Perturbation Theory of the Hooke\u27s Law Model for the Two‐Electron Atom

The Hooke model for the two‐electron atom replaces the electron–nuclear interaction by a harmonic oscillator potential, but retains the Coulomb repulsion of the electrons. The first‐order perturbation equation for the electron repulsion is solved analytically, and the exact first‐, second‐, and third‐order perturbation energies are obtained. A similar Z-1 perturbation treatment is carried out for the Hartree–Fock equation and other variational approximations. The Z-1 of the correlation energy is compared with that for helium-like atoms and found to be similar

Sand in the wheels, or oiling the wheels, of international finance? : New Labour's appeal to a 'new Bretton Woods'

Tony Blair’s political instinct typically is to associate himself only with the future. As such, his explicit appeal to ‘the past’ in his references to New Labour’s desire to establish a “new Bretton Woods” is sufficient in itself to arouse some degree of analytical curiosity (see Blair 1998a). The fact that this appeal was made specifically in relation to Bretton Woods is even more interesting. The resonant image of the international economic context established by the original Bretton Woods agreements invokes a style and content of policy-making which Tony Blair typically dismisses as neither economically nor politically consistent with his preferred vision of the future (see Blair 2000c, 2001b)

Teaching with Digital 3D Models of Minerals and Rocks

The disruption to geoscience curricula due to the COVID-19 pandemic highlights the difficulty of making mineral and rock samples accessible to students online rather than through traditional lab classes. In spring 2020, our community had to adapt rapidly to remote instruction; this transition amplified existing disparities in access to geoscience education but can be a catalyst to increase accessibility and flexibility in instruction permanently. Fortunately, a rich collection of 3D mineral and rock samples is being generated by a community of digital modelers (e.g., Perkins et al., 2019)

Some mechanisms of "spontaneous" polarization of superfluid He-4

Previously, a quantum "tidal" mechanism of polarization of the atoms of He-II was proposed, according to which, as a result of interatomic interaction, each atom of He-II acquires small fluctuating dipole and multipole moments, oriented chaotically on the average. In this work, we show that, in the presence of a temperature or density gradient in He-II, the originally chaotically oriented tidal dipole moments of the atoms become partially ordered, which results in volume polarization of He-II. It is found that the gravitational field of the Earth induces electric induction U =10(-7)V in He-II (for vessel dimensions of the order of 10 cm). We study also the connection of polarization and acceleration, and discuss a possible nature of the electric signal dU = kdT/2e observed by A.S. Rybalko in experiments with second sound.Comment: 13 pages; the calculation is extended and refined; v4: reconstructio

Catchment Level Water Resource Constraints on UK Policies for Low-Carbon Energy System Transitions by 2030.

The UK government has proposed different low-carbon energy system options that lead to meeting its greenhouse gas emissions target of 80% reduction on 1990 levels by 2050. While these energy system options meet emission targets at feasible economic cost, water requirement for the deployment of the proposed energy technology mix is not adequately accounted for. This may become critical, as some of the proposed energy technologies are relatively more water-intensive, and could result in significant future water resource constraints. Previous studies have analyzed the potential water resource constraints of future energy systems in the UK at national scale. However, water must be considered as a local resource with significant regional variability. This paper uses a linear spatial-downscaling model to allocate water-intensive energy system infrastructure/technologies at catchment level, and estimates water requirements for the deployment of these technologies for the Committee on Climate Change Carbon Budgets in 2030. The paper concludes that while national-scale analysis shows minimal long-term water related impacts, catchment level appraisal of water resource requirements reveals significant constraints in some locations. This has important implications for regions where the water-energy nexus must be analyzed at appropriate spatial resolution to capture the full water resource impact of national energy policy

Proteome-based plasma biomarkers for Alzheimer's disease

Alzheimer's disease is a common and devastating disease for which there is no readily available biomarker to aid diagnosis or to monitor disease progression. Biomarkers have been sought in CSF but no previous study has used two-dimensional gel electrophoresis coupled with mass spectrometry to seek biomarkers in peripheral tissue. We performed a case-control study of plasma using this proteomics approach to identify proteins that differ in the disease state relative to aged controls. For discovery-phase proteomics analysis, 50 people with Alzheimer's dementia were recruited through secondary services and 50 normal elderly controls through primary care. For validation purposes a total of 511 subjects with Alzheimer's disease and other neurodegenerative diseases and normal elderly controls were examined. Image analysis of the protein distribution of the gels alone identifies disease cases with 56% sensitivity and 80% specificity. Mass spectrometric analysis of the changes observed in two-dimensional electrophoresis identified a number of proteins previously implicated in the disease pathology, including complement factor H (CFH) precursor and α-2-macroglobulin (α- 2M). Using semi-quantitative immunoblotting, the elevation of CFH and α- 2M was shown to be specific for Alzheimer's disease and to correlate with disease severity although alternative assays would be necessary to improve sensitivity and specificity. These findings suggest that blood may be a rich source for biomarkers of Alzheimer's disease and that CFH, together with other proteins such as α- 2M may be a specific markers of this illness. © 2006 The Author(s).link_to_subscribed_fulltex

Amyloid prions in fungi

ABSTRACT Prions are infectious protein polymers that have been found to cause fatal diseases in mammals. Prions have also been identified in fungi (yeast and filamentous fungi), where they behave as cytoplasmic non-Mendelian genetic elements. Fungal prions correspond in most cases to fibrillary β-sheet-rich protein aggregates termed amyloids. Fungal prion models and, in particular, yeast prions were instrumental in the description of fundamental aspects of prion structure and propagation. These models established the “protein-only” nature of prions, the physical basis of strain variation, and the role of a variety of chaperones in prion propagation and amyloid aggregate handling. Yeast and fungal prions do not necessarily correspond to harmful entities but can have adaptive roles in these organisms.</jats:p