Politisierung des Wissens: Gesellschaftliche Grundlagen und politische Folgen von Wissenskonflikten in polarisierten Welten

Mit der Entwicklung hin zur Wissensgesellschaft gewinnt nicht bloß wissenschaftliches Wissen an Bedeutung, etwa für die Legitimierung politischer Entscheidungen, sondern wird auch zunehmend zum Gegenstand politischer und gesellschaftlicher Konflikte. Vor dem Hintergrund wissenspolitischer Konflikte diskutiert der Beitrag die wissenssoziologischen Implikationen der aktuellen Debatten über einen „antiliberalen Backlash“ und eine „große Regression“, die zunehmende Thematisierung der Politisierung des Wissens als ein multidimensionales Phänomen sowie die politiktheoretischen Implikationen der Wissensproblematik der Politik

Excuse Me, Something Is Unfair! - Implications of Perceived Fairness of Service Robots

Fairness is an important aspect for individuals and teams. This also applies for human-robot interaction (HRI). Especially if intelligent robots provide services to multiple humans, humans may feel treated unfairly by robots. Most work in this area deals with the aspects of fair algorithms, task allocation and decision support. This work focuses on a different, yet little explored perspective, which looks at fairness in HRI from a human-centered perspective in human-robot teams. We present an experiment in which a service robot was responsible for distributing resources among competing team members. We investigated how different strategies of distribution influence the perceived fairness and the perception of the robot. Our study shows that humans might perceive technically efficient algorithms as unfair, especially if humans personally experience negative consequences. This also had negative impact on human perception of the robot, which should be considered in the design of future robots

Symposion

Das Politische drängt sich gegenwärtig in den gesellschaftlichen Vordergrund wie schon lange nicht mehr. Das Symposion nimmt diese Situation zum Anlass, um das Verhältnis von Politik und Soziologie grundsätzlich auf den Prüfstand zu stellen: Aus unterschiedlichen Blickwinkeln wird die Frage beleuchtet, wie wir das Politische heute soziologisch denken müssen, um den gesellschaftlichen Phänomenen unserer Zeit wissenschaftlich gerecht werden zu können. Die Beiträge des Symposions loten dazu das Potential Politischer Soziologie theoretisch und methodisch aus. Gemeinsam führen sie vor Augen, dass es Grund gibt, die Stellung des Politischen in der Gesellschaft innerhalb der Soziologie viel offensiver und grundsätzlicher zu diskutieren, als dies derzeit der Fall ist. Politics and the political system have become topics of intense public debates we have not witnessed in a long time. The symposium takes stock of these debates by systematically scrutinizing the relation between politics and sociology. More specifically, it explores how we might think about politics sociologically, in a way that does justice to current social developments. The contributions to the symposium address this question from different theoretical and epistemological perspectives, thereby unpacking the conceptual and methodological potentials of political sociology. Together, they draw attention to the importance of understanding political processes in order to get a better grip on current workings of society

Lexical access speed and the development of phonological recoding during immediate serial recall

A recent Registered Replication Report (RRR) of the development of verbal rehearsal during serial recall revealed that children verbalized at younger ages than previously thought, but did not identify sources of individual differences. Here, we use mediation analysis to reanalyze data from the 934 children ranging from 5 to 10 years old from the RRR for that purpose. From ages 5 to 7, the time taken for a child to label pictures (i.e. isolated naming speed) predicted the child’s spontaneous use of labels during a visually presented serial reconstruction task, despite no need for spoken responses. For 6- and 7-year-olds, isolated naming speed also predicted recall. The degree to which verbalization mediated the relation between isolated naming speed and recall changed across development. All relations dissipated by age 10. The same general pattern was observed in an exploratory analysis of delayed recall for which greater demands are placed on rehearsal for item maintenance. Overall, our findings suggest that spontaneous phonological recoding during a standard short-term memory task emerges around age 5, increases in efficiency during the early elementary school years, and is sufficiently automatic by age 10 to support immediate serial recall in most children. Moreover, the findings highlight the need to distinguish between phonological recoding and rehearsal in developmental studies of short-term memory

Lexical access speed and the development of phonological recoding during immediate serial recall

A recent Registered Replication Report (RRR) of the development of verbal rehearsal during serial recall revealed that children verbalized at younger ages than previously thought, but did not identify sources of individual differences. Here, we use mediation analysis to reanalyze data from the 934 children ranging from 5 to 10 years old from the RRR for that purpose. From ages 5 to 7, the time taken for a child to label pictures (i.e. isolated naming speed) predicted the child’s spontaneous use of labels during a visually presented serial reconstruction task, despite no need for spoken responses. For 6- and 7-year-olds, isolated naming speed also predicted recall. The degree to which verbalization mediated the relation between isolated naming speed and recall changed across development. All relations dissipated by age 10. The same general pattern was observed in an exploratory analysis of delayed recall for which greater demands are placed on rehearsal for item maintenance. Overall, our findings suggest that spontaneous phonological recoding during a standard short-term memory task emerges around age 5, increases in efficiency during the early elementary school years, and is sufficiently automatic by age 10 to support immediate serial recall in most children. Moreover, the findings highlight the need to distinguish between phonological recoding and rehearsal in developmental studies of short-term memory

Sarcoma classification by DNA methylation profiling

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

Kinase inhibitors suppress the growth of oncogene driven cancer but also enforce the selection of treatment resistant cells that are thought to promote tumor relapse in patients. Here, we report transcriptomic and functional genomics analyses of cells and tumors within their microenvironment across different genotypes that persist during kinase inhibitor treatment. We uncover a conserved, MAPK/IRF1-mediated inflammatory response in tumors that undergo stemness- and senescence-associated reprogramming. In these tumor cells, activation of the innate immunity sensor RIG-I via its agonist IVT4, triggers an interferon and a pro-apoptotic response that synergize with concomitant kinase inhibition. In humanized lung cancer xenografts and a syngeneic Egfr-driven lung cancer model these effects translate into reduction of exhausted CD8+ T cells and robust tumor shrinkage. Overall, the mechanistic understanding of MAPK/IRF1-mediated intratumoral reprogramming may ultimately prolong the efficacy of targeted drugs in genetically defined cancer patients

Comprehensive genomic profiles of small cell lung cancer

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Dex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer