Landings and discards on the pulse trawl MFV "Vertrouwen"TX68 in 2009

The catches in terms of landings and discards were monitored onboard MFV “Vertrouwen” TX68, fishing with two pulse trawls using the Verburg-Holland system during four weeks in June-August 2009. The average fishing speed was about 5 knots. The fishing area of the four trips was east of the coast of England and fishing depth was 36m on average with a minimum depth of 20 m and a maximum depth of 46 m. For this study the standard sampling procedure for the yearly monitoring of discards of conventional beam trawl fleet was applied (van Helmond and van Overzee, 2008). Sampled numbers of fish per haul were raised to numbers and weight per hour, for both. When compared with conventional beam trawls in previous years it seems that with the pulse trawl more sole in number and weights per unit of time was discarded and less plaice was discarded. However, the average discard percentages of as well plaice as sole for the pulse trawl of this study were within range with the average discard percentages of conventional beam trawls in 2005, 2006 and 2007 (van Keeken, 2006; van Helmond and van Overzee, 2007; van Helmond and van Overzee, 2008) . This study gives a general impression of the performance in terms of catches of fishing with a pulse trawl using the Verburg-Holland system. However it is recommended to conduct a comparative study on performance of a beam trawl and a pulse trawl, where the two vessels of similar size fish simultaneously, like was done in 2006 by van Marlen et al. This is to exclude the effects of time and area of fishing

Subjective localization of electrocutaneous stimuli

Studying the perception of spatiotemporal stimulus patterns in various modalities may yield important information on the way in which humans process sensory information. The perception of tactile and nociceptive cutaneous stimulus patterns have been studied by Stolle et al. [1] and Trojan et al. [2][4] respectively. Among other things, both authors studied subjective localization of single stimuli. In Trojan et al. [4], two types of mislocalization patterns were observed for nociceptive single stimuli when comparing the localization reports with the stimulus locations: (1) overall proximal or distal displacement and (2) expansion or contraction of the stimulus area.\ud It is unknown whether tactile and nociceptive stimuli at the same skin site are perceived as being at the same site. Therefore, comparing the spatial perception of tactile and nociceptive cutaneous stimuli may provide new insights into their processing. This comparison can only be successfully made by applying nociceptive and tactile stimuli at the same skin site in the same experiment. This can be done by using a device which has recently been developed at our institute and which we refer to as the bimodal stimulation electrode [3]. \ud Recording the perceived locations of stimuli can be done by letting subjects report these on a scale. The most intuitive scale for this is the stimulated arm itself. However, this would bias the perception of stimulus location by providing visual information of the electrode locations. The goal of the present research was to (1) create and (2) test a setup which allows subjects to report perceived stimulus locations on their own arm without seeing the electrode positions. This was achieved by building a setup consisting of a touch screen (Provision Visboard) which presents a digital image of the subject’s own arm (without electrodes) and which is positioned over this arm after the electrodes have been attached. Subjects can report the localizations by pointing at the screen using a pointer

Attentional processes of high-skilled soccer players with congenital hemiparesis: Differences related to the side of the hemispheric lesion

Contains fulltext : 72909.pdf (publisher's version ) (Closed access)We investigated attentional processes that support the performance of high-skilled soccer players with hemiparetic cerebral palsy. Participants (N = 10) dribbled a slalom course as quickly and accurately as possible under two attentional-focus manipulation conditions. In the task-relevant focus condition, they attended to the foot that was in contact with the ball, whereas in the task-irrelevant focus condition, they monitored a series of words played on a tape. The time taken to complete the slalom course was registered. Performances of individuals with left and right hemiparesis were compared to explore differential effects of hemispheric lesion. The high-skilled players with congenital hemiparesis showed similar attentional-focus effects as those previously reported in the literature for high-skilled players without neurological disorders (Beilock et al., 2002; Ford et al., 2005). Task-relevant focus increased dribbling time, whereas a task-irrelevant focus did not result in a significant change in dribbling time. These findings generalized to each of the five participants with left hemiparesis (i.e., damage to the right hemisphere). By contrast, the effects of a task-relevant focus were less consistent for participants with right hemiparesis (i.e., left-hemisphere damage). This corroborates suggestions that the reinvestment of procedural knowledge is a left-lateralized function. The implications for the training of individuals with congenital brain damage are discussed

