371 research outputs found

    Wind and boundary layers in Rayleigh-Benard convection. Part 2: boundary layer character and scaling

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    The effect of the wind of Rayleigh-Benard convection on the boundary layers is studied by direct numerical simulation of an L/H=4 aspect-ratio domain with periodic side boundary conditions for Ra={10^5, 10^6, 10^7} and Pr=1. It is shown that the kinetic boundary layers on the top- and bottom plate have some features of both laminar and turbulent boundary layers. A continuous spectrum, as well as significant forcing due to Reynolds stresses indicates undoubtedly a turbulent character, whereas the classical integral boundary layer parameters -- the shape factor and friction factor (the latter is shown to be dominated by the pressure gradient) -- scale with Reynolds number more akin to laminar boundary layers. This apparent dual behavior is caused by the large influence of plumes impinging onto and detaching from the boundary layer. The plume-generated Reynolds stresses have a negligible effect on the friction factor at the Rayleigh numbers we consider, which indicates that they are passive with respect to momentum transfer in the wall-parallel direction. However, the effect of Reynolds stresses cannot be neglected for the thickness of the kinetic boundary layer. Using a conceptual wind model, we find that the friction factor C_f should scale proportional to the thermal boundary layer thickness as C_f ~ lambda_Theta, while the kinetic boundary layer thickness lambda_u scales inversely proportional to the thermal boundary layer thickness and wind Reynolds number lambda_u ~ lambda_Theta^{-1} Re^{-1}. The predicted trends for C_f and \lambda_u are in agreement with DNS results

    Social and gender analysis report: Barotse Floodplain, Western Province,Zambia

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    There is increasing awareness that integrating gender into development frameworks is critical for effective implementation of development strategies. In working to alleviate rural poverty, the CGIAR Research Program on Aquatic Agricultural Systems (AAS) recognizes that “business as usual” gender integration approaches will not deliver lasting and widespread improvements in agricultural productivity, poverty reduction and food security. In response, AAS operationalized a gender transformative approach. The approach is informed by conceptual frameworks that explicitly recognize the potent influence of social relations on creating and perpetuating gender inequalities. In this way, AAS aims to address the underlying causes of rural poverty and gender inequality in Zambia’s Barotse Floodplain, where people rely extensively on riverine and wetland ecosystems for food and livelihood security. A central question guiding the research program is “How do social norms and gendered power relations influence agricultural development outcomes?” The findings presented in this report provide insights that help answer this question. The report presents a review of literature relevant to livelihoods, ecosystem services, and gender and social relations in Zambia, with a specific focus on Western Province, where AAS is currently implemented. It also presents a synthesis of findings of a social and gender analysis conducted in 2013 in 10 focal communities situated in and around the Barotse Floodplain

    Extracellular Vesicles:An Important Biomarker in Recurrent Pregnancy Loss?

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    Recurrent pregnancy loss (RPL) has an estimated incidence of 1–3% of all couples. The etiology is considered to be multifactorial. Extracellular vesicles (EVs) take part in numerous different physiological processes and their contents show the originating cell and pathophysiological states in different diseases. In pregnancy disorders, changes can be seen in the composition, bioactivity and concentration of placental and non-placental EVs. RPL patients have an increased risk of pregnancy complications. The aim of this prospective study was to examine whether measuring different specific EV markers in plasma before and during pregnancy could be used as predictors of pregnancy loss (PL) in women with RPL. Thirty-one RPL patients were included in this study; 25 had a live birth (LB group) and six had a new PL (PL group). Five blood samples were obtained, one before achieved pregnancy and the others in gestational week 6, 8, 10 and 16. Moreover, some of the patients received intravenous immunoglobulin (IVIG) infusions as part of treatment, and it was also examined whether this treatment influenced the EV levels. Seventeen EV markers specific for the immune system, coagulation, placenta and hypoxia were analyzed in the samples with EV Array, a method able to capture small EVs by using an antibody panel targeting membrane proteins. Comparing the LB and PL groups, one EV marker, CD9, showed a significant increase from before pregnancy to gestational week 6 in the PL group. The changes in the other 16 markers were nonsignificant. One case of late-onset PL showed steeply increasing levels, with sudden decrease after gestational week 10 in nine of 17 markers. Moreover, there was an overall increase of all 17 markers after IVIG treatment in the LB group, which was significant in 15 of the markers. Whether increases in EVs positive for CD9 characterize RPL patients who subsequently miscarry should be investigated in future larger studies

