Uso de museos y exposiciones de Madrid para el estudio del cambio social. Una propuesta de mejora en las prácticas docentes de los estudios de comunicación

Este proyecto de innovación docente se propone alinear las necesidades docentes de la enseñanza del Cambio Social, la necesaria formación en contenidos audiovisuales y la disposición de los museos y exposiciones de abrirse a público joven y convertirse en espacios formativos y de reflexión sobre el cambio social. Es clara la necesidad de las profesiones comunicativas de encontrar nichos de empleo

Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish

The importance of histamine in the physiology of the testis in mammals and reptiles has been recently shown. Histamine receptors (Hrs) are well conserved in fish and are functional in several fish species. We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream. Moreover, cimetidine, which acts in vitro as an agonist of Hrh1 and Hrh2 on this species, was intraperitoneally injected in one and two years old gilthead seabream males. After three and five days of cimetidine injection, we found that this compound differently modified the gonadal hrs transcript levels and affects the testicular cell renewal and the gene expression of steroidogenesis-related molecules as well as the serum steroid levels. Our data point to cimetidine as a reproductive disruptor and elucidate a role for histamine in the gonad of this hermaphrodite fish species through Hr signalling.Postprint2,616

Producción de ganado bovino de carne con bienestar animal

Objective: To review several factors related to animal welfare which affect beef cattle productivity and meat quality. Approach: The human population increase has risen the demand for animal products. Therefore it has been necessary to produce them in an intensive way, without considering animal welfare. Nowadays beef cattle producers are aware of the different factors that affect animal welfare, such as nutrition, environmental conditions, housing, handling, diseases, transportation, and slaughter; because national and international markets demand animal products in which animal welfare has been taken into account, are innocuous and have high quality for the final consumerObjetivo: Revisar diferentes factores relacionados con bienestar animal que afectan la producción y calidad de carne en bovinos. Aproximación: El aumento de la población mundial ha incrementado la demanda de productos de origen animal, siendo necesario producirlos en forma intensiva, sin tomar en cuenta el bienestar animal. Actualmente los productores de ganado para carne están cada vez más conscientes de los diferentes factores que afectan el bienestar como son la nutrición, condiciones ambientales, instalaciones, manejo, enfermedades, transporte y sacrificio, ya que los mercados nacionales e internacionales demandan productos obtenidos bajo normas de bienestar animal,garantizando productos cárnicos inocuos y de alta calidad para los consumidores finales

Perineal Management and Episiotomy Practice in Chile

Episiotomy is a common intervention used during the second stage of delivery. Current use of this procedure is restricted to certain births due to several complications. Almost all births in Chile are delivered by a gynecologist or a midwife in the public or private health system where episiotomy is performed. The objective of this study is to identify strengths and weakness in aspects of perineal management and episiotomy practice among obstetric health care providers with the purpose of promoting practice assessment and updating skills and competencies. Design: Questionnaire-based-cross-sectional study. Method: Anonymous questionnaire applied to gynecologists and midwives of public and private hospitals, between October and December 2019 using the Instrument designed by Cornet et al. addressing questions such as affiliation, number of births/year, knowledge of anatomy, knowledge of episiotomy, knowledge of perineal tear, competence in perineal repair, and presence of expert in perineal trauma at their unit. Results: 189 surveys responded, 51% from midwives and 37.6% from doctors. 71% of total were trained at their medical or midwifery schools and 69% during postgraduate internships. Episiotomy practice criteria: 19% always in primigravida patients and 14,3% always in premature deliveries. Majority of professionals, 79.4% with less than 100 deliveries a year had incorrect answers about depth or sphincter tear prevention technique. Conclusions: The majority of professionals indicated insufficient training capacities in relation to episiotomy techniques. Undergraduate programs should strength training on this intervention, national guidelines must include routine episiotomy performance in order to unify criteria

Horses’ welfare during transport

Horse transport is standard in the equine industry, and horses are transported for different reasons and activities. Therefore, knowing the factors involved during transport and horse management is critical. Horses are the most transported animals worldwide. However, this is a stressful event for horses. Factors such as vehicle type, driver's experience, length of journey, animal orientation in the vehicle, injuries, and diseases affect horses' welfare. Factors involved in horse transport might be known and considered to have adequate horse welfare.Objective: To review the literature related to horses’ welfare during transport. Approach: Transporting horses is a common practice in the equine industry and obeys to different reasons and activities. Therefore, understanding the factors that intervene during transport and management of the horses is critical. Limitations on study/implications: Horses are the most transported animals globally, this being a very stressful event. Different factors affect their welfare during this process, such as the type of vehicle, the driver’s expertise, the length of the trip, the orientation of the animal in the vehicle, lesions and diseases. Conclusions: The factors involved in horses’ transport should be known and taken into account, to ensure the horses’ welfare

