LIMITES E POSSIBILIDADES DA CONTRIBUIÇÃO DO PROGRAMA SALA DE LEITURA NA FORMAÇÃO DE LEITORES NO CONTEXTO ESCOLAR

Ancorado na abordagem Histórico Cultural, trata-se de um estudo de caso e representa uma investigação qualitativa cujo objetivo é discutir acerca das possibilidades e limites da contribuição do Programa Sala de Leitura para a formação de leitores no contexto escolar. O lócus escolhido para a aplicação da pesquisa foi a sala de leitura Clarisse Lispector, sediada na Escola Estadual Professora Djanira Velho, município de Ribeirão Preto/SP. A coleta de dados foi efetuada através de entrevista semiestruturada e interações via grupo focal, realizadas, respectivamente, com a mediadora da sala de leitura e com os sete alunos integrantes da amostra. Identifica e descreve as práticas que ocorrem na sala de leitura. Os resultados reconhecem as potencialidades da sala de leitura na formação leitora dos educandos e aponta os limites a serem superados mediante sugestões que se apoiam na oferta de momentos de leitura livre e no ensino de estratégias de leitur

Support and follow-up needs of patients discharged from intensive care after severe COVID-19: a mixed-methods study of the views of UK general practitioners and intensive care staff during the pandemic’s first wave

Objectives To identify follow-up services planned for patients with COVID-19 discharged from intensive care unit (ICU) and to explore the views of ICU staff and general practitioners (GPs) regarding these patients’ future needs and care coordination.Design This is a sequential mixed-methods study using online surveys and semistructured interviews. Interview data were inductively coded and thematically analysed. Survey data were descriptively analysed.Setting GP surgeries and acute National Health Service Trusts in the UK.Participants GPs and clinicians leading care for patients discharged from ICU.Primary and secondary outcomes Usual follow-up practice after ICU discharge, changes in follow-up during the pandemic, and GP awareness of follow-up and support needs of patients discharged from ICU.Results We obtained 170 survey responses and conducted 23 interviews. Over 60% of GPs were unaware of the follow-up services generally provided by their local hospitals and whether or not these were functioning during the pandemic. Eighty per cent of ICUs reported some form of follow-up services, with 25% of these suspending provision during the peak of the pandemic and over half modifying their provision (usually to provide the service remotely). Common themes relating to barriers to provision of follow-up were funding complexities, remit and expertise, and communication between ICU and community services. Discharge documentation was described as poor and lacking key information. Both groups mentioned difficulties accessing services in the community and lack of clarity about who was responsible for referrals and follow-up.Conclusions The pandemic has highlighted long-standing issues of continuity of care and complex funding streams for post-ICU follow-up care. The large cohort of ICU patients admitted due to COVID-19 highlights the need for improved follow-up services and communication between specialists and GPs, not only for patients with COVID-19, but for all those discharged from ICU

Percepciones maternas sobre las prácticas alimentarias en escolares de Monterrey, México

El objetivo de este estudio fue explorar las percepciones maternas sobre las prácticas alimentarias de niños en edad escolar que presentan diferente estado nutricional residentes en el área metropolitana de Monterrey, Nuevo León, México. Se realizó un estudio cualitativo fenomenológico, mediante entrevistas semi-estructuradas a 91 madres de familia con un hijo entre 6 y 11 años de edad, durante el año 2015 y 2017. Los resultados evidenciaron que las madres de familia fueron las responsables de la adquisición y preparación de las comidas aun cuando tuvieran un empleo. Para la elaboración de los alimentos la madre cocinó según los gustos de la familia siendo esto una forma de expresarles su cariño. Las emociones de las madres con respecto a la aceptación de los alimentos, los gustos, rechazos y el número de comidas diarias que realizan los hijos, varió dependiendo del estado nutricional. La alimentación durante los días de la semana fue diferente a la de los fines de semana. Las prácticas alimentarias fueron parte de acontecimientos y significados sociales aprendidos por las madres de familia y que no siempre estuvieron acorde con los cánones nutricionales establecidos por los expertos

Human iPSC derived disease model of MERTK-associated retinitis pigmentosa

Retinitis pigmentosa (RP) represents a genetically heterogeneous group of retinal dystrophies affecting mainly the rod photoreceptors and in some instances also the retinal pigment epithelium (RPE) cells of the retina. Clinical symptoms and disease progression leading to moderate to severe loss of vision are well established and despite significant progress in the identification of causative genes, the disease pathology remains unclear. Lack of this understanding has so far hindered development of effective therapies. Here we report successful generation of human induced pluripotent stem cells (iPSC) from skin fibroblasts of a patient harboring a novel Ser331Cysfs*5 mutation in the MERTK gene. The patient was diagnosed with an early onset and severe form of autosomal recessive RP (arRP). Upon differentiation of these iPSC towards RPE, patient-specific RPE cells exhibited defective phagocytosis, a characteristic phenotype of MERTK deficiency observed in human patients and animal models. Thus we have created a faithful cellular model of arRP incorporating the human genetic background which will allow us to investigate in detail the disease mechanism, explore screening of a variety of therapeutic compounds/reagents and design either combined cell and gene- based therapies or independent approaches.This work was supported by Andalusian Health Council (PI-0324-2013), Instituto de Salud Carlos III (PI13/01331), Spanish Ministry of Economy and Competitiveness-FEDER BFU2012-36845, Instituto de Salud Carlos III RETICS RD12/0034/0010 and Academy of Finland (218050; 272808)

Visceral leishmaniasis caused by Leishmania (Leishmania) amazonensis associated with Hodgkin’s lymphoma

Visceral leishmaniasis (VL) is mainly caused by Leishmania (Leishmania) donovani and Leishmania (L.) infantum; however, other Leishmania species have been associated with VL. We report a case of a patient simultaneously diagnosed with VL caused by Leishmania (L.) amazonensis and Hodgkin’s lymphoma. After treatment with liposomal amphotericin B and chemotherapy, the patient presented a clinical cure. This case report reinforces the hypothesis that other Leishmania species can cause visceral lesions mainly related to immunosuppression

Mixed Methods EvAluation of the high-volume low-complexity Surgical hUb pRogrammE (MEASURE): a mixed methods study protocol

Introduction The waiting list for elective surgery in England recently reached over 7.8 million people and waiting time targets have been missed since 2010. The high-volume low complexity (HVLC) surgical hubs programme aims to tackle the backlog of patients awaiting elective surgery treatment in England. This study will evaluate the impact of HVLC surgical hubs on productivity, patient care and the workforce. Methods and analysis This 4-year project consists of six interlinked work packages (WPs) and is informed by the Consolidated Framework for Implementation Research. WP1: Mapping current and future HVLC provision in England through document analysis, quantitative data sets (eg, Hospital Episodes Statistics) and interviews with national service leaders. WP2: Exploring the effects of HVLC hubs on key performance outcomes, primarily the volume of low-complexity patients treated, using quasi-experimental methods. WP3: Exploring the impact and implementation of HVLC hubs on patients, health professionals and the local NHS through approximately nine longitudinal, multimethod qualitative case studies. WP4: Assessing the productivity of HVLC surgical hubs using the Centre for Health Economics NHS productivity measure and Lord Carter’s operational productivity measure. WP5: Conducting a mixed-methods appraisal will assess the influence of HVLC surgical hubs on the workforce using: qualitative data (WP3) and quantitative data (eg, National Health Service (NHS) England’s workforce statistics and intelligence from WP2). WP6: Analysing the costs and consequences of HVLC surgical hubs will assess their achievements in relation to their resource use to establish value for money. A patient and public involvement group will contribute to the study design and materials. Ethics and dissemination The study has been approved by the East Midlands—Nottingham Research Ethics Committee 23/EM/0231. Participants will provide informed consent for qualitative study components. Dissemination plans include multiple academic and non-academic outputs (eg, Peer-reviewed journals, conferences, social media) and a continuous, feedback-loop of findings to key stakeholders (eg, NHS England) to influence policy development

Consumo de Antibióticos y su Relación con el Desarrollo de Anemia Hemolítica Autoinmune

Autoimmune hemolytic anemia is characterized as an immune disorder in which there is the presence of antibodies directed against antigens present in the erythrocyte membrane, resulting in a decrease in the half-life or destruction of red blood cells. According to its epidemiology, it can occur at any age and its causes can be varied, and even its association with the consumption of different drugs such as antibiotics, especially penicillins and cephalosporins, although it is rare, it is of great importance due to the impact on quality. of the patient's life. Therefore, we carried out a bibliographic search of articles in English and Spanish in different databases, resulting in different case reports that reveal the relationship in the development of autoimmune hemolytic anemia as a consequence of the consumption of antibiotics.La anemia hemolítica autoinmune se caracteriza por ser un trastorno de carácter inmunitario en el cual se da la presencia de anticuerpos dirigidos contra antígenos presentes en la membrana eritrocitaria dando como consecuencia la disminución de la vida media o destrucción de los hematíes. Según su epidemiología, puede presentarse a cualquier edad y sus causas pueden ser variadas, e incluso su asociación con el consumo de diferentes fármacos como los antibióticos, especialmente penicilinas y cefalosporinas, aunque es poco frecuente es de gran importancia debido a la afectación de la calidad de vida del paciente. Por ende, realizamos una búsqueda bibliográfica de artículos en inglés y español en diferentes bases de datos dando como resultado diferentes reportes de casos que nos dan a conocer la relación en el desarrollo de anemia hemolítica autoinmune como consecuencia del consumo de antibióticos