The effects of atmosphere conditions on gamma-ray astronomy

The High Energetic Stereoscopic System (H.E.S.S.) experiment is an array of imaging atmospheric Cherenkov (IAC) telescopes of the next generation, with enlarged mirrors and advanced detector electronics compared to its predecessors. As a member of the international H.E.S.S. collaboration, the Durham 7-rау astronomy group took over the responsibility for design, construction and commissioning of calibration systems for the H.E.S.S. telescopes and atmospheric monitoring devices. The atmosphere is an essential part of the detector system for the IAC technique, monitoring of the atmosphere's parameter is therefore important for energy calibration of the detector and variability studies of 7-ray sources to distinguish between detector and source fluctuations. A weather station, several infrared radiometers and an infrared LIDAR system have been installed to provide constant monitoring of all relevant parameters. This thesis reports about the work performed for the design and commissioning of the calibration module. Furthermore, the technicalities of the LIDAR system and the IR radiometer, their use in terms of 7-ray astronomy, especially studies about the variability of zenith angle dependencies and the correlation with other atmospheric parameters and telescope trigger rates are discussed

Planet Four: Terrains - Discovery of Araneiforms Outside of the South Polar Layered Deposits

We present the results of a systematic mapping of seasonally sculpted terrains on the South Polar region of Mars with the Planet Four: Terrains (P4T) online citizen science project. P4T enlists members of the general public to visually identify features in the publicly released Mars Reconnaissance Orbiter CTX images. In particular, P4T volunteers are asked to identify: 1) araneiforms (including features with a central pit and radiating channels known as 'spiders'); 2) erosional depressions, troughs, mesas, ridges, and quasi-circular pits characteristic of the South Polar Residual Cap (SPRC) which we collectively refer to as 'Swiss cheese terrain', and 3) craters. In this work we present the distributions of our high confidence classic spider araneiforms and Swiss cheese terrain identifications. We find no locations within our high confidence spider sample that also have confident Swiss cheese terrain identifications. Previously spiders were reported as being confined to the South Polar Layered Deposits (SPLD). Our work has provided the first identification of spiders at locations outside of the SPLD, confirmed with high resolution HiRISE imaging. We find araneiforms on the Amazonian and Hesperian polar units and the Early Noachian highland units, with 75% of the identified araneiform locations in our high confidence sample residing on the SPLD. With our current coverage, we cannot confirm whether these are the only geologic units conducive to araneiform formation on the Martian South Polar region. Our results are consistent with the current CO2 jet formation scenario with the process exploiting weaknesses in the surface below the seasonal CO2 ice sheet to carve araneiform channels into the regolith over many seasons. These new regions serve as additional probes of the conditions required for channel creation in the CO2 jet process. (Abridged)Comment: accepted to Icarus - Supplemental data files are available at https://www.zooniverse.org/projects/mschwamb/planet-four-terrains/about/results - Icarus print version available at http://www.sciencedirect.com/science/article/pii/S001910351730055

Martian Araneiforms: A Review

Araneiforms are enigmatic dendritic negative topography features native to Mars. Found across a variety of substrates and exhibiting a range of scales, morphologies, and activity level, they are hypothesized to form via insolation-induced basal sublimation of seasonal CO2 ice. With no direct Earth analog, araneiforms are an example of how our understanding of extant surface features can evolve through a multipronged approach using high resolution change-detection imaging, conceptual and numerical modeling, and analog laboratory work. This review offers a primer on the current state of knowledge of Martian araneiforms. We outline the development of their driving conceptual hypothesis and the various methodologies used to study their formation. We furthermore present open questions and identify future laboratory and modeling work and mission objectives that may address these questions. Finally, this review highlights how the study of araneiforms may be used as a proxy for local conditions and perhaps even past seasonal dynamics on Mars. We also reflect on the lessons learnt from studying them and opportunities for comparative planetology that can be harnessed in understanding unusual features on icy worlds that have no Earth analog

