394 research outputs found
Planetary Science Virtual Observatory architecture
In the framework of the Europlanet-RI program, a prototype of Virtual
Observatory dedicated to Planetary Science was defined. Most of the activity
was dedicated to the elaboration of standards to retrieve and visualize data in
this field, and to provide light procedures to teams who wish to contribute
with on-line data services. The architecture of this VO system and selected
solutions are presented here, together with existing demonstrators
Recovery of surface reflectance spectra and evaluation of the optical depth of aerosols in the near-IR using a Monte-Carlo approach: Application to the OMEGA observations of high latitude regions of Mars
We present a model of radiative transfer through atmospheric particles based
on Monte Carlo methods. This model can be used to analyze and remove the
contribution of aerosols in remote sensing observations. We have developed a
method to quantify the contribution of atmospheric dust in near-IR spectra of
the Martian surface obtained by the OMEGA imaging spectrometer on board Mars
Express. Using observations in the nadir pointing mode with significant
differences in solar incidence angles, we can infer the optical depth of
atmospheric dust, and we can retrieve the surface reflectance spectra free of
aerosol contribution. Martian airborne dust properties are discussed and
constrained from previous studies and OMEGA data. We have tested our method on
a region at 90{\deg}E and 77{\deg}N extensively covered by OMEGA, where
significant variations of the albedo of ice patches in the visible have been
reported. The consistency between reflectance spectra of ice-covered and
ice-free regions recovered at different incidence angles validates our
approach. The optical depth of aerosols varies by a factor 3 in this region
during the summer of Martian year 27. The observed brightening of ice patches
does not result from frost deposition but from a decrease in the dust
contamination of surface ice and (to a lower extent) from a decrease in the
optical thickness of atmospheric dust. Our Monte Carlo-based model can be
applied to recover the spectral reflectance characteristics of the surface from
OMEGA spectral imaging data when the optical thickness of aerosols can be
evaluated. It could prove useful for processing image cubes from the Compact
Reconnaissance Imaging Spectrometer for Mars (CRISM) on board the Mars
Reconnaissance Orbiter (MRO)
The EPN-TAP protocol for the Planetary Science Virtual Observatory
A Data Access Protocol has been set up to search and retrieve Planetary
Science data in general. This protocol will allow the user to select a subset
of data from an archive in a standard way, based on the IVOA Table Access
Protocol (TAP). The TAP mechanism is completed by an underlying Data Model and
reference dictionaries. This paper describes the principle of the EPN- TAP
protocol and interfaces, underlines the choices that have been made, and
discusses possible evolutions.Comment: 21 pages. Submitted to Astronomy & Computing, S.I. Virtual
Observator
Thermal maps and properties of comet 67P as derived from Rosetta/VIRTIS data
After a 10-year cruise, the Rosetta
spacecraft began a close exploration of its main target,
comet 67P/Churyumov-Gerasimenko, in July 2014.
Since then, the Visible InfraRed Thermal Imaging
Spectrometer (VIRTIS) acquired hyperspectral
images of the cometâs surface with an unprecedented
spatial resolution. VIRTIS data are routinely used to
map the surface composition and to retrieve surface
temperatures on the dayside of the comet.
The thermal behavior of the surface of comet 67P
is related to composition and physical properties that
provide information about the nature and evolution of
those materials.
Here we present temperature maps of comet 67P
that were observed by Rosetta under different illumination conditions and different local solar times
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity
Antigen-presenting cell (APC) activation is enhanced by vaccine adjuvants. Most vaccines are based on the assumption that adjuvant activity of Toll-like receptor (TLR) agonists depends on direct, functional activation of APCs. Here, we sought to establish whether TLR stimulation in non-hematopoietic cells contributes to flagellinâs mucosal adjuvant activity. Nasal administration of flagellin enhanced T-cell-mediated immunity, and systemic and secretory antibody responses to coadministered antigens in a TLR5-dependent manner. Mucosal adjuvant activity was not affected by either abrogation of TLR5 signaling in hematopoietic cells or the presence of flagellin-specific, circulating neutralizing antibodies. We found that flagellin is rapidly degraded in conducting airways, does not translocate into lung parenchyma and stimulates an early immune response, suggesting that TLR5 signaling is regionalized. The flagellin-specific early response of lung was regulated by radioresistant cells expressing TLR5 (particularly the airway epithelial cells). Flagellin stimulated the epithelial production of a small set of mediators that included the chemokine CCL20, which is known to promote APC recruitment in mucosal tissues. Our data suggest that (i) the adjuvant activity of TLR agonists in mucosal vaccination may require TLR stimulation of structural cells and (ii) harnessing the effect of adjuvants on epithelial cells can improve mucosal vaccines.Fil: Van Maele, Laurye. Institut Pasteur de Lille. Lille; Francia. Univ Lille Nord de France. