Radio Jet-Ambient Medium Interactions on Parsec Scales in the Blazar 1055+018

As part of our study of the magnetic fields of AGN we have recently observed a large sample of blazars with the Very Long Baseline Array. Here we report the discovery of a striking two-component jet in the source 1055+018, consisting of an inner spine with a transverse magnetic field, and a fragmentary but distinct boundary layer with a longitudinal magnetic field. The polarization distribution in the spine strongly supports shocked-jet models while that in the boundary layer suggests interaction with the surrounding medium. This behavior suggests a new way to understand the differing polarization properties of strong- and weak-lined blazars.Comment: LaTex; 10 pages; 6 figures; reference fix; to appear in ApJL, 518, 1999 June 2

Utilizing x-ray computed tomography for heritage conservation : the case of megalosaurus bucklandii

Of key importance to any cultural institution is the practice of conservation, the method by which specimens at risk of severe degradation or destruction are treated to ensure that they survive into the future. However, surface inspection is often insufficient to properly inform conservators of the best treatment approach, and where there is little to no record of the conservational history of an object it can be difficult to identify exactly what form of conservation has been undertaken. X-Ray Computed Tomography (XCT) grants a way to overcome these issues by allowing conservators to non-destructively investigate the subsurface details of an artefact to provide essential information on condition of a specimen. Here, the potential of this approach is demonstrated using the first XCT scans of the iconic dentary of Megalosaurus bucklandii Mantell, 1827 (1); the first dinosaur ever named and described scientifically. XCT analysis reveals that the degree of repair is less extensive than previously thought and also elucidates two different material types, M1 and M2, thought to be representative of at least two phases of repair. Finally the potential of this approach is further explored, highlighting its importance for conservation practice, identifying forgeries and hoaxes in addition to potential applications in public engagement

Resonant Kelvin-Helmholtz modes in sheared relativistic flows

Qualitatively new aspects of the (linear and non-linear) stability of sheared relativistic (slab) jets are analyzed. The linear problem has been solved for a wide range of jet models well inside the ultrarelativistic domain (flow Lorentz factors up to 20; specific internal energies $\approx 60c^2$). As a distinct feature of our work, we have combined the analytical linear approach with high-resolution relativistic hydrodynamical simulations, which has allowed us i) to identify, in the linear regime, resonant modes specific to the relativistic shear layer ii) to confirm the result of the linear analysis with numerical simulations and, iii) more interestingly, to follow the instability development through the non-linear regime. We find that very high-order reflection modes with dominant growth rates can modify the global, long-term stability of the relativistic flow. We discuss the dependence of these resonant modes on the jet flow Lorentz factor and specific internal energy, and on the shear layer thickness. The results could have potential applications in the field of extragalactic relativistic jets.Comment: Accepted for publication in Physical Review E. For better quality images, please check http://www.mpifr-bonn.mpg.de/staff/mperucho/Research.htm

Faraday rotation in the MOJAVE blazars: 3C 273 a case study

Radio polarimetric observations of Active Galactic Nuclei can reveal the magnetic field structure in the parsec-scale jets of these sources. We have observed the gamma-ray blazar 3C 273 as part of our multi-frequency survey with the Very Long Baseline Array to study Faraday rotation in a large sample of jets. Our observations re-confirm the transverse rotation measure gradient in 3C 273. For the first time the gradient is seen to cross zero which is further indication for a helical magnetic field and spine-sheath structure in the jet. We believe the difference to previous epochs is due to a different part of the jet being illuminated in our observations.Comment: 6 pages, 3 figures. To appear in the proceedings of "Beamed and Unbeamed Gamma-rays from Galaxies", held in Muonio, Finland, April 11-15, 2011. Journal of Physics: Conference Serie

Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells

IL-21 is known to promote anti-tumour immunity due to its ability to promote T cell responses and counteract Treg-mediated suppression. It has also been shown to limit Treg frequencies during tumour-antigen stimulations. However, whether this represents inhibition of FOXP3 induction in naïve CD4 T cells or curtailed expansion of natural Treg remains unclear. Moreover, whether this effect is maintained in an environment of tumour-derived immunosuppressive factors is not known. Here, we show that in the context of a number of cancers, naïve CD45RA+ CD4 T cells are induced to express high levels of FOXP3, and that FOXP3 expression correlates with inhibition of T cell proliferation. FOXP3 expression was most potently induced by tumours secreting higher levels of total and active TGFβ1 and this induction could be potently counteracted with IL-21, restoring T cell proliferation. We conclude that Treg induction in naïve T cells is a common phenomenon amongst a number of different cancers and that the ability of IL-21 to counteract this effect is further evidence of its promise in cancer therapy

Physical Electronics

Contains reports on three research projects

Evidence for early disk-locking among low-mass members of the Orion Nebula Cluster

We present high-resolution spectroscopic observations for 91 PMS stars in ONC with masses in the range 0.10-0.25Msun carried out with the multi-fiber spectrograph FLAMES@ESO. Our aim is to better understand the disk-locking scenario in very low-mass stars. We have derived radial velocities, vsini, and full width at 10% of the Halpha emission peak. Using published measurements of infrared excess as disk tracer, and equivalent width of the NIR CaII line lambda8542, mid-IR difference [3.6]-[8.0]micron derived by Spitzer data, and 10% Halpha width as diagnostic of the level of accretion, we have looked for any correlation between vsini divided by the radius and presence of disk and accretion. Four low-mass stars are SB2 systems. The distribution of rotation periods derived from our vsini measurements is unimodal with a peak of few days. Our is lower than the one expected for a random distribution. We find no evidence for a population of fast rotators close to the break-up velocity. A clear correlation between vsini/R and Delta(Ic-K) has been found. While for stars with no circumstellar disk a spread in the rotation rates is seen, stars with a circumstellar disk show an abrupt drop in their rotation rates by a factor of ~5. On the other hand, only a partial correlation between vsini and accretion is observed when other indicators are used. The X-ray coronal activity level shows no dependence on vsini/R suggesting that all stars are in a saturated regime limit. The critical velocity is probably below our vsini detection limit of 9 km/s. The ONC low-mass stars in our sample at present seem to be not locked, but the clear correlation we find between rotation and IR color excess suggests that they were locked once. In addition, the percentage of accretors seems to scale inversely to the stellar mass.Comment: 16 pages, 2 Tables, 17 figures. Accepted by Astronomy and Astrophysics. Full version of abstract is available in the manuscrip

'Caught Between a Rock and a Hard Place': Anti-discrimination Legislation in the Liberal State and the Fate of the Australian Disability Discrimination Act

This article offers a critical analysis of some of the practical implications for disabled people of the Disability Discrimination Act of 1992. Specifically, it raises questions about politics and the role of the law as an instrument of social change?taking greater account of the interests of disabled people?on the one hand, and of the reliance of the social model of disability on a strategy based upon legal rights on the other. The article also suggests that the constraining effects of Australia's constitutional protections of rights and its federal system of government hinder the mildly progressive elements of the Disability Discrimination Act. To illustrate this, the paper employs empirical evidence to suggest that these effects have been exacerbated by the passage of the Human Rