404 research outputs found
Hadronic B Decays Involving Even Parity Charmed Mesons
Hadronic B decays containing an parity-even charmed meson in the final state
are studied. Specifically we focus on the Cabibbo-allowed decays and , where denotes generically a p-wave charmed meson.
The transition form factors are studied in the improved version
of the Isgur-Scora-Grinstein-Wise quark model. We apply heavy quark effective
theory and chiral symmetry to study the strong decays of p-wave charmed mesons
and determine the magnitude of the mixing angle. Except
the decay to the predictions for agree
with experiment. The sign of mixing angle is found to be
positive in order to avoid a severe suppression on the production of
. The interference between color-allowed and color-suppressed
tree amplitudes is expected to be destructive in the decay . Hence, an observation of the ratio
can be used to test the relative signs of
various form factors as implied by heavy quark symmetry. Although the predicted
at the level of exceeds the
present upper limit, it leads to the ratio
as expected from the factorization
approach and from the ratio . Therefore, it is
crucial to have a measurement of this mode to test the factorization
hypothesis. For decays, it is expected that \bar
D_{s0}^*D\gsim \bar D_{s1}D as the decay constants of the multiplet
become the same in the heavy quark limit.Comment: 27 pages, Belle's new data on DD_s^{**} productions in B decays and
on the radiative decay D_{s1}-> D_s\gamma are updated and discussed. Add two
reference
Q**2-dependence of deep inelastic lepton scattering off nuclear targets
Deep inelastic scattering of leptons off nuclear targets is analized within
the convolution model taking into account nucleon-nucleon correlations. We show
that in the nuclear medium nucleons are distributed according to a function
that exhibits a sizeable Q**2-dependence and reduces to the ordinary light-cone
distribution in the Bjorken limit. At Q**2 1 this
Q**2-dependence turns out to be stronger than the one associated with the
nucleon structure function, predicted by pertubative quantum chromodynamics.Comment: 11 pages including figs. Figs. can be sent by PS-fil
Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects
OBJECTIVE: We investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between subjects with different CYP3A4 and CYP3A5 genotypes. METHODS: Plasma concentrations of midazolam, and of total (conjugated + unconjugated) 1'OH-midazolam, and 4'OH-midazolam were measured after the oral administration of 7.5 mg or of 75 micro g of midazolam in 21 healthy subjects. RESULTS: CYP3A5*7, CYP3A4*1E, CYP3A4*2, CYP3A4*4, CYP3A4*5, CYP3A4*6, CYP3A4*8, CYP3A4*11, CYP3A4*12, CYP3A4*13, CYP3A4*17 and CYP3A4*18 alleles were not identified in the 21 subjects. CYP3A5*3, CYP3A5*6, CYP3A4*1B and CYP3A4*1F alleles were identified in 20, 1, 4 and 2 subjects, respectively. No statistically significant differences were observed for the AUC(inf) values between the different genotypes after the 75- micro g or the 7.5-mg dose. CONCLUSION: Presently, CYP3A4 and CYP3A5 genotyping methods do not sufficiently reflect the inter-individual variability of CYP3A activity
Global QCD Analysis and the CTEQ Parton Distributions
The CTEQ program for the determination of parton distributions through a
global QCD analysis of data for various hard scattering processes is fully
described. A new set of distributions, CTEQ3, incorporating several new types
of data is reported and compared to the two previous sets of CTEQ
distributions. Comparison with current data is discussed in some detail. The
remaining uncertainties in the parton distributions and methods to further
reduce them are assessed. Comparisons with the results of other global analyses
are also presented.Comment: (Change in Latex style only: 2up style removed since many don't have
it.) 35 pages, 23 figures separately submitted as uuencoded compressed
ps-file; Michigan State Report # MSU-HEP/41024 and CTEQ 40
Heavy-quark mass dependence in global PDF analyses and 3- and 4-flavour parton distributions
We study the sensitivity of our recent MSTW 2008 NLO and NNLO PDF analyses to
the values of the charm- and bottom-quark masses, and we provide additional
public PDF sets for a wide range of these heavy-quark masses. We quantify the
impact of varying m_c and m_b on the cross sections for W, Z and Higgs
production at the Tevatron and the LHC. We generate 3- and 4-flavour versions
of the (5-flavour) MSTW 2008 PDFs by evolving the input PDFs and alpha_S
determined from fits in the 5-flavour scheme, including the eigenvector PDF
sets necessary for calculation of PDF uncertainties. As an example of their
use, we study the difference in the Z total cross sections at the Tevatron and
LHC in the 4- and 5-flavour schemes. Significant differences are found,
illustrating the need to resum large logarithms in Q^2/m_b^2 by using the
5-flavour scheme. The 4-flavour scheme is still necessary, however, if cuts are
imposed on associated (massive) b-quarks, as is the case for the experimental
measurement of Z b bbar production and similar processes.Comment: 40 pages, 11 figures. Grids can be found at
http://projects.hepforge.org/mstwpdf/ and in LHAPDF V5.8.4. v2: version
published in EPJ
Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity.
OBJECTIVE: We investigated whether the oral administration of a low dose (75 micro g) of midazolam, a CYP3A probe, can be used to measure the in vivo CYP3A activity. METHODS: Plasma concentrations of midazolam, 1'OH-midazolam and 4'OH-midazolam were measured after the oral administration of 7.5 mg and 75 micro g midazolam in 13 healthy subjects without medication, in four subjects pretreated for 2 days with ketoconazole (200 mg b.i.d.), a CYP3A inhibitor, and in four subjects pretreated for 4 days with rifampicin (450 mg q.d.), a CYP3A inducer. RESULTS: After oral administration of 75 micro g midazolam, the 30-min total (unconjugated + conjugated) 1'OH-midazolam/midazolam ratios measured in the groups without co-medication, with ketoconazole and with rifampicin were (mean+/-SD): 6.23+/-2.61, 0.79+/-0.39 and 56.1+/-12.4, respectively. No side effects were reported by the subjects taking this low dose of midazolam. Good correlations were observed between the 30-min total 1'OH-midazolam/midazolam ratio and midazolam clearance in the group without co-medication (r(2)=0.64, P<0.001) and in the three groups taken together (r(2)=0.91, P<0.0001). Good correlations were also observed between midazolam plasma levels and midazolam clearance, measured between 1.5 h and 4 h. CONCLUSION: A low oral dose of midazolam can be used to phenotype CYP3A, either by the determination of total 1'OH-midazolam/midazolam ratios at 30 min or by the determination of midazolam plasma levels between 1.5 h and 4 h after its administration
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Neutron structure function and inclusive DIS from H-3 and He-3 at large Bjorken-x
A detailed study of inclusive deep inelastic scattering (DIS) from mirror A =
3 nuclei at large values of the Bjorken variable x is presented. The main
purpose is to estimate the theoretical uncertainties on the extraction of the
neutron DIS structure function from such nuclear measurements. On one hand,
within models in which no modification of the bound nucleon structure functions
is taken into account, we have investigated the possible uncertainties arising
from: i) charge symmetry breaking terms in the nucleon-nucleon interaction, ii)
finite Q**2 effects neglected in the Bjorken limit, iii) the role of different
prescriptions for the nucleon Spectral Function normalization providing baryon
number conservation, and iv) the differences between the virtual nucleon and
light cone formalisms. Although these effects have been not yet considered in
existing analyses, our conclusion is that all these effects cancel at the level
of ~ 1% for x < 0.75 in overall agreement with previous findings. On the other
hand we have considered several models in which the modification of the bound
nucleon structure functions is accounted for to describe the EMC effect in DIS
scattering from nuclei. It turns out that within these models the cancellation
of nuclear effects is expected to occur only at a level of ~ 3%, leading to an
accuracy of ~ 12 % in the extraction of the neutron to proton structure
function ratio at x ~ 0.7 -0.8$. Another consequence of considering a broad
range of models of the EMC effect is that the previously suggested iteration
procedure does not improve the accuracy of the extraction of the neutron to
proton structure function ratio.Comment: revised version to appear in Phys. Rev. C; main modifications in
Section 4; no change in the conclusion
Charm System Tests of CPT and Lorentz Invariance with FOCUS
We have performed a search for CPT violation in neutral charm meson
oscillations. While flavor mixing in the charm sector is predicted to be small
by the Standard Model, it is still possible to investigate CPT violation
through a study of the proper time dependence of a CPT asymmetry in right-sign
decay rates for and \d0b\to K^+\pi^-. This asymmetry is
related to the CPT violating complex parameter and the mixing parameters
and : . Our 95% confidence
level limit is . Within the
framework of the Standard Model Extension incorporating general CPT violation,
we also find 95% confidence level limits for the expressions involving
coefficients of Lorentz violation of GeV, GeV, and GeV,
where is the factor which incorporates mixing parameters ,
and the doubly Cabibbo suppressed to Cabibbo favored relative strong phase
.Comment: 12 pages 5 figure
The S-wave from the decay
Using data from FOCUS (E831) experiment at Fermilab, we present a model
independent partial-wave analysis of the S-wave amplitude from the
decay . The S-wave is a generic complex function to be
determined directly from the data fit. The P- and D-waves are parameterized by
a sum of Breit-Wigner amplitudes. The measurement of the S-wave amplitude
covers the whole elastic range of the system.Comment: 13 pages, 9 figures, submitted to Physics Letters
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