D-003 (Saccharum officinarum): The forgotten lipid-lowering agent.

Reduction of elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C), is essential in primary and secondary prevention of cardiovascular disease (CVD). Therefore there is still a large need for new effective drugs, which would be able to essentially reduce LDL-C and in the consequence CV residual risk. D-003 is a mixture of high aliphatic primary acids purified from sugarcane (Saccharum officinarum) wax. It showed promising hypocholesterolemic effects in both animal and human studies; it significantly lowers both serum total cholesterol (TC) and LDL-C, and increases high-density lipoprotein cholesterol (HDL-C). In addition, it showed a favorable safety profile. In this review, we evaluated the profile of D-003 as a lipid-lowering agent based on data from available preclinical and clinical studies

Campylobacter jejuni colonization promotes the translocation of Escherichia coli to extra-intestinal organs and disturbs the short-chain fatty acids profiles in the chicken gut

For a long time Campylobacter was only considered as a commensal microorganism in avian hosts restricted to the ceca, without any pathogenic features. The precise reasons for the symptomless chicken carriers are still unknown, but investigations of the gastrointestinal ecology of broiler chickens may improve our understanding of the microbial interactions with the host. Therefore, the current studies were conducted to investigate the effects of Campylobacter jejuni colonization on Escherichia coli translocation and on the metabolic end products (short-chain fatty acids, SCFAs). Following oral infection of 14 day old broiler chickens with 1 × 108 CFU of Campylobacter jejuni NCTC 12744 in two independent animal trials, it was found that C. jejuni heavily colonized the intestine and disseminate to extra-intestinal organs. Moreover, in both animal trials, the findings revealed that C. jejuni promoted the translocation of E. coli with a higher number encountered in the spleen and liver at 14 days post infection (dpi). In addition, Campylobacter affected the microbial fermentation in the gastrointestinal tract of broilers by reducing the amount of propionate, isovalerate, and isobutyrate in the cecal digesta of the infected birds at 2 dpi and, at 7 and 14 dpi, butyrate, isobutyrate, and isovalerate were also decreased. However, in the jejunum, the C. jejuni infection lowered only butyrate concentrations at 14 dpi. These data indicated that C. jejuni may utilize SCFAs as carbon sources to promote its colonization in the chicken gut, suggesting that Campylobacter cannot only alter gut colonization dynamics but might also influence physiological processes due to altered microbial metabolite profiles. Finally, the results demonstrated that C. jejuni can cross the intestinal epithelial barrier and facilitates the translocation of Campylobacter itself as well as of other enteric microorganisms such as E. coli to extra-intestinal organs of infected birds. Altogether, our findings suggest that the Campylobacter carrier state in chicken is characterised by multiple changes in the intestinal barrier function, which supports multiplication and survival within the host

Action of Salt Formation on the Bifunctional Nature of 12- Molybdophosphoric Acid and Their Relationship to the Catalytic Activity

Acidic properties and the catalytic activity of 12-molybdophosphates (M"nn+H3-,PM012040; M = Cu2+, BP+, Cr3+ and X = 1-3) have been studied. The results are discussed as the effect of these catalyst components on the partial charge on oxygen atom which is in a relation with the acidity. It is shown that the oxygen-hydrogen bond is weakened as the value of partial charge on oxygen (-bo) becomes more negative, while the vapor-phase dehydration activity of 2 propanol is explained on the basis of the reacting zone wideness taking into account the pseudo liquid phase nature of the heteropoly compounds. Correlation, the percentage conversion of 2-propanol with the fractional charge on molybdenum atom was successful to interpret the effect of the redox properties of these catalysts on their catalytic activity

A Bestiary of Higher Dimensional Taub-NUT-AdS Spacetimes

We present a menagerie of solutions to the vacuum Einstein equations in six, eight and ten dimensions. These solutions describe spacetimes which are either locally asymptotically adS or locally asymptotically flat, and which have non-trivial topology. We discuss the global structure of these solutions, and their relevance within the context of M-theory.Comment: 11 pages, LaTex(v4: Comments and references added

Performance, Combustion Characteristics and Emission Tests of Single Cylinder Engine Running on Fusel Oil - Diesel Blended (F20) Fuel