Prevalence of submicroscopic malaria infection in immigrants living in Spain

BACKGROUND: The importance of submicroscopic malaria infections in high-transmission areas could contribute to maintain the parasite cycle. Regarding non-endemic areas, its importance remains barely understood because parasitaemia in these afebrile patients is usually below the detection limits for microscopy, hence molecular techniques are often needed for its diagnosis. In addition to this, the lack of standardized protocols for the screening of submicroscopic malaria in immigrants from endemic areas may underestimate the infection with Plasmodium spp. The aim of this study was to assess the prevalence of submicroscopic malaria in afebrile immigrants living in a non-endemic area. METHODS: A prospective, observational, multicentre study was conducted. Afebrile immigrants were included, microscopic observation of Giemsa-stained thin and thick blood smears, and two different molecular techniques detecting Plasmodium spp. were performed. Patients with submicroscopic malaria were defined as patients with negative blood smears and detection of DNA of Plasmodium spp. with one or both molecular techniques. Demographic, clinical, analytical and microbiological features were recorded and univariate analysis by subgroups was carried out with STATA v15. RESULTS: A total of 244 afebrile immigrants were included in the study. Of them, 14 had a submicroscopic malaria infection, yielding a prevalence of 5.7% (95% confidence interval 3.45-9.40). In 71.4% of the positive PCR/negative microscopy cases, Plasmodium falciparum alone was the main detected species (10 out of the 14 patients) and in 4 cases (28.6%) Plasmodium vivax or Plasmodium ovale were detected. One patient had a mixed infection including three different species. CONCLUSIONS: The prevalence of submicroscopic malaria in afebrile immigrants was similar to that previously described in Spain. Plasmodium vivax and P. ovale were detected in almost a third of the submicroscopic infections. Screening protocols for afebrile immigrants with molecular techniques could be useful for a proper management of these patients.This work was funded by projects PI14/01671, PI17/01791 and PI14CIII/00014, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness) and cofounded by the European Regional Development Fund, and approved by the Ethics Committee of our Institution. There was no funding from the PCR manufacturers; they did not play any role in data analysis or in the reporting of the results.S

Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing

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Mapa de anomalía de Bouguer del Pirineo Suroccidental

Las relaciones geométricas y cinemáticas entre las unidades de basamento de los Pirineos Suroccidentales, específicamente entre la terminación de la Zona Axial y el afloramiento de los Macizos Vascos, son desconocidas y potencialmente muy complejas (Oliva-Urcia, 2018). La gravimetría se ha aplicado con éxito en otras regiones pirenaicas para resolver la geometría de las unidades de cobertera y basamento debido al contraste de densidad existente en las rocas involucradas. Con el objetivo de resolver dichas relaciones y sus implicaciones en la comprensión 4D de esta parte de la cadena, hemos llevado a cabo un exhaustivo programa de adquisición de datos gravimétricos (2018-2020) entre los valles de Salazar (al oeste) y del Aragón Subordán (hacia el este) en el marco del proyecto 3DGeoEU (GeoERA-H2020). Más de 1500 nuevas estaciones (varias de ellas en alta montaña) junto con > 1700 puntos de la base de datos SITOPO, ¿ 1200 de campañas mineras, y > 500 de anteriores proyectos del IGME hacen un total de > 5000 estaciones gravimétricas armonizadas. Además, se han recopilado > 500 datos de densidad de bases de datos o muestreados en el campo. En este trabajo presentaremos los mapas de anomalías Bouguer y de anomalía residual obtenidos, junto con una revisión de las principales estructuras cartográficas en la zona

Discourse Analysis and Terminology in Languages for Specific Purposes

Aquest importantíssim recull conté estudis i reflexions sobre temes rellevants en la recerca sobre LSP: anglès mèdic, el llenguatge de la publicitat i periodístic, telecomunicacions i terminologia informàtica, llenguatge comercial i jurídic... Malgrat que gran part dels treballs aplegats es refereixen a l'anglès, també hi ha que tracten l'alemany, francès i altres llengües. Conté textos en anglès, francés, portuguès i castellà

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions