Mesoscale roughness of Venus

The global distribution of multi-kilometer (approx. 9 km) length scale 'roughness' (hereafter mesoscale roughness or MR) on Venus can be estimated from the Magellan global altimetry dataset (GxDR) and then compared with MR data derived for Earth from 5' ETOP5 data and for Mars (from USGS Mars DTM dataset). The mesoscale roughness parameter (MR) represents the RMS variance in meters of the actual planetary surface topography relative to the best fitting tangent plane defined on the basis of a 3x3 pixel sliding window. The best-fit plane was computed using a least-squares solution which minimizes delta H, the sum of the squares of the differences between the 9 local elevation values (H(sub i)), and the elevation of best-fit plane at the same grid location. Using the best-fit plane and delta H, we have computed the RMS 'roughness' var(delta R), where this parameter is always minimized on the basis of its calculation using least squares. We have called this 'ruggedness' parameter the Mesoscale Roughness (MR) because it is directly related to the high-frequency variance of topography after mesoscale slopes and tilts (i.e., for Venus, the baseline over which MR is computed (dx) is approx. 8.8 km and dx for Earth is approx. 9.3 km) are removed. As such, MR represents the degree to which a planetary surface is more rugged than approximately 10 km scale facets or tilts. It should not be confused with the radar 'RMS Roughness' parameter computed at 0.1 to 10 m length scales on the basis of the Magellan radar altimeter echo. We will use our MR parameter to investigate the global ruggedness properties of Venus as they relate to geological provinces and in comparison with the spatial pattern of MR for Earth and Mars

Anomalous mass dependence of radiative quark energy loss in a finite-size quark-gluon plasma

We demonstrate that for a finite-size quark-gluon plasma the induced gluon radiation from heavy quarks is stronger than that for light quarks when the gluon formation length becomes comparable with (or exceeds) the size of the plasma. The effect is due to oscillations of the light-cone wave function for the in-medium $q\to gq$ transition. The dead cone model by Dokshitzer and Kharzeev neglecting quantum finite-size effects is not valid in this regime. The finite-size effects also enhance the photon emission from heavy quarks.Comment: 8 pages, 3 figure

Prevalence, patterns, and predictors of meditation use among US adults: A nationally representative survey

Emerging evidence suggests substantial health benefits from using meditation. While there are some indications that the popularity of meditation is increasing, little is known about the prevalence, patterns, and predictors of meditation use in the general population. In this secondary analysis of data from the 2012 US National Health Interview Survey (NHIS) (n = 34,525), lifetime and 12-month prevalence of meditation use were 5.2% and 4.1%, respectively. Compared to non-users, those who had used meditation in the past 12 months were more likely to be 40-64 years, female, non-Hispanic White, living in the West, at least college-educated, not in a relationship, diagnosed with one or more chronic conditions, smoking, consuming alcohol and physically active. Meditation was mainly used for general wellness (76.2%), improving energy (60.0%), and aiding memory or concentration (50.0%). Anxiety (29.2%), stress (21.6%), and depression (17.8%) were the top health problems for which people used meditation; 63.6% reported that meditation had helped a great deal with these conditions. Only 34.8% disclosed their use of meditation with a health provider. These findings indicate that about 9.3 million US adults have used meditation in the past 12 months; and that mental health problems were the most important reason for meditation use

Heterogeneous Perceptions of Social-Ecological Change Among Small-Scale Fishermen in the Central Gulf of California: Implications for Adaptive Response

As changes in climate, governance, and organization reshape the dynamics of small-scale fisheries around the globe, the persistence of many local livelihoods appears contingent upon the ability of resource users to respond and adapt. Though significant scholarship has considered the limiting roles of resources and infrastructure, recent research has highlighted the importance of local learning and knowledge. Rather than being driven by forces exogenous to local communities, it is increasingly recognized that adaptation may be limited by perceptions and processes within them. Here, we explore knowledge production and adaptive response within a small-scale fishery in the central Gulf of California following system perturbation. Using mixed methods from the natural and social sciences, we (1) identify local drivers of social-ecological change, (2) document knowledge concerning their causes and consequences across a diverse group of small-scale fishermen, and (3) identify patterns of intracultural agreement and disagreement associated with divergent adaptive response. Results indicate that perceptions of social-ecological change were heterogeneous and that gear ownership and target species diversification were critical factors in determining the cultural models through which fishermen understood and responded to changes in the resource system. Unlike other user groups, owner-operator fishermen pursuing generalist livelihood strategies held consensus beliefs regarding changes to system structure and function and demonstrated increased ability to modify fishing tactics with the best practices for sustainable use. Our findings highlight how local knowledge can be used to assess the proximate impacts of external drivers of change and provide insight into the cultural models influencing in situ decision-making and adaptive response within modern fishery systems

