Fear of Birth Defects Is a Major Barrier to Soil-Transmitted Helminth Treatment (STH) for Pregnant Women in the Philippines

The World Health Organization recommends anthelminthic treatment for pregnant women after the first trimester in soil-transmitted helminth (STH) endemic regions to prevent adverse maternal-fetal consequences. Although studies have shown the high prevalence of infection in the Philippines, no research has evaluated deworming practices. We hypothesized that pregnant women are not receiving deworming treatment and we aimed to identify barriers to World Health Organization guideline implementation. We conducted key informant interviews with local Department of Health (DOH) administrators, focus group discussions with nurses, midwives, and health care workers, and knowledge, attitudes, and practices surveys with women of reproductive age to elicit perspectives about deworming during pregnancy. Key informant interviews revealed that healthcare workers were not deworming pregnant women due to inadequate drug supply, infrastructure and personnel as well as fear of teratogenicity. Focus group discussions showed that healthcare workers similarly had not implemented guidelines due to infrastructure challenges and concerns for fetal malformations. The majority of local women believed that STH treatment causes side effects (74.8%) as well as maternal harm (67.3%) and fetal harm (77.9%). Women who were willing to take anthelminthics while pregnant had significantly greater knowledge as demonstrated by higher Treatment Scores (mean rank 146.92 versus 103.1, z = −4.40, p<0.001) and higher Birth Defect Scores (mean rank 128.09 versus 108.65, z = −2.43, p = 0.015). This study concludes that World Health Organization guidelines are not being implemented in the Philippines. Infrastructure, specific protocols, and education for providers and patients regarding anthelminthic treatment are necessary for the successful prevention of STH morbidity and mortality among pregnant women

Synthesis of benzothiazolopyrazoloisonicotinohydrazide derivatives and their nitro regioisomers for antitubercular activity

1388-1399The history of incessant struggle and the current global burden associated with emerging infectious disease especially tuberculosis, guided us to define the scope of this research project, and to identify research gaps in synthesizing some heterocyclic compounds for anti-tubercular activity. In this research project, we have synthesized a series of novel heterocyclic (benzothiazoles) compounds viz N'-((1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-phenyl-1H-pyrazol-4-yl) methylene)isonicotinohydrazide 12a-c their 5-nitro 15a-c and 4-nitro 18a-c derivatives, by a series of reactions of their respective synthons. The completion of reaction and the purity of the synthesized compounds have been established by chromatographic analysis. All the newly synthesized compounds satisfactorily show acceptable analysis for their anticipated structures, which have been confirmed based on physicochemical and spectral data. These newly synthesized compounds have been primarily evaluated for their in&nbsp;vitro anti-tubercular activity by Ziehl-Neelsen stain method. Compounds 15a, 15b, 15c, 18b and 18c have shown 100% inhibition at 25 mg/ mL and MIC values of around 45 nM against M. tuberculosis H37Rv (ATCC 27294). Cytotoxicity on THP-1 cell line shows that all the tested compounds are safe

Synthesis of benzothiazolopyrazoloisonicotinohydrazide derivatives and their nitro regioisomers for antitubercular activity

The history of incessant struggle and the current global burden associated with emerging infectious disease especially tuberculosis, guided us to define the scope of this research project, and to identify research gaps in synthesizing some heterocyclic compounds for anti-tubercular activity. In this research project, we have synthesized a series of novel heterocyclic (benzothiazoles) compounds viz N'-((1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-phenyl-1H-pyrazol-4-yl) methylene)isonicotinohydrazide 12a-c their 5-nitro 15a-c and 4-nitro 18a-c derivatives, by a series of reactions of their respective synthons. The completion of reaction and the purity of the synthesized compounds have been established by chromatographic analysis. All the newly synthesized compounds satisfactorily show acceptable analysis for their anticipated structures, which have been confirmed based on physicochemical and spectral data. These newly synthesized compounds have been primarily evaluated for their in vitro anti-tubercular activity by Ziehl-Neelsen stain method. Compounds 15a, 15b, 15c, 18b and 18c have shown 100% inhibition at 25 mg/ mL and MIC values of around 45 nM against M. tuberculosis H37Rv (ATCC 27294). Cytotoxicity on THP-1 cell line shows that all the tested compounds are safe.

Alexa Controlled Smart Ev System

Electric vehicles (EVs) are becoming more prevalent on the road and in the grid of power plants in the design of EVs, the energy system and management are crucial components. Fully battery electric vehicles (FBEVs) and hybrid electric vehicles are the two main forms of EVs. Alexa Controlled Electric Vehicle is a new concept that integrates Amazon's Alexa voice assistant into an electric two-wheeler. This innovative combination has the potential to revolutionize the way we ride bicycles, offering a safer, more convenient, and more enjoyable experience. Riders of the Alexa Controlled Electric Vehicle could control various aspects of their ride using voice commands. For example, they could: Turn the vehicle on or off through their phone, Adjust the vehicle's speed and lighting, Lock and unlock the vehicle and Control the vehicle's horn. These features would not only enhance convenience but also improve safety. The Lock and Unlock feature eliminates the need for keys, while controlling the vehicle's horn and lights introduces a new way to locate the vehicle in parking areas and utilize the headlights as emergency lights in forested areas. The Alexa Controlled Electric Vehicle (2 wheeler) is still in the early stages of development, but it has the potential to change the way we think about transportation. This innovative concept could make riding bikes safer, more convenient, and more enjoyable for everyone