    Jet-induced cratering of a granular surface with application to lunar spaceports

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    The erosion of lunar soil by rocket exhaust plumes is investigated experimentally. This has identified the diffusion-driven flow in the bulk of the sand as an important but previously unrecognized mechanism for erosion dynamics. It has also shown that slow regime cratering is governed by the recirculation of sand in the widening geometry of the crater. Scaling relationships and erosion mechanisms have been characterized in detail for the slow regime. The diffusion-driven flow occurs in both slow and fast regime cratering. Because diffusion-driven flow had been omitted from the lunar erosion theory and from the pressure cratering theory of the Apollo and Viking era, those theories cannot be entirely correct.Comment: 13 pages, link to published version: http://cedb.asce.org/cgi/WWWdisplay.cgi?090000

    The calibration of the Sudbury Neutrino Observatory using uniformly distributed radioactive sources

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    The production and analysis of distributed sources of 24Na and 222Rn in the Sudbury Neutrino Observatory (SNO) are described. These unique sources provided accurate calibrations of the response to neutrons, produced through photodisintegration of the deuterons in the heavy water target, and to low energy betas and gammas. The application of these sources in determining the neutron detection efficiency and response of the 3He proportional counter array, and the characteristics of background Cherenkov light from trace amounts of natural radioactivity is described.Comment: 24 pages, 13 figure

    Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions

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    The global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income countries and population migration to higher-income countries. The host of quantitative evidence documenting these changes has not been assembled at the global level. The purpose of this study is to estimate trends in the future number of newborns with SCA and the number of lives that could be saved in under-five children with SCA by the implementation of different levels of health interventions.First, we calculated projected numbers of newborns with SCA for each 5-y interval between 2010 and 2050 by combining estimates of national SCA frequencies with projected demographic data. We then accounted for under-five mortality (U5m) projections and tested different levels of excess mortality for children with SCA, reflecting the benefits of implementing specific health interventions for under-five patients in 2015, to assess the number of lives that could be saved with appropriate health care services. The estimated number of newborns with SCA globally will increase from 305,800 (confidence interval [CI]: 238,400-398,800) in 2010 to 404,200 (CI: 242,500-657,600) in 2050. It is likely that Nigeria (2010: 91,000 newborns with SCA [CI: 77,900-106,100]; 2050: 140,800 [CI: 95,500-200,600]) and the Democratic Republic of the Congo (2010: 39,700 [CI: 32,600-48,800]; 2050: 44,700 [CI: 27,100-70,500]) will remain the countries most in need of policies for the prevention and management of SCA. We predict a decrease in the annual number of newborns with SCA in India (2010: 44,400 [CI: 33,700-59,100]; 2050: 33,900 [CI: 15,900-64,700]). The implementation of basic health interventions (e.g., prenatal diagnosis, penicillin prophylaxis, and vaccination) for SCA in 2015, leading to significant reductions in excess mortality among under-five children with SCA, could, by 2050, prolong the lives of 5,302,900 [CI: 3,174,800-6,699,100] newborns with SCA. Similarly, large-scale universal screening could save the lives of up to 9,806,000 (CI: 6,745,800-14,232,700) newborns with SCA globally, 85% (CI: 81%-88%) of whom will be born in sub-Saharan Africa. The study findings are limited by the uncertainty in the estimates and the assumptions around mortality reductions associated with interventions.Our quantitative approach confirms that the global burden of SCA is increasing, and highlights the need to develop specific national policies for appropriate public health planning, particularly in low- and middle-income countries. Further empirical collaborative epidemiological studies are vital to assess current and future health care needs, especially in Nigeria, the Democratic Republic of the Congo, and India

    Mortality Measurement Matters: Improving Data Collection and Estimation Methods for Child and Adult Mortality

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    Colin Mathers and Ties Boerma discuss three research articles in PLoS Medicine that address the measurement and analysis of child and adult mortality data collected through death registration, censuses, and household surveys

    The rogue nature of hiatuses in a global warming climate

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    The nature of rogue events is their unlikelihood and the recent unpredicted decade-long slowdown in surface warming, the so-called hiatus, may be such an event. However, given decadal variability in climate, global surface temperatures were never expected to increase monotonically with increasing radiative forcing. Here surface air temperature from 20 climate models is analyzed to estimate the historical and future likelihood of hiatuses and “surges” (faster than expected warming), showing that the global hiatus of the early 21st century was extremely unlikely. A novel analysis of future climate scenarios suggests that hiatuses will almost vanish and surges will strongly intensify by 2100 under a “business as usual” scenario. For “CO2 stabilisation” scenarios, hiatus, and surge characteristics revert to typical 1940s values. These results suggest to study the hiatus of the early 21st century and future reoccurrences as rogue events, at the limit of the variability of current climate modelling capability
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