Antimicrobial efficacy of nanosilver, sodium hypochlorite and chlorhexidine gluconate against Enterococcus faecalis

The purpose of this study was to compare the antibacterial efficacy of nanosilver (NS), chlorhexidine gluconate (CHX) and sodium hypochlorite (NaOCl) against Enterococcus faecalis. Two tests of minimum inhibitory concentration (MIC) and zone of inhibition were carried out using NS, NaOCl and CHX. 70-fold concentration of NaOCl is required for the same antibacterial effect of NS. CHX precipitated in contact with the culture medium and was excluded from MIC test. The means and standard deviations of the zones of inhibition for 5.25% NaOCl, 0.33% NaOCl, 25 μg/ml NS, 50 μg/ml NS, 4000 μg/ml NS and 2% CHX were 12.16 ± 1.46, 6.91 ± 0.66, 10.00 ± 0.42, 12.00 ± 0.60, 13.33 ± 1.23 and 24.80 ± 1.11, respectively. Statistical analysis using ANOVA showed significant differences among groups (p < 0.001). A post hoc Tukey test revealed no significant differences between 5.25% NaOCl and 4000 μg/ml NS (p = 0.057). However, the zones of inhibition for 2% CHX were significantly larger than those seen around the filter papers saturated with undiluted NaOCl and NS (p < 0.001 for both). This study revealed that NS in a remarkably lower concentration would possess the same bactericidal effect as 5.25% NaOCl.Key words: Chlorhexidine gluconate, Enterococcus faecalis, nanosilver, sodium hypochlorite

