Simplified Space Vector Pulse Width Modulation based on Switching Schemes with Reduced Switching Frequency and Harmonics for Five Level Cascaded H-Bridge Inverter

This paper presents a simplified control strategy of spacevector pulse width modulation technique with a three segment switching sequence and seven segment switching sequence for high power applications of multilevel inverters. In the proposed method, the inverter switching sequences are optimized for minimization of device switching frequency and improvement of harmonic spectrum by using the three most desired switching states and one suitable redundant state for each space vector. The proposed three-segment sequence is compared with conventional seven-segment sequence for five level Cascaded H-Bridge inverter with various values of switching frequencies including very low frequency. The output spectrum of the proposed sequence design shows the reduction of device switching frequency, current and line voltage THD, thereby minimizing the filter size requirement of the inverter, employed in industrial applications, where sinusoidal output voltage is required

REAL-TIME MULTI-PATIENT MONITORING SYSTEM USING ARM AND WIRELESS SENSOR NETWORK

Mobile Multi patient monitoring device has become increasingly important in Hospital wards to record real-time data during normal activity for better treatment. However, the current quality and reliability have not been satisfactory due to the size, weight, distance of coverage and also high power consumption. This paper provides a solution for enhancing the reliability, flexibility by improving the performance and power management of the real-time multi-patient monitoring system (MPMS). In the current proposed system the patient health is continuously monitored by the MPMS and the acquired data is transmitted to a centralized ARM server using Wireless Sensor Networks. A ZigBee node is connected to every patient monitor system which will send the patient\u27s vital information .Upon system boot up, the mobile patient monitor system will continuously monitor the patients vital parameters like Heart Beat, body temperature etc and will periodically send those parameters to a centralized server using ZigBee node configured as co-coordinator. If a particular patient’s health parameter falls below the threshold value, a buzzer alert is triggered by the ARM server. Along with a buzzer an automated SMS is posted to the pre-configured Doctors mobile number using a standard GSM module interfaced to the ARM server. The Doctor is continuously connected to the ARM server using GSM Module and he/she can get a record of a particular patient’s information by just posting a SMS message to the centralized ARM server. This will reduce treatment time, cost and power consumption to a greater extent. At the same time, the efficiency of examining ward will be improved by making the system more real-time and robust

Obstetric outcome in primigravida with unengaged versus engaged fetal head at term

Background: Labour although a physiological process can present challenges to clinician and patient. Primigravida and nulliparae are obstetric high-risk group, especially the very young and the elderly, where pregnancy and labour must be supervised. The study was done to compare the maternal and fetal outcome in primigravida with unengaged and engaged head at term.Methods: A prospective study was done for a period of 18 months from June 2018 to December 2019 in Department of Obstetrics and Gynaecology Adichunchanagiri Institute of Medical Sciences and Research Center. 100 women with unengaged head at term (group A) and 100 women with engaged head at term (group B) as controls were selected.  All the relevant data was filled in the partogram. Following observations were made, station of fetal head at the onset of labour, course of labour, duration of labour, any medical or surgical interventions or caesarean delivery. Data was analysed by SPSS 20.0 software and p value<0.05 was taken as statistically significant.Results: in group A 49% and 63% in group B had vaginal delivery. 17% of group A and 14% of group B had instrumental vaginal delivery. Caesarean delivery was 34% in group A and 23% in group B. The mean total duration of labour was 13.53 hours in group A and 9.73 hours in group B. P value was 0.000.Conclusions: Duration of labour was more in group A than group B.  Proper supervision and timely intervention in cases with an unengaged head can have vaginal delivery

Single-Cell Gene Expression Analysis Identifies Chronic Alcohol-Mediated Shift in Hepatocyte Molecular States After Partial Hepatectomy.

The analysis of molecular states of individual cells, as defined by their mRNA expression profiles and protein composition, has gained widespread interest in studying biological phenomena ranging from embryonic development to homeostatic tissue function and genesis and evolution of cancers. Although the molecular content of individual cells in a tissue can vary widely, their molecular states tend to be constrained within a transcriptional landscape partly described by the canonical archetypes of a population of cells. In this study, we sought to characterize the effects of an acute (partial hepatectomy) and chronic (alcohol consumption) perturbation on the molecular states of individual hepatocytes during the onset and progression of liver regeneration. We analyzed the expression of 84 genes across 233 individual hepatocytes acquired using laser capture microdissection. Analysis of the single-cell data revealed that hepatocyte molecular states can be considered as distributed across a set of four states irrespective of perturbation, with the proportions of hepatocytes in these states being dependent on the perturbation. In addition to the quiescent, primed, and replicating hepatocytes, we identified a fourth molecular state lying between the primed and replicating subpopulations. Comparison of the proportions of hepatocytes from each experimental condition in these four molecular states suggested that, in addition to aberrant priming, a slower transition from primed to replication state could contribute toward ethanol-mediated suppression of liver regenerative response to partial hepatectomy

Androgen Receptor CAG Repeat Polymorphism and Epigenetic Influence among the South Indian Women with Polycystic Ovary Syndrome

