13 research outputs found
Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial
2012 Report on ther State of the Art of Rare Disease Activities in Europe of the European Union Committee of Experts on Rare Diseases (Ireland)
‘The most notorious trouble spot along the entire border’: exploring the dynamics of political violence in an Irish border town, 1971–1974
Tuning Superhydrophobic Nanostructures To Enhance Jumping-Droplet Condensation
It
was recently discovered that condensation growing on a nanostructured
superhydrophobic surface can spontaneously jump off the surface, triggered
by naturally occurring coalescence events. Many reports have observed
that droplets must grow to a size of order 10 μm before jumping
is enabled upon coalescence; however, it remains unknown how the critical
jumping size relates to the topography of the underlying nanostructure.
Here, we characterize the dynamic behavior of condensation growing
on six different superhydrophobic nanostructures, where the topography
of the nanopillars was systematically varied. The critical jumping
diameter was observed to be highly dependent upon the height, diameter,
and pitch of the nanopillars: tall and slender nanopillars promoted
2 μm jumping droplets, whereas short and stout nanopillars increased
the critical size to over 20 μm. The topology of each surface
is successfully correlated to the critical jumping diameter by constructing
an energetic model that predicts how large a nucleating embryo needs
to grow before it can inflate into the air with an apparent contact
angle large enough for jumping. By extending our model to consider
any possible surface, it is revealed that properly designed nanostructures
should enable nanometric jumping droplets, which would further enhance
jumping-droplet condensers for heat transfer, antifogging, and antifrosting
applications
Health diplomacy in action: the cancer legacy of the Good Friday Agreement
2023 marks the 25th anniversary of the Good Friday Agreement, which led peace in Northern Ireland. As well as its impact on peace and reconciliation, the Good Friday Agreement has also had a lasting positive impact on cancer research and cancer care across the island of Ireland. Pursuant to the Good Friday Agreement, a Memorandum of Understanding (MOU) was signed between the respective Departments of Health in Ireland, Northern Ireland and the US National Cancer Institute (NCI), giving rise to the Ireland - Northern Ireland - National Cancer Institute Cancer Consortium, an unparalleled tripartite agreement designed to nurture and develop linkages between cancer researchers, physicians and allied healthcare professionals across Ireland, Northern Ireland and the US, delivering world class research and better care for cancer patients on the island of Ireland and driving research and innovation in the US. </p
Health diplomacy in action: The cancer legacy of the good friday agreement
2023 marks the 25th anniversary of the Good Friday Agreement, which led peace in Northern Ireland. As well as its impact on peace and reconciliation, the Good Friday Agreement has also had a lasting positive impact on cancer research and cancer care across the island of Ireland. Pursuant to the Good Friday Agreement, a Memorandum of Understanding (MOU) was signed between the respective Departments of Health in Ireland, Northern Ireland and the US National Cancer Institute (NCI), giving rise to the Ireland – Northern Ireland – National Cancer Institute Cancer Consortium, an unparalleled tripartite agreement designed to nurture and develop linkages between cancer researchers, physicians and allied healthcare professionals across Ireland, Northern Ireland and the US, delivering world class research and better care for cancer patients on the island of Ireland and driving research and innovation in the US.</p
ATP6V0C variants impair vacuolar V-ATPase causing a neurodevelopmental disorder often associated with epilepsy
The vacuolar H+-ATPase (V-ATPase) is an enzymatic complex that functions in an ATP-dependent manner to pump protons across membranes and acidify organelles, thereby creating the proton/pH gradient required for membrane trafficking by several different types of transporters. We describe heterozygous point variants in ATP6V0C, encoding the c-subunit in the membrane bound integral domain of the V-ATPase, in 27 patients with neurodevelopmental abnormalities with or without epilepsy. Corpus callosum hypoplasia and cardiac abnormalities were also present in some patients. In silico modeling suggested that the patient variants interfere with the interactions between the ATP6V0C and ATP6V0A subunits during ATP hydrolysis. Consistent with decreased V-ATPase activity, functional analyses conducted in Saccharomyces cerevisiae revealed reduced LysoSensor fluorescence and reduced growth in media containing varying concentrations of CaCl2. Knockdown of ATP6V0C in Drosophila resulted in increased duration of seizure-like behavior, and the expression of selected patient variants in Caenorhabditis elegans led to reduced growth, motor dysfunction, and reduced lifespan. In summary, this study establishes ATP6V0C as an important disease gene, describes the clinical features of the associated neurodevelopmental disorder, and provides insight into disease mechanisms