Modelling of novel-structured copper barium tin sulphide thin film solar cells

[EN] In this work, a novel structured Cu2BaSnS4 (CBTS)/ZnS/Zn(O, S) photovoltaic device is proposed. A nontoxic, earth-abundant and auspicious quaternary semiconductor compound copper barium tin sulphide (Cu2BaSnS4) is used as an absorber layer. We propose a novel Zn(O, S) buffer layer for a high-power conversion efficiency (PCE) of CBTS-based thin film photovoltaic cells. Solar cell capacitance simulator software is used for device modelling and simulations are performed under a 1.5 AM illumination spectrum. The proposed device is investigated by means of numerical modelling and optimized the parameters to maximize its efficiency. Promising optimized functional parameters had been achieved from the proposed structure with back surface field layer with a PCE of 18.18%, a fill factor of 83.45%, a short-circuit current of 16.13 mA cm¿2 and an open-circuit voltage of 1.3 V. The promising results give an imperative standard for possible manufacturing of high efficiency, eco-friendly inorganic CBTS-based photovoltaic cells.This work was supported by Ministerio de Economia y Competitividad (ENE2016-77798-C4-2-R) and Generalitat valenciana (Prometeus 2014/044).Hameed, KY.; Baig, F.; Toura, H.; Marí, B.; Beg, S.; Khani, NAK. (2019). Modelling of novel-structured copper barium tin sulphide thin film solar cells. Bulletin of Materials Science. 42(5):1-8. https://doi.org/10.1007/s12034-019-1919-9S18425Ge J, Koirala P, Grice C R, Roland P J, Yu Y, Tan X et al 2017 Adv. Energy Mater. 7 1601803Khattak Y H, Mahmood T, Alam K, Sarwar T, Ullah I and Ullah H 2014 Am. J. Electr. Power Energy Syst. 3 86Steinmann V, Brandt R E and Buonassisi T 2015 Nat. Photonics 9 355Jackson P, Hariskos D, Wuerz R, Kiowski O, Bauer A, Friedlmeier T M et al 2015 Phys. Status Solidi: Rapid. Res. Lett. 9 28Shin D, Saparov B and Mitzi D B 2017 Adv. Energy Mater. 7 1602366Paper C, Le A, Universit D, Universit B, Universit M A, Marchionna S et al 2017 Eur. Photovolt. Sol. Energy Conf. 33 25Khattak Y H, Baig F, Ullah S, Marí B, Beg S and Ullah H 2018 J. Renew. Sustain. Energy 10 033501Fontané X, Izquierdo-Roca V, Saucedo E, Schorr S, Yukhymchuk V O, Valak M Y et al 2012 J. Alloys Compd. 539 190Zhang X, Bao N, Ramasamy K, Wang Y-H A, Yifeng Wang B L and Gupta A 2012 Chem. Commun. 48 4956Adewoyin A D, Olopade M A and Chendo M 2017 Optik—Int. J. Light Electron Opt. 133 122Boutebakh F Z, Zeggar M L, Attaf N and Aida M S 2017 Optik—Int. J. Light Electron Opt. 144 180Ananthakumar S, Ram Kumar J and Moorthy Babu S 2016 Optik—Int. J. Light Electron Opt. 127 10360Jianjun L, Dongxiao W, Xiuling L and Zeng Y 2018 Adv. Sci. 5 1700744Khattak Y H, Baig F, Ullah S, Marí B, Beg S and Ullah H 2018 Optik—Int. J. Light Electron Opt. 164 547Xiao Z, Meng W, Li J V. and Yan Y 2017 ACS Energy Lett. 2 29Shin D, Saparov B, Zhu T, Huhn W P, Blum V and Mitzi D B 2016 Chem. Mater. 28 477Repins I L, Romero M J, Li J V, Wei S-H, Kuciauskas D, Jiang C-S et al 2013 J. Photovoltaics 3 439Zhou H, Hsu W-C, Duan H-S, Bob B, Yang W, Song T-B et al 2013 Energy Environ. Sci. 6 2822Khattak Y H, Baig F, Toura H, Ullah S, Marí B, Beg S et al 2018 Curr. Appl. Phys. 18 633Ge J, Roland P J, Koirala P, Meng W, Young J L, Petersen R et al 2017 Chem. Mater. 29 916Ge J and Yan Y 2017 J. Mater. Chem. C 5 6406Hong F, Lin W, Meng W and Yan Y 2016 Phys. Chem. Chem. Phys. 18 4828Todorov T, Gunawan O and Guha S 2016 Mol. Syst. Des. Eng. 1 370Baig F, Ullah H, Khattak Y H and Mari Soucase B 2016 Int. Ren. Sus. En. Conf. 596, https://doi.org/10.1109/IRSEC.2016.7983899Lin L-Y, Qiu Y, Zhang Y and Zhang H 2016 Chinese Phys. Lett. 33 10780Platzer B C, Törndahl T, Abou-Ras D, Malmström J, Kessler J and Stolt L 2006 J. Appl. Phys. 100 044506Persson C, Platzer-Björkman C, Malmström J, Törndahl T and Edoff M 2006 Phys. Rev. Lett. 97 146403Burgelman M, Nollet P and Degrave S 2000 Thin Solid Films 361 527Khattak Y H, Baig F, Soucase B M and Beg S 2018 Mater. Focus 84 758Simya O K, Mahaboobbatcha A and Balachander K A 2015 Superlattices Microstruct. 82 248Shin D, Zhu T, Huang X, Gunawan O, Blum V and Mitzi D B 2017 Adv. Mater. 29 1Saha U and Alam M K 2018 Phys. Status Solidi: Rapid Res. Lett. 12 1Zhu T, Huhn W P, Wessler G C, Shin D, Saparov B, Mitzi D B et al 2017 Chem. Mater. 29 7868Ge J, Grice C R and Yan Y 2017 J. Mater. Chem. A 5 2920Baig F, Khattak Y H, Marí B, Beg S, Gillani S R and Ahmed A 2018 Optik—Int. J. Light Electron Opt. 170 463Khattak Y H, Baig F, Ullah S, Marí B, Beg S and Gillani S R 2018 Optik—Int. J. Light Electron Opt. 171 45

Optimal generation of Fock states in a weakly nonlinear oscillator

We apply optimal control theory to determine the shortest time in which an energy eigenstate of a weakly anharmonic oscillator can be created under the practical constraint of linear driving. We show that the optimal pulses are beatings of mostly the transition frequencies for the transitions up to the desired state and the next leakage level. The time of a shortest possible pulse for a given nonlinearity scale with the nonlinearity parameter delta as a power law of alpha with alpha=-0.73 +/-0.029. This is a qualitative improvement relative to the value alpha=1 suggested by a simple Landau-Zener argument.Comment: 10 pages, 6 figure

