Structure and dynamics of penumbral filaments

High-resolution observations of sunspots have revealed the existence of dark cores inside the bright filaments of the penumbra. Here we present the stationary solution of the heat transfer equation in a stratified penumbra consisting of nearly horizontal magnetic flux tubes embedded in a stronger and more vertical field. The tubes and the external medium are in horizontal mechanical equilibrium. This model produces bright filaments with dark cores as a consequence of the higher density of the plasma inside the flux tube, which shifts the surface of optical depth unity toward higher (cooler) layers. Our results suggest that the surplus brightness of the penumbra is a natural consequence of the Evershed flow, and that magnetic flux tubes about 250 km in diameter can explain the morphology of sunspot penumbra.Comment: 6 pages, 4 figures, conference proceedings: SEA, 2008, Santander, Spai

Fluxtube model atmospheres and Stokes V zero-crossing wavelengths

First results of the inversion of Stokes I and V profiles from plage regions near disk center are presented. Both low and high spatial resolution spectra of FeI 6301.5 and FeI 6302.5 A obtained with the Advanced Stokes Polarimeter (ASP) have been considered for analysis. The thin flux tube approximation, implemented in an LTE inversion code based on response functions, is used to describe unresolved magnetic elements. The code allows the simultaneous and consistent inference of all atmospheric quantities determining the radiative transfer with the sole assumption of hydrostatic equilibrium. By considering velocity gradients within the tubes we are able to match the full ASP Stokes profiles. The magnetic atmospheres derived from the inversion are characterized by the absence of significant motions in high layers and strong velocity gradients in deeper layers. These are essential to reproduce the asymmetries of the observed profiles. Our scenario predicts a shift of the Stokes V zero-crossing wavelengths which is indeed present in observations made with the Fourier Transform Spectrometer.Comment: To appear in ApJ Letters (1997) (in press

On the validity of the 630 nm Fe I nm lines for the magnetometry of the internetwork quiet Sun

The purpose of this work is to analyze the reliability of the magnetic field strengths inferred from the 630 nm pair of Fe I lines at internetwork quiet Sun regions. Some numerical experiments have been performed that demonstrate the inability of these lines to recover the magnetic field strength in such low flux solar regions. It is shown how different model atmospheres, with magnetic field strengths ranging from few hundred Gauss to kiloGauss, give rise to Stokes profiles that can not be distinguished. The reasons for this degeneracy are discussed.Comment: Accepted for publication in A&

Models and Observations of Sunspot Penumbrae

The mysteries of sunspot penumbrae have been under an intense scrutiny for the past 10 years. During this time, some models have been proposed and refuted, while the surviving ones had to be modified, adapted and evolved to explain the ever-increasing array of observational constraints. In this contribution I will review two of the present models, emphasizing their contributions to this field, but also pinpointing some of their inadequacies to explain a number of recent observations at very high spatial resolution. To help explaining these new observations I propose some modifications to each of them. These modifications bring those two seemingly opposite models closer together into a general picture that agrees well with recent 3D magneto-hydrodynamic simulations.Comment: 9 pages, 1 color figure. Review talk to appear in the proceedings of the International Workshop of 2008 Solar Total Eclipse: Solar Magnetism, Corona and Space Weather--Chinese Space Solar Telescope Scienc

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

This work was supported by Agencia Aragonesa para la Investigación y Desarrollo (ARAID), Ministerio de Economía y Competitividad (CTQ2013-44367-C2-2-P to R.H.-G.) and Diputación General de Aragón (DGA; B89 to R.H.-G.) and the EU Seventh Framework Programme (2007–2013) under BioStruct-X (grant agreement 283570 and BIOSTRUCTX 5186, to R.H.-G.). T.K.S. was supported by the Wellcome Trust grant 093228 and European Community’s Seventh Framework Programme under grant agreement No. 602773 (Project KINDRED).Malaria is a life-threatening disease caused by different species of the protozoan parasite Plasmodium, with P. falciparum being the deadliest. Increasing parasitic resistance to existing antimalarials makes the necessity of novel avenues to treat this disease an urgent priority. The enzymes responsible for the synthesis of phosphatidylcholine and phosphatidylethanolamine are attractive drug targets to treat malaria as their selective inhibition leads to an arrest of the parasite’s growth and cures malaria in a mouse model. We present here a detailed study that reveals a mode of action for two P. falciparum choline kinase inhibitors both in vitro and in vivo. The compounds present distinct binding modes to the choline/ethanolamine-binding site of P. falciparum choline kinase, reflecting different types of inhibition. Strikingly, these compounds primarily inhibit the ethanolamine kinase activity of the P. falciparum choline kinase, leading to a severe decrease in the phosphatidylethanolamine levels within P. falciparum, which explains the resulting growth phenotype and the parasites death. These studies provide an understanding of the mode of action, and act as a springboard for continued antimalarial development efforts selectively targeting P. falciparum choline kinase.Publisher PDFPeer reviewe