Alcohols produced from a renewable source are amongst the important alternative fuels for internal combustion engines. Investigations on alternative fuels for compression ignition engines regarded as one of the major research areas. This paper details an experimental examination of the performance and emissions in single cylinder compression ignition engines operating with fusel oil F20 and pure diesel F0 at five engine speeds and 50% engine load. The test results indicated that the engine power and torque slightly decrease with the F20 at low speeds compared with pure diesel. Further, the in-cylinder pressure was decreased at all engine speed for F20 in comparison with pure diesel. The volumetric efficiency and fuel consumption were increased for F20 due the low heating value of fusel oil. The results showed that CO2 and CO emissions were increased because of the water content, low heating value and low cetane number for fusel oil. The maximum reduction in NOx emissions was 18% for F20 at 1500 rpm

Performance and Combustion Characteristics of an SI Engine Fueled With Fusel Oil-Gasoline at Different Water Content

The main objective of the current study is to investigate the impacts of fusel oil-gasoline blends with different water content on performance and combustion characteristics of an SI engine. The water content of fusel oil is reduced by employing rotary extractor method. The parameters examined in the current study are the effects of test fuels upon engine performance criteria, fuel combustion, location of CA50 and coefficient of variation of indicated mean effective pressure (COVIMEP). The experiments are conducted in a SI engine with two blending ratio of gasoline-fusel oil (FBWE10 and FAWE10) in addition to pure gasoline as a standard fuel under different engine speeds and constant 45% of WOT engine load. The study results reveal that engine power, torque, and brake thermal efficiency have slightly improved with fusel oil-gasoline blends that were obvious clearly after reduction of water content. On the other hand, though the brake specific fuel consumption of FAWE10 slightly improve compared to FBWE10 but still higher than gasoline. Furthermore, the peak in-cylinder pressure, rate of heat release, and rate of pressure rise enhanced with fusel oil-gasoline blends. The (CA 0–10) and (CA 10–90) duration could be simultaneously decreased by reducing the water content of fusel oil, all of that are helpful to improve the stability of combustion and thought to be reasons for the reduction in COVIMEP. As a conclusion, the reduction of fusel oil water content has played positively to enhance the combustion and performance characteristics of the fuel blend and result in more stable engine operation

Prescribing patterns of gastrointestinal drugs in private clinics in Benghazi-Libya

Background: Prescription analysis can pinpoint areas of improvement in encounters issued by prescribing physicians. The present study was carried out to analyze prescribing trends for outpatients among consultants in the city of Benghazi-Libya.Methods: A total of 4000 prescriptions were collected from private pharmacies around the city of Benghazi, Libya. Indicators addressed included the patient's name, age, sex, and address, and the physician's name, address, and signature. The percentage of prescriptions lacking this information was calculated. Drugs prescribed by dosage, duration of treatment were also considered. The study focused on the commonly prescribed classes of gastrointestinal drugs and the most frequently prescribed drug of each common class. No attempt was made to evaluate the incidence of various gastrointestinal disorders. Results are expressed as frequency and percentage of prescribed medicines.Results: Information present in prescriptions and pertaining to the patient were name (2972, 74.3%), age (468, 11.7%), date of visit (107, 2.7%) while those for prescriber were name (1902, 47.6%) and signature (3612, 90.3%). None of the prescriptions contained sex of patient, his/her address, or registration number of the prescriber. All prescribed drugs were in brand names. Polypharmacy was not evident as all prescriptions contained 1-2 drugs.The number of prescriptions with a gastrointestinal drug(s) counted to 421 (10.5%) out of the total 4000 prescriptions. The most commonly prescribed classes of gastrointestinal drugs include in order, anti-hyperacidity, anti-emetics, anti-spasmodic, laxatives and anti-diarrheal with the most frequently prescribed drug of each therapeutic class being omeprazole (67, 48.9%), metoclopramide (57, 57%), hyoscine-N-butyl bromide (42, 55.3%), bisacodyl (44, 59.5%) and loperamide (30, 88.3%) respectively.Conclusions: The results of the present study indicate the need to improve prescribing among physicians, a task that can be achieved through inclusion of related topics such as prescription writing and rational drug use in undergraduate curricula and continuing medical educational programs

Infectious bronchitis vaccine virus detection and part-S1 genetic variation following single or dual inoculation in broiler chicks.

An investigation was undertaken of the extent of genetic variation occurring within infectious bronchitis virus (IBV) vaccine strains following vaccination of day-old broiler chicks. Chicks were divided into seven groups, with two groups receiving single Massachusetts (Mass) vaccinations while the other four were inoculated with combinations of different IBV serotypes; Mass, 793B, D274 and Arkansas (Ark). The remaining group was maintained as an unvaccinated control. Following vaccination, swabs and tissues collected at intervals were pooled and RNA was extracted for detection of IBV by reverse transcription polymerase chain reaction. Positive amplicons were sequenced for the part-S1 gene and compared to the original vaccine strain sequences. Single nucleotide polymorphisms, amino acid variations and hydrophobicity changes were identified and recorded for each sampling point. A total of 106 single nucleotide polymorphisms were detected within 28 isolates. The average single nucleotide polymorphism counts of swab isolates were greater than those found in tissue samples. This translated into 64 amino acid changes; however only six resulted in a change to the hydrophobicity properties. All hydrophobic alterations occurred within swab isolates and the majority were recovered at 3 days post vaccination suggesting such changes to be detrimental to early virus survival. Nucleotide deletions were seen only in the group given the combination of Mass and Ark. Of the 16 sequenced samples in this group, 13 contained the same AAT deletion at position 1033 1035 in the Ark strains. Findings presented in this study demonstrate alteration in the S1 nucleotide sequence following co-administration of live IBV vaccines

Detection of the Crab Nebula using a Random Forest Analysis of the first TAIGA IACT Data

The Tunka Advanced Instrument for Gamma- and cosmic-ray Astronomy (TAIGA) is a multicomponent experiment for the measurement of TeV to PeV gamma- and cosmic rays. Our goal is to establish a novel hybrid direct air shower technique, sufficient to access the energy domain of the long-sought Pevatrons. The hybrid air Cherenkov light detection technique combines the strengths of the HiSCORE shower front sampling array, and two $\thicksim$4 m class, $\sim$9.6 deg field of view Imaging Air Cherenkov Telescopes (IACTs). The HiSCORE array provides good angular and shower core position resolution, while the IACTs provide the image shape and orientation for gamma-hadron separation. In future, an additional muon detector will be used for hadron tagging at $\ge$ 100 TeV energies. Here, only data from the first IACT of the TAIGA experiment are used. A random forest algorithm was trained using Monte Carlo (MC) simulations and real data, and applied to 85 h of selected observational data tracking the Crab Nebula at a mean zenith angle of 33.5 deg, resulting in a threshold energy of 6 TeV for this dataset. The analysis was performed using the gammapy package. A total of 163.5 excess events were detected, with a statistical significance of 8.5 sigma. The observed spectrum of the Crab Nebula is best fit with a power law above 6 TeV with a flux normalisation of $(3.20\pm0.42)\cdot10^{-10} TeV^{-1} cm^{-2} s^{-1})$ at a reference energy of 13 TeV and a spectral index of $-2.74\pm0.16$.Comment: 8 pages, 9 figures, accepted by MNRA

Проблемы теневой экономики в Украине

Brain inflammation plays a central role in multiple sclerosis (MS). Besides lymphocytes, the astroglia and microglia mainly contribute to the cellular composition of the inflammatory infiltrate in MS lesions. Several studies were able to demonstrate that cortical lesions are characterized by lower levels of inflammatory cells among activated microglia/macrophages. The underlying mechanisms for this difference, however, remain to be clarified. In the current study, we compared the kinetics and extent of microglia and astrocyte activation during early and late cuprizone-induced demyelination in the white matter tract corpus callosum and the telencephalic gray matter. Cellular parameters were related to the expression profiles of the chemokines Ccl2 and Ccl3. We are clearly able to demonstrate that both regions are characterized by early oligodendrocyte stress/apoptosis with concomitant microglia activation and delayed astrocytosis. The extent of microgliosis/astrocytosis appeared to be greater in the subcortical white matter tract corpus callosum compared to the gray matter cortex region. The same holds true for the expression of the key chemokines Ccl2 and Ccl3. The current study defines a model to study early microglia activation and to investigate differences in the neuroinflammatory response of white vs. gray matter