Schizophrenia and cardiometabolic abnormalities: A Mendelian randomization study

Background: Individuals with a diagnosis of schizophrenia are known to be at high risk of premature mortality due to poor physical health, especially cardiovascular disease, diabetes, and obesity. The reasons for these physical health outcomes within this patient population are complex. Despite well-documented cardiometabolic adverse effects of certain antipsychotic drugs and lifestyle factors, schizophrenia may have an independent effect. / Aims: To investigate if there is evidence that schizophrenia is causally related to cardiometabolic traits (blood lipids, anthropometric traits, glycaemic traits, blood pressure) and vice versa using bi-directional two-sample Mendelian randomization (MR) analysis. / Methods: We used 185 genetic variants associated with schizophrenia from the latest Psychiatric Genomics Consortium GWAS (n = 130,644) in the forward analysis (schizophrenia to cardiometabolic traits) and genetic variants associated with the cardiometabolic traits from various consortia in the reverse analysis (cardiometabolic traits to schizophrenia), both at genome-wide significance (5 × 10−8). The primary method was inverse-variance weighted MR, supported by supplementary methods such as MR-Egger, as well as median and mode-based methods. / Results: In the forward analysis, schizophrenia was associated with slightly higher low-density lipoprotein (LDL) cholesterol levels (0.013 SD change in LDL per log odds increase in schizophrenia risk, 95% CI, 0.001–0.024 SD; p = 0.027) and total cholesterol levels (0.013 SD change in total cholesterol per log odds increase in schizophrenia risk, 95% CI, 0.002–0.025 SD; p = 0.023). However, these associations did not survive multiple testing corrections. There was no evidence of a causal effect of cardiometabolic traits on schizophrenia in the reverse analysis. / Discussion: Dyslipidemia and obesity in schizophrenia patients are unlikely to be driven primarily by schizophrenia itself. Therefore, lifestyle, diet, antipsychotic drugs side effects, as well as shared mechanisms for metabolic dysfunction and schizophrenia such as low-grade systemic inflammation could be possible reasons for the apparent increased risk of metabolic disease in people with schizophrenia. Further research is needed to examine the shared immune mechanism hypothesis

Petroleum hydrocarbon assessment in the wastewaters of petrochemical special economic zone and sediment benchmark calculation of the coastal area - northwest of the Persian Gulf

Petrochemical industries can potentially impact the environment due to their activities and products. This case study has considered adverse effects of petrochemical industries that are located inside the PETZONE with respect to the presence of polycyclic aromatic hydrocarbons and total petroleum hydrocarbon in wastewater effluents. The average concentrations of ∑PAHs group I and II were lower than the guideline values, thus the effluents of the study area can be considered unpolluted. Also, the average concentration of TPH was lower than the guideline value at all almost stations except the effluent outlets of the Razi and Imam Khomeini petrochemical (BI-PC) companies which are proximal to Khowr-e Musa Bay. Thus, they may have an adverse impact on the aquatic ecosystem of the Bay. Therefore, the concentration of TPH was monitored in the sediments of the Bay (around the PETZONE coastal area) which was relatively moderate compared in the study area. Also, the sum of Chronic Potency Ratio of PAHs in sediments showed that the chronic benchmark was not more than the guideline at all stations (it is exceeded when the sum exceeds 1.0) except in the vicinity of the Aromatic effluent outlet of BI-PC. Thus, the chronic benchmark at this station indicates that it has the potential to cause a chronic effect on sediment-residence organisms like crabs, clams and worms. Moreover, PAHs concentration level in this station approached the NOAA sediment quality guideline value (ERL) of 4000 (ng/g dry weight)

High Fidelity Quantum Gates in the Presence of Dispersion

We numerically demonstrate the control of motional degrees of freedom of an ensemble of neutral atoms in an optical lattice with a shallow trapping potential. Taking into account the range of quasimomenta across different Brillouin zones results in an ensemble whose members effectively have inhomogeneous control fields as well as spectrally distinct control Hamiltonians. We present an ensemble-averaged optimal control technique that yields high fidelity control pulses, irrespective of quasimomentum, with average fidelities above 98%. The resulting controls show a broadband spectrum with gate times in the order of several free oscillations to optimize gates with up to 13.2% dispersion in the energies from the band structure. This can be seen as a model system for the prospects of robust quantum control. This result explores the limits of discretizing a continuous ensemble for control theory

Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19/CYP2D6 genes play a role? A UK population-based study

