Evaluation of leptin and insulin resistance in patients with cholelithiasis

266-272The association between insulin resistance, lipoproteins and leptin was evaluated in cholelithiasis. The study group included <span style="mso-bidi-font-size: 12.0pt" lang="EN-GB">55 women (68.8%) and 25 men (31.3%) with a mean age and SD of 50.56 ± 14.28 yrs. The control group included 25 women <span style="mso-bidi-font-size: 12.0pt" lang="EN-GB">(62.5%) and 15 men (37.5%) with a mean age of 50.93 ± 11.73 yrs. Serum leptin levels were measured by the enzyme immunoassay method. HOMA-IR was determined by using fasting glucose and insulin levels. <span style="mso-bidi-font-size: 12.0pt" lang="EN-GB">Insulin, total cholesterol (TC), LDL-C, HOMA-IR (p<0.01) and leptin (p<0.001) were significantly higher in the cholelithiasis group, compared to the controls. In patients with a HOMA-IR >2.2, age, body mass index (BMI), glucose, insulin, triglycerides (TG), TC and leptin levels were higher than in patients with a HOMA-IR 100 mg/dl, mean BMI, HOMA-IR, insulin, TG, TC and leptin levels were significantly higher than in patients with glucose levels 150 mg/dl, mean age, BMI, glucose, insulin, TC, leptin and HOMA-IR were significantly higher than in patients with TG levels 25 kg/m2, mean age, glucose, insulin, TG, TC, leptin, HOMA-IR were significantly higher than in patients with BMI <25. In cholelithiasis group, there was a positive correlation between leptin and age, BMI, glucose, insulin, TG, TC, LDL-C or HOMA-IR. In conclusion, we found a positive association between increased leptin levels and abnormal lipoprotein metabolism in cholelithiasis. Cholelithiasis subjects with insulin resistance showed higher cardiometabolic risk factors than those without it. </span

Results of gastrointestinal endoscopic examinations in patients with iron defıciency anemia

Endoscopic procedures are usually carried out in order to diagnose the cause of iron deficiency anemia (IDA). We aimed to evaluate endoscopic findings of our patients with iron deficiency anemia retrospectively.Materials and methods: We retrospectively reviewed our computerized data of patients who attended to Haydarpasa Numune Education and Research Hospital Gastroentology Endoscopy Unit between 2008 and 2010 years. Patients in whom upper gastrointestinal endoscopy and/or colonoscopy were performed in order to diagnose the cause of IDA were included in this study.Results: This study included 490 patients with iron deficiency anemia in whom upper gastrointestinal endoscopy and/or colonoscopy were performed. The mean age of patients was 58.94 ± 14.8 years. Of these patients, 288 (172 female, 116 male) underwent only upper gastrointestinal endoscopy, 116 (61 female, 55 male) underwent only colonoscopy and 84 (39 male, 45 female) underwent both upper gastrointestinal endoscopy and colonoscopy. The rates of failure to reveal the cause of IDA in patients in whom either upper gastrointestinal endoscopy or colonoscopy had been performed were 18.75% and 46.55%, respectively. On other hand, the ratio of failure to reveal the cause of IDA was 3.48% in patients in whom both upper gastrointestinal endoscopy and colonoscopy had been performed.Conclusion: When referring any patient with iron deficiency anemia to endoscopy unit, ordering both upper gastrointestinal endoscopy and colonoscopy may allow us to find the reason more accurately