New national and regional bryophyte records, 49

Peer reviewe

New national and regional bryophyte records, 33

WOS: 000313348700006…Russian Foundation for Basic Research [12-04-01476, 11-04-01247-a]; Program of Presidium of the Russian Academy of Sciences [12-Pi-4-1018]; Vologda Department of the Russian Geographic Society; TUBITAK; Myndel Botanica Fundation; CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas) [PIP 2012-2014]; Polish Ministry of Science and Higher Education [NN 303 796 940, N N 303 469 338]; Development for Innovations' Operational Programme [CZ.1.05/2.1.00/03.0100]; Structural Funds of the European Union; state budget of the Czech Republic; Spanish Ministry of Science and Innovation [CGL2010-15693, GL2011-28857]; Scientific and Technological Research Council of Turkey TUBITAK [111T359]; [TAMOP-4.2.2.B-10/1-2010-0018]The research of M. V. Dulin had the financial support of the Russian Foundation for Basic Research (projects no. 12-04-01476) and the Program of Presidium of the Russian Academy of Sciences (no. 12-Pi-4-1018). The research of L. E. Kurbatova was financially supported by grants from the Russian Foundation for Basic Research (project no. 11-04-01247-a). D. A. Philippov is grateful to the Vologda Department of the Russian Geographic Society for support. M. Kirmaci and E. Agcagil are very grateful to TUBITAK for providing a student scholarship to the second author and to Beata Papp (Hungarian Natural History Museum) for confirming the species.; J. R. Flores and G. M. Suarez had Financial support from the Myndel Botanica Fundation and PIP 2012-2014 CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas). The contributions by H. Bednarek-Ochyra and R. Ochyra have been financially supported by the Polish Ministry of Science and Higher Education through grants no. NN 303 796 940 for H. Bednarek-Ochyra and no. N N 303 469 338 for R. Ochyra. They also thank the Curators at BM, PC and S for kindly allowing them to examine the herbarium material used in their study. The field work of R. Ochyra and Marc Leboubier on Iles Crozet and Iles Kerguelen was organised within the programme 136 ECOBIO of the French Polar Institute (IPEV). The investigations of P. Szucs and A. Bidlo have been carried out with the sponsorship of TAMOP-4.2.2.B-10/1-2010-0018. The contribution by V. Plasek, G. J. Wolski and J. Sawicki is part of a research project of the Institute of Environmental Technologies, reg. no. CZ.1.05/2.1.00/03.0100, supported by the 'Research and Development for Innovations' Operational Programme financed by the Structural Funds of the European Union and by the state budget of the Czech Republic.; B. Vigalondo, F. Lara, I. Draper & R. Garilleti are grateful to Belen Albertos, Rafael Medina and Belen Estebanez for their valuable field work and to the Spanish Ministry of Science and Innovation for financial support (projects CGL2010-15693 and CGL2011-28857). T. Ezer and R. Kara are indebted to the Scientific and Technological Research Council of Turkey TUBITAK (project no. 111T359)

THE RELATIONSHIP BETWEEN SERUM DNA LEVELS AND SEROLOGICAL MARKERS, ALT

Introduction: Determination of Hepatitis B virus (HBV) by molecular methods is increasingly common. Together with biochemical and serological diagnostic methods and a histopathological assessment is important to detect necrosis, inflammation, and fibrosis in the liver. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values are tests often used to predict the histological stages of chronic hepatitis.Materials and methods: One hundred seventy-three patients who were referred to the Kahramanmaras Necip Fazil City Hospital Microbiology Laboratory with prediagnosis of HBV infection between September 2012-January 2016, were evaluated with necroinflammatory activity levels/ histological activity index (HAI) and fibrosis scores according to the ISHAK classification criteria, and the results were compared with alanine aminotransferase (ALT), aspartate aminotransferase (AST), and HBV-DNA serum levels of the time of biopsy.Results: The study included 63 female and 109 male patients. The mean age was 39.39 +/- 13.4 years. There was statistically significant difference in age, ALT, AST, and HBV DNA levels between patients in the high fibrosis group and the low fibrosis group (p: 0.034, 0.002, 0.0001, and 0.007, respectively). There was significant difference between patients from severe HAI and mild to moderate HAI groups in terms of AST values (p: 0.045). AST was found to be a risk factor for fibrosis, and ALT and AST were found to be risk factors for HAI. HBV DNA, ALT, and AST levels of HBe-Ag positive patients were significantly higher compared to HBe-Ag negative patients (p: 0,0001, 0,027, 0,008).Conclusions: In our study, advanced age, high HBV DNA, ALT and AST levels were found to be associated with fibrosis, and high AST levels were found to be associated with liver necroinflammation. It is thought that serum ALT and AST levels could be useful parameters for liver necroinflammation and fibrosis. Evaluation of these parameters in chronic hepatitis B patients as indicator parameters for advanced stages of fibrosis and necroinflammation would be a right approach