Background: Dyslipidaemia is an important cardiovascular risk factor for people with severe mental illness, contributing to premature mortality. The link between antipsychotics and dyslipidaemia is well established, while evidence on antidepressants is mixed. Aims: To investigate if antidepressant/antipsychotic use was associated with lipid parameters in UK Biobank participants and if CYP2C19 and CYP2D6 genetic variation plays a role. Methods: Review of self-reported prescription medications identified participants taking antidepressants/antipsychotics. Total, low-, and high-density lipoprotein cholesterol (L/HDL-C) and triglycerides derived from blood samples. CYP2C19 and CYP2D6 metabolic phenotypes were assigned from genetic data. Linear regression investigated aims, adjusted for key covariates. Results: Of 469,739 participants, 36,043 took antidepressants (53% female, median age 58, 17% taking cholesterol-lowering medications) and 3255 took antipsychotics (58% female, median age 57, 27% taking cholesterol-lowering medications). Significant associations were found between use of each amitriptyline, fluoxetine, citalopram/escitalopram, sertraline, paroxetine and venlafaxine with higher total cholesterol, LDL-C, and triglycerides and lower HDL-C, compared to participants not taking each medication. Venlafaxine was associated with the worst lipid profile (total cholesterol, adjusted mean difference: 0.21 mmol/L, 95% confidence interval (CI): 0.17 to 0.26, p < 0.001). Antipsychotic use was significantly associated with lower HDL-C and higher triglycerides. In participants taking sertraline, CYP2C19 intermediate metabolisers had higher HDL-C (0.05 mmol/L, 95% CI: 0.01 to 0.09, p = 0.007) and lower triglycerides (−0.17 mmol/L, 95% CI: −0.29 to −0.05, p = 0.007), compared to normal metabolisers. Conclusions: Antidepressants were significantly associated with adverse lipid profiles, potentially warranting baseline and regular monitoring. Further research should investigate the mechanistic pathways underlying the protective effects of the CYP2C19 intermediate metaboliser phenotype on HDL-C and triglycerides in people taking sertraline

Survival rate in patients with ICU-acquired infections and its related factors in Iran�s hospitals

Background: Hospital-acquired infections (HAIs) are a well-known cause of morbidity and mortality in hospitalized patients. This study aimed at investigating the survival rate in patients with ICU-acquired infections (ICU-AIs) and its related factors in Iran�s hospitals. Methods: Data were obtained from the Iranian Nosocomial Infections Surveillance (INIS), which registers all necessary information on the main types of infection from different units of each included hospital. One thousand one hundred thirty-four duplicate cases were removed from the analysis using the variables of name, father�s name, age, hospital code, infection code, and bedridden date. From 2016 to 2019, 32,998 patients diagnosed with ICU-AI from about 547 hospitals. All patients were followed up to February 29, 2020. Results: The median age of patients with ICU-AIs was 61 (IQR = 46) years. 45.5, 20.69, 17.63, 12.08, and 4.09 of infections were observed in general, surgical, internal, neonatal and pediatric ICUs, respectively. Acinetobacter (16.52), E.coli (12.01), and Klebsiella (9.93) were the major types of microorganisms. From total, 40.76 of infected patients (13,449 patients) died. The 1, 3, 6-months and overall survival rate was 70, 25.72, 8.21 1.48 in ICU-AI patients, respectively. The overall survival rate was 5.12, 1.34, 0.0, 51.65, and 31.08 for surgical, general, internal, neonatal and pediatric ICU, respectively. Hazard ratio shows a significant relationship between age, hospitalization-infection length, infection type, and microorganism and risk of death in patients with ICU-AI. Conclusions: Based on the results, it seems that the nosocomial infections surveillance system should be more intelligent. This intelligence should act differently based on related factors such as the age of patients, hospitalization-infection length, infection type, microorganism and type of ward. In other words, this system should be able to dynamically provide the necessary and timely warnings based on the factors affecting the survival rate of infection due to the identification, intervention and measures to prevent the spread of HAIs based on a risk severity system. © 2021, The Author(s)

Davidson on Self‐Knowledge: A Transcendental Explanation

Davidson has attempted to offer his own solution to the problem of self-knowledge, but there has been no consensus between his commentators on what this solution is. Many have claimed that Davidson’s account stems from his remarks on disquotational specifications of self-ascriptions of meaning and mental content, the account which I will call the “Disquotational Explanation”. It has also been claimed that Davidson’s account rather rests on his version of content externalism, which I will call the “Externalist Explanation”. I will argue that not only are these explanations of self-knowledge implausible, but Davidson himself has already rejected them. Thus, neither can be attributed to Davidson as his suggested account of self-knowledge. I will then introduce and support what I take to be Davidson’s official and independent account of self-knowledge, that is, his “Transcendental Explanation”. I will defend this view against certain potential objections and finally against the objections made by William Child