265 research outputs found
Mevalonate kinase deficiency (MKD): long-term follow-up of clinical and biological features in 40 patients
Dislocation core field. I. Modeling in anisotropic linear elasticity theory
Aside from the Volterra field, dislocations create a core field, which can be
modeled in linear anisotropic elasticity theory with force and dislocation
dipoles. We derive an expression of the elastic energy of a dislocation taking
full account of its core field and show that no cross term exists between the
Volterra and the core fields. We also obtain the contribution of the core field
to the dislocation interaction energy with an external stress, thus showing
that dislocation can interact with a pressure. The additional force that
derives from this core field contribution is proportional to the gradient of
the applied stress. Such a supplementary force on dislocations may be important
in high stress gradient regions, such as close to a crack tip or in a
dislocation pile-up
Direct identification of extended defects as vortex pinning centers in melt textured YBa2Cu3O7-Y2BaCuO5 composites
Single domain YBa2Cu3O7-Y2BaCuO5 melt textured ceramic composites have revealed a very rich microstructure, which has usually impeded, by using standard measurements, to evaluate the contribution of each defect to the enhancement of the critical current. We have measured the inplane magnetoresistance anisotropy and the anisotropic in-plane inductive critical currents and we show that together with the microstructural TEM analysis, the contribution of the different extended pinning centers can be separated. These results have allowed us to infer the kind of microstructure modifications required to improve the critical current. In particular, we present an isostatic pressing deformation technique as a very promising post-processing treatment to strongly increase the critical currents of these composites.Peer Reviewe
Comparison between classical potentials and ab initio for silicon under large shear
The homogeneous shear of the {111} planes along the direction of bulk
silicon has been investigated using ab initio techniques, to better understand
the strain properties of both shuffle and glide set planes. Similar
calculations have been done with three empirical potentials, Stillinger-Weber,
Tersoff and EDIP, in order to find the one giving the best results under large
shear strains. The generalized stacking fault energies have also been
calculated with these potentials to complement this study. It turns out that
the Stillinger-Weber potential better reproduces the ab initio results, for the
smoothness and the amplitude of the energy variation as well as the
localization of shear in the shuffle set
PROBIOGAS:Promotion of Biogas for Electricity and Heat Production in EU-Countries. Economic and Environmental Benefits of Biogas from Centralised Co-digestion
Calcitization of aragonitic bryozoans in Cenozoic tropical carbonates from East Kalimantan, Indonesia
© The Author(s) 2016. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The file attached is the published version of the article
Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet
Background: Medication error is a global threat to patient safety, particularly in pediatrics. Yet, this issue remains understudied in this population, in both hospital and community settings.
Objectives: To characterize medication errors involving pediatrics reported to the French Medication Error Guichet, and compare them with medication errors in adults, in each of the hospital and community settings.
Methods: This was a retrospective secondary data analysis of medication errors reported throughout 2013-2017. Descriptive and multivariate analyses were performed to compare actual and potential medication error reports between pediatrics (aged 18 and <60 years). Two subanalyses of actual medication errors with adverse drug reaction (ADR), and serious ADR were conducted.
Results: We analyzed 4,718 medication error reports. In pediatrics, both in hospital (n=791) and community (n=1,541) settings, antibacterials for systemic use (n=121, 15.7%; n=157, 10.4%, respectively) and wrong dose error type (n=391, 49.6%; n=549, 35.7%, respectively) were frequently reported in medication errors. These characteristics were also significantly more likely to be associated with reported errors in pediatrics compared with adults. In the hospital setting, analgesics (adjusted odds ratio (aOR)=1.59; 95% confidence interval (CI) 1.03:2.45), and blood substitutes and perfusion solutions (aOR=3.74; 95%CI 2.24:6.25) were more likely to be associated with reported medication errors in pediatrics; the latter drug class (aOR=3.02; 95%CI 1.59:5.72) along with wrong technique (aOR=2.28; 95%CI 1.01:5.19) and wrong route (aOR=2.74; 95%CI 1.22:6.15) error types related more to reported medication errors with serious ADR in pediatrics. In the community setting, the most frequently reported pediatric medication errors involved vaccines (n=389, 25.7%). Psycholeptics (aOR=2.42; 95%CI 1.36:4.31) were more likely to be associated with reported medication errors with serious ADR in pediatrics. Wrong technique error type (aOR=2.71; 95%CI 1.47:5.00) related more to reported medication errors with ADR in pediatrics.
Conclusions: We identified pediatric-specific medication error patterns in the hospital and community settings. Our findings inform focused error prevention measures, and pave the way for interventional research targeting the needs of this population
Site testing for submillimetre astronomy at Dome C, Antarctica
Over the past few years a major effort has been put into the exploration of
potential sites for the deployment of submillimetre astronomical facilities.
Amongst the most important sites are Dome C and Dome A on the Antarctic
Plateau, and the Chajnantor area in Chile. In this context, we report on
measurements of the sky opacity at 200 um over a period of three years at the
French-Italian station, Concordia, at Dome C, Antarctica. We also present some
solutions to the challenges of operating in the harsh polar environ- ment. Dome
C offers exceptional conditions in terms of absolute atmospheric transmission
and stability for submillimetre astron- omy. Over the austral winter the PWV
exhibits long periods during which it is stable and at a very low level (0.1 to
0.3 mm). Higher values (0.2 to 0.8 mm) of PWV are observed during the short
summer period. Based on observations over three years, a transmission of around
50% at 350 um is achieved for 75% of the time. The 200-um window opens with a
typical transmission of 10% to 15% for 25% of the time. Dome C is one of the
best accessible sites on Earth for submillimetre astronomy. Observations at 350
or 450 {\mu}m are possible all year round, and the 200-um window opens long
enough and with a sufficient transparency to be useful. Although the polar
environment severely constrains hardware design, a permanent observatory with
appropriate technical capabilities is feasible. Because of the very good
astronomical conditions, high angular resolution and time series (multi-year)
observations at Dome C with a medium size single dish telescope would enable
unique studies to be conducted, some of which are not otherwise feasible even
from space
e-Pilly TROP Maladies infectieuses tropicales
Lâe-Pilly TROP est un ouvrage dâinfectiologie tropicale destinĂ© aux mĂ©decins et aux Ă©tudiants en mĂ©decine des pays francophones du Sud. La prise en compte des diffĂ©rents niveaux de la pyramide sanitaire dans ces pays le rend aussi accessible aux infirmiers des centres de santĂ© communautaires urbains et des structures de santĂ© intermĂ©diaires des zones rurales. Par dĂ©finition, les Pays En DĂ©veloppement accroissant progressivement leurs capacitĂ©s de diagnostic biologique et de traitement, les outils de prise en charge correspondent aux moyens des niveaux pĂ©riphĂ©riques comme Ă ceux des niveaux hospitaliers de rĂ©fĂ©rence
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