A global climatology of total columnar water vapour from SSM/I and MERIS

A global time series of total columnar water vapour from combined data of the Medium Resolution Imaging Spectrometer (MERIS) onboard ESA's Environmental Satellite (ENVISAT) and the Special Sensor Microwave/Imager (SSM/I) onboard the satellite series of the US Defense Meteorological Satellite Program (DMSP) is presented. The unique data set, generated in the framework of the ESA Data User Element (DUE) GlobVapour project, combines atmospheric water vapour observations over land and ocean, derived from measurements in the near- infrared and the microwave range, respectively. Daily composites and monthly means of total columnar water vapour are available as global maps on rectangular latitude–longitude grids with a spatial resolution of 0.05° × 0.05° over land and 0.5° × 0.5° over ocean for the years 2003 to 2008. The data are stored in NetCDF files and is fully compliant with the NetCDF Climate Forecast convention. Through the combination of high-quality microwave observations and near-infrared observations over ocean and land surfaces, respectively, the data set provides global coverage. The combination of both products is carried out such that the individual properties of the microwave and near-infrared products, in particular their uncertainties, are not modified by the merging process and are therefore well defined. Due to the global coverage and the provided uncertainty estimates this data set is potentially of high value for climate research. The SSM/I-MERIS TCWV data set is freely available via the GlobVapour project web page (www.globvapour.info) with associated doi:10.5676/DFE/WV_COMB/FP. In this paper, the details of the data set generation, i.e. the satellite data used, the retrieval techniques and merging approaches, are presented. The derived level 3 products are compared to global radiosonde data from the GCOS upper air network (GUAN), showing a high agreement with a root-mean-square deviation of roughly 4.4 kg m−2 and a small wet bias well below 1 kg m−2. Furthermore, the data set is shown to be free of seasonal biases. The consistency of the MERIS and SSM/I retrievals is demonstrated by applying the MERIS retrieval to sun glint areas over ocean

A global climatology of total columnar water vapour from SSM/I and MERIS

A global time series of total columnar water vapour from combined data of the Medium Resolution Imaging Spectrometer (MERIS) onboard ESA's Environmental Satellite (ENVISAT) and the Special Sensor Microwave/Imager (SSM/I) onboard the satellite series of the US Defense Meteorological Satellite Program (DMSP) is presented. The unique data set, generated in the framework of the ESA Data User Element (DUE) GlobVapour project, combines atmospheric water vapour observations over land and ocean, derived from measurements in the near- infrared and the microwave range, respectively. Daily composites and monthly means of total columnar water vapour are available as global maps on rectangular latitude–longitude grids with a spatial resolution of 0.05° × 0.05° over land and 0.5° × 0.5° over ocean for the years 2003 to 2008. The data are stored in NetCDF files and is fully compliant with the NetCDF Climate Forecast convention. Through the combination of high-quality microwave observations and near-infrared observations over ocean and land surfaces, respectively, the data set provides global coverage. The combination of both products is carried out such that the individual properties of the microwave and near-infrared products, in particular their uncertainties, are not modified by the merging process and are therefore well defined. Due to the global coverage and the provided uncertainty estimates this data set is potentially of high value for climate research. The SSM/I-MERIS TCWV data set is freely available via the GlobVapour project web page (www.globvapour.info) with associated doi:10.5676/DFE/WV_COMB/FP. In this paper, the details of the data set generation, i.e. the satellite data used, the retrieval techniques and merging approaches, are presented. The derived level 3 products are compared to global radiosonde data from the GCOS upper air network (GUAN), showing a high agreement with a root-mean-square deviation of roughly 4.4 kg m−2 and a small wet bias well below 1 kg m−2. Furthermore, the data set is shown to be free of seasonal biases. The consistency of the MERIS and SSM/I retrievals is demonstrated by applying the MERIS retrieval to sun glint areas over ocean

Effectiveness and tolerability of pegylated interferon alfa-2b in combination with ribavirin for treatment of chronic hepatitis C: the PegIntrust Study

