Effects of cellulose nanofibrils on the structure and properties of maleic anhydride crosslinked poly(vinyl alcohol) electrospun nanofibers

Nanofibers of poly(vinyl alcohol) (PVA) reinforced with cellulose nanofibrils (CNFs) and/or crosslinked with maleic anhydride (MA) were produced by electrospinning technique to compare the additivation effects of the polymeric matrix. The results suggested that the PVA mass fraction equal to 14%, CNFs volumetric fraction of 3% and maleic acid at the molar ratio 20:1 are the best proportions for renewable base fibres production. In this study, the best electrospinning parameters for membranes production were obtained at the applied voltage of 24 kV, needle tip-to-collector distance of 14.5 cm, feed rate of 0.3 mL h1 and using a plate collector. CNFs and MA additions allow to improve nanofiber thermal properties and resistance to water degradation, which result in an eco-friendlier, biocompatible and long-term biodegradable nanofiber mats with diameters of 74±33 nm for water filtration purposes.The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for funding the project UID/CTM/00264/2013 and A. Zille contract IF/00071/2015.info:eu-repo/semantics/publishedVersio

Quantum Processes in Neurophotonics and the Origin of the Brain\u27s Spatiotemporal Hierarchy

We review the brain\u27s complex dynamical organization necessary for cognition and consciousness and conclude that, rather than a linear computer of neuronal synapses, the brain seems to function more as a nonlinear spatiotemporal hierarchy of interacting, dynamically layered systems. The brain\u27s hierarchy apparently spans multiple layers covering at least 12 orders of magnitude reaching from large (nearly brain-wide, ∼10 cm), relatively slow (\u3c100 \u3eHertz, “Hz”) processes based on neuronal membranes and synaptic network activities (e.g., electroencephalography, “EEG”), downward and inward to increasingly smaller and faster molecular scales inside neurons including kilohertz (103 Hz), megahertz (106 Hz), gigahertz (109 Hz), and terahertz (1012 Hz) dynamics of cytoskeletal filaments and their constituents at micrometer, nanometer and subnanometer size scales. These faster, smaller processes delve into biomolecular quantum states whose properties are suggested to offer solutions to questions related to cognition and consciousness, but also in the traditional view considered unlikely in the “warm, wet, and noisy” biological brain milieu. Here we contend that functional neurological quantum states—nontrivial in their manifestation at mesoscopic and macroscopic scales and possibly useful for signaling and information processing—can originate in either (1) photoexcited transition-state dipoles of aromatic networks, driven by endogenous photon emissions generated during aerobic processes, or (2) collective electronic behaviors due to van der Waals interactions in such aromatic networks, which can result in a hierarchical cascade of coherent oscillations spanning 12 or more orders of magnitude. Cognitive processing and consciousness may occur in this cascade due to nonlinear amplification of resonances among coherent brain states.https://nsuworks.nova.edu/cps_facbooks/1587/thumbnail.jp

Screening for subtelomeric chromosome abnormalities in children with idiopathic mental retardation using multiprobe telomeric FISH and the new MAPH telomeric assay.

Subtelomeric chromosomal abnormalities are emerging as an important cause of human genetic disorders. The scope of this investigation was to screen a selected group of children with idiopathic mental retardation for subtelomeric anomalies using the multiprobe telomeric FISH method and also to develop and test a new assay, the MAPH telomeric assay, in the same group of patients. The new MAPH telomeric assay uses the recently published MAPH methodology that permits the measurement of locus copy number by hybridisation with a specifically designed set of probes located at the end of human chromosomes. Seventy patients with idiopathic mental retardation have been screened using the established multiprobe telomeric FISH assay and the new MAPH telomeric assay, for all telomeres. One patient with de novo 8p subtelomeric deletion was identified. The new MAPH telomeric assay confirmed the same results in both normal and abnormal samples. This is the first description of the use of MAPH methodology to detect chromosomal imbalances near the telomeres in idiopathic mentally retarded patients. The new MAPH telomeric assay offers a new, fast, accurate and cost effective diagnostic tool to detect chromosomal imbalances near telomeres in mentally retarded patients, as well as the characterisation of known chromosomal abnormalities, spontaneous recurrent miscarriages, infertility, hematological malignancies, preimplantation genetic diagnosis, and other fields of clinical and research interests