Relational quality and media use in interpersonal relationships

Author final draft doi:10.1177/1461444807080339This study examined the relationship between relational quality and media use in interpersonal relationships. In addition, the impacts of other potentially important variables such as sex and relationship type of participants and their partners were explored. College student participants focused on interaction experiences with an acquaintance, friend, romantic partner, or family member. Questions addressed the sex of relational partners, how much of participants’ total communication with relational partners is conducted in each of three media (i.e., face-to-face, phone, and internet), and the quality of relationships. Results indicated that participant sex and partner sex did not affect reported media use, whereas relationship type had significant effects on the extent to which face-to-face and telephone communication were used. Specifically, among the college students studied, face-to-face communication was used least with family members and the telephone was used most with family members. Relationships with acquaintances had the lowest relational quality and romantic relationships, while closer, were less satisfying than either family or friendship relationships. Same-sex relationships were perceived as more satisfying than cross-sex relationships. Finally, media use did not predict relational closeness or satisfaction. Results are discussed in light of previous research on mediated interpersonal communication and conceptualizations of the role of communication technology in one’s social life are highlighted

Comprehensive characterization of the Published Kinase Inhibitor Set

Despite the success of protein kinase inhibitors as approved therapeutics, drug discovery has focused on a small subset of kinase targets. Here we provide a thorough characterization of the Published Kinase Inhibitor Set (PKIS), a set of 367 small-molecule ATP-competitive kinase inhibitors that was recently made freely available with the aim of expanding research in this field and as an experiment in open-source target validation. We screen the set in activity assays with 224 recombinant kinases and 24 G protein-coupled receptors and in cellular assays of cancer cell proliferation and angiogenesis. We identify chemical starting points for designing new chemical probes of orphan kinases and illustrate the utility of these leads by developing a selective inhibitor for the previously untargeted kinases LOK and SLK. Our cellular screens reveal compounds that modulate cancer cell growth and angiogenesis in vitro. These reagents and associated data illustrate an efficient way forward to increasing understanding of the historically untargeted kinome

Applications of electrified dust and dust devil electrodynamics to Martian atmospheric electricity

Atmospheric transport and suspension of dust frequently brings electrification, which may be substantial. Electric fields of 10 kVm-1 to 100 kVm-1 have been observed at the surface beneath suspended dust in the terrestrial atmosphere, and some electrification has been observed to persist in dust at levels to 5 km, as well as in volcanic plumes. The interaction between individual particles which causes the electrification is incompletely understood, and multiple processes are thought to be acting. A variation in particle charge with particle size, and the effect of gravitational separation explains to, some extent, the charge structures observed in terrestrial dust storms. More extensive flow-based modelling demonstrates that bulk electric fields in excess of 10 kV m-1 can be obtained rapidly (in less than 10 s) from rotating dust systems (dust devils) and that terrestrial breakdown fields can be obtained. Modelled profiles of electrical conductivity in the Martian atmosphere suggest the possibility of dust electrification, and dust devils have been suggested as a mechanism of charge separation able to maintain current flow between one region of the atmosphere and another, through a global circuit. Fundamental new understanding of Martian atmospheric electricity will result from the ExoMars mission, which carries the DREAMS (Dust characterization, Risk Assessment, and Environment Analyser on the Martian Surface)-MicroARES (Atmospheric Radiation and Electricity Sensor) instrumentation to Mars in 2016 for the first in situ measurements

First measurement of Xi(-) polarization in photoproduction

Despite decades of studies of the photoproduction of hyperons, both their production mechanisms and their spectra of excited states are still largely unknown. While the parity-violating weak decay of hyperons offers a means of measuring their polarization, which could help discern their production mechanisms and identify their excitation spectra, no such study has been possible for doubly strange baryons in photoproduction, due to low production cross sections. However, by making use of the reaction γp→K+K+Ξ−, we have measured, for the first time, the induced polarization, P, and the transferred polarization from circularly polarized real photons, characterized by Cx and Cz, to recoiling Ξ−s. The data were obtained using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab for photon energies from just over threshold (2.4 GeV) to 5.45 GeV. These first-time measurements are compared, and are shown to broadly agree, with model predictions in which cascade photoproduction proceeds through the decay of intermediate hyperon resonances that are produced via relativistic meson exchange, offering a new step forward in the understanding of the production and polarization of doubly-strange baryons

Assignment of a gene (NEMI) for autosomal dominant nemaline myopathy to chromosome I

Nemaline myopathy (NEM) is a neuromuscular disorder characterized by the presence, in skeletal muscle, of nemaline rods composed at least in part of α-actinin. A candidate gene and linkage approach was used to localize the gene (NEM1) for an autosomal dominant form (MIM 161800) in one large kindred with 10 living affected family members. Markers on chromosome 19 that were linked to the central core disease gene, a marker at the complement 3 locus, and a marker on chromosome 1 at the α-actinin locus exclude these three candidate genes. The family was fully informative for APOA2, which is localized to 1q21-q23. NEM1 was assigned to chromosome 1 by close linkage for APOA2, which is localized to 1q21-q23. NEM1 was assigned to chromosome 1 by close linkage to APOA2, with a lod score of 3.8 at a recombination fraction of 0. Recombinants with NGFB (1p13) and AT3 (1q23-25.1) indicate that NEM1 lies between 1p13 and 1q25.1. In total, 47 loci were investigated on chromosomes 1, 2, 4, 5, 7–11, 14, 16, 17, and 19, with no indications of significant linkage other than to markers on chromosome 1