A new sample of bright galaxy pairs in UZC

We present a new sample of bright galaxy pairs extracted applying an objective selection code to UZC catalog.The sample is volume limited to M$_{zw}$ = -18.9 +5 log ${\it h}$ and contains 89 galaxy pairs.We analyze the kinematical, morphological and photometrical properties of galaxies belonging to this sample. We show that velocity separation, $| \Delta v_{r} |$, between pair members is significantly lower in spiral type (S+S) pairs than in early-type (E+E) and mixed (E+S) pairs.This indicates that truly isolated galaxy pairs are more likely to be found among S+S pairs. We show that ellipticals are rare and underluminous in B and that late spirals (T $\ge$ 4) are overluminous. We confirm that the formation of bright ellipticals is a phenomenon linked to group/cluster environment, while galaxy-galaxy interaction may enhance blue luminosity of disk galaxies through SF phenomena. This last statement is supported by the presence of strong FIR emission from early spirals in this sample and by the high frequency of AGN/SB phenomenon, revealed mainly in pairs of low relative radial velocity separation and showing signs of interaction.Comment: A & A accepted, 6 pages, 6 figure

Studying the evolution of large-scale structure with the VIMOS-VLT Deep Survey

The VIMOS-VLT Deep Survey (VVDS) currently offers a unique combination of depth, angular size and number of measured galaxies among surveys of the distant Universe: ~ 11,000 spectra over 0.5 deg2 to I_{AB}=24 (VVDS-Deep), 35,000 spectra over ~ 7 deg2 to I_{AB}=22.5 (VVDS-Wide). The current ``First Epoch'' data from VVDS-Deep already allow investigations of galaxy clustering and its dependence on galaxy properties to be extended to redshifts ~1.2-1.5, in addition to measuring accurately evolution in the properties of galaxies up to z~4. This paper concentrates on the main results obtained so far on galaxy clustering. Overall, L* galaxies at z~ 1.5 show a correlation length r_0=3.6\pm 0.7. As a consequence, the linear galaxy bias at fixed luminosity rises over the same range from the value b~1 measured locally, to b=1.5 +/- 0.1. The interplay of galaxy and structure evolution in producing this observation is discussed in some detail. Galaxy clustering is found to depend on galaxy luminosity also at z~ 1, but luminous galaxies at this redshift show a significantly steeper small-scale correlation function than their z=0 counterparts. Finally, red galaxies remain more clustered than blue galaxies out to similar redshifts, with a nearly constant relative bias among the two classes, b_{rel}~1.4, despite the rather dramatic evolution of the color-density relation over the same redshift range.Comment: 14 pages. Extended, combined version of two invited review papers presented at: 1) XXVIth Astrophysics Moriond Meeting: "From Dark Halos to Light", March 2006, proc. edited by L.Tresse, S. Maurogordato and J. Tran Thanh Van (Editions Frontieres); 2) Vulcano Workshop 2006 "Frontier Objects in Astrophysics and Particle Physics", May 2006, proc. edited by F. Giovannelli & G. Mannocchi, Italian Physical Society (Editrice Compositori, Bologna

The Th17 axis in psoriatic disease : pathogenetic and therapeutic implications

Psoriasis and psoriatic arthritis represent two paradigmatic conditions characterized by chronic inflammation and possibly autoimmunity, despite the absence of known serum autoantibodies. The two diseases, albeit strongly correlated from clinical, genetic, and epidemiogical standpoints, manifest significant differences in terms of etiology and pathogenetic mechanisms. Nonetheless, Th17 cells appear crucial to both diseases, and IL23 is the cytokine involved in determining the fate of naive CD4+ cells to differentiate into a pathogenic phenotype. This basic experimental observation led to a clear understanding of the immune dysfunction causing psoriasis and psoriatic arthritis but, more importantly, also led to new therapeutic approaches. In recent years, monoclonal antibodies directed to IL12/IL23 (ustekinumab) or IL17 (secukinumab, ixekizumab, brodalumab) are being investigated or have proven to be beneficial for patients with psoriatic disease, thus further supporting the view that Th17 cells play a pivotal role in disease onset and perpetuation. These most recent reports indeed represent significant developments that may allow overcoming the TNF\u3b1 pathway as the major therapeutic target in chronic inflammation

Geometrical tests of cosmological models. III. The cosmology-evolution diagram at z=1

The rotational velocity of distant galaxies, when interpreted as a size (luminosity) indicator, may be used as a tool to select high redshift standard rods (candles) and probe world models and galaxy evolution via the classical angular diameter-redshift or Hubble diagram tests. We implement the proposed testing strategy using a sample of 30 rotators spanning the redshift range 0.2<z<1 with high resolution spectra and images obtained by the VIMOS/VLT Deep Redshift Survey (VVDS) and the Great Observatories Origins Deep Survey (GOODs). We show that by applying at the same time the angular diameter-redshift and Hubble diagrams to the same sample of objects (i.e. velocity selected galactic discs) one can derive a characteristic chart, the cosmology-evolution diagram, mapping the relation between global cosmological parameters and local structural parameters of discs such as size and luminosity. This chart allows to put constraints on cosmological parameters when general prior information about discs evolution is available. In particular, by assuming that equally rotating large discs cannot be less luminous at z=1 than at present (M(z=1) < M(0)), we find that a flat matter dominated cosmology (Omega_m=1) is excluded at a confidence level of 2sigma and an open cosmology with low mass density (Omega_m = 0.3) and no dark energy contribution is excluded at a confidence level greater than 1 sigma. Inversely, by assuming prior knowledge about the cosmological model, the cosmology-evolution diagram can be used to gain useful insights about the redshift evolution of the structural parameters of baryonic discs hosted in dark matter halos of nearly equal masses.Comment: 14 pages and 11 figures. A&A in pres

Clinical presentation and survival of smear-positive pulmonary tuberculosis patients of a University General Hospital in a developing country

From January 1995 to August 1997 we evaluated prospectively the clinical presentation, laboratory findings and short-term survival of smear-positive pulmonary tuberculosis (TB) patients who sought care at our hospital. After providing informed, written consent, the patients were interviewed and laboratory tests were performed. Information about survivorship and death was collected through September 1998. Eighty-six smear-positive pulmonary TB patients were enrolled; 26.7% were HIV-seropositive. Seventeen HIV-seronegative pulmonary TB patients (19.8%) presented chronic diseases in addition to TB. In the multiple logistic regression analysis a CD4+ cell count or = 50 years were independently associated with decreased survival. Among HIV-seronegative persons, the presence of an additional disease increased the risk of death of almost six-fold. Use of antiretroviral drugs was associated with a lower risk of death among HIV-seropositive smear-positive pulmonary TB patients (RH = 0.32, 95% CI 0.10-0.92). In our study smear-positive pulmonary TB patients had a low short-term survival rate that was strongly associated with HIV infection, age and co-morbidities. Therapy with antiretroviral drugs reduced the short-term risk of death among HIV-seropositive patients after TB diagnosis