62 research outputs found

    ART2 et apprentissage de séquences de mots : l'ordre compte

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    ISBN : 978-2-9532965-0-1Un réseau Adaptive Resonance Theory a été utilisé pour simuler l'apprentissage des formes orthographiques des mots vus par les enfants. Il a été démontré qu'une modélisation par carte auto-organisatrice permet de rendre compte des performances de l'enfant si on conserve les probabilités d'apparition des mots de la base d'apprentissage. Nous montrons dans cet article avec ART2, que l'ordre d'apparition des mots joue aussi un rôle significatif dans la discrimination des mots plus ou moins orthographiquement voisins. Il en découle une hypothése de construction de corpus favorable é l'apprentissage de la lecture de ce type de mots

    Antibody Evasion by a Gammaherpesvirus O-Glycan Shield

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    All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is incomplete. In this study, we used Bovine Herpesvirus 4 (BoHV-4) to determine how its gp350 homolog - gp180 - contributes to virus replication and neutralization. A lack of gp180 had no impact on the establishment and maintenance of BoHV-4 latency, but markedly sensitized virions to neutralization by immune sera. Antibody had greater access to gB, gH and gL on gp180-deficient virions, including neutralization epitopes. Gp180 appears to be highly O-glycosylated, and removing O-linked glycans from virions also sensitized them to neutralization. It therefore appeared that gp180 provides part of a glycan shield for otherwise vulnerable viral epitopes. Interestingly, this O-glycan shield could be exploited for neutralization by lectins and carbohydrate-specific antibody. The conservation of O-glycosylation sites in all gp350 homologs suggests that this is a general evasion mechanism that may also provide a therapeutic target

    HelexKids:a word frequency database for Greek and Cypriot primary school children

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    In this article, we introduce HelexKids, an online written-word database for Greek-speaking children in primary education (Grades 1 to 6). The database is organized on a grade-by-grade basis, and on a cumulative basis by combining Grade 1 with Grades 2 to 6. It provides values for Zipf, frequency per million, dispersion, estimated word frequency per million, standard word frequency, contextual diversity, orthographic Levenshtein distance, and lemma frequency. These values are derived from 116 textbooks used in primary education in Greece and Cyprus, producing a total of 68,692 different word types. HelexKids was developed to assist researchers in studying language development, educators in selecting age-appropriate items for teaching, as well as writers and authors of educational books for Greek/Cypriot children. The database is open access and can be searched online at www.helexkids.org

    Unexpectedly good spellers too. Associations and dissociations in reading and spelling French

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