Front Psychiatry

OBJECTIVE: During the COVID-19 pandemic, older people and patients with psychiatric disorders had an increased risk of being isolated. The French National Authority for Health has recommended a reinforced follow-up of these patients. Cross-sectional studies reported an increased risk of developing anxiety and depression during pandemic. The aim of our study was to identify factors associated with higher anxiety during the pandemic in older patients with psychiatric disorders. METHODS: STERACOVID is a multicenter cohort study with 117 patients followed-up by phone in two French geriatric psychiatry units. In this work, we used cross-sectional data from a prospective follow-up conducted between January and May 2021. RESULTS: We found that coping strategies, personality, and living conditions were associated with general anxiety (GA) level during the pandemic period. Higher GA was associated with less positive thinking coping strategy, more avoidance strategies, a lower level of extraversion, a higher level of neuroticism, more time spent watching the news, a higher feeling of loneliness, and a lack of physical contact. FINDINGS: Our study identified factors associated with a poorer experience of pandemic crisis. Special attention should be paid to patients with a high level of neuroticism and a high feeling of loneliness. Support could aim to help patients use more functional strategies: reducing avoidance strategies and increasing positive thinking. Finally, reducing time watching news could also be an interesting prevention perspective. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT04760795

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

Rubin-Euclid Derived Data Products:Initial Recommendations

This report is the result of a joint discussion between the Rubin and Euclid scientific communities. The work presented in this report was focused on designing and recommending an initial set of Derived Data products (DDPs) that could realize the science goals enabled by joint processing. All interested Rubin and Euclid data rights holders were invited to contribute via an online discussion forum and a series of virtual meetings. Strong interest in enhancing science with joint DDPs emerged from across a wide range of astrophysical domains: Solar System, the Galaxy, the Local Volume, from the nearby to the primaeval Universe, and cosmology

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

La situation de la communication interne en PME : ébauche d'une typologie

Cet article aborde le thème de la communication interne, c’est-à-dire l’ensemble des transmissions et échanges d’information internes dans le contexte particulier de la PME. On y propose une typologie de la situation de la communication interne qui repose sur deux dimensions pertinentes puisque liées au dirigeant, acteur central de la PME. Ces dimensions tiennent, d’une part, à l’intérêt qu’il manifeste pour la communication interne dans son entreprise et; d’autre part, à ses représentations concernant les acteurs de l’entreprise. La typologie est illustrée à l’aide de 10 exemples concrets tirés d’études in situ réalisées dans des PMI d’une cinquantaine de salariés. Elle constitue un moyen original de diagnostic et d’orientation pour l’action.This paper deals with the internal communication problem, understood as the transmission and exchange of information within a small to medium sized business. A classification of the situation of internal communication in the particular context of small to medium sized business is suggested. It is based on two dimensions that are relevant to this kind of firm as it focuses : on the one hand on the interest he has in the internal communication for the development of his firm, on the other, on the representation he has of the employees of the firm. The classification is illustrated with ten real cases that stem from in situ surveys, conducted in companies of about 50 employees. It is an original tool for diagnosis and action.Este articulo aborda el tema de la comunicación interna, es decir, el conjunto de las transmisiones e intercambios de información internos en el contexto particular de la PyME. Se propone una tipología de la situación de la comunicación interna que reposa sobre dos dimensiones relacionadas con el dirigente, actor central de la PyME. Una de estas dimensiones cubre el interés que manifiesta el dirigente por la comunicación interna en su empresa y la otra, las representaciones de este sobre los actores de la empresa. La tipología, ilustrada por diez ejemplos concretos extraídos de estudios in situ realizados en diferentes PyMEs de aproximadamente cincuenta de empleados, constituye un medio original de diagnóstico y de orientación para la acción

Informatisation de la gestion des compétences : évaluation de la démarche dans une collectivité territoriale

Notion répandue mais difficile à cerner, la gestion des compétences peut être définie comme une instrumentation sur laquelle les acteurs professionnels de la GRH se fondent pour instruire leurs décisions de gestion (Gilbert, 2003). Constituée d'un « ensemble de pratiques visant à acquérir, stimuler et réguler les compétences des salariés » (Defélix et Retour, 2003), elle permet d'améliorer l'adéquation entre les compétences nécessaires et les compétences disponibles, pour optimiser la compéti..

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Complex oxides on semiconductors for nanoelectronic applications

March 15-19, 2015International audienceno abstrac

Complex oxides on semiconductors for nanoelectronic applications

March 15-19, 2015International audienceno abstrac