Paediatricians provide higher quality care to children and adolescents in primary care: A systematic review

Aim: The number of primary care paediatricians is decreasing in Europe without a justifiable reason. We aimed to compare the clinical practice of paediatricians and family doctors attending children and adolescents in primary care. Methods: MEDLINE, Embase, CENTRAL, TRIP and Google Scholar were searched from December 2008 to February 2018. No language or study design restrictions were applied. Three reviewers assessed eligibility of the studies. Seven pairs of reviewers performed the data extraction and assessed the methodological quality independently. Discrepancies were resolved by consensus. Results: Fifty-four, out of 1150 studies preselected, were included. We found that paediatricians show more appropriate pharmacology prescription patterns for the illness being treated; they achieve higher vaccination rates and have better knowledge of vaccines and fewer doubts about vaccine safety; their knowledge and implementation of different screening tests are better; they prescribe psychoactive drugs more cautiously and more in line with current practice guidelines; their evaluation and treatment of obesity and lipid disorders follow criteria more consistently with current clinical practice guidelines; and they perform fewer diagnostic test, show a more suitable use of the test and request fewer referrals to specialists. Conclusion: According to published data, in developed countries, paediatricians provide higher quality care to children than family doctors

Interpretation of HINODE SOT/SP asymmetric Stokes profiles observed in quiet Sun network and internetwork

We present the first interpretation of the Stokes profile asymmetries measured in the FeI 630 nm lines by SOT/SP, in both quiet Sun internetwork (IN) and network regions. The inversion is carried out under the hypothesis of MISMA, where the unresolved structure is assumed to be optically thin. We analyze a 29.52"x31.70" subfield carefully selected to be representative of the properties of a 302"x162" quiet Sun field-of-view at disk center. The inversion code is able to reproduce the observed asymmetries in a very satisfactory way. The inversion code interprets 25% of inverted profiles as emerging from pixels in which both positive and negative polarities coexist. kG field strengths are found at the base of the photosphere in both network and IN; in the case of the latter, both kG fields and hG fields are admixed. When considering the magnetic properties at the mid photosphere most kG fields are gone, and the statistics is dominated by hG fields. We constrain the magnetic field of only 4.5% of the analyzed photosphere (and this percentage reduces to 1.3% when referred to all pixels, including those with low polarization not analyzed). The rest of the plasma is consistent with the presence of weak fields not contributing to the detected polarization signals. The average flux densities derived in the full subfield and in IN regions are higher than the ones derived from the same dataset by Milne-Eddington inversion. The existence of large asymmetries in SOT/SP polarization profiles is uncovered. These are not negligible in quiet Sun data. The MISMA inversion code reproduces them in a satisfactory way, and provides a statistical description of the magnetized IN and network which partly differs and complements the results obtained so far. From this it follows the importance of having a complete interpretation of the line profile shapes.Comment: 11 pages, 9 figures, 1 table - Accepted for publication on A&

Molecular Mechanisms of Kidney Injury and Repair

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of damage and regeneration in the kidney. CKD predisposes to acute kidney injury (AKI) which, in turn, promotes CKD progression. This implies that CKD or the AKI-to-CKD transition are associated with dysfunctional kidney repair mechanisms. Current therapeutic options slow CKD progression but fail to treat or accelerate recovery from AKI and are unable to promote kidney regeneration. Unraveling the cellular and molecular mechanisms involved in kidney injury and repair, including the failure of this process, may provide novel biomarkers and therapeutic tools. We now review the contribution of different molecular and cellular events to the AKI-to-CKD transition, focusing on the role of macrophages in kidney injury, the different forms of regulated cell death and necroinflammation, cellular senescence and the senescence-associated secretory phenotype (SAPS), polyploidization, and podocyte injury and activation of parietal epithelial cells. Next, we discuss key contributors to repair of kidney injury and opportunities for their therapeutic manipulation, with a focus on resident renal progenitor cells, stem cells and their reparative secretome, certain macrophage subphenotypes within the M2 phenotype and senescent cell clearance

Supersonic Evershed flow outside Sunspots

We report on the discovery of mostly horizontal field channels just outside sunspot penumbrae (in the so-called `moat' region) that are seen to sustain supersonic flows (line-of-sight component of 6 km s{-1}). The spectral signature of these supersonic flows corresponds to circular polarization profiles with an additional, satellite, third lobe of the same sign as the parent sunspot' Stokes V blue lobe, for both downflows and upflows. This is consistent with an outward directed flow that we interpret as the continuation of the magnetized Evershed flow outside sunspots at supersonic speeds. In Stokes Q and U, a clear signature of a transverse field connecting the two flow streams is observed. Such an easily detectable spectral signature should allow for a clear identification of these horizontal field channels in other spectropolarimetric sunspot data. For the spot analyzed in this paper, a total of 5 channels with this spectral signature have been unambiguously found