An action principle for Vasiliev's four-dimensional higher-spin gravity

We provide Vasiliev's fully nonlinear equations of motion for bosonic gauge fields in four spacetime dimensions with an action principle. We first extend Vasiliev's original system with differential forms in degrees higher than one. We then derive the resulting duality-extended equations of motion from a variational principle based on a generalized Hamiltonian sigma-model action. The generalized Hamiltonian contains two types of interaction freedoms: One set of functions that appears in the Q-structure of the generalized curvatures of the odd forms in the duality-extended system; and another set depending on the Lagrange multipliers, encoding a generalized Poisson structure, i.e. a set of polyvector fields of ranks two or higher in target space. We find that at least one of the two sets of interaction-freedom functions must be linear in order to ensure gauge invariance. We discuss consistent truncations to the minimal Type A and B models (with only even spins), spectral flows on-shell and provide boundary conditions on fields and gauge parameters that are compatible with the variational principle and that make the duality-extended system equivalent, on shell, to Vasiliev's original system.Comment: 37 pages. References added, corrected typo

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.

BackgroundCoenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress.MethodsWe performed a dose escalation study to test the hypothesis that CoQ10 therapy is safe, well-tolerated, and improves biomarkers of oxidative stress in patients receiving hemodialysis therapy. Plasma concentrations of F2-isoprostanes and isofurans were measured to assess systemic oxidative stress and plasma CoQ10 concentrations were measured to determine dose, concentration and response relationships.ResultsFifteen of the 20 subjects completed the entire dose escalation sequence. Mean CoQ10 levels increased in a linear fashion from 704 ± 286 ng/mL at baseline to 4033 ± 1637 ng/mL, and plasma isofuran concentrations decreased from 141 ± 67.5 pg/mL at baseline to 72.2 ± 37.5 pg/mL at the completion of the study (P = 0.003 vs. baseline and P < 0.001 for the effect of dose escalation on isofurans). Plasma F2-isoprostane concentrations did not change during the study.ConclusionsCoQ10 supplementation at doses as high as 1800 mg per day was safe in all subjects and well-tolerated in most. Short-term daily CoQ10 supplementation decreased plasma isofuran concentrations in a dose dependent manner. CoQ10 supplementation may improve mitochondrial function and decrease oxidative stress in patients receiving hemodialysis.Trial registrationThis clinical trial was registered on clinicaltrials.gov [NCT00908297] on May 21, 2009

On gravitational interactions for massive higher spins in AdS3AdS_3

In this paper we investigate gravitational interactions of massive higher spin fields in three dimensional $AdS$ space with arbitrary value of cosmological constant including flat Minkowski space. We use frame-like gauge description for such massive fields adopted to three-dimensional case. At first, we carefully analyze the procedure of switching on gravitational interactions in the linear approximation on the example of massive spin-3 field and then proceed with the generalization to the case of arbitrary integer spin field. As a result we construct a cubic interaction vertex linear in spin-2 field and quadratic in higher spin field on $AdS_3$ background. As in the massless case the vertex does not contain any higher derivative corrections to the Lagrangian and/or gauge transformations. Thus, even after switching on gravitational interactions, one can freely consider any massless or partially massless limits as well as the flat one.Comment: 21 pages. Some clarifications and 1 new reference added. Version to appear in the J.Phys.A special volume on "Higher Spin Theories and AdS/CFT" edited by Matthias Gaberdiel and Mikhail Vasilie

Propagating modes of non-Abelian tensor gauge field of second rank

In the recently proposed extension of the YM theory, non-Abelian tensor gauge field of the second rank is represented by a general tensor whose symmetric part describes the propagation of charged gauge boson of helicity two and its antisymmetric part - the helicity zero charged gauge boson. On the non-interacting level these polarizations are similar to the polarizations of the graviton and of the Abelian antisymmetric B field, but the interaction of these gauge bosons carrying non-commutative internal charges cannot be directly identified with the interaction of gravitons or B field. Our intention here is to illustrate this result from different perspectives which would include Bianchi identity for the corresponding field strength tensor and the analysis of the second-order partial differential equation which describes in this theory the propagation of non-Abelian tensor gauge field of the second rank.Comment: 22 pages, Latex fil

The acceleration and storage of radioactive ions for a neutrino factory

The term beta-beam has been coined for the production of a pure beam of electron neutrinos or their antiparticles through the decay of radioactive ions circulating in a storage ring. This concept requires radioactive ions to be accelerated to a Lorentz gamma of 150 for 6He and 60 for 18Ne. The neutrino source itself consists of a storage ring for this energy range, with long straight sections in line with the experiment(s). Such a decay ring does not exist at CERN today, nor does a high-intensity proton source for the production of the radioactive ions. Nevertheless, the existing CERN accelerator infrastructure could be used as this would still represent an important saving for a beta-beam facility. This paper outlines the first study, while some of the more speculative ideas will need further investigations.Comment: Accepted for publication in proceedings of Nufact02, London, 200

Iron Age and Anglo-Saxon genomes from East England reveal British migration history

British population history has been shaped by a series of immigrations, including the early Anglo-Saxon migrations after 400 CE. It remains an open question how these events affected the genetic composition of the current British population. Here, we present whole-genome sequences from 10 individuals excavated close to Cambridge in the East of England, ranging from the late Iron Age to the middle Anglo-Saxon period. By analysing shared rare variants with hundreds of modern samples from Britain and Europe, we estimate that on average the contemporary East English population derives 38% of its ancestry from Anglo-Saxon migrations. We gain further insight with a new method, rarecoal, which infers population history and identifies fine-scale genetic ancestry from rare variants. Using rarecoal we find that the Anglo-Saxon samples are closely related to modern Dutch and Danish populations, while the Iron Age samples share ancestors with multiple Northern European populations including Britain

