97 research outputs found
Front Psychiatry
OBJECTIVE: During the COVID-19 pandemic, older people and patients with psychiatric disorders had an increased risk of being isolated. The French National Authority for Health has recommended a reinforced follow-up of these patients. Cross-sectional studies reported an increased risk of developing anxiety and depression during pandemic. The aim of our study was to identify factors associated with higher anxiety during the pandemic in older patients with psychiatric disorders. METHODS: STERACOVID is a multicenter cohort study with 117 patients followed-up by phone in two French geriatric psychiatry units. In this work, we used cross-sectional data from a prospective follow-up conducted between January and May 2021. RESULTS: We found that coping strategies, personality, and living conditions were associated with general anxiety (GA) level during the pandemic period. Higher GA was associated with less positive thinking coping strategy, more avoidance strategies, a lower level of extraversion, a higher level of neuroticism, more time spent watching the news, a higher feeling of loneliness, and a lack of physical contact. FINDINGS: Our study identified factors associated with a poorer experience of pandemic crisis. Special attention should be paid to patients with a high level of neuroticism and a high feeling of loneliness. Support could aim to help patients use more functional strategies: reducing avoidance strategies and increasing positive thinking. Finally, reducing time watching news could also be an interesting prevention perspective. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov, identifier NCT04760795
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
Rubin-Euclid Derived Data Products:Initial Recommendations
This report is the result of a joint discussion between the Rubin and Euclid scientific communities. The work presented in this report was focused on designing and recommending an initial set of Derived Data products (DDPs) that could realize the science goals enabled by joint processing. All interested Rubin and Euclid data rights holders were invited to contribute via an online discussion forum and a series of virtual meetings. Strong interest in enhancing science with joint DDPs emerged from across a wide range of astrophysical domains: Solar System, the Galaxy, the Local Volume, from the nearby to the primaeval Universe, and cosmology
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
La situation de la communication interne en PMEÂ : Ă©bauche d'une typologie
Cet article aborde le thĂšme de la communication interne, câest-Ă -dire lâensemble des transmissions et Ă©changes dâinformation internes dans le contexte particulier de la PME. On y propose une typologie de la situation de la communication interne qui repose sur deux dimensions pertinentes puisque liĂ©es au dirigeant, acteur central de la PME. Ces dimensions tiennent, dâune part, Ă lâintĂ©rĂȘt quâil manifeste pour la communication interne dans son entreprise et; dâautre part, Ă ses reprĂ©sentations concernant les acteurs de lâentreprise. La typologie est illustrĂ©e Ă lâaide de 10 exemples concrets tirĂ©s dâĂ©tudes in situ rĂ©alisĂ©es dans des PMI dâune cinquantaine de salariĂ©s. Elle constitue un moyen original de diagnostic et dâorientation pour lâaction.This paper deals with the internal communication problem, understood as the transmission and exchange of information within a small to medium sized business. A classification of the situation of internal communication in the particular context of small to medium sized business is suggested. It is based on two dimensions that are relevant to this kind of firm as it focuses : on the one hand on the interest he has in the internal communication for the development of his firm, on the other, on the representation he has of the employees of the firm. The classification is illustrated with ten real cases that stem from in situ surveys, conducted in companies of about 50 employees. It is an original tool for diagnosis and action.Este articulo aborda el tema de la comunicaciĂłn interna, es decir, el conjunto de las transmisiones e intercambios de informaciĂłn internos en el contexto particular de la PyME. Se propone una tipologĂa de la situaciĂłn de la comunicaciĂłn interna que reposa sobre dos dimensiones relacionadas con el dirigente, actor central de la PyME. Una de estas dimensiones cubre el interĂ©s que manifiesta el dirigente por la comunicaciĂłn interna en su empresa y la otra, las representaciones de este sobre los actores de la empresa. La tipologĂa, ilustrada por diez ejemplos concretos extraĂdos de estudios in situ realizados en diferentes PyMEs de aproximadamente cincuenta de empleados, constituye un medio original de diagnĂłstico y de orientaciĂłn para la acciĂłn
Informatisation de la gestion des compétences : évaluation de la démarche dans une collectivité territoriale
Notion rĂ©pandue mais difficile Ă cerner, la gestion des compĂ©tences peut ĂȘtre dĂ©finie comme une instrumentation sur laquelle les acteurs professionnels de la GRH se fondent pour instruire leurs dĂ©cisions de gestion (Gilbert, 2003). ConstituĂ©e d'un « ensemble de pratiques visant Ă acquĂ©rir, stimuler et rĂ©guler les compĂ©tences des salariĂ©s » (DefĂ©lix et Retour, 2003), elle permet d'amĂ©liorer l'adĂ©quation entre les compĂ©tences nĂ©cessaires et les compĂ©tences disponibles, pour optimiser la compĂ©ti..
Complex oxides on semiconductors for nanoelectronic applications
March 15-19, 2015International audienceno abstrac
Complex oxides on semiconductors for nanoelectronic applications
March 15-19, 2015International audienceno abstrac
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