22 research outputs found

    Radio-frequency spectrum coding in ultra-long fibre laser based cryptography

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    We propose a new approach for secret key exchange involving the variation of the cavity length of an ultra-long fibre laser. The scheme is based on the realisation that the free spectral range of the laser cavity can be used as an information carrier. We present a proof-of-principle demonstration of this new concept using a 50-km-long fibre laser to link two users, both of whom can randomly add an extra 1-km-long fibre segment

    Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

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    Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

    Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

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    Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

    Broadband light generation in PPLN crystal and its interplay with spatial nonlinear effects

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    International audienceWe study spatio-temporal nonlinear dynamics in periodically-poled lithium niobate crystal. We discuss broadband conversion via cascading second harmonic generation in self-defocusing and self-focusing regime. Measurements well agree with simulations

    Thermal performance investigation of double pass-finned plate solar air heater

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    In this paper, the double pass-finned plate solar air heater was investigated theoretically and experimentally. An analytical model for the air heater was presented. Numerical calculations had been performed under Tanta (latitude, 30° 47'N and longitude, 31°E) prevailing weather conditions. The theoretical predictions indicated that the agreement with the measured performance is fairly good. Comparisons between the measured outlet temperatures of flowing air, temperature of the absorber plate and output power of the double pass-finned and v-corrugated plate solar air heaters were also presented. The effect of mass flow rates of air on pressure drop, thermal and thermohydraulic efficiencies of the double pass-finned and v-corrugated plate solar air heaters were also investigated. The results showed that the double pass v-corrugated plate solar air heater is 9.3-11.9% more efficient compared to the double pass-finned plate solar air heater. It was also indicated that the peak values of the thermohydraulic efficiencies of the double pass-finned and v-corrugated plate solar air heaters were obtained when the mass flow rates of the flowing air equal 0.0125 and 0.0225 kg/s, respectively.Solar air heaters Double pass Fins Thermal performance Thermohydraulic efficiency
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