver was associated with how they respond to the challenge of child care; 2) whether negative child temperament alone or in combination with insecure attachment was associated with how they respond to the challenge of child care; and 3) whether the nature of children\u27s attachment to their teacher explained how they respond to the challenge of child care. Saliva samples were collected on three child care days at mid-morning and mid-afternoon. Temperament was assessed by both parents (CBQ; Putnam & Rothbart, 2006) and teachers (T-CBQ; Gunnar, Tout, de Haan, Pierce, S., & Stanbury, 1997) and attachment security was measured using the AQS (Waters, 1995) with the primary caregiver and lead teacher. Children rated as high in both security and dependency to their primary caregiver were more likely than secure children with low dependency or insecure children to show rising cortisol across the day at child care. In addition, children who scored lower on the teacher sorted AQS sociability factor (but not on the CBQ or T-CBQ temperament factors) were more likely to show rising cortisol across the day at child care. Finally, higher security with teachers was associated with falling cortisol across the day at child care. These results suggest that in the process of acquiring a solidified working model of secure attachment to primary caregivers, children who are secure but still dependent may be more stress reactive to out-of-home care. Furthermore, as these results demonstrate that secure relationships with teachers may buffer children from flat or rising cortisol at child care, they suggest a concrete avenue for intervention

Association between 5-HTTLPR and Borderline Personality Disorder Traits among Youth

This study provides the first genetic association examination of borderline personality disorder (BPD) traits in children and adolescents (ages 9–15) using two independent samples of youth recruited from the general community. We tested the a priori hypothesis that the serotonin transporter promoter gene (5-HTTLPR) would relate specifically to BPD traits in youth. This association was hypothesized based on prior genetic association research with BPD adults and theory positing that emotion dysregulation may be a core risk process contributing to BPD. Youth provided DNA via buccal cells. Both youth and a parent completed self-report measures assessing youth's BPD traits and depressive symptoms. Results from both Study 1 (N = 242) and an independent replication sample of Study 2 (N = 144) showed that carriers of the short allele of 5-HTTLPR exhibited the highest levels of BPD traits. This relation was observed even after controlling for the substantial co-occurrence between BPD traits and depressive symptoms. This specific association between 5-HTTLPR and BPD traits among youth supports previous genetic associations with adults diagnosed with BPD and provides preliminary support for a developmental extension of etiological risk for BPD among youth

Parental depression and child cognitive vulnerability predict children\u27s cortisol reactivity

Risk for depression is expressed across multiple levels of analysis. For example, parental depression and cognitive vulnerability are known markers of depression risk, but no study has examined their interactive effects on children\u27s cortisol reactivity, a likely mediator of early depression risk. We examined relations across these different levels of vulnerability using cross-sectional and longitudinal methods in two community samples of children. Children were assessed for cognitive vulnerability using self-reports (Study 1; n = 244) and tasks tapping memory and attentional bias (Study 2; n = 205), and their parents were assessed for depression history using structured clinical interviews. In both samples, children participated in standardized stress tasks and cortisol reactivity was assessed. Cross-sectionally and longitudinally, parental depression history and child cognitive vulnerability interacted to predict children\u27s cortisol reactivity; associations between parent depression and elevated child cortisol activity were found when children also showed elevated depressotypic attributions as well as attentional and memory biases. Findings indicate that models of children\u27s emerging depression risk may benefit from the examination of the interactive effects of multiple sources of vulnerability across levels of analysis