The present study was carried out to assess the role of androgen receptor CAG repeat polymorphism and X chromosome inactivation (XCI) pattern among Indian PCOS women and controls which has not been hitherto explored and also to test the hypothesis that shorter CAG alleles would be preferentially activated in PCOS. CAG repeat polymorphism and X chromosome methylation patterns were compared between PCOS and non-PCOS women. 250 PCOS women and 299 controls were included for this study. Androgen receptor CAG repeat sizes, XCI percentages, and clinical and biochemical parameters were measured. The mean CAG repeat number is similar between the cases (18.74±0.13) and controls (18.73±0.12). The obese PCOS women were significantly more frequent in the <18 and >20 CAG repeat category than the lean PCOS women, yielding a highly significant odds (p = 0.001). Among the women with non-random X-inactivation, alleles with <19 repeats were more frequently activated among cases than controls (p = 0.33). CAG repeat polymorphism by itself cannot be considered as a useful marker for discriminating PCOS. We observed a trend of preferential activation of the shorter allele among the PCOS cases with non random XCI pattern. In the obese PCOS women, this microsatellite variation may account for the hyperandrogenicity to a larger extent than the lean PCOS women

Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts

The use of titanium dioxide (TiO2) in various industrial applications (eg, production of paper, plastics, cosmetics, and paints) has been expanding thereby increasing the occupational and other environmental exposure of these nanoparticles to humans and other species. However, the health effects of exposure to TiO2 nanoparticles have not been systematically assessed even though recent studies suggest that such exposure induces inflammatory responses in lung tissue and cells. Because the effects of such nanoparticles on human neural cells are unknown, we have determined the putative cytotoxic effects of these nanoparticles on human astrocytes-like astrocytoma U87 cells and compared their effects on normal human fibroblasts. We found that TiO2 micro- and nanoparticles induced cell death on both human cell types in a concentration-related manner. We further noted that zinc oxide (ZnO) nanoparticles were the most effective, TiO2 nanoparticles the second most effective, and magnesium oxide (MgO) nanoparticles the least effective in inducing cell death in U87 cells. The cell death mechanisms underlying the effects of TiO2 micro- and nanoparticles on U87 cells include apoptosis, necrosis, and possibly apoptosis-like and necrosis-like cell death types. Thus, our findings may have toxicological and other pathophysiological implications on exposure of humans and other mammalian species to metallic oxide nanoparticles

Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case

Background: We attempt to ascertain if the 3 linked single nucleotide polymorphisms (SNPs) of the Progesterone Recepto

Evaluation of the impact of high-resolution winds on the coastal waves

This study discusses the impact of high-resolution winds on the coastal waves and analyses the effectiveness of the high-resolution winds in recreating the fine-scale features along the coastal regions during the pre-monsoon season (March–May). The influence of the diurnal variation of winds on waves is studied for the Tamil Nadu coastal region using wind fields from weather research and forecast (WRF) (3 km) and European Centre for Medium-Range Weather Forecasts (ECMWF) (27.5 km). The improvement in the coastal forecast is then quantified with wave rider buoy observations. The high-resolution wind fields simulated fine-scale features like land–sea breeze events and showed good agreement with observation results. The error in the wave height and period is reduced by 8% and 46%, respectively, with the use of high-resolution forcing winds WRF over ECMWF, although the overestimation of wave energy on high frequencies due to overestimated WRF winds remains as a challenge in forecasting. The analysis also shows the importance of accurate wave forecast during a short-duration sudden wind (~12 m/s) occurrence in southern Tamil Nadu near Rameswaram during the pre-monsoon period. Low pressure forms over Tamil Nadu due to the land surface heating, resulting in a sudden increase of winds. High winds and steep waves which cause damage to the property of the coastal community near Rameswaram also were well simulated in the high-resolution forecast system with WRF winds

A Single Cell Transcriptomics Map of Paracrine Networks in the Intrinsic Cardiac Nervous System

We developed a spatially-tracked single neuron transcriptomics map of an intrinsic cardiac ganglion, the right atrial ganglionic plexus (RAGP) that is a critical mediator of sinoatrial node (SAN) activity. This 3D representation of RAGP used neuronal tracing to extensively map the spatial distribution of the subset of neurons that project to the SAN. RNA-seq of laser capture microdissected neurons revealed a distinct composition of RAGP neurons compared to the central nervous system and a surprising finding that cholinergic and catecholaminergic markers are coexpressed, suggesting multipotential phenotypes that can drive neuroplasticity within RAGP. High-throughput qPCR of hundreds of laser capture microdissected single neurons confirmed these findings and revealed a high dimensionality of neuromodulatory factors that contribute to dynamic control of the heart. Neuropeptide-receptor coexpression analysis revealed a combinatorial paracrine neuromodulatory network within RAGP informing follow-on studies on the vagal control of RAGP to regulate cardiac function in health and disease

Performance of the ocean state forecast system at Indian National Centre for Ocean Information Services

The reliability of the operational Ocean State Forecast system at the Indian National Centre for Ocean Information Services (INCOIS) during tropical cyclones that affect the coastline of India is described in this article. The performance of this system during cyclone Thane that severely affected the southeast coast of India during the last week of December 2011 is reported here. Spec-tral wave model is used for forecasting the wave fields generated by the tropical cyclone and vali-dation of the same is done using real-time automated observation systems. The validation results indicate that the forecasted wave parameters agree well with the measurements. The feedback from the user community indicates that the forecast was reliable and highly useful. Alerts based on this operational ocean state forecast system are thus useful for protecting the property and lives of the coastal communities along the coastline of India. INCOIS is extending this service for the benefit of the other countries along the Indian Ocean rim