Beach development behind detached breakwater.

Merged with duplicate record 10026.1/2650 on 06.20.2017 by CS (TIS)Concurrent wave and morphology data were collected around a coastal protection scheme on the U. K. south coast. The scheme consists of eight detached breakwaters protecting a renourished sand and shingle beach, and is situated in a strongly macro-tidal environment. The development of the beach morphology is described. The beach trapped sand and shingle moving eastwards into it, and lost material from the eastern end. While the beach was designed to maintain a shingle beach, it was found that the scheme was most effective at trapping sand, which led to tombolo formation behind the updrift breakwaters. Current engineering design methods for describing beach development were applied to the scheme. Empirical techniques were found to be poor predictors of the salient length, although the simplest methods were reasonable guides to the scheme response over a variety of tidal levels. The US Army Corps of Engineers one-line model GENESIS (Hanson, 1989) was applied to the scheme. Using observed values of beach, structure and wave conditions, it was necessary to exaggerate transport due to longshore gradients in wave height relative to transport due to oblique wave approach to correctly describe salient formation. While it was possible to reduce model calibration errors, model validation was not successful. This was due to the inability of the model to allow tombolo formation, and also due to the lack of a 'constant! beach profile, due to the different behaviour of the sand and shingle. Empiricalo rthogonafl unctiona nalysisw as carriedo ut on the beachs urveyd ata.F rom the limited records available, it was clear that the scheme reduced profile variance behind it, compared to the updrift and downdrift shorelinesT. he schemea lso led to morec omplex3 D seasonaml ovementso f beachm aterial,i n contrastto the predominantly2 D responseu pdrift

Pseudo-C3-symmetric titanium complexes for asymmetric catalysis

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Temporal development of coastal ecosystems in the Baltic Sea over the past two decades

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Eutrophication in marine waters: harmonization of MSFD methodological standards at EU level

The Marine Strategy Framework Directive (MSFD) establishes the framework for the protection, conservation and sustainable use of the marine environment at the Union level. Because of its potential negative effects on the marine water quality, eutrophication is one of the criteria assessed under MSFD. This report presents the results of the joint work between JRC and a network of Member States (MS) eutrophication designated experts to assess the level of harmonization in Eutrophication methodological standards and threshold definition at regional and EU level. The information compiled at regional and national level showed that although methodologies are defined already for all the criteria, the degree of harmonization of methodological approaches across MS and regions is in some cases very low. In addition further developments are needed for some regions to agree on common indicators and threshold values. Based on these results the report highlights existing gaps and proposes recommendations to improve the eutrophication assessment framework at EU level.JRC.D.2-Water and Marine Resource

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy. Methods: We did an international, prospective, randomised, open-label, blinded-endpoint trial in adult participants with ischaemic stroke or transient ischaemic attack (TIA) within 48 h of onset. Participants were assigned in a 1:1 ratio using computer randomisation to receive loading doses and then 30 days of intensive antiplatelet therapy (combined aspirin 75 mg, clopidogrel 75 mg, and dipyridamole 200 mg twice daily) or guideline-based therapy (comprising either clopidogrel alone or combined aspirin and dipyridamole). Randomisation was stratified by country and index event, and minimised with prognostic baseline factors, medication use, time to randomisation, stroke-related factors, and thrombolysis. The ordinal primary outcome was the combined incidence and severity of any recurrent stroke (ischaemic or haemorrhagic; assessed using the modified Rankin Scale) or TIA within 90 days, as assessed by central telephone follow-up with masking to treatment assignment, and analysed by intention to treat. This trial is registered with the ISRCTN registry, number ISRCTN47823388. Findings: 3096 participants (1556 in the intensive antiplatelet therapy group, 1540 in the guideline antiplatelet therapy group) were recruited from 106 hospitals in four countries between April 7, 2009, and March 18, 2016. The trial was stopped early on the recommendation of the data monitoring committee. The incidence and severity of recurrent stroke or TIA did not differ between intensive and guideline therapy (93 [6%] participants vs 105 [7%]; adjusted common odds ratio [cOR] 0·90, 95% CI 0·67–1·20, p=0·47). By contrast, intensive antiplatelet therapy was associated with more, and more severe, bleeding (adjusted cOR 2·54, 95% CI 2·05–3·16, p<0·0001). Interpretation: Among patients with recent cerebral ischaemia, intensive antiplatelet therapy did not reduce the incidence and severity of recurrent stroke or TIA, but did significantly increase the risk of major bleeding. Triple antiplatelet therapy should not be used in routine clinical practice

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy.Methods: We did an international, prospective, randomised, open-label, blinded-endpoint trial in adult participants with ischaemic stroke or transient ischaemic attack (TIA) within 48 h of onset. Participants were assigned in a 1:1 ratio using computer randomisation to receive loading doses and then 30 days of intensive antiplatelet therapy (combined aspirin 75 mg, clopidogrel 75 mg, and dipyridamole 200 mg twice daily) or guideline-based therapy (comprising either clopidogrel alone or combined aspirin and dipyridamole). Randomisation was stratified by country and index event, and minimised with prognostic baseline factors, medication use, time to randomisation, stroke-related factors, and thrombolysis. The ordinal primary outcome was the combined incidence and severity of any recurrent stroke (ischaemic or haemorrhagic; assessed using the modified Rankin Scale) or TIA within 90 days, as assessed by central telephone follow-up with masking to treatment assignment, and analysed by intention to treat. This trial is registered with the ISRCTN registry, number ISRCTN47823388.Findings: 3096 participants (1556 in the intensive antiplatelet therapy group, 1540 in the guideline antiplatelet therapy group) were recruited from 106 hospitals in four countries between April 7, 2009, and March 18, 2016. The trial was stopped early on the recommendation of the data monitoring committee. The incidence and severity of recurrent stroke or TIA did not differ between intensive and guideline therapy (93 [6%] participants vs 105 [7%]; adjusted common odds ratio [cOR] 0·90, 95% CI 0·67–1·20, p=0·47). By contrast, intensive antiplatelet therapy was associated with more, and more severe, bleeding (adjusted cOR 2·54, 95% CI 2·05–3·16,

Hydrografi &amp; hydrokemi

Mätningar utförs av Umeå Marina Forskningscentrum åtta gånger på utsjöstationerna och sju gånger på stationerna i Örefjärden. De hydrografiska variabler som mäts är temperatur och konduktivitet (salthalt). De hydrokemiska variablerna mäts på upp till 9 olika djup vid varje station. De variabler som mäts är totala koncentrationer av fosfor och kväve, löst oorganiskt kväve respektive fosfor, kisel, syrekoncentration och syremättnad. Mätningarna kompletteras av en vinterprovtagning med stor geografisk täckning, som utförs av SMHI. Vid denna provtagning tas prover från 17 olika djup på 23 stationer