Industry 4.0

Во всем мире традиционная обрабатывающая промышленность находится в процессе цифрового преобразования, которое вызвано стремительно растущими технологиями (например, роботы, автономные беспилотные летательные аппараты, 3D- печать). Компании и их производственные процессы должны подстроиться под эти быстрые изменения, если они не хотят отстать от развития их индустрии. Around the world, traditional manufacturing industry is in the throes of a digital transformation that is accelerated by exponentially growing technologies (e.g. intelligent robots, autonomous drones, sensors, 3D printing). Companies and their industrial processes need to adapt to this rapid change if they are not to be left behind by developments in their sector and by their competitors

The Organic Research Centre; Elm Farm Bulletin 84 July 2006

Regular bulletin with technical updates of the Organic Advisory Service Issue contains: Battling on for Avian Flu preventive vaccination; Organic Colombian Blacktail eggs; UK Co-existence - GMOand non-GMO crops; Aspects of Poultry Behaviour; CAP in the service of biodiversity; Seeing the Wood, the Trees and the Catch 22; Beware of organic market "statistics"; A central role in energy review

Elm Farm Organic Research Centre Bulletin 83 April 2006

Regular bulleting with technical updates from Organic Advisory Service Issue contains: Testing for Tolerance - a pragmatic view GM Debate Vaccination nation - to jab or not to jab Future shape of OCIS Evolutionary wheat makes the grade? NIAB tracks health of organic cereal seed Stopping erosion of soil quality - the organic way Care needed to halt butterfly collapse Aspects of poultry behaviour: How free range is free range? On choosing an organic wheat A local education challenge New Wakelyns Science Building Organic vegetable market growt

A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score

Genome-wide association studies have identified a number of single-nucleotide polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of evidence suggests a complex connection of SNPs and the transcriptional and epigenetic regulation of gene expression, which is poorly understood. In the current study, we investigated the interplay between genetic risk variants, shifts in methylation and mRNA levels in whole blood from 223 adolescents distinguished by a risk for developing psychiatric disorders. We analyzed 37 SNPs previously associated with psychiatric diseases in relation to genome-wide DNA methylation levels using linear models, with Bonferroni correction and adjusting for cell-type composition. Associations between DNA methylation, mRNA levels and psychiatric disease risk evaluated by the Development and Well-Being Assessment (DAWBA) score were identified by robust linear models, Pearson's correlations and binary regression models. We detected five SNPs (in HCRTR1, GAD1, HADC3 and FKBP5) that were associated with eight CpG sites, validating five of these SNP-CpG pairs. Three of these CpG sites, that is, cg01089319 (GAD1), cg01089249 (GAD1) and cg24137543 (DIAPH1), manifest in significant gene expression changes and overlap with active regulatory regions in chromatin states of brain tissues. Importantly, methylation levels at cg01089319 were associated with the DAWBA score in the discovery group. These results show how distinct SNPs linked with psychiatric diseases are associated with epigenetic shifts with relevance for gene expression. Our findings give a novel insight on how genetic variants may modulate risks for the development of psychiatric diseases

CPVMatch - Concentrating photovoltaic modules using advanced technologies and cells for highest efficiencies

This paper presents the project Concentrating Photovoltaic modules using advanced technologies and cells for highest efficiencies (CPVMatch), which is funded from the European Union’s Horizon 2020 research and innovation programme. V multi-junction solar cells and CPV modules. Concerning cells, novel wafer bonded four-junction solar cells made of GaInP/GaAs//GaInAs/Ge are optimized with the target of reaching 48% efficiency under concentration at the end of the project. Moreover, multi-junction solar cell technologies with advanced materials - like ternary IV element mixtures (i.e. SiGeSn) and nanostructured anti-reflective coatings - are investigated. Concerning CPV modules the project focuses on both Fresnel-based and mirror-based technologies with a target efficiency of 40% under high concentrations beyond 800x. Achromatic Fresnel lenses for improved light management without secondary optics are investigated. In addition, smart, mirror-based HCPV modules are developed, which include a new mirror-based design, the integration of high efficiency, low cost DC/DC converters and an intelligent tracking sensor (PSD sensor) at module level. A profound life-cycle and environmental assessment and the development of adapted characterization methods of new multi-junction cells and HCPV modules complete the work plan of CPVMatch

Limiter lock systems at TEXTOR: flexible tools for plasma-wall investigation

Limiter lock systems on the top and the bottom of the TEXTOR vessel are essential elements for experimental investigations of plasma-wall interaction in a tokamak. The lock systems are designed as user facilities that allow the insertion of wall elements (limiter) and tools for diagnostic (electrical probes, gas injection) without breaking the TEXTOR vacuum. The specially designed holder on top of the central carrier and a powerful vacuum pump system permit the exchange of components within similar to1 h. Up to ten electrical signals, four thermocouples, and a gas supply can be connected at the holder interface. Between discharges, the inserted component can be positioned radially and turned with respect to the toroidal magnetic field. Additionally, the central carrier is electrically isolated to apply bias voltages and currents up to 1 kV and 1 kA, respectively.An important feature of the lock system is the good access for optical spectroscopic observation of the inserted components in the vicinity of the edge plasma. The whole spectrum from ultraviolet to infrared is covered by spectrometers and filters combined with cameras. Toroidally and poloidally resolved measurements are obtained front the view on top of the probes while the tangential poloidal view delivers radially and toroidally resolved information.A programmable logic controller (Simatic S5) that is operated inside the TEXTOR bunker and from remote locations outside the concrete wall drives all possible features of the lock system

Role of Linker Functionality in Polymers Exhibiting Main-Chain Thermally Activated Delayed Fluorescence

Excellent performance has been reported for organic light‐emitting diodes (OLEDs) based on small molecule emitters that exhibit thermally activated delayed fluorescence. However, the necessary vacuum processing makes the fabrication of large‐area devices based on these emitters cumbersome and expensive. Here, the authors present high performance OLEDs, based on novel, TADF polymers that can be readily processed from a solution. These polymers are based on the acridine‐benzophenone donor–acceptor motif as main‐chain TADF chromophores, linked by various conjugated and non‐conjugated spacer moieties. The authors’ extensive spectroscopic and electronic analysis shows that in particular in case of alkyl spacers, the properties and performance of the monomeric TADF chromophores are virtually left unaffected by the polymerization. They present efficient solution‐processed OLEDs based on these TADF polymers, diluted in oligostyrene as a host. The devices based on the alkyl spacer‐based TADF polymers exhibit external quantum efficiencies (EQEs) ≈12%, without any outcoupling‐enhancing measures. What's more, the EQE of these devices does not drop substantially upon diluting the polymer down to only ten weight percent of active material. In contrast, the EQE of devices based on the monomeric chromophore show significant losses upon dilution due to loss of charge percolation