Tobacco use and attitudes towards a smoke-free policy : survey in the World Health Organization in Geneva

La consommation de tabac est la première cause de mortalité dans les pays occidentaux. Plusieurs études scientifiques ont également montré l'impact du tabagisme passif sur la santé. L'Organisation mondiale de la santé (OMS) a récemment identifié le contrôle du tabagisme (actif et passif) comme l'une de ses priorités pour les prochaines décennies. Ce contrôle peut être réalisé dans le cadre d'environnements professionnels sans fumée et de l'aide aux fumeurs souhaitant arrêter de fumer. Le lieu de travail devrait donc être aménagé afin de protéger les non-fumeurs de la fumée d'autrui. Une telle stratégie permet de réduire la consommation de cigarettes et fait progresser les fumeurs dans leur désaccoutumance au tabac. En 1999, le groupe "Tobacco free initiative" de l'OMS a mandaté l'Unité de prévention, (unité commune à l'Institut universitaire de médecine sociale et préventive et à la Policlinique médicale universitaire de Lausanne) de réaliser une enquête chez les employés de l'OMS. Les objectifs de cette enquête étaient les suivants : décrire la perception des employés et leurs connaissances en termes de contrôle du tabagisme ; déterminer leur exposition au tabagisme passif; connaître leur attitude envers une organisation totalement "smoke free" ; évaluer l'intérêt des fumeurs à bénéficier d'une aide à la désaccoutumance dans le cadre de leur activité professionnelle. [P. 4]]]> Health Policy ; Health Promotion ; Smoking ; Tobacco Smoke Pollution ; World Health Organization eng https://serval.unil.ch/resource/serval:BIB_D5D9E0FEA957.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D5D9E0FEA9577 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D5D9E0FEA9577 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_D5D9FE1D5924 2022-05-07T01:27:53Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_D5D9FE1D5924 Firewalls Prevent Systemic Dissemination of Vectors Derived from Human Adenovirus Type 5 and Suppress Production of Transgene-Encoded Antigen in a Murine Model of Oral Vaccination. info:doi:10.3389/fcimb.2018.00006 info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2018.00006 info:eu-repo/semantics/altIdentifier/pmid/29423380 Revaud, J. Unterfinger, Y. Rol, N. Suleman, M. Shaw, J. Galea, S. Gavard, F. Lacour, S.A. Coulpier, M. Versillé, N. Havenga, M. Klonjkowski, B. Zanella, G. Biacchesi, S. Cordonnier, N. Corthésy, B. Ben Arous, J. Richardson, J.P. info:eu-repo/semantics/article article 2018 Frontiers in cellular and infection microbiology, vol. 8, pp. 6 info:eu-repo/semantics/altIdentifier/eissn/2235-2988 urn:issn:2235-2988 <![CDATA[To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastric administration of vectors encoding firefly luciferase or a model antigen, detectable levels of transgene-encoded protein or mRNA were confined to the intestine, and restricted to delimited anatomical zones. Expression of luciferase in the form of multiple small bioluminescent foci in the distal ileum, cecum, and proximal colon suggested multiple crossing points. Many foci were unassociated with visible Peyer's patches, implying that transduced cells lay in proximity to villous rather than follicle-associated epithelium, as supported by detection of transgene-encoded antigen in villous epithelial cells. Transgene-encoded mRNA but not protein was readily detected in Peyer's patches, suggesting that post-transcriptional regulation of viral gene expression might limit expression of transgene-encoded antigen in this tissue. To characterize the pathways by which the vector crossed the intestinal epithelium and encountered sentinel cells, a fluorescent-labeled vector was administered to mice by the intragastric route or inoculated into ligated intestinal loops comprising a Peyer's patch. The vector adhered selectively to microfold cells in the follicle-associated epithelium, and, after translocation to the subepithelial dome region, was captured by phagocytes that expressed CD11c and lysozyme. In conclusion, although a large number of crossing events took place throughout the intestine within and without Peyer's patches, multiple firewalls prevented systemic dissemination of vector and suppressed production of transgene-encoded protein in Peyer's patches

Inferring odontocete life history traits in dentine using a multiproxy approach (δ15N, δ44/42Ca and trace elements)

