Investigaciones sobre paz, conflictos y violencia en México

En cumplimiento a la normatividad sobre el acceso abierto de la investigación científica, esta obra se pone a disposición del público en su versión electrónica en el repositorio de la uaemex (http:// ri.uaemex.mx) para su uso en línea con fines académicos y no de lucro, por lo que se prohíbe la reproducción parcial o total, directa o indirecta del contenido de esta presentación impresa sin contar previamente con la autorización expresa y por escrito de GEMAporrúa, en términos de lo así previsto por la Ley Federal del Derecho de Autor y, en su caso, por los tratados internacionales aplicables.Bajo la idea de que "merecemos un mundo distinto al que tenemos", este libro ofrece una serie de reflexiones y análisis sobre la paz, algunos conflictos y ciertas formas de violencia desde el "campo" interdisciplinario denominado Estudios para la Paz y el Desarrollo, que se alienta en la Universidad Autónoma del Estado de México, dentro del programa de Maestría del mismo nombre. Quienes escriben en el texto se ubican: o en el ángulo de la investigación para la paz en estricto sentido, o en el ángulo de la investigación para la paz en sentido amplio, que se estimulan y difunden en dicho programa, y que, desde diferentes posturas, alientan escenarios o acciones encaminadas hacia la paz. El libro está dividido en tres secciones, mismas que corresponden a los temas de paz, conflictos y violencia, donde aparecen reflexiones teóricas o empíricas de autores formados o relacionados en el campo

Mexican radiation dermatitis management consensus

Abstract Background: Radiotherapy (RT) is an essential element in cancer treatment: 50–70% of cancer patients receive RT at some time of the course of their disease. Of these, almost 95% experience some grade of radiation dermatitis (RD). RD can affect patient’s quality of life during and after treatment. Consequently, the management of RD is important. There are few randomized controlled clinical trials on interventions used to prevent and treat RD and no standardized consensus on RD management. A panel of opinion leaders of the Mexican Society of Radiotherapy (SOMERA) took part in a study of oncologic practice in Mexico. The following clinical guide is referenced both by the national practice reality and international evidence. Materials and methods: This RD management guide is based on input provided by 25 Mexican radiation oncologists, whose criteria were gathered using the Delphi Method and article review. Results: Twenty-one questions about experience in RD treatment were voted. More than 80% of the panel agreed with: the use of dermocosmetics/medical device in prevention and in treatment of RD grades 1–2. As for grade 3, they recommend individualizing each case and dermatologist evaluation. Topical steroids should be used when there is skin itching or pain. Consider the use of natural soaking elements. Skin care must be continued to avoid or reduce severity of late radiation skin lesions. Conclusion: This consensus was developed as a supportive educational tool that can be adapted to individual clinical needs, useful for professionals involved in the treatment of RT patients.  

una mirada desde las Ciencias de la Conducta

Este libro es el resultado de los trabajos presentados en el 1er Congreso Internacional "Convivencia y bienestar con sentido humanista para una cultura de paz"

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Aspirara un mundo distinto

En cumplimiento a la normatividad sobre el acceso abierto de la investigación científica, esta obra se pone a disposición del público en su versión electrónica en el repositorio de la uaemex (http:// ri.uaemex.mx) para su uso en línea con fines académicos y no de lucro, por lo que se prohíbe la reproducción parcial o total, directa o indirecta del contenido de esta presentación impresa sin contar previamente con la autorización expresa y por escrito de GEMAporrúa, en términos de lo así previsto por la Ley Federal del Derecho de Autor y, en su caso, por los tratados internacionales aplicables.Bajo la idea de que "merecemos un mundo distinto al que tenemos", este libro ofrece una serie de reflexiones y análisis sobre la paz, algunos conflictos y ciertas formas de violencia desde el "campo" interdisciplinario denominado Estudios para la Paz y el Desarrollo, que se alienta en la Universidad Autónoma del Estado de México, dentro del programa de Maestría del mismo nombre. Quienes escriben en el texto se ubican: o en el ángulo de la investigación para la paz en estricto sentido, o en el ángulo de la investigación para la paz en sentido amplio, que se estimulan y difunden en dicho programa, y que, desde diferentes posturas, alientan escenarios o acciones encaminadas hacia la paz. El libro está dividido en tres secciones, mismas que corresponden a los temas de paz, conflictos y violencia, donde aparecen reflexiones teóricas o empíricas de autores formados o relacionados en el campo

How to develop research by Professors and students to achieve a better teaching: transfer of results within and from the public University

El proyecto trata de mejorar la visibilidad de la relación entre investigación y docencia, permitiendo a los estudiantes conocer otra labor de sus profesores en la Universidad y animando su participación en actividades de transferencia a la sociedad.This project tries to enhance the visibility between research and teaching. It allows the students to know other tasks carried out by the University Professors. It seeks ways to promote their participation in activities of transfer of knowledge to society.Depto. de Derecho Mercantil, Financiero y TributarioFac. de DerechoFALSEsubmitte

Neonatal Infection Due to SARS-CoV-2: An Epidemiological Study in Spain

Objective: Coronavirus disease 2019 (COVID-19) cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to increase worldwide. Although some data from pediatric series are available, more evidence is required, especially in neonates, a group with specific characteristics that deserve special attention. This study aimed to describe general and clinical characteristics, management, and treatment of postnatal-acquired (community and nosocomial/hospital-acquired) COVID-19 neonatal cases in Spain. Methods: This was a national prospective epidemiological study that included cases from a National Registry supported by the Spanish Society of Neonatology. Neonates with postnatal SARS-CoV-2 infection were included in this study. General data and infection-related information (mode and source of transmission, age at diagnosis, clinical manifestations, need for hospitalization, admission unit, treatment administered, and complementary studies performed, hospital stay associated with the infection) were collected. Results: A total of 40 cases, 26 community-acquired and 14 nosocomial were registered. Ten were preterm newborns (2 community-acquired and 8 nosocomial COVID-19 cases). Mothers (in both groups) and healthcare workers (in nosocomial cases) were the main source of infection. Hospital admission was required in 22 community-acquired cases [18 admitted to the neonatal intermediate care unit (NIMCU) and 4 to the neonatal intensive care unit (NICU)]. Among nosocomial COVID-19 cases (n = 14), previously admitted for other reasons, 4 were admitted to the NIMCU and 10 to the NICU. Ten asymptomatic patients were registered (5 in each group). In the remaining cases, clinical manifestations were generally mild in both groups, including upper respiratory airways infection, febrile syndrome or acute gastroenteritis with good overall health. In both groups, most severe cases occurred in preterm neonates or neonates with concomitant pathologies. Most of the cases did not require respiratory support. Hydroxychloroquine was administered to 4 patients in the community-acquired group and to 2 patients in the nosocomial group. Follow-up after hospital discharge was performed in most patients. Conclusions: This is the largest series of COVID-19 neonatal cases in Spain published to date. Although clinical manifestations were generally mild, prevention, treatment, and management in this group are essential