8,789 research outputs found
Bosonic versus fermionic pairs of topological spin defects in monolayered high-T_c superconductors
The energy associated with bosonic and fermionic pairs of topological spin
defects in doped antiferromagnetic quantum spin-1/2 square lattice is estimated
within a resonating valence bond scenario, as described by a t-t'-J-like model
Hamiltonian, plus a t-perpendicular, responsible of a three-dimensional
screening of the electrostatic repulsion within the bosonic pairs. For
parameters appropriate for monolayered high-T_c superconductors, both fermionic
and bosonic pairs show x^2-y^2 symmetry. We find a critical value of doping
such that the energy of the bosonic pairs goes below twice the energy of two
fermionic pairs at their Fermi level. This finding could be related to the
onset of high-T_c superconductivity.Comment: 10 pages, 6 figures. To be published in Phys. Rev.
Deep and superficial amygdala nuclei projections revealed in vivo by probabilistic tractography
Copyright © 2011 Society for Neuroscience and the authors. The The Journal of Neuroscience uses a Creative Commons Attribution-NonCommercial-ShareAlike licence: http://creativecommons.org/licenses/by-nc-sa/4.0/.Despite a homogenous macroscopic appearance on magnetic resonance images, subregions of the amygdala express distinct functional profiles as well as corresponding differences in connectivity. In particular, histological analysis shows stronger connections for superficial (i.e., centromedial and cortical), compared with deep (i.e., basolateral and other), amygdala nuclei to lateral orbitofrontal cortex and stronger connections of deep compared with superficial, nuclei to polymodal areas in the temporal pole. Here, we use diffusion weighted imaging with probabilistic tractography to investigate these connections in humans. We use a data-driven approach to segment the amygdala into two subregions using k-means clustering. The identified subregions are spatially contiguous and their location corresponds to deep and superficial nuclear groups. Quantification of the connection strength between these amygdala clusters and individual target regions corresponds to qualitative histological findings in non-human primates, indicating such findings can be extrapolated to humans. We propose that connectivity profiles provide a potentially powerful approach for in vivo amygdala parcellation and can serve as a guide in studies that exploit functional and anatomical neuroimaging.The Wellcome Trust, a Max Planck Research Award and Swiss National Science Foundation
An O(M(n) log n) algorithm for the Jacobi symbol
The best known algorithm to compute the Jacobi symbol of two n-bit integers
runs in time O(M(n) log n), using Sch\"onhage's fast continued fraction
algorithm combined with an identity due to Gauss. We give a different O(M(n)
log n) algorithm based on the binary recursive gcd algorithm of Stehl\'e and
Zimmermann. Our implementation - which to our knowledge is the first to run in
time O(M(n) log n) - is faster than GMP's quadratic implementation for inputs
larger than about 10000 decimal digits.Comment: Submitted to ANTS IX (Nancy, July 2010
The impact of parental narcissistic traits on self-esteem in adulthood
Very little research directly addresses the question of how a parent\u27s narcissistic traits affect the development of their children into adulthood. In this qualitative study, 9 adults were interviewed to explore how they experienced the effects of a parent\u27s narcissism, especially in relation to their understanding of their own self-esteem in adulthood. All 9 participants identified these parental traits as having an impact on their self-esteem, and nearly all of them (n=8) felt these experiences significantly affected their lives as adults. Many participants described needing external support or validation from others to feel competent or worthy, and some reported feeling as if their entire sense of self was based on how successful they felt in terms of their physical appearance, social life, or educational or career achievements. Participants reported that these effects shaped their relationships with friends or romantic partners in adulthood, and one expressed worrying about the potential impact on her children. Future research should identify factors that mediate the effect of parental narcissism on a child\u27s development in order to provide the most effective interventions
Forecasting and Granger Modelling with Non-linear Dynamical Dependencies
Traditional linear methods for forecasting multivariate time series are not
able to satisfactorily model the non-linear dependencies that may exist in
non-Gaussian series. We build on the theory of learning vector-valued functions
in the reproducing kernel Hilbert space and develop a method for learning
prediction functions that accommodate such non-linearities. The method not only
learns the predictive function but also the matrix-valued kernel underlying the
function search space directly from the data. Our approach is based on learning
multiple matrix-valued kernels, each of those composed of a set of input
kernels and a set of output kernels learned in the cone of positive
semi-definite matrices. In addition to superior predictive performance in the
presence of strong non-linearities, our method also recovers the hidden dynamic
relationships between the series and thus is a new alternative to existing
graphical Granger techniques.Comment: Accepted for ECML-PKDD 201
A Stable Sparse Fear Memory Trace in Human Amygdala
Pavlovian fear conditioning is highly conserved across species, providing a powerful model of aversive learning. In rodents, fear memory is stored and reactivated under the influence of the amygdala. There is no evidence for an equivalent mechanism in primates, and an opposite mechanism is proposed whereby primate amygdala contributes only to an initial phase of aversive learning, subsequently ceding fear memory to extra-amygdalar regions. Here, we reexamine this question by exploiting human high-resolution functional magnetic resonance imaging in conjunction with multivariate methods. By assuming a sparse neural coding, we show it is possible, at an individual subject level, to discriminate responses to conditioned (CS+ and CS-) stimuli in both basolateral and centro-cortical amygdala nuclei. The strength of this discrimination increased over time and was tightly coupled to the behavioral expression of fear, consistent with an expression of a stable fear memory trace. These data highlight that the human basolateral and centro-cortical amygdala support initial learning as well more enduring fear memory storage. A sparse neuronal representation for fear, here revealed by multivariate pattern classification, resolves why an enduring memory trace has proven elusive in previous human studies
Ken&Barbie selectively regulates the expression of a subset of JAK/STAT pathway target genes.
SummaryA limited number of evolutionarily conserved signal transduction pathways are repeatedly reused during development to regulate a wide range of processes. Here we describe a new negative regulator of JAK/STAT signaling and identify a potential mechanism by which the pleiotropy of responses resulting from pathway activation is generated in vivo. As part of a genetic interaction screen, we have identified Ken & Barbie (Ken) [1], which is an ortholog of the mammalian proto-oncogene BCL6 [2], as a negative regulator of the JAK/STAT pathway. Ken genetically interacts with the pathway in vivo and recognizes a DNA consensus sequence overlapping that of STAT92E in vitro. Tissue culture-based assays demonstrate the existence of Ken-sensitive and Ken-insensitive STAT92E binding sites, while ectopically expressed Ken is sufficient to downregulate a subset of JAK/STAT pathway target genes in vivo. Finally, we show that endogenous Ken specifically represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles. Ken therefore represents a novel regulator of JAK/STAT signaling whose dynamic spatial and temporal expression is capable of selectively modulating the transcriptional repertoire elicited by activated STAT92E in vivo
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