Funding Information: The authors thank F. Demaret and W. Dabin (Observatoire Pelagis) for helping secure odontocete milk and tooth samples. This work was funded by the Conseil National de la Recherche Scientifique (CNRS) INSU INTERRVIE program (Early Whale Resource Use and Diet project) to J.E.M. The authors thank LGLTPE (UMR 5276) and ENS de Lyon for supporting the MC‐ICP mass spectrometry platform. Nitrogen isotope measurements were performed on the “Ecologie Isotopique” platform of LEHNA (UMR 5023). The authors thank F. Arnauld‐Godet and E. Albalat for technical support on the MC‐ICP platform of the LGLTPE. The authors thank the anonymous reviewers and the editor R. Bol for their constructive comments that helped improve the quality of this work. Funding Information: The authors thank F. Demaret and W. Dabin (Observatoire Pelagis) for helping secure odontocete milk and tooth samples. This work was funded by the Conseil National de la Recherche Scientifique (CNRS) INSU INTERRVIE program (Early Whale Resource Use and Diet project) to J.E.M. The authors thank LGLTPE (UMR 5276) and ENS de Lyon for supporting the MC-ICP mass spectrometry platform. Nitrogen isotope measurements were performed on the “Ecologie Isotopique” platform of LEHNA (UMR 5023). The authors thank F. Arnauld-Godet and E. Albalat for technical support on the MC-ICP platform of the LGLTPE. The authors thank the anonymous reviewers and the editor R. Bol for their constructive comments that helped improve the quality of this work. Publisher Copyright: © 2023 The Authors. Rapid Communications in Mass Spectrometry published by John Wiley & Sons Ltd.Peer reviewedPublisher PD

LYRA: an autonomous bridge stays and hangers monitoring solution

peer reviewe

Uniformisation et automatisation du monitoring des tensions dans les suspentes et haubans de ponts

La détermination des tensions des haubans et suspentes de ponts par mesures accélérométriques est maitrisée et utilisée depuis longtemps au SPW (ServicePublic de Wallonie), mais la méthode utilisée ne permet pas un calcul correct pour les suspentes présentant des géométries complexes, et le contrôle est effectué de manière ponctuelle avec une périodicité variable. Le projet présenté, issu d’une collaboration avec l’Université de Liège et la société V2i, spécialisée dans l’acquisition et le traitement vibratoire, a permis de développer un système performant d’instrumentation basé sur cette technique et destiné à remplacer la méthodologie actuelle: (1) Les algorithmes d’acquisition et de traitement des données issues des accéléromètres sans fil permettent un calcul précis des tensions pour toute géométrie complexe des suspentes (raideur flexionnelle, encastrements partiels,...); (2) Les données, recueillies plusieurs fois par jour, sont traitées et transmises sur le cloud, permettent un suivi sécuritaire en continu via une gestion automatisée des alertes mises en place.Peer reviewe

Characterization and regulation of the expression of scyllatoxin (Leiurotoxin I) receptors in the human neuroblastoma cell line NB-OK 1

Abstract125I-[Tyr2]scyllatoxin allowed to label a single class of high-affinity receptors in membranes from the human neuroblastoma cell line NB-OK 1. The Kd of these receptors was 60 pM for scyllatoxin (Leiurotoxin I) and 20 pM for apamin and the Bmax was low (3.8 fmol/mg membrane protein). K+ increased toxin binding at low concentrations but exerted opposite effects at high concentrations. Ca2+, guanidinium and Na+ exerted only inhibitory effects on binding. Scyllatoxin binding sites were overexpressed 2.5-fold after a 24-h cell pretreatment with 2 mM butyrate. This effect was suppressed by cycloheximide

Le tuf calcaire de La Celle-sur-Seine (Seine et Marne) : nouvelles données sur un site clé du stade 11 dans le Nord de la France