Holography, Unfolding and Higher-Spin Theory

Holographic duality is argued to relate classes of models that have equivalent unfolded formulation, hence exhibiting different space-time visualizations for the same theory. This general phenomenon is illustrated by the $AdS_4$ higher-spin gauge theory shown to be dual to the theory of 3d conformal currents of all spins interacting with 3d conformal higher-spin fields of Chern-Simons type. Generally, the resulting 3d boundary conformal theory is nonlinear, providing an interacting version of the 3d boundary sigma model conjectured by Klebanov and Polyakov to be dual to the $AdS_4$ HS theory in the large $N$ limit. Being a gauge theory it escapes the conditions of the theorem of Maldacena and Zhiboedov, which force a 3d boundary conformal theory to be free. Two reductions of particular higher-spin gauge theories where boundary higher-spin gauge fields decouple from the currents and which have free boundary duals are identified. Higher-spin holographic duality is also discussed for the cases of $AdS_3/CFT_2$ and duality between higher-spin theories and nonrelativistic quantum mechanics. In the latter case it is shown in particular that ($dS$) $AdS$ geometry in the higher-spin setup is dual to the (inverted) harmonic potential in the quantum-mechanical setup.Comment: 57 pages, V2: Acknowledgements, references, comments, clarifications and new section on reductions of particular HS theories associated with free boundary theories are added. Typos corrected, V3. Minor corrections: clarification in section 9 is added and typos correcte

Access for All?:Sozialinvestitionen in der frühkindlichen Bildung und Betreuung im europäischen Vergleich

Die Investition in kindbezogene Sozialpolitik ist heute ein zentrales Anliegen europäischer Wohlfahrtsstaaten. Frühkindlicher Bildung und Betreuung kommt die Schlüsselrolle zu, Bildungserfolg und Elternerwerbstätigkeit zu fördern zwecks Chancengleichheit und Armutsbekämpfung. Der international verbreitete Sozialinvestitionsdiskurs lenkt leicht davon ab, dass große Unterschiede in den nationalen Systemen frühkindlicher Bildung und Betreuung bestehen, und diese unterschiedlich in die nationalen Wohlfahrtsstaatsregime eingebettet sind. Am Beispiel Schwedens, Deutschlands und Großbritanniens werden verschiedene Kinderbetreuungssysteme einer kritischen Analyse unterzogen mit Hinblick auf ihr „Sozialinvestitionspotenzial“. Die Untersuchung zeigt, dass frühkindliche Bildungsangebote nicht als Allheilmittel zur Vorbeugung sozialer Ungleichheit fungieren können. Falls nicht mit weiteren, auf Gleichheit ausgerichtete Maßnahmen im Bildungs- und sozialen Sicherungsbereich kombiniert, ist zu erwarten, dass sich eine gegenteilige Wirkungslogik der Sozialinvestitionsstrategie entfaltet, die herkunftsbezogene Bildungsungleichheit noch verstärkt.The importance of investing in early childhood is widely acknowledged in policy circles. Particularly formal Early Childhood Education and Care (ECEC) is seen as key to creating equal opportunities and combating poverty by increasing educational achievement of children and supporting parental employment. This social investment perspective has in recent decades supported the rapid development and expansion of ECEC in most European countries. However, the international social investment discourse masks fundamental differences in European ECEC systems and detracts attention from the way ECEC is embedded in the wider welfare regime of a country. This paper critically examines the ‘social investment potential’ of ECEC systems by comparing an early social investment country, Sweden, with two ‘late movers’, the UK and Germany. It argues that investing in ECEC is not per se a panacea for social inclusion. To the contrary, if not combined with other, partly ‘traditional’ equality measures both in education and social protection, ECEC investment may have the opposite effect of increasing social inequality

Relationship between alcohol-attributable disease and socioeconomic status, and the role of alcohol consumption in this relationship: a systematic review and meta-analysis

Background: Studies show that alcohol consumption appears to have a disproportionate impact on people of low socioeconomic status. Further exploration of the relationship between alcohol consumption, socioeconomic status and the development of chronic alcohol-attributable diseases is therefore important to inform the development of effective public health programmes. Methods: We used systematic review methodology to identify published studies of the association between socioeconomic factors and mortality and morbidity for alcohol-attributable conditions. To attempt to quantify differences in the impact of alcohol consumption for each condition, stratified by SES, we (i) investigated the relationship between SES and risk of mortality or morbidity for each alcohol-attributable condition, and (ii) where, feasible explored alcohol consumption as a mediating or interacting variable in this relationship. Results: We identified differing relationships between a range of alcohol-attributable conditions and socioeconomic indicators. Pooled analyses showed that low, relative to high socioeconomic status, was associated with an increased risk of head and neck cancer and stroke, and in individual studies, with hypertension and liver disease. Conversely, risk of female breast cancer tended to be associated with higher socioeconomic status. These findings were attenuated but held when adjusted for a number of known risk factors and other potential confounding factors. A key finding was the lack of studies that have explored the interaction between alcohol-attributable disease, socioeconomic status and alcohol use. Conclusions: Despite some limitations to our review, we have described relationships between socioeconomic status and a range of alcohol-attributable conditions, and explored the mediating and interacting effects of alcohol consumption where feasible. However, further research is needed to better characterise the relationship between socioeconomic status alcohol consumption and alcohol-attributable disease risk so as to gain a greater understanding of the mechanisms and pathways that influence the differential risk in harm between people of low and high socioeconomic status