Spatially resolved ultrafast precessional magnetization reversal

Spatially resolved measurements of quasi-ballistic precessional magnetic switching in a microstructure are presented. Crossing current wires allow detailed study of the precessional switching induced by coincident longitudinal and transverse magnetic field pulses. Though the response is initially spatially uniform, dephasing occurs leading to nonuniformity and transient demagnetization. This nonuniformity comes in spite of a novel method for suppression of end domains in remanence. The results have implications for the reliability of ballistic precessional switching in magnetic devices.Comment: 17 pages (including 4 figures), submitted to Phys. Rev. Let

Estimation of Sounding Uncertainty from Measurements of Water Mass Variability

Analysis techniques are introduced that allow for estimation of potential sounding uncertainty due to water mass variability from reconnaissance campaigns in which oceanographic parameters are measured at a high temporal and spatial resolution. The analysis techniques do not require sounding data, thus analyses can be tailored to match any survey system; this allows for pre-analysis campaigns to optimize survey instrumentation and sound speed profiling rates such that a desired survey specification can be maintained. Additionally, the output of the analysis methods can potentially provide a higher fidelity estimation of sounding uncertainty due to water mass variability than uncertainty models in common use.Se presentan análisis técnicos que permiten una estimación de posibles incertidumbres en los sondeos, debidas a la variabilidad de la masa de agua, procedentes de campañas de reconocimiento en las que los parámetros oceanográficos son medidos con una resolución temporal y espacial elevada. Los análisis técnicos no requieren los datos de sondeos, así pues dichos análisis pueden adaptarse a cualquier sistema hidrográfico. Esto permite campañas de análisis previos para optimizar la instrumentación hidrográfica y los niveles de descripción de la velocidad del sonido, para que pueda mantenerse una especificación hidrográfica deseada. Además, el resultado de los métodos analíticos puede proporcionar potencialmente una estimación de la fidelidad de las incertidumbres en los sondeos, debidas a una variabilidad de la masa de agua mayor que la de los modelos de incertidumbres que se utilizan corrientemente.Des techniques d’analyse sont introduites afin de permettre l’estimation de l’incertitude potentielle des sondes due à la variabilité de la masse d’eau à partir de campagnes de reconnaissance dans lesquelles les paramètres océanographiques sont mesurés avec une haute résolution temporelle et spatiale. Les techniques d’analyse ne nécessitant pas de données de sondes, les analyses peuvent donc être ajustées pour s’adapter à tout système de levés ; ceci permet aux campagnes de pré-analyse d’optimiser l’instrumentation hydrographique ainsi que les niveaux de profilage de la vitesse du son de manière à conserver une spécification de levé souhaitée. En outre, le résultat des méthodes d’analyse peut potentiellement fournir une estimation à plus haute fidélité, en ce qui concerne les incertitudes des sondes du fait de la variabilité de la masse d’eau, que les modèles d’incertitude en usage

Vegetation Patterns in and among Pannes (Calcareous Intradunal Ponds) at the Indiana Dunes National Lakeshore, Indiana

The relationships between plant species composition and dispersion, water chemistry and water depth/depth to water table were studied in five calcareous intradunal ponds (pannes) bordering the southern tip of Lake Michigan. The panne systems contained eight plant species threatened and endangered in Indiana. The aquatic zone was dominated by Chara, the pond edge by Rhynchospora capillacea, Juncus balticus and Utricularia cornuta, and the area surrounding the pond by Hypericum kalmianum. The water chemistry was typical of hardwater ponds in the area, probably affecting species composition but not species dispersion within the pannes. A significant correlation between the first axis scores from a reciprocal-averaging ordination and water depth/depth to water was demonstrated. Panne species are fitted to a model based on hydrology proposed by van der Laan for dune-slack vegetation in the Netherlands

Theology, News and Notes - Vol. 30, No. 03

Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1082/thumbnail.jp

Network mechanisms of intentional learning.

