Quantitative Stability and Optimality Conditions in Convex Semi-Infinite and Infinite Programming

This paper concerns parameterized convex infinite (or semi-infinite) inequality systems whose decision variables run over general infinite-dimensional Banach (resp. finite-dimensional) spaces and that are indexed by an arbitrary fixed set T . Parameter perturbations on the right-hand side of the inequalities are measurable and bounded, and thus the natural parameter space is $l_{\infty}(T)$. Based on advanced variational analysis, we derive a precise formula for computing the exact Lipschitzian bound of the feasible solution map, which involves only the system data, and then show that this exact bound agrees with the coderivative norm of the aforementioned mapping. On one hand, in this way we extend to the convex setting the results of [4] developed in the linear framework under the boundedness assumption on the system coefficients. On the other hand, in the case when the decision space is reflexive, we succeed to remove this boundedness assumption in the general convex case, establishing therefore results new even for linear infinite and semi-infinite systems. The last part of the paper provides verifiable necessary optimality conditions for infinite and semi-infinite programs with convex inequality constraints and general nonsmooth and nonconvex objectives. In this way we extend the corresponding results of [5] obtained for programs with linear infinite inequality constraints

Magnetic measurements and kinetic energy of the superconducting condensate in SmBa_2Cu_3O_{7-\delta}

We report in-field kinetic energy results in the temperature region closely below the transition temperature of two differently prepared polycrystalline samples of the superconducting cuprate SmBa$_{\text{2}}$Cu$_{\text{3}}$O$_{7-\delta}$. The kinetic energy was determined from magnetization measurements performed above the irreversibility line defined by the splitting between the curves obtained according the ZFC and FC prescriptions. The results are analyzed in the intermediate field regime where the London approximation can be used for describing the magnetization. From the analysis, estimations were carried out for the penetration depth and the upper critical field of the studied samples.The difference between the kinectic energy magnitudes for the two studied samples is ascribed to effects from granularity.Comment: 11 pages, 6 figures, accepted for publication in Brazilian Journal of Physics Vol. 4

Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice

Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients. We hypothesize that specific Fcγ receptors for IgG constant region participate in atherogenesis by regulating the inflammatory state of lesional macrophages. In vivo we examined the role of activating Fcγ receptors in atherosclerosis progression using bone marrow transplantation from mice deficient in γ-chain (the common signaling subunit of activating Fcγ receptors) to hyperlipidemic mice. Hematopoietic deficiency of Fcγ receptors significantly reduced atherosclerotic lesion size, which was associated with decreased number of macrophages and T lymphocytes, and increased T regulatory cell function. Lesions of Fcγ receptor deficient mice exhibited increased plaque stability, as evidenced by higher collagen and smooth muscle cell content and decreased apoptosis. These effects were independent of changes in serum lipids and antibody response to oxidized low-density lipoproteins. Activating Fcγ receptor deficiency reduced pro-inflammatory gene expression, nuclear factor-κB activity, and M1 macrophages at the lesion site, while increasing anti-inflammatory genes and M2 macrophages. The decreased inflammation in the lesions was mirrored by a reduced number of classical inflammatory monocytes in blood. In vitro, lack of activating Fcγ receptors attenuated foam cell formation, oxidative stress and pro-inflammatory gene expression, and increased M2-associated genes in murine macrophages. Our study demonstrates that activating Fcγ receptors influence the macrophage phenotypic balance in the artery wall of atherosclerotic mice and suggests that modulation of Fcγ receptor-mediated inflammatory responses could effectively suppress atherosclerosis

Supporting conference attendees with visual decision making interfaces

Recent efforts in recommender systems research focus increasingly on human factors affecting recommendation acceptance, such as transparency and user control. In this paper, we present IntersectionExplorer, a scalable visualization to interleave the output of several recommender engines with user-contributed relevance information, such as bookmarks and tags. Two user studies at conferences indicate that this approach is well suited for technical audiences in smaller venues, and allowed the identification of applicability limitations for less technical audiences attending larger events. Copyright held by the owner/author(s)