Planet Four: Probing springtime winds on Mars by mapping the southern polar CO2 jet deposits

The springtime sublimation process of Mars’ southern seasonal polar CO2 ice cap features dark fan-shaped de- posits appearing on the top of the thawing ice sheet. The fan material likely originates from the surface below the ice sheet, brought up via CO2 jets breaking through the seasonal ice cap. Once the dust and dirt is released into the atmosphere, the material may be blown by the surface winds into the dark streaks visible from orbit. The location, size and direction of these fans record a number of parameters important to quantifying seasonal winds and sublimation activity, the most important agent of geological change extant on Mars. We present results of a systematic mapping of these south polar seasonal fans with the Planet Four online citizen science project. Planet Four enlists the general public to map the shapes, directions, and sizes of the seasonal fans visible in orbital images. Over 80,000 volunteers have contributed to the Planet Four project, reviewing 221 images, from Mars Reconnaissance Orbiter’s HiRISE (High Resolution Imaging Science Experiment) camera, taken in southern spring during Mars Years 29 and 30. We provide an overview of Planet Four and detail the processes of combining multiple volunteer assessments together to generate a high delity catalog of ∼ 400000 south polar seasonal fans. We present the results from analyzing the wind directions at several locations monitored by HiRISE over two Mars years, providing new insights into polar surface winds

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Mars Reconnaissance Orbiter (MRO) Context Camera (CTX) In-Flight Calibration Files

The Context Camera (CTX) on board NASA’s Mars Reconnaissance Orbiter (MRO) has been in orbit since 2006 and has so far delivered more than 130.000 images. Since the beginning of the mission, the images have exhibited a darkening effect increasing from the center of the images towards the edges, creating visible seam lines when multiple images are stitched together. Due to the symmetric decrease in reflectance plots averaged over all lines, this problem is often referred to as ”frown” effect. The Integrated Software for Imagers and Spectrometers (ISIS) pipeline compensates for the frown effect by applying a flatfield correction during the standard calibration routine ctxcal, but the flatfield file used is based only on the first year of the mission. Therefore it does not compensate for the effects caused by progressive change of the sensor signal during mission time. To address the progressively changing frown effect over the mission time, we create a separate flatfield for each month of the mission, designated by the first three characters of the product id. First we perform a standard calibration on all related images, usually consisting of about 300 to 1000 images per month. We use the ISIS program makeflat and feed it with the pre-processed images for the respective mission month, excluding images taken with the spatial summing mode different to one, whose number of samples in the cross-direction is smaller. In this repository, we provide the flatfield files and accompanying example scripts that can be used directly in the ISIS environment

Polygonal cracks in the seasonal semi-translucent CO2 ice layer in Martian polar areas

In this paper, we use morphological and numerical methods to test the hypothesis that seasonally formed fracture patterns in the Martian polar regions result from the brittle failure of seasonal CO2 slab ice. The observations by the High Resolution Imaging Science Experiment (HiRISE) of polar regions of Mars show very narrow dark elongated linear patterns that are observed during some periods of time in spring, disappear in summer and re-appear again in the following spring. They are repeatedly formed in the same areas but they do not repeat the exact pattern from year to year. This leads to the conclusion that they are cracks formed in the seasonal ice layer. Some of models of seasonal surface processes rely on the existence of a transparent form of CO2 ice, so-called slab ice. For the creation of the observed cracks the ice is required to be a continuous media, not an agglomeration of relatively separate particles like a firn. The best explanation for our observations is a slab ice with relatively high transparency in the visible wavelength range. This transparency allows a solid state green-house effect to act underneath the ice sheet raising the pressure by sublimation from below. The trapped gas creates overpressure and the ice sheet breaks at some point creating the observed cracks. We show that the times when the cracks appear are in agreement with the model calculation, providing one more piece of evidence that CO2 slab ice covers polar areas in spring