Utilizing RNAi Technology to Develop Novel Agricultural Pesticides

A general description of why RNAi based pesticide technology is a breakthrough technology able to target only pests while not harming others. This presentation gives a summary of RNAi technology, the current drawbacks of conventional pesticides, and our research on how RNAi can be used against the two-spotted spidermite; a polyphagic pest that causes significant financial damage to Canadian and worldwide agricultur

Nursing the Primary Care Shortage Back to Health: How Expanding Nurse Practitioner Autonomy Can Safely and Economically Meet the Growing Demand for Basic Health Care

This article first discusses the history and educational requirements of the Nurse Practitioner profession. It then discusses the policy reasons why Nurse Practitioners should, and do, play an important role in the country\u27s health care delivery system. The core of the article deals with the legal issues surrounding the NP\u27s scope of practice including the need for collaborative agreements with physicians, authority to prescribe drugs, and identification. Finally the article discusses how NPs fit into the health insurance scheme and their liability for malpractice

X-ray Bursts from the Accreting Millisecond Pulsar XTE J1814-338

Since the discovery of the accreting millisecond pulsar XTE J1814-338 a total of 27 thermonuclear bursts have been observed from the source with the Proportional Counter Array (PCA) onboard the Rossi X-ray Timing Explorer (RXTE). Spectroscopy of the bursts, as well as the presence of continuous burst oscillations, suggests that all but one of the bursts are sub-Eddington. The remaining burst has the largest peak bolometric flux of 2.64 x E^-8 erg/sec/cm^2, as well as a gap in the burst oscillations, similar to that seen in Eddington limited bursts from other sources. Assuming this burst was Eddington limited we obtain a source distance of about 8 kpc. All the bursts show coherent oscillations at the 314.4 Hz spin frequency. The burst oscillations are strongly frequency and phase locked to the persistent pulsations. Only two bursts show evidence for frequency drift in the first few seconds following burst onset. In both cases the initial drift corresponds to a spin down of a few tenths of a Hz. The large oscillation amplitude during the bursts confirms that the burst flux is modulated at the spin frequency. We detect, for the first time, a significant first harmonic component in burst oscillations. The ratio of countrate in the first harmonic to that in the fundamental can be > 0.25 and is, on average, less than that of the persistent pulsations. If the pulsations result from a single bright region on the surface, the harmonic strength suggests the burst emission is beamed, perhaps due to a stronger magnetic field than in non-pulsing LMXBs. Alternatively, the harmonic content could result from a geometry with two bright regions.Comment: AASTeX, 15 pages, 4 figures. Accepted for publication in the Astrophysical Journal Letter

Six new candidate ultracompact X-ray binaries

Ultracompact X-ray binaries (UCXBs) appear able to sustain accretion onto the compact accretor at rates lower than in wider X-ray binaries. This may be understood by the smaller accretion disks in UCXBs: a lower X-ray luminosity suffices to keep a disk completely ionized through irradiation and, thus, keep the viscosity at a sufficiently high level to allow effective transport of matter to the compact object. We employ this distinguishing factor on data from RXTE and BeppoSAX to identify six new candidate UCXBs, thus increasing the population by one quarter. The candidates are drawn from the population of persistently accreting and type-I X-ray bursting low-mass X-ray binaries. The X-ray bursts establish the low-mass X-ray binary nature and provide a handle on the accretion rate. We find that the low accretion rates are supported by the long burst recurrence times and the hard X-ray spectra of the persistent emission as derived from the 2nd INTEGRAL catalog of soft gamma-ray sources. We discuss the peculiar light curves of some new UCXB candidates.Comment: Section 2 corrected and improved thanks to comments by J.-P. Lasota. Accepted for publication in Astronomy and Astrophysic

Discovery of a Second Millisecond Accreting Pulsar: XTE J1751-305

We report the discovery by the RXTE PCA of a second transient accreting millisecond pulsar, XTE J1751-305, during regular monitoring observations of the galactic bulge region. The pulsar has a spin frequency of 435 Hz, making it one of the fastest pulsars. The pulsations contain the signature of orbital Doppler modulation, which implies an orbital period of 42 minutes, the shortest orbital period of any known radio or X-ray millisecond pulsar. The mass function, f_x = (1.278 +/- 0.003) x 10^{-6} M_sun, yields a minimum mass for the companion of between 0.013 and 0.017 M_sun, depending on the mass of the neutron star. No eclipses were detected. A previous X-ray outburst in June, 1998, was discovered in archival All-Sky Monitor data. Assuming mass transfer in this binary system is driven by gravitational radiation, we constrain the orbital inclination to be in the range 30-85 deg, and the companion mass to be 0.013-0.035 M_sun. The companion is most likely a heated helium dwarf. We also present results from the Chandra HRC-S observations which provide the best known position of XTE J1751-305.Comment: Astrophysical Journal Letters, Accepted, (AASTeX

Soft Phase Lags of Pulsed Emission from the Millisecond X-ray Pulsar SAX J1808.4-3658

We report the discovery of phase shifts between X-ray pulses at different energies in the newly discovered millisecond (ms) X-ray pulsar SAX J1808.4-3658. The results show that low-energy pulses lag high-energy pulses by as much as $\sim$0.2 ms (or $\sim$8% of the pulse period). The measurements were made in two different ways: (1) computing cross power spectra between different energy bands, and (2) cross-correlating the folded pulse profiles in different energy bands; consistent results were obtained. We speculate that the observed soft lags might be related to the lateral expansion and subsequent cooling of a ``hot spot'' on the neutron star surface in which the pulsed X-ray emission originates. Also presented is the possibility of producing soft lags via Compton down scattering of hard X-ray photons from the hot spot in the cool surrounding atmosphere. We will discuss possible X-ray production mechanisms for SAX J1808.4-3658 and constraints on the emission environment, based on the observed soft lags, pulse profiles, and energy spectrum.Comment: 11 pages, including four figures. To appear in ApJ Letter