Background and study aims : Large international clinical trials conducted in the past 5 years rapidly improved the treatment of chronic hepatitis C; however, it is unclear whether the advances seen in clinical trials are being paralleled by similar improvements in routine clinical practice. PegIntrust is a Belgian community-based trial evaluating the sustained virological response. Patients and Methods : Observational study of 219 patients receiving pegylated interferon alfa-2b (1.5 mu g/kg/wk) and weight. based ribavirin (800-1200 mg/day) for 48 weeks. Primary study end point was sustained virological response (SVR), defined as undetectable HCV RNA 6 months after the completion of treatment. Results : In total, 108 patients (49.3 %) had undetectable HCV RNA at the end of therapy, 91(41.6%) attaining SVR. Of the 111 patients without an end-of-treatment response, 28 were non-responders, and 21 had virological breakthrough. In total, 134 patients attained early virological response (EVR); 88 (65.7%) of those patients attained SVR. In contrast, 82 (96.5 %) of the 85 patients who did not attain EVR also did not attain SVR. Age, fibrosis score and baseline viral load were identified as important predictors of treatment outcome. The most frequently reported serious adverse events resulting in treatment discontinuation were anemia (n = 10), fatigue/asthenia/malaise (n = 6) and fever (n = 3). Conclusion : Our data indicate that treatment of chronic hepatitis C with PEG-IFN alfa-2b plus weight-based ribavirin results in favourable treatment outcomes in a Belgian cohort of patients treated in community-based clinical practice. (Ada gastroenterol. belg., 2010, 73, 5-11)

Gene conversion in human rearranged immunoglobulin genes

Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V<sub>H</sub> segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these is very similar to primary V(D)J recombination, involving the RAG proteins acting upon recombination signal sequences, and this has recently been proven to occur. Other sequences, many of which show partial V<sub>H</sub> replacements with no addition of untemplated nucleotides at the V<sub>H</sub>–V<sub>H</sub> joint, have been proposed to occur by an unusual RAG-mediated recombination with the formation of hybrid (coding-to-signal) joints. These appear to occur in cells already undergoing somatic hypermutation in which, some authors are convinced, RAG genes are silenced. We recently proposed that the latter type of V<sub>H</sub> replacement might occur by homologous recombination initiated by the activity of AID (activation-induced cytidine deaminase), which is essential for somatic hypermutation and gene conversion. The latter has been observed in other species, but not in human Ig genes, so far. In this paper, we present a new analysis of sequences published as examples of the second type of rearrangement. This not only shows that AID recognition motifs occur in recombination regions but also that some sequences show replacement of central sections by a sequence from another gene, similar to gene conversion in the immunoglobulin genes of other species. These observations support the proposal that this type of rearrangement is likely to be AID-mediated rather than RAG-mediated and is consistent with gene conversion

Making justice more accessible

From the point of view of the Citizen, Justice is not always readily accessible. Either because it is a lengthy process, potentially expensive, sometimes unclear or simply scary, people will often avoid or withdraw from a judicial process, especially in those cases that involve relatively small amounts. This results in the giving up of a basic right, with the potential loss of rightful benefits. In this paper we briefly analyze the main aspects that impair access to Justice nowadays. We then move on to look at recent technological developments in the field of Online Dispute Resolution to argue that these can, in the near future, have a significant role in improving access to Justice. Specifically, we analyze the UMCourt Conflict Resolution Framework, developed by our research team, and address the different dimensions in which such tools contribute to make Justice more accessible, namely through better access to useful information, support in decision-making or more cost-effective processes.Development Fund through the COMPETE Programme (operational programme for competitiveness) and by National Funds through the FCT - Fundação para a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology) within projects FCOMP-01-0124-FEDER-028980 (PTDC/EEISII/1386/ 2012) and PEst-OE/EEI/UI0752/201

Bilateral Assessment of Functional Tasks for Robot-assisted Therapy Applications

This article presents a novel evaluation system along with methods to evaluate bilateral coordination of arm function on activities of daily living tasks before and after robot-assisted therapy. An affordable bilateral assessment system (BiAS) consisting of two mini-passive measuring units modeled as three degree of freedom robots is described. The process for evaluating functional tasks using the BiAS is presented and we demonstrate its ability to measure wrist kinematic trajectories. Three metrics, phase difference, movement overlap, and task completion time, are used to evaluate the BiAS system on a bilateral symmetric (bi-drink) and a bilateral asymmetric (bi-pour) functional task. Wrist position and velocity trajectories are evaluated using these metrics to provide insight into temporal and spatial bilateral deficits after stroke. The BiAS system quantified movements of the wrists during functional tasks and detected differences in impaired and unimpaired arm movements. Case studies showed that stroke patients compared to healthy subjects move slower and are less likely to use their arm simultaneously even when the functional task requires simultaneous movement. After robot-assisted therapy, interlimb coordination spatial deficits moved toward normal coordination on functional tasks