1,284 research outputs found
Synchronous Meteorological Satellite Phase B Study Report
Design of base line system for synchronous meteorological satellit
Circuit Theory
Contains reports on two research projects.Lincoln Laboratory, Purchase Order DDL-B222U.S. Air Force under Air Force Contract AF19(604)-520
High-resolution wide-band Fast Fourier Transform spectrometers
We describe the performance of our latest generations of sensitive wide-band
high-resolution digital Fast Fourier Transform Spectrometer (FFTS). Their
design, optimized for a wide range of radio astronomical applications, is
presented. Developed for operation with the GREAT far infrared heterodyne
spectrometer on-board SOFIA, the eXtended bandwidth FFTS (XFFTS) offers a high
instantaneous bandwidth of 2.5 GHz with 88.5 kHz spectral resolution and has
been in routine operation during SOFIA's Basic Science since July 2011. We
discuss the advanced field programmable gate array (FPGA) signal processing
pipeline, with an optimized multi-tap polyphase filter bank algorithm that
provides a nearly loss-less time-to-frequency data conversion with
significantly reduced frequency scallop and fast sidelobe fall-off. Our digital
spectrometers have been proven to be extremely reliable and robust, even under
the harsh environmental conditions of an airborne observatory, with
Allan-variance stability times of several 1000 seconds. An enhancement of the
present 2.5 GHz XFFTS will duplicate the number of spectral channels (64k),
offering spectroscopy with even better resolution during Cycle 1 observations.Comment: Accepted for publication in A&A (SOFIA/GREAT special issue
Circuit Theory
Contains reports on three research projects.Lincoln Laboratory (Purchase Order DDL-B222)United States Department of the ArmyUnited States Department of the NavyUnited States Department of the Air Force (Contract AF19(604)-5200
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Macular Pigment and Visual Function in Patients With Glaucoma: The San Diego Macular Pigment Study.
PurposeAlthough recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation.MethodsThis cross-sectional study included 85 glaucoma patients and 22 controls. All subjects had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) and zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF) technology was employed to study the relationship between MP and glaucoma. The association between MP volume and glaucoma was investigated using linear regression models accounting for potential confounding factors.ResultsGlaucoma patients had significantly worse SAP mean deviation (MD) and lower RNFL thickness in the study eye compared to control subjects (P < 0.001 for both). MP (volume) was comparable between groups (P = 0.436). In the univariable model, diagnosis of glaucoma was not associated with MP volume (R2 = 1.22%; P = 0.257). Dietary intake of L and Z was positively and significantly related to MP in the univariable (P = 0.022) and multivariable (P = 0.020) models.ConclusionsThese results challenge previous studies that reported that glaucoma is associated with low MP. Dietary habits were found to be the main predictor of MP in this sample. Further research is merited to better understand the relationship between glaucoma, MP, and visual performance in these patients
Widely tunable, non-degenerate three-wave mixing microwave device operating near the quantum limit
We present the first experimental realization of a widely frequency tunable,
non-degenerate three-wave mixing device for quantum signals at GHz frequency.
It is based on a new superconducting building-block consisting of a ring of
four Josephson junctions shunted by a cross of four linear inductances. The
phase configuration of the ring remains unique over a wide range of magnetic
fluxes threading the loop. It is thus possible to vary the inductance of the
ring with flux while retaining a strong, dissipation-free, and noiseless
non-linearity. The device has been operated in amplifier mode and its noise
performance has been evaluated by using the noise spectrum emitted by a voltage
biased tunnel junction at finite frequency as a test signal. The unprecedented
accuracy with which the crossover between zero-point-fluctuations and shot
noise has been measured provides an upper-bound for the noise and dissipation
intrinsic to the device.Comment: Accepted for Physical Review Letters. Supplementary material can be
found in the source packag
W-band 0.3W PHEMT MMIC power amplifier module
A compact (1.8 by 3.0 by 3.8 cm) WR-10 waveguide amplifier module providing 310-mW power output, 20-dB gain, and 5 GHz of 1-dB bandwidth at a center frequency of 96 GHz is described. The module is comprised of 22 identical PHEMT chips, 4-way microstrip power combiners and dividers, and a 4-way waveguide power combiner
Presenting signs and patient co-variables in Gaucher disease : outcome of the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi initiative
© 2018 The Authors. Internal Medicine Journal by Wiley Publishing Asia Pty Ltd on behalf of Royal Australasian College of Physicians.Background: Gaucher disease (GD) presents with a range of signs and symptoms. Physicians can fail to recognise the early stages of GD owing to a lack of disease awareness, which can lead to significant diagnostic delays and sometimes irreversible but avoidable morbidities. Aim: The Gaucher Earlier Diagnosis Consensus (GED-C) initiative aimed to identify signs and co-variables considered most indicative of early type 1 and type 3 GD, to help non-specialists identify ‘at-risk’ patients who may benefit from diagnostic testing. Methods: An anonymous, three-round Delphi consensus process was deployed among a global panel of 22 specialists in GD (median experience 17.5 years, collectively managing almost 3000 patients). The rounds entailed data gathering, then importance ranking and establishment of consensus, using 5-point Likert scales and scoring thresholds defined a priori. Results: For type 1 disease, seven major signs (splenomegaly, thrombocytopenia, bone-related manifestations, anaemia, hyperferritinaemia, hepatomegaly and gammopathy) and two major co-variables (family history of GD and Ashkenazi-Jewish ancestry) were identified. For type 3 disease, nine major signs (splenomegaly, oculomotor disturbances, thrombocytopenia, epilepsy, anaemia, hepatomegaly, bone pain, motor disturbances and kyphosis) and one major co-variable (family history of GD) were identified. Lack of disease awareness, overlooking mild early signs and failure to consider GD as a diagnostic differential were considered major barriers to early diagnosis. Conclusion: The signs and co-variables identified in the GED-C initiative as potentially indicative of early GD will help to guide non-specialists and raise their index of suspicion in identifying patients potentially suitable for diagnostic testing for GD.Peer reviewedFinal Published versio
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