Interactive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood

- Background: Given mixed findings as to whether stressful experiences and relationships are associated with increases or decreases in children's cortisol reactivity, we tested whether a child's developmental history of risk exposure explained variation in cortisol reactivity to an experimentally induced task. We also tested whether the relationship between cortisol reactivity and children's internalizing and externalizing problems varied as a function of their developmental history of stressful experiences and relationships. - Method: Participants included 400 children (M = 9.99 years, SD = 0.74 years) from the Children's Experiences and Development Study. Early risk exposure was measured by children's experiences of harsh, nonresponsive parenting at 3 years. Recent risk exposure was measured by children's exposure to traumatic events in the past year. Children's cortisol reactivity was measured in response to a social provocation task and parents and teachers described children's internalizing and externalizing problems. - Results: The effect of recent exposure to traumatic events was partially dependent upon a child's early experiences of harsh, nonresponsive parenting: the more traumatic events children had recently experienced, the greater their cortisol reactivity if they had experienced lower (but not higher) levels of harsh, nonresponsive parenting at age 3. The lowest levels of cortisol reactivity were observed among children who had experienced the most traumatic events in the past year and higher (vs. lower) levels of harsh, nonresponsive parenting in early childhood. Among youth who experienced harsh, nonresponsive parent–child relationships in early childhood and later traumatic events, lower levels of cortisol reactivity were associated with higher levels of internalizing and externalizing problems. - Conclusions: Hypothalamic–pituitary–adrenal (HPA) axis reactivity to psychological stressors and the relationship between HPA axis reactivity and children's internalizing and externalizing problems vary as a function of a child's developmental history of exposure to stressful relationships and experiences

Longitudinal examination of infant baseline and reactivity cortisol from ages 7 to 16 months

This study characterized the longitudinal evolution of HPA axis functioning from 7 to 16 months of age and identified individual and environmental factors that shape changes in HPA axis functioning over time. Participants were 167 mother–infant dyads drawn from a larger longitudinal study, recruited based on maternal history of being maltreated during childhood. Salivary cortisol levels were assessed before and after age‐appropriate psychosocial stressors when infants were 7 and 16 months old. Maternal observed parenting and maternal reports of infant and environmental characteristics were obtained at 7 months and evaluated as predictors of changes in infant baseline cortisol and reactivity from 7 to 16 months. Results revealed that infants did not show a cortisol response at 7 months, but reactivity to psychosocial stress emerged by 16 months. Individual differences in cortisol baseline and reactivity levels over time were related to infant sex and maternal overcontrolling behaviors, underscoring the malleable and socially informed nature of early HPA axis functioning. Findings can inform prevention and intervention efforts to promote healthy stress regulation during infancy. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 356–364, 2015.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110887/1/dev21296.pd

A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: A longitudinal cohort study

Background: In this study, we investigated whether an abnormal hypothalamic-pituitary-adrenal (HPA) axis response to psychosocial stress at 18 years of age is associated with musculoskeletal (MS) pain alone and MS pain combined with increased pain sensitivity at 22 years of age. Methods: The study sample included 805 participants from the Western Australian Pregnancy Cohort (Raine) Study who participated in the Trier Social Stress Test (TSST) at age 18 years. Number of pain sites, pain duration, pain intensity and pain frequency were assessed at age 22 to measure severity of MS pain. Cold and pressure pain thresholds were determined at age 22. Group-based trajectory modeling was applied to establish cortisol response patterns based on the TSST. Logistic regression was used to study the association of TSST patterns with MS pain alone and MS pain combined with increased cold or pressure pain sensitivity, adjusted for relevant confounding factors. All analyses were stratified by sex. Results: The mean (standard deviation) age during the TSST was 18.3 (0.3) years, and during MS pain assessment it was 22.2 (0.6). Forty-five percent of the participants were female. Three cortisol response patterns were identified, with cluster 1 (34 % of females, 21 % of males) reflecting hyporesponse, cluster 2 (47 %, 54 %) reflecting intermediate response and cluster 3 (18 %, 24 %) reflecting hyperresponse of the HPA axis. MS pain was reported by 42 % of females and 33 % of males at age 22 years. Compared with females in cluster 2, females in cluster 1 had an increased likelihood of having any MS pain (odds ratio 2.3, 95 % confidence interval 1.0-5.0) and more severe MS pain (2.8, 1.1-6.8) if their cold pain threshold was above the median. In addition, females in cluster 1 had an increased likelihood (3.5, 1.3-9.7) of having more severe MS pain if their pressure pain threshold was below the median. No statistically significant associations were observed in males. Conclusions: This study suggests that a hyporesponsive HPA axis at age 18 years is associated with MS pain at 22 years in young females with increased pain sensitivity

A Halfway House Program for Deaf Psychiatric Patients

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