Electromagnetic Emission and Energy Loss in the QGP

I discuss why photon production from the Quark Gluon Plasma (QGP) presents an interesting problem, both experimentally and theoretically. I show how the photon emission rate can be computed under the simplifying assumption that the QGP fully thermalizes. The theoretical issues are very similar to those for jet energy loss; so it should be possible to treat them in a common formalism and relate the predictions of one phenomenon to those of the other.Comment: 8 pages, invited talk at Quark Matter 200

An intelligent assistant for exploratory data analysis

In this paper we present an account of the main features of SNOUT, an intelligent assistant for exploratory data analysis (EDA) of social science survey data that incorporates a range of data mining techniques. EDA has much in common with existing data mining techniques: its main objective is to help an investigator reach an understanding of the important relationships ina data set rather than simply develop predictive models for selectd variables. Brief descriptions of a number of novel techniques developed for use in SNOUT are presented. These include heuristic variable level inference and classification, automatic category formation, the use of similarity trees to identify groups of related variables, interactive decision tree construction and model selection using a genetic algorithm

GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer.

BACKGROUND: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute two important characteristics of carcinoma progression toward invasive cancer. Despite an extensive characterization of each of them separately, the links between EMT and glucose metabolism of tumor cells remain elusive. Here we show that the neuronal glucose transporter GLUT3 contributes to glucose uptake and proliferation of lung tumor cells that have undergone an EMT. RESULTS: Using a panel of human non-small cell lung cancer (NSCLC) cell lines, we demonstrate that GLUT3 is strongly expressed in mesenchymal, but not epithelial cells, a finding corroborated in hepatoma cells. Furthermore, we identify that ZEB1 binds to the GLUT3 gene to activate transcription. Importantly, inhibiting GLUT3 expression reduces glucose import and the proliferation of mesenchymal lung tumor cells, whereas ectopic expression in epithelial cells sustains proliferation in low glucose. Using a large microarray data collection of human NSCLCs, we determine that GLUT3 expression correlates with EMT markers and is prognostic of poor overall survival. CONCLUSIONS: Altogether, our results reveal that GLUT3 is a transcriptional target of ZEB1 and that this glucose transporter plays an important role in lung cancer, when tumor cells loose their epithelial characteristics to become more invasive. Moreover, these findings emphasize the development of GLUT3 inhibitory drugs as a targeted therapy for the treatment of patients with poorly differentiated tumors

Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds.

In Escherichia coli, the biogenesis of both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ATP-binding cassette-type cysteine/GSH transporter, CydDC. Recombinant CydDC was purified as a heterodimer and found to be an active ATPase both in soluble form with detergent and when reconstituted into a lipid environment. Two-dimensional crystals of CydDC were analyzed by electron cryomicroscopy, and the protein was shown to be made up of two non-identical domains corresponding to the putative CydD and CydC subunits, with dimensions characteristic of other ATP-binding cassette transporters. CydDC binds heme b. Detergent-solubilized CydDC appears to adopt at least two structural states, each associated with a characteristic level of bound heme. The purified protein in detergent showed a weak basal ATPase activity (approximately 100 nmol Pi/min/mg) that was stimulated ∼3-fold by various thiol compounds, suggesting that CydDC could act as a thiol transporter. The presence of heme (either intrinsic or added in the form of hemin) led to a further enhancement of thiol-stimulated ATPase activity, although a large excess of heme inhibited activity. Similar responses of the ATPase activity were observed with CydDC reconstituted into E. coli lipids. These results suggest that heme may have a regulatory role in CydDC-mediated transmembrane thiol transport

CGC, QCD Saturation and RHIC data (Kharzeev-Levin-McLerran-Nardi point of view)

This is the talk given at the Workshop:"Focus on Multiplicitioes", Bari, Italy, 17-19 June,2004.. In this talk, we are going to discuss ion-ion and deuteron - nucleus RHIC data and show that they support, if not more, the idea of the new QCD phase: colour glass condensate with saturated parton density. .Comment: 26 pages with 33 figure