Brillouin light scattering study of Co2_{2}Cr0.6_{0.6}Fe0.4_{0.4}Al and Co2_{2}FeAl Heusler compounds

The thermal magnonic spectra of Co$_{2}$Cr$_{0.6}$Fe$_{0.4}$Al (CCFA) and Co$_2$FeAl were investigated using Brillouin light scattering spectroscopy (BLS). For CCFA, the exchange constant A (exchange stiffness D) is found to be 0.48 $\mu$erg/cm (203 meV A$^2$), while for Co$_2$FeAl the corresponding values of 1.55 $\mu$erg/cm (370 meV A$^2$) were found. The observed asymmetry in the BLS spectra between the Stokes and anti-Stokes frequencies was assigned to an interplay between the asymmetrical profiles of hybridized Damon-Esbach and perpendicular standing spin-wave modes, combined with the optical sensitivity of the BLS signal to the upper side of the CCFA or Co$_2$FeAl film

Model of nutritional supplementation with hepatotrophic factors increases cell proliferation in the liver of healthy rats

Foram avaliados dois protocolos de administração, em ratos sadios, de uma solução de fatores hepatotróficos (FH), composta por aminoácidos, vitaminas, sais minerais, glicose, insulina, glucagon e triiodotironina (T3). A solução foi administrada durante 10 dias, 40mg/kg/dia, i.p., em duas, grupo 2xFH (n=15), ou três doses, grupo 3xFH (n=15), diárias. Foram observados os efeitos na proliferação celular dos hepatócitos, na angiogênese e na matriz extracelular hepática, assim como as possíveis reações adversas. Os animais dos grupos 2xFH e 3xFH apresentaram aumento da massa hepática de 30,1% e 22,5%, respectivamente, em relação ao grupo-controle (CT; n=15). O índice de proliferação hepatocelular foi maior nos grupos 2xFH (1,4%) e 3xFH (1,2%) em relação ao grupo CT (0,53%), e a densitometria relativa do fator de crescimento do endotélio vascular pelo imunoblot não revelou diferença estatística entre os três grupos. Nos grupos 2xFH e 3xFH, houve redução do colágeno intersticial em relação ao grupo CT. A solução de FH estimulou o crescimento hepático e reduziu o volume de colágeno perissinusoidal. A administração em três doses diárias resultou em mortalidade de 26,7%, possivelmente pelo excessivo estresse da manipulação e pela menor adaptação fisiológica dos ratos, o que não ocorreu nos grupos 2xFH e CT. Para esse tipo de abordagem em ratos, o procedimento experimental mais apropriado, seguro, com melhor chance de adaptação dos animais e com resultados significativos é a aplicação dos FH em duas doses diárias.Two protocols of hepatotrophic factors (HF) administration, in solution composed by aminoacids, vitamins, mineral salts, glucose, insulin, glucagon, and triiodothyronine were evaluated in healthy rats. This solution was administered for 10 days, (40mg/kg/day) i.p., in two (group 2xFH; n=15) or three daily doses (group 3xFH n=15). The effects on hepatocytes cell proliferation, angiogenesis, and hepatic extracellular matrix, and also possible adverse reactions were analyzed. Animals of groups 2xFH and 3xFH presented an increase in hepatic mass of 30.1% and 22.5%, respectively, when compared rats of control group (CT; n=15). Hepatocellular proliferation index was higher in rats of groups 2xFH (1.4%) and 3xFH (1.2%) when compared to CT group animals (0.53%), and the relative densitometry of the vascular endothelial growth factor analyzed with immunoblot did not show a significant difference among the three groups. Rats of groups 2xFH and 3xFH showed a reduction of interstitial collagen when compared to CT rats. HF solution stimulated hepatic growth and reduced the volume of perisinusoidal collagen. Administration in three daily doses resulted in 26.7% mortality, possibly due to excessive stress from manipulation and lower physiological adaptation of rats, which did not occur in rats of groups 2xFH and CT. The more appropriate and safer experimental procedure for this approach in rats with higher chance of animal adaptation and significant results is the application of HF in two daily doses