The ability to learn new tasks rapidly is a prominent characteristic of human behaviour. This ability relies on flexible cognitive systems that adapt in order to encode temporary programs for processing non-automated tasks. Previous functional imaging studies have revealed distinct roles for the lateral frontal cortices (LFCs) and the ventral striatum in intentional learning processes. However, the human LFCs are complex; they house multiple distinct sub-regions, each of which co-activates with a different functional network. It remains unclear how these LFC networks differ in their functions and how they coordinate with each other, and the ventral striatum, to support intentional learning. Here, we apply a suite of fMRI connectivity methods to determine how LFC networks activate and interact at different stages of two novel tasks, in which arbitrary stimulus-response rules are learnt either from explicit instruction or by trial-and-error. We report that the networks activate en masse and in synchrony when novel rules are being learnt from instruction. However, these networks are not homogeneous in their functions; instead, the directed connectivities between them vary asymmetrically across the learning timecourse and they disengage from the task sequentially along a rostro-caudal axis. Furthermore, when negative feedback indicates the need to switch to alternative stimulus-response rules, there is additional input to the LFC networks from the ventral striatum. These results support the hypotheses that LFC networks interact as a hierarchical system during intentional learning and that signals from the ventral striatum have a driving influence on this system when the internal program for processing the task is updated.This work was supported by Medical Research Council Grant (U1055.01.002.00001.01) and a European Research GrantPCIG13-GA-2013-618351 to AH. JBR is supported by the Wellcome Trust (103838). The authors report no conflicts of interest.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.neuroimage.2015.11.06

Global, regional, and national burden of hepatitis B, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019

Publisher Copyright: © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-of-sample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings: In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4·1% (95% uncertainty interval [UI] 3·7 to 4·5), corresponding to 316 million (284 to 351) infected people. There was a 31·3% (29·0 to 33·9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76·8% (76·2 to 77·5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5·9% [–5·6 to 19·2]) and between 2015 and 2019 (by 2·9% [–5·9 to 11·3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation: The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination. Funding: Bill & Melinda Gates Foundation.Peer reviewe

Prevention of anxiety among at-risk children: a systematic review and meta-analysis

Background Anxiety disorders are common, often start in childhood and run a chronic course. As such there is a need for effective prevention. Methods We conducted a systematic review and meta-analyses of randomized, controlled trials to prevent the onset of anxiety disorders in ‘at risk’ young people. Diagnostic and symptom outcomes were examined. Putative moderators were tested as was publication bias. Results We included 16 trials (2545 young people). Two trials reported diagnostic outcomes, and significant effects were found for these at end-of-programme (RR = .09, 95%CI = .02 to .16), 6- (RR = .17, 95%CI = .06 to .27) and 12-month (RR = .31, 95%CI .17 to .45) follow-ups. Based on 16 trials, improved anxiety symptoms were significant compared to nonattention controls only, with small effect sizes reported by young people at the end-of-programmes, 6- and 12-month follow-ups; and by parents at the end of the programmes and 12-, but not 6-, month follow-ups. There was no evidence of significant moderation or publication bias. Conclusions Fourteen studies included children and young people who presented with elevated anxiety symptoms, but anxiety disorder was not ruled out in the participants in these studies. Hence, these studies might be reporting results of mixed prevention/early intervention programmes. Prevention programmes that target developmental risk factors, not only disorder maintaining factors, appear most promising. The clinically meaningful impact of anxiety disorder prevention programmes remains unknown

Campus Alberta: A Collaborative, Multi-University Counsellor Training Initiative

Permission to include this article granted by NATCONThe need for trained counselors/counseling psychologists, and for counselor education, training, and accreditation, are topics of continued discussion within professional organizations, accrediting bodies, universities, and other training institutions. Following an exploratory meeting in 1998 to discuss the need for additional graduate counselor education in Alberta, an advisory committee was formed with representatives from Alberta universities and major stakeholder groups. This paper describes an innovative approach to inter-university collaboration in the delivery of graduate programming emerging from that initiative. The initiative works on the premise that the current model of graduate education must be changed to reduce the barriers to continuing professional development. The new graduate program in counseling has a two-stage process. The first stage focuses on the fundamentals of counseling theory and practice. In the second stage, students select relevant assessment and intervention modules and develop an area of counseling specialization. The program is a learner-driven delivery system within the context of adult education and professional development. Through this collaboration, the needs of students can be better served while maintaining high standards of academic excellence and professional practice. (JDM

The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor

Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear matrix-targeting signal that directs the AML1 protein to appropriate gene regulatory sites within the nucleus. Here we report that substitution of the chromosome 8-derived ETO protein for the multifunctional C terminus of AML1 precludes targeting of the factor to AML1 subnuclear domains. Instead, the AML1/ETO fusion protein is redirected by the ETO component to alternate nuclear matrix-associated foci. Our results link the ETO chromosomal translocation in AML with modifications in the intranuclear trafficking of the key hematopoietic regulatory factor, AML1. We conclude that misrouting of gene regulatory factors as a consequence of chromosomal translocations is an important characteristic of acute leukemias