Antimicrobial efficacy of nanosilver, sodium hypochlorite and chlorhexidine gluconate against Enterococcus faecalis

The purpose of this study was to compare the antibacterial efficacy of nanosilver (NS), chlorhexidine gluconate (CHX) and sodium hypochlorite (NaOCl) against Enterococcus faecalis. Two tests of minimum inhibitory concentration (MIC) and zone of inhibition were carried out using NS, NaOCl and CHX. 70-fold concentration of NaOCl is required for the same antibacterial effect of NS. CHX precipitated in contact with the culture medium and was excluded from MIC test. The means and standard deviations of the zones of inhibition for 5.25% NaOCl, 0.33% NaOCl, 25 μg/ml NS, 50 μg/ml NS, 4000 μg/ml NS and 2% CHX were 12.16 ± 1.46, 6.91 ± 0.66, 10.00 ± 0.42, 12.00 ± 0.60, 13.33 ± 1.23 and 24.80 ± 1.11, respectively. Statistical analysis using ANOVA showed significant differences among groups (p < 0.001). A post hoc Tukey test revealed no significant differences between 5.25% NaOCl and 4000 μg/ml NS (p = 0.057). However, the zones of inhibition for 2% CHX were significantly larger than those seen around the filter papers saturated with undiluted NaOCl and NS (p < 0.001 for both). This study revealed that NS in a remarkably lower concentration would possess the same bactericidal effect as 5.25% NaOCl.Key words: Chlorhexidine gluconate, Enterococcus faecalis, nanosilver, sodium hypochlorite

Fast X-ray Transients and Their Connection to Gamma-Ray Bursts

Fast X-ray transients (FXTs) with timescales from seconds to hours have been seen by numerous space instruments. We have assembled archival data from Ariel-5, HEAO-1 (A-1 and A-2), WATCH, ROSAT, and Einstein to produce a global fluence-frequency relationship for these events. Fitting the log N-log S distribution over several orders of magnitude to simple power law we find a slope of -1.0. The sources of FXTs are undoubtedly heterogeneous, the -1 power law is an approximate result of the summation of these multiple sources. Two major contributions come from gamma-ray bursts and stellar flares. Extrapolating from the BATSE catalog of GRBs, we find that the fraction of X-ray flashes that can be the X-ray counterparts of gamma-ray bursts is a function of fluence. Certainly most FXTs are not counterparts of standard gamma-ray bursts. The fraction of FXTs from non-GRB sources, such as magnetic stars, is greatest for the faintest FXTs. Our understanding of the FXT phenomenon remains limited and would greatly benefit from a large, homogeneous data set, which requires a wide-field, sensitive instrument.Comment: 36 pages, 8 figure

Jet trails and Mach cones: The interaction of microquasars with the ISM

A sub-set of microquasars exhibit high peculiar velocity with respect to the local standard of rest due to the kicks they receive when being born in supernovae. The interaction between the radio plasma released by microquasar jets from such high-velocity binaries with the ISM must lead to the production of trails and bow shocks similar to what is observed in narrow-angle tailed radio galaxies and pulsar wind nebulae. We present a set of numerical simulations of this interaction that illuminate the long term dynamical evolution and the observational properties of these microquasar bow shock nebulae and trails. We find that this interaction always produces a structure that consists of a bow shock, a trailing neck, and an expanding bubble. Using our simulations to model emission, we predict that the shock surrounding the bubble and the neck should be visible in H{\alpha} emission, the interior of the bubble should be visible in synchrotron radio emission, and only the bow shock is likely to be detectable in X-ray emission. We construct an analytic model for the evolution of the neck and bubble shape and compare this model with observations of X-ray binary SAX J1712.6-3739.Comment: 33 pages, 13 figures, 1 table; Accepted to Ap

Identification of the LMXB and Faint X-ray Sources in NGC 6652

We have detected three new x-ray point sources, in addition to the known low-mass x-ray binary (LMXB) X1832-330, in the globular cluster NGC 6652 with a Chandra 1.6 ksec HRC-I exposure. Star 49 (M_{V}~4.7), suggested by Deutsch et al.(1998) as the optical candidate for the LMXB, is identified (<0.3") not with the LMXB, but with another, newly detected source (B). Using archival HST images, we identify (<0.3") the LMXB (A) and one of the remaining new sources (C) with blue variable optical counterparts at M_{V}~3.7 and 5.3 respectively. The other new source (D) remains unidentified in the crowded cluster core. In the 0.5-2.5 keV range, assuming a 5 keV thermal bremsstrahlung spectrum and N_{H}=5.5*10^{20}, source A has intrinsic luminosity L_{X}~5.3*10^{35} ergs/s. Assuming a 1 keV thermal bremsstrahlung spectrum, B has L_{X}~4.1*10^{33} ergs/s, while C and D have L_{X}~8*10^{32}$ ergs/s. Source B is probably a quiescent LMXB, while source C may be either a luminous CV or quiescent LMXB.Comment: 14 pages, 3 figures, accepted by Astrophysical Journa