399 research outputs found

    Deep-Elaborative Learning Of Introductory Management Accounting For Business Students

    Get PDF
    Research by Choo and Tan (1990; 1995) suggests that accounting students, who engage in deep-elaborative learning, have a better understanding of the course materials. The purposes of this paper are: (1) to describe a deep-elaborative instructional approach (hereafter DEIA) that promotes deep-elaborative learning of introductory management accounting for business students, and (2) to report the relationship between the DEIA and the students’ learning and recommendation of the DEIA in introductory management accounting

    Three-portal technique for anterior cruciate ligament reconstruction: Use of a central medial portal

    Get PDF
    Standard endoscopic reconstruction of the anterior cruciate ligament (ACL) is performed with the use of 2 arthroscopic portals. The surgical error most commonly associated with ACL reconstruction is improper positioning of the tunnel. Errors in femoral tunnel position may be related to poor visualization of the lateral wall. When anatomic double-bundle ACL reconstruction is performed, proper visualization of the lateral wall is essential to ensure correct placement of both tunnels. We propose the use of a central portal, in addition to more standard anterolateral and anteromedial portals, to enhance visualization of the lateral wall. In addition, the arthroscope can be moved interchangeably throughout the portals during the procedure for improved viewing during specific steps. An accessory anteromedial portal placed inferiorly and medially allows placement of the femoral tunnels while providing a high central anteromedial portal for best visualization of the lateral wall. As a result, no notchplasty is required, and a more anatomic reconstruction can be performed

    Implementasi Role Playing Game Berbasis Flash (Studi Kasus Petualangan Fredo Bangkitnya Hantu tanpa Kepala)

    Get PDF
    At this moment game is entertainment liked by many people. Game expand very fast, either from graphic and type of game. Is seen from growth of type of game, there are various type circulating like fighting, arcade, Role Playing Game, shooting which earn to be played offline and online. Though circulate many types of game, but every type have the negative and positif excess. Therefore writer take this topic of making game under type of role playing game with developing concept which there becoming newer concept. Concept the developed is concept of weapon tree and upgrade weapon to replace weapon sales concept, and concept of random quest making each time player start newly game will see the random place of quest. Writer make the title of game is "Petualangan Fredo", development of this game use Macromedia Flash. Usage of Macromedia Flash because this software have ability of good graphic, result of this software not require high hardware for run this software

    Numerical simulations in 3-dimensions of reaction–diffusion models for brain tumour growth

    Get PDF
    We work with a well-known model of reaction–diffusion type for brain tumour growth and accomplish full 3-dimensional (3d) simulations of the tumour in time on two types of imaging data, the 3d Shepp–Logan head phantom image and an MRI T1-weighted brain scan from the Internet Brain Segmentation Repository. The source term is such that we have logistic growth. These simulations are obtained using standard finite difference approximations with novel calculations to increase speed and accuracy. Moreover, biological background to the model, its well-posedness together with a variational formulation are given. The variational formulation enable the feasibility of different derivations and modifications of the model

    Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in South-Western Uganda

    Get PDF
    BACKGROUND: Determination of the prevalence and drug susceptibility of the M. tuberculosis strains is important in tuberculosis control. We determined the genetic diversity and susceptibility profiles of mycobacteria isolated from tuberculosis patients in Mbarara, South Western Uganda. METHODS: We enrolled, consecutively; all newly diagnosed and previously treated smear-positive TB patients aged ≥ 18 years. The isolates were characterized using regions of difference (RD) analysis and spoligotyping. Drug resistance against rifampicin and isoniazid were tested using the Genotype(® )MDRTBplus assay and the indirect proportion method on Lowenstein-Jensen media. HIV-1 testing was performed using two rapid HIV tests. RESULTS: A total of 125 isolates from 167 TB suspects (60% males) with a mean age 33.7 years and HIV prevalence of 67.9% (55/81) were analyzed. Majority (92.8%) were new cases while only 7.2% were retreatment cases. All the 125 isolates were identified as M. tuberculosis strict sense with the majority (92.8%) of the isolates being modern strains while seven (7.2%) isolates were ancestral strains. Spoligotyping revealed 79 spoligotype patterns, with an overall diversity of 63.2%. Sixty two (49.6%) of the isolates formed 16 clusters consisting of 2-15 isolates each. A majority (59.2%) of the isolates belong to the Uganda genotype group of strains. The major shared spoligotypes in our sample were SIT 135 (T2-Uganda) with 15 isolates and SIT 128 (T2) with 3 isolates. Sixty nine (87%) of the 79 patterns had not yet been defined in the SpolDB4.0.database. Resistance mutations to either RIF or INH were detected in 6.4% of the isolates. Multidrug resistance, INH and RIF resistance was 1.6%, 3.2% and 4.8%, respectively. The rpoβ gene mutations seen in the sample were D516V, S531L, H526Y H526D and D516V, while one strain had a Δ1 mutation in the wild type probes. There were three strains with katG (codon 315) gene mutations only while one strain showed the inhA promoter gene mutation. CONCLUSION: The present study shows that the TB epidemic in Mbarara is caused by modern M. tuberculosis strains mainly belonging to the Uganda genotype and anti-TB drug resistance rate in the region is low

    The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response

    Get PDF
    We determined the molecular mechanism of cell death response by MutS homologs in distinction to the repair event. Key protein–DNA contacts differ in the interaction of MutS homologs with cisplatinated versus mismatched DNA. Mutational analyses of protein–DNA contacts, which were predicted by molecular dynamics (MD) simulations, were performed. Mutations in suggested interaction sites can affect repair and cell death response independently, and to different extents. A glutamate residue is identified as the key contact with cisplatin-DNA. Mutation of the residue increases cisplatin resistance due to increased non-specific DNA binding. In contrast, the conserved phenylalanine that is instrumental and indispensable for mismatch recognition during repair is not required for cisplatin cytotoxicity. These differences in protein–DNA interactions are translated into localized conformational changes that affect nucleotide requirements and inter-subunit interactions. Specifically, the ability for ATP binding/hydrolysis has little consequence for the MMR-dependent damage response. As a consequence, intersubunit contacts are altered that most likely affect the interaction with downstream proteins. We here describe the interaction of MutS homologs with DNA damage, as it differs from the interaction with a mismatch, and its structural translation into all other functional regions of the protein as a mechanism to initiate cell death response and concomitantly inhibit repair

    Raise the age implementation

    Get PDF
    This PowerPoint presentation gives statistics on the Raise the Age Implementation in South Carolina

    Raise the Age Senate Select Committee

    Get PDF
    This PowerPoint presentation gives statistics on the Raise the Age Implementation in South Carolina
    • …
    corecore