De ontwikkeling van een informatiesysteem voor invasieve plantensoorten

De laatste decennia kent de Nederlandse flora een sterke toename van exoten. Soorten die door een sterke uitbreiding of verdichting van hun areaal overlast veroorzaken, worden invasieve soorten genoemd. De overlast van invasieve soorten (vaak kortweg invasieven genoemd) kan bestaan uit economische schade en gezondheids- en/of veiligheidsproblemen. Het Ministerie van Landbouw, Natuur en Voedselkwaliteit heeft daarom het Uitvoeringsconsortium Invasieve Plantensoorten een FES‑subsidie verleend om in vier jaar tijd een informatiesysteem over potentieel invasieve exotische plantensoorten op te zetten. Doel is informatie aan te leveren op basis waarvan ingeschat kan worden hoe groot de kans is dat exotische soorten zich bij introductie in Nederland invasief zullen gaan gedragen. Daarnaast is het doel hulp te bieden bij het herkennen van zulke soorten als ze worden geïmporteerd. Het informatiesysteem is ondergebracht in Q-bank

Clinical characterization of 66 patients with congenital retinal disease due to the deep-intronic c.2991+1655A>G mutation in CEP290

Purpose: To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients. Methods: Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Foveal outer nuclear layer (ONL) and ellipsoid zone (EZ) presence was assessed using spectral-domain optical coherence tomography (SD-OCT). Differences between compound heterozygous and homozygous patients were analyzed based on visual performance and visual development. Results: A total of 66 patients were included. The majority of patients had either light perception or no light perception. In the remaining group of 14 patients, median BCVA was 20/195 Snellen (0.99 LogMAR; range 0.12-1.90) for the right eye, and 20/148 Snellen (0.87 LogMAR; range 0.22-1.90) for the left. Homozygous patients tended to be more likely to develop light perception compared to more severely affected compound heterozygous patients (P = 0.080) and are more likely to improve from no light perception to light perception (P = 0.022) before the age of 6 years. OCT data were available in 12 patients, 11 of whom had retained foveal ONL and EZ integrity up to 48 years (median 23 years) of age. Conclusions: Homozygous patients seem less severely affected compared to their compound-heterozygous peers. Improvement of visual function may occur in the early years of life, suggesting a time window for therapeutic intervention up to the approximate age of 17 years. This period may be extended by an intact foveal ONL and EZ on OCT

Changes in pathways and vectors of biological invasions in Northwest Europe

We assessed how establishment patterns of non-native freshwater, marine and terrestrial species into Northwest Europe (using Great Britain, France, Belgium and the Netherlands as the study countries) have changed over time, and identified the prevalent pathways and vectors of recent arrivals. Data were extracted from 33 sources on (a) presence/absence and (b) first year of observation in the wild in each country, and (c) continent(s) of origin, (d) invasion pathway(s), (e) invasion vector(s) and (f) environment(s) for 359 species, comprising all non-native Mollusca, Osteichthyes (bony fish), Anseriformes (wildfowl) and Mammalia, and non-native invasive Angiospermae present in the area. Molluscs, fish and wildfowl, particularly those originating from South America, arrived more recently into Northwest Europe than other groups, particularly mammals, invasive plants and species originating from North America. Non-deliberate introductions, those of aquatic species and those from elsewhere in Europe and/or Asia increased strongly in importance after the year 2000 and were responsible for 69, 83 and 89 % of new introductions between 2001 and 2015, respectively. Non-deliberate introductions and those from Asia and North America contributed significantly more to introductions of invasive species in comparison to other non-native species. From the 1960s, ornamental trade has increased in importance relative to other vectors and was responsible for all deliberate introductions of study groups since 2001. Non-deliberate introductions of freshwater and marine species originating from Southeast Europe and Asia represent an increasingly important ecological and economic threat to Northwest Europe. Invertebrates such as molluscs may be particularly dangerous due to their small size and difficulties in detection. Prevention of future invasions in this respect will require intensive screening of stowaways on boats and raising of public awareness.Research leading to this study was funded by the European Regional Development Fund through the EU co-funded Interreg 2Seas project RINSE (reducing the impact of non-native species in Europe; www.rinse-europe.eu), which seeks to improve awareness of the threats posed by INNS, and the methods to address them. AZ and BG received financial support from RINSE. AZ is supported by a Postdoctoral Research Fellowship of the University of Nottingham, Malaysia Campus. BG holds a Postdoctoral Research Fellowship from the Spanish Ministry of Economy and Competitiveness (JCI-2012-11908)

Nationwide treatment and outcomes of intrahepatic cholangiocarcinoma

Background: Most data on the treatment and outcomes of intrahepatic cholangiocarcinoma (iCCA) derives from expert centers. This study aimed to investigate the treatment and outcomes of all patients diagnosed with iCCA in a nationwide cohort. Methods: Data on all patients diagnosed with iCCA between 2010 and 2018 were obtained from the Netherlands Cancer Registry. Results: In total, 1747 patients diagnosed with iCCA were included. Resection was performed in 292 patients (17%), 548 patients (31%) underwent palliative systemic treatment, and 867 patients (50%) best supportive care (BSC). The OS median and 1-, and 3-year OS were after resection: 37.5 months (31.0–44.0), 79.2%, and 51.6%,; with systemic therapy, 10.0 months (9.2–10.8), 38.4%, and 5.1%, and with BSC 2.2 months (2.0–2.5), 10.4%, and 1.3% respectively. The resection rate for patients who first presented in academic centers was 33% (96/292) compared to 13% (195/1454) in non-academic centers (P < 0.001). Discussion: Half of almost 1750 patients with iCCA over an 8 year period did not receive any treatment with a 1-year OS of 10.4%. Three-year survival was about 50% after resection, while long-term survival was rare after palliative treatment. The resection rate was higher in academic centers compared to non-academic centers

Complete solutions to the metric of spherically collapsing dust in an expanding spacetime with a cosmological constant

We present semi-analytical solutions to the background equations describing the Lema\^itre-Tolman-Bondi (LTB) metric as well as the homogeneous Friedmann equations, in the presence of dust, curvature and a cosmological constant Lambda. For none of the presented solutions any numerical integration has to be performed. All presented solutions are given for expanding and collapsing phases, preserving continuity in time and radius. Hence, these solutions describe the complete space time of a collapsing spherical object in an expanding universe. In the appendix we present for completeness a solution of the Friedmann equations in the additional presence of radiation, only valid for the Robertson-Walker metric.Comment: 23 pages, one figure. Numerical module for evaluation of the solutions released at http://web.physik.rwth-aachen.de/download/valkenburg/ColLambda/ Matches published version, published under Open Access. Note change of titl

Perceiving the equation of state of Dark Energy while living in a Cold Spot

The Cold Spot could be an adiabatic perturbation on the surface of last scattering, in which case it is an over-density with comoving radius of the order of 1 Gpc. We assess the effect that living in a similar structure, without knowing it, has on our perception of the equation of state of Dark Energy. We find that structures of dimensions such that they could cause the Cold Spot on the CMB, affect the perceived equation of state of Dark Energy possibly up to ten percent.Comment: 17 pages, 5 figures, matches published versio

Average luminosity distance in inhomogeneous universes

The paper studies the correction to the distance modulus induced by inhomogeneities and averaged over all directions from a given observer. The inhomogeneities are modeled as mass-compensated voids in random or regular lattices within Swiss-cheese universes. Void radii below 300 Mpc are considered, which are supported by current redshift surveys and limited by the recently observed imprint such voids leave on CMB. The averaging over all directions, performed by numerical ray tracing, is non-perturbative and includes the supernovas inside the voids. Voids aligning along a certain direction produce a cumulative gravitational lensing correction that increases with their number. Such corrections are destroyed by the averaging over all directions, even in non-randomized simple cubic void lattices. At low redshifts, the average correction is not zero but decays with the peculiar velocities and redshift. Its upper bound is provided by the maximal average correction which assumes no random cancelations between different voids. It is described well by a linear perturbation formula and, for the voids considered, is 20% of the correction corresponding to the maximal peculiar velocity. The average correction calculated in random and simple cubic void lattices is severely damped below the predicted maximal one after a single void diameter. That is traced to cancellations between the corrections from the fronts and backs of different voids. All that implies that voids cannot imitate the effect of dark energy unless they have radii and peculiar velocities much larger than the currently observed. The results obtained allow one to readily predict the redshift above which the direction-averaged fluctuation in the Hubble diagram falls below a required precision and suggest a method to extract the background Hubble constant from low redshift data without the need to correct for peculiar velocities.Comment: 34 pages, 21 figures, matches the version accepted in JCA

Characterization of invasive and colonizing isolates of Streptococcus agalactiae in East African adults

Ninety-five colonizing isolates and 74 invasive isolates of Streptococcus agalactiae from Kenyan adults were characterized by using capsular serotyping and multilocus sequence typing. Twenty-two sequence types clustering into five clonal complexes were found. Data support the view that S. agalactiae isolates belonging to a limited number of clonal complexes are invasive in adults worldwide

The (co-)occurrence of problematic video gaming, substance use, and psychosocial problems in adolescents

Aims. The current study explored the nature of problematic (addictive) video gaming and the association with game type, psychosocial health, and substance use. Methods. Data were collected using a paper and pencil survey in the classroom setting. Three samples were aggregated to achieve a total sample of 8478 unique adolescents. Scales included measures of game use, game type, the Video game Addiction Test (VAT), depressive mood, negative self-esteem, loneliness, social anxiety, education performance, and use of cannabis, alcohol and nicotine (smoking). Results. Findings confirmed problematic gaming is most common amongst adolescent gamers who play multiplayer online games. Boys (60%) were more likely to play online games than girls (14%) and problematic gamers were more likely to be boys (5%) than girls (1%). High problematic gamers showed higher scores on depressive mood, loneliness, social anxiety, negative self-esteem, and self-reported lower school performance. Nicotine, alcohol, and cannabis using boys were almost twice more likely to report high PVG than non-users. Conclusions. It appears that online gaming in general is not necessarily associated with problems. However, problematic gamers do seem to play online games more often, and a small subgroup of gamers – specifically boys – showed lower psychosocial functioning and lower grades. Moreover, associations with alcohol, nicotine, and cannabis use are found. It would appear that problematic gaming is an undesirable problem for a small subgroup of gamers. The findings encourage further exploration of the role of psychoactive substance use in problematic gaming