NITROGEN, PHOSPHORUS, AND POTASSIUM RANGE OF VERMICOMPOST USING EISENIA FETIDA AND PERIONYX EXCAVATUS

The aim of the presentation is to produce vermicomposting from organic kitchen solid wastes using two types of earthworms such as Eisenia fetida and Perionyx excavatus and check the nitrogen, phosphorus, and potassium level between E. fetida and P. excavatus. This study examines the potential of the E. fetida and P. excavatus in the vermicompost of kitchen waste. As kitchen waste is rich in organic material. Physical and biochemical parameters were analyzed during the period of 60 days. Pre-decomposition is 15 days and subsequent vermicomposting is 60 days indicates, the rule of these species of vermitechnology increase was found in all the parameters such as total nitrogen (%), available phosphorus (%), and exchangeable potassium (%) while a decrease was found in pH and carbon-to-nitrogen ratio in E. fetida as the timing of vermicomposting increased from 0 days to 60 days

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Assessment of Dental Anxiety among College Students in Salem - A Cross Sectional Study

Background: Mitigating dental anxiety in the present context is essential for enhancing individual oral health and cultivating a more informed, healthier community. Aim: The study aims to assess the prevalence of dental anxiety among college students and identify factors that contribute to their apprehension about dental visit. Materials and methods: A descriptive Cross- sectional study was done in Salem between April to June 2024 among college students. Data were collected from 385students by face to face interview using semi-structured questionnaire. Chi-Square test was used to examine the association. Results: The Prevalence of dental anxiety among the study population was 85%. Majority of the study participants were anxious for (slightly extreme anxious) tooth drilled procedure (Frequency 74%, 2.69 +1.34SD) followed by higher anxiety for local anesthetic injection (67%, 2.47 +1.349SD) and for scaling treatment (64%, 2.21+1.15SD). Women demonstrated a significantly higher level of dental anxiety than men (p<0.05) and also participants belonging to the family income level of < RS.37,325 shows high level of dental anxiety (p<0.05). Conclusion: Results shows that Gender and family income were significantly associated with dental anxiety, out of all the socio demographic factors. Reducing avulsion brought on by dental anxiety in clinics and improving patient management are two benefits of addressing dental anxiety levels in various groups. Keywords: Dental fear, Oral Health status, Traumatic Dental Experience, Socio Demographic Factor

Increasing Compliance with Mass Drug Administration Programs for Lymphatic Filariasis in India through Education and Lymphedema Management Programs

Global elimination of lymphatic filariasis requires giving drugs at least annually to populations who live at risk of becoming infected with the parasite. At least 80% of people at risk need to take the drugs annually for 5 or more years to stop transmission of the infection. People suffering from the long-term effects of infection, such as swollen legs, benefit from programs that teach self-care of their affected limbs. In this study, we assessed the impact of an educational campaign that, after addressing previously identified predictors of compliance, significantly improved drug compliance. The specific factors improving compliance included knowing about the drug distribution in advance, knowing that everyone is at risk for acquiring the infection, knowing that the drug distribution was for lymphatic filariasis prevention, and knowing at least one component of leg care. We also found that areas with programs to assist people with swollen legs had greater increases in compliance. This research provides evidence that program evaluation can be used to improve drug compliance. In addition, our work shows for the first time that programs to benefit people with swollen legs caused by lymphatic filariasis also increase the participation of people without disease in drug treatment programs

A multicenter, community-based, mixed methods assessment of the acceptability of a triple drug regimen for elimination of lymphatic filariasis

BackgroundMany countries will not reach elimination targets for lymphatic filariasis in 2020 using the two-drug treatment regimen (diethylcarbamazine citrate [DEC] and albendazole [DA]). A cluster-randomized, community-based safety study performed in Fiji, Haiti, India, Indonesia and Papua New Guinea tested the safety and efficacy of a new regimen of ivermectin, DEC and albendazole (IDA).Methodology/principal findingsTo assess acceptability of IDA and DA, a mixed methods study was embedded within this community-based safety study. The study objective was to assess the acceptability of IDA versus DA. Community surveys were performed in each country with randomly selected participants (>14 years) from the safety study participant list in both DA and IDA arms. In depth interviews (IDI) and focus group discussions (FGD) assessed acceptability-related themes. In 1919 individuals, distribution of sex, microfilariae (Mf) presence and circulating filarial antigenemia (CFA), adverse events (AE) and age were similar across arms. A composite acceptability score summed the values from nine indicators (range 9-36). The median (22.5) score indicated threshold of acceptability. There was no difference in scores for IDA and DA regimens. Mean acceptability scores across both treatment arms were: Fiji 33.7 (95% CI: 33.1-34.3); Papua New Guinea 32.9 (95% CI: 31.9-33.8); Indonesia 30.6 (95% CI: 29.8-31.3); Haiti 28.6 (95% CI: 27.8-29.4); India 26.8 (95% CI: 25.6-28) (PConclusions/significanceIDA and DA regimens for LF elimination were highly and equally acceptable in individuals participating in the community-based safety study in Fiji, Haiti, India, Indonesia, and Papua New Guinea. Country variation in acceptability was significant. Acceptability of the professionalism of the treatment delivery was highlighted