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; FranciaFil: Fougeron, Delphine. Institut Pasteur de Lille. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Janot, Laurent. University of OrlĂ©ans. OrlĂ©ans; Francia. Institut de Transgenose. Orleans; FranciaFil: Didierlaurent, A.. Imperial College of London. Londres; Reino UnidoFil: Cayet, D.. Institut Pasteur de Lille. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Tabareau, J.. Institut Pasteur de Lille. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Rumbo, MartĂn. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de Estudios InmunolĂłgicos y FisiopatolĂłgicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios InmunolĂłgicos y FisiopatolĂłgicos; ArgentinaFil: Corvo Chamaillard, S.. Institut Pasteur de Lille. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Boulenoir, S.. Institut Pasteur de Lille. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Jeffs, S. Imperial College of London. Londres; Reino UnidoFil: Vande Walle, L. Department of Medical Protein Research. Ghent; BĂ©lgica. University of Ghent; BĂ©lgicaFil: Lamkanfi, M.. Department of Medical Protein Research. Ghent; BĂ©lgica. University of Ghent; BĂ©lgicaFil: Lemoine, Y.. Univ Lille Nord de France. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Institut Pasteur de Lille. Lille; FranciaFil: Erard, F.. Institut de Transgenose. Orleans; Francia. University of OrlĂ©ans. OrlĂ©ans; FranciaFil: Hot, D.. Univ Lille Nord de France. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Institut Pasteur de Lille. Lille; FranciaFil: Hussell, Tracy. Imperial College of London. Londres; Reino Unido. University of Manchester; Reino UnidoFil: Ryffel, B.. Institut de Transgenose. Orleans; Francia. University of OrlĂ©ans. OrlĂ©ans; FranciaFil: Benecke, Arndt G.. Institut des Hautes Ătudes Scientifiques and Centre National de la Recherche Scientifique; FranciaFil: Sirard, J.C.. Univ Lille Nord de France. Lille; Francia. Institut National de la SantĂ© et de la Recherche MĂ©dicale; Francia. Institut Pasteur de Lille. Lille; Franci
lncRNA requirements for mouse acute myeloid leukemia and normal differentiation
A substantial fraction of the genome is transcribed in a cell type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here we systematically characterize transcriptional dynamics during hematopoiesis and in hematological malignancies. Our analysis of annotated and de novo assembled lncRNAs showed many are regulated during differentiation and mis-regulated in disease. We assessed lncRNA function via an in vivo RNAi screen in a model of acute myeloid leukemia. This identified several lncRNAs essential for leukemia maintenance, and found that a number act by promoting leukemia stem cell signatures. Leukemia blasts show a myeloid differentiation phenotype when these lncRNAs were depleted, and our data indicates that this effect is mediated via effects on the c-MYC oncogene. Bone marrow reconstitutions showed that a lncRNA expressed across all progenitors was required for the myeloid lineage, whereas the other leukemia-induced lncRNAs were dispensable in the normal setting
Laboratory Measurements of Synthetic Pyroxenes and their Mixtures with Iron Sulfides as Inorganic Refractory Analogues for Rosetta/VIRTIS' Surface Composition Analysis of 67P/CG
The Visible and InfraRed Thermal Imaging Spectrometer VIRTIS on board Rosetta provided 0.25-5.1 ”m spectra of 67P/CG's surface (Capaccioni et al., 2015). Thermally corrected reflectance spectra display a low albedo of 0.06 at 0.65 ”m, different red VIS and IR spectral slopes, and a broad 3.2 ”m band. This absorption feature is due to refractory surface constituents attributed to organic components, but other refractory constituents influence albedo and spectral slopes. Possible contributions of inorganic components to spectral characteristics and spectral variations across the surface should be understood based on laboratory studies and spectral modeling. Although a wide range of silicate compositions was found in "cometary" anhydrous IDPs and cometary dust, Mg-rich crystalline mafic minerals are dominant silicate components. A large fraction of silicate grains are Fe-free enstatites and forsterites that are not found in terrestrial rocks but can be synthesized in order to provide a basis for laboratory studies and comparison with VIRTIS data. We report the results of the synthesis, analyses, and spectral reflectance measurements of Fe-free low-Ca pyroxenes (ortho- and clinoenstatites). These minerals are generally very bright and almost spectrally featureless. However, even trace amounts of Fe-ions produce a significant decrease in the near-UV reflectance and hence can contribute to slope variations. Iron sulfides (troilite, pyrrhotite) are among the most plausible phases responsible for the low reflectance of 67P's surface from the VIS to the NIR. The darkening efficiency of these opaque phases is strongly particle-size dependent. Here we present a series of reflectance spectra of fine-grained synthetic enstatite powders mixed in various proportions with iron sulfide powders. The influence of dark sulfides on reflectance in the near-UV to near-IR spectral ranges is investigated. This study can contribute to understand the shape of reflectance spectra of 67P's surface at different spectral ranges. Implications for the VIRTIS data analysis are discussed
- âŠ