De nouvelles études morphostratigraphiques et biostratigraphiques ainsi que des datations ont été entreprises sur le célèbre dépôt de tuf calcaire de La Celle-sur-Seine afin d'obtenir une reconstruction détaillée des successions paléoenvironnementales et climatiques enregistrées dans cette formation interglaciaire du Pléistocène moyen. L'approche développée a privilégié l'aspect pluridisciplinaire afin d'exploiter la richesse paléontologique du gisement, de mieux appréhender ses caractères morphostratigraphiques et de préciser sa position chronologique. Les premiers résultats obtenus à partir des études malacologiques montrent que le dépôt, composé de tufs et de niveaux limono-argileux, s'est construit en progradant le long du versant. Ainsi l'épaisseur totale de la formation atteint près de 9 mètres. Les malacofaunes permettent de reconstituer une évolution paléoenvironnementale correspondant au début puis à l'optimum d'une phase climatique interglaciaire. Les niveaux sommitaux sont, eux, caractérisés par un net recul de la couverture forestière.La création de nouveaux profils stratigraphiques a permis la découverte dans un niveau de limon gris tufacé d'une abondante faune de mammifères accompagnée par quelques silex taillés. Cet horizon appartient à la malacozone la plus riche en taxons thermophiles qui est interprétée comme la phase optimum de l'Interglaciaire. La signification environnementale et climatique du cortège mammalogique, qui comprend en particulier de l'hippopotame et du macaque, corrobore les résultats malacologiques. L'industrie lithique est de type bifaciale en cohérence avec les récoltes de bifaces acheuléens effectuées à la fin du 19ème siècle. La composition du cortège de mollusques permet de rapprocher la faune de La Celle de "l'assemblage à Lyrodiscus", caractéristique des tufs du stade 11 dans le nord-ouest de l'Europe. Cette attribution chronologique est confirmée par les premières mesures radiométriques obtenus par U-Th sur des échantillons de tuf induré et par RPE/U-Th sur une dent de cheval. Enfin la révision des collections paléontologiques d'empreintes foliaires permet, en conjonction avec les données malacologiques, d'initier la discussion sur l'interprétation paléoclimatique du biome à Lyrodiscus. L'association floristique et faunique de La Celle qui comprend quelques taxons arboréens méditerranéens et nombre de gastéropodes éteints ou de répartition actuelle centre-européenne et océanique rend compte d'un environnement tempéré de forêt humide. La présence de ces espèces allochtones dans le nord de la France est mise en parallèle avec la durée exceptionnellement longue du Stade Isotopique Marin (SIM) 11 et de faibles amplitudes de températures saisonnières, qui auraient permis à plusieurs taxons méridionaux de coloniser cette zone septentrionale, plutôt qu'avec un climat plus tempéré que l'actuel.New morpho and biostratigraphical studies have been undertaken at the famous calcareous tufa deposit of La Celle-sur-Seine in order to obtain a detailed paleoenvironmental and climatic reconstruction from this Middle Pleistocene Interglacial formation. Multiproxy approach allows to study palaeontological contain of the tufa as well as its morphostratigraphical aspects and chronological allocation. First results from malacological study show that the tufa edificated downwards the slope reaching a total thickness of 9 metres high. Moreover molluscs show palaeoenvironmental succession corresponding to the early part of an Interglacial period followed by an optimum phase. Finally, at the top of the deposit faunas clearly indicate decrease of forest biotopes.Excavation of new profiles have allowed to discover a grey silty tufa horizon (lgt) yielding abundant mammal remains and a few lithic artefacts. This level is part of the molluscs zone 3 corresponding to the climatic optimum. Palaeoenvironmental and climatic conditions inferred from mammal assemblage (including Hippopotamus and Macaca) strengthened the malacological interpretation. The lithic industry is identified as Acheulean and appears in agreement with earliest handaxes discoveries during the late 19th century.La Celle malacological fauna belongs to the well-known MIS 11 "Lyrodiscus assemblage" in north-west Europe. This chronological allocation is confirmed by first U-series radiometric measures. Finally reappraisal of leaf print collections allows together with malacological data to discuss palaeoclimatic interpretation of the "Lyrodiscus biome". Flora and fauna from La Celle include a few mediterranean trees and several extinct gastropods together with few molluscs of central Europe modern range, allowing to describe a forest and humid lanscape. Presence of these peculiar species in northern France is thought to be related with the long length of MIS 11 and lower seasonal temperature contrast, that have allowed northern colonisation by southern species, rather than with occurrence of temperature higher than today

Pátio cercado por árvores de espinho e outras frutas, sem ordem e sem simetria: O quintal em vilas e arraiais de Minas Gerais (séculos XVIII e XIX)

This article analyses urban and rural backyards in Minas Gerais, in the late18th and early 19th centuries. Sources include probate records, foreign travelers accounts, administrative documents and iconography. These spaces are interpreted as a part of material culture, as provisioning grounds, and places of sociability and family intimacy. The connections of yards within households and the surrounding streetscapes are examined, revealing that they can be viewed as instruments of balance in the overall urban landscape.O texto objetiva analisar os quintais urbanos e rurais em Minas Gerais, ao final do século XVIII e início do século XIX. Interpreta evidências documentais de inventários post mortem, narrativas de viajantes estrangeiros, documentos administrativos e iconográficos, interpretando esses espaços, na perspectiva da cultura material, como lugares de abastecimento alimentar, sociabilidades e da intimidade familiar. Considera a ligação dos quintais com a casa e as ruas e os vê como espaços de equilibrio da paisagem urbana

Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial

Background—Children account for a substantial proportion of cases and deaths from Ebola virus disease. We aimed to assess the safety and immunogenicity of a two-dose heterologous vaccine regimen, comprising the adenovirus type 26 vector-based vaccine encoding the Ebola virus glycoprotein (Ad26.ZEBOV) and the modified vaccinia Ankara vectorbased vaccine, encoding glycoproteins from the Ebola virus, Sudan virus, and Marburg virus, and the nucleoprotein from the Tai Forest virus (MVA-BN-Filo), in a paediatric population in Sierra Leone. Methods—This randomised, double-blind, controlled trial was done at three clinics in Kambia district, Sierra Leone. Healthy children and adolescents aged 1–17 years were enrolled in three age cohorts (12–17 years, 4–11 years, and 1–3 years) and randomly assigned (3:1), via computer-generated block randomisation (block size of eight), to receive an intramuscular injection of either Ad26.ZEBOV (5 × 1010 viral particles; first dose) followed by MVA-BN-Filo (1 × 108 infectious units; second dose) on day 57 (Ebola vaccine group), or a single dose of meningococcal quadrivalent (serogroups A, C, W135, and Y) conjugate vaccine (MenACWY; first dose) followed by placebo (second dose) on day 57 (control group). Study team personnel (except for those with primary responsibility for study vaccine preparation), participants, and their parents or guardians were masked to study vaccine allocation. The primary outcome was safety, measured as the occurrence of solicited local and systemic adverse symptoms during 7 days after each vaccination, unsolicited systemic adverse events during 28 days after each vaccination, abnormal laboratory results during the study period, and serious adverse events or immediate reportable events throughout the study period. The secondary outcome was immunogenicity (humoral immune response), measured as the concentration of Ebola virus glycoprotein-specific binding antibodies at 21 days after the second dose. The primary outcome was assessed in all participants who had received at least one dose of study vaccine and had available reactogenicity data, and immunogenicity was assessed in all participants who had received both vaccinations within the protocol-defined time window, had at least one evaluable post-vaccination sample, and had no major protocol deviations that could have influenced the immune response. This study is registered at ClinicalTrials.gov, NCT02509494. Findings—From April 4, 2017, to July 5, 2018, 576 eligible children or adolescents (192 in each of the three age cohorts) were enrolled and randomly assigned. The most common solicited local adverse event during the 7 days after the first and second dose was injection-site pain in all age groups, with frequencies ranging from 0% (none of 48) of children aged 1–3 years after placebo injection to 21% (30 of 144) of children aged 4–11 years after Ad26.ZEBOV vaccination. The most frequently observed solicited systemic adverse event during the 7 days was headache in the 12–17 years and 4–11 years age cohorts after the first and second dose, and pyrexia in the 1–3 years age cohort after the first and second dose. The most frequent unsolicited adverse event after the first and second dose vaccinations was malaria in all age cohorts, irrespective of the vaccine types. Following vaccination with MenACWY, severe thrombocytopaenia was observed in one participant aged 3 years. No other clinically significant laboratory abnormalities were observed in other study participants, and no serious adverse events related to the Ebola vaccine regimen were reported. There were no treatment-related deaths. Ebola virus glycoprotein-specific binding antibody responses at 21 days after the second dose of the Ebola virus vaccine regimen were observed in 131 (98%) of 134 children aged 12–17 years (9929 ELISA units [EU]/mL [95% CI 8172–12 064]), in 119 (99%) of 120 aged 4–11 years (10 212 EU/mL [8419–12 388]), and in 118 (98%) of 121 aged 1–3 years (22 568 EU/mL [18 426–27 642]). Interpretation—The Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen was well tolerated with no safety concerns in children aged 1–17 years, and induced robust humoral immune responses, suggesting suitability of this regimen for Ebola virus disease prophylaxis in children

Safety and long-term immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: a combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial

Background The Ebola epidemics in west Africa and the Democratic Republic of the Congo highlight an urgent need for safe and effective vaccines to prevent Ebola virus disease. We aimed to assess the safety and long-term immunogenicity of a two-dose heterologous vaccine regimen, comprising the adenovirus type 26 vector-based vaccine encoding the Ebola virus glycoprotein (Ad26.ZEBOV) and the modified vaccinia Ankara vector-based vaccine, encoding glycoproteins from Ebola virus, Sudan virus, and Marburg virus, and the nucleoprotein from the Tai Forest virus (MVA-BN-Filo), in Sierra Leone, a country previously affected by Ebola. Methods The trial comprised two stages: an open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2. The study was done at three clinics in Kambia district, Sierra Leone. In stage 1, healthy adults (aged ≥18 years) residing in or near Kambia district, received an intramuscular injection of Ad26.ZEBOV (5×1010 viral particles) on day 1 (first dose) followed by an intramuscular injection of MVA-BN-Filo (1×108 infectious units) on day 57 (second dose). An Ad26.ZEBOV booster vaccination was offered at 2 years after the first dose to stage 1 participants. The eligibility criteria for adult participants in stage 2 were consistent with stage 1 eligibility criteria. Stage 2 participants were randomly assigned (3:1), by computer-generated block randomisation (block size of eight) via an interactive web-response system, to receive either the Ebola vaccine regimen (Ad26.ZEBOV followed by MVA-BN-Filo) or an intramuscular injection of a single dose of meningococcal quadrivalent (serogroups A, C, W135, and Y) conjugate vaccine (MenACWY; first dose) followed by placebo on day 57 (second dose; control group). Study team personnel, except those with primary responsibility for study vaccine preparation, and participants were masked to study vaccine allocation. The primary outcome was the safety of the Ad26.ZEBOV and MVA-BN-Filo vaccine regimen, which was assessed in all participants who had received at least one dose of study vaccine. Safety was assessed as solicited local and systemic adverse events occurring in the first 7 days after each vaccination, unsolicited adverse events occurring in the first 28 days after each vaccination, and serious adverse events or immediate reportable events occurring up to each participant’s last study visit. Secondary outcomes were to assess Ebola virus glycoprotein-specific binding antibody responses at 21 days after the second vaccine in a per-protocol set of participants (ie, those who had received both vaccinations within the protocol-defined time window, had at least one evaluable post-vaccination sample, and had no major protocol deviations that could have influenced the immune response) and to assess the safety and tolerability of the Ad26.ZEBOV booster vaccination in stage 1 participants who had received the booster dose. This study is registered at ClinicalTrials.gov, NCT02509494. Findings Between Sept 30, 2015, and Oct 19, 2016, 443 participants (43 in stage 1 and 400 in stage 2) were enrolled; 341 participants assigned to receive the Ad26.ZEBOV and MVA-BN-Filo regimen and 102 participants assigned to receive the MenACWY and placebo regimen received at least one dose of study vaccine. Both regimens were well tolerated with no safety concerns. In stage 1, solicited local adverse events (mostly mild or moderate injection-site pain) were reported in 12 (28%) of 43 participants after Ad26.ZEBOV vaccination and in six (14%) participants after MVA-BN-Filo vaccination. In stage 2, solicited local adverse events were reported in 51 (17%) of 298 participants after Ad26.ZEBOV vaccination, in 58 (24%) of 246 after MVA-BN-Filo vaccination, in 17 (17%) of 102 after MenACWY vaccination, and in eight (9%) of 86 after placebo injection. In stage 1, solicited systemic adverse events were reported in 18 (42%) of 43 participants after Ad26.ZEBOV vaccination and in 17 (40%) after MVA-BN-Filo vaccination. In stage 2, solicited systemic adverse events were reported in 161 (54%) of 298 participants after Ad26.ZEBOV vaccination, in 107 (43%) of 246 after MVA-BN-Filo vaccination, in 51 (50%) of 102 after MenACWY vaccination, and in 39 (45%) of 86 after placebo injection. Solicited systemic adverse events in both stage 1 and 2 participants included mostly mild or moderate headache, myalgia, fatigue, and arthralgia. The most frequent unsolicited adverse event after the first dose was headache in stage 1 and malaria in stage 2. Malaria was the most frequent unsolicited adverse event after the second dose in both stage 1 and 2. No serious adverse event was considered related to the study vaccine, and no immediate reportable events were observed. In stage 1, the safety profile after the booster vaccination was not notably different to that observed after the first dose. Vaccine-induced humoral immune responses were observed in 41 (98%) of 42 stage 1 participants (geometric mean binding antibody concentration 4784 ELISA units [EU]/mL [95% CI 3736–6125]) and in 176 (98%) of 179 stage 2 participants (3810 EU/mL [3312–4383]) at 21 days after the second vaccination. Interpretation The Ad26.ZEBOV and MVA-BN-Filo vaccine regimen was well tolerated and immunogenic, with persistent humoral immune responses. These data support the use of this vaccine regimen for Ebola virus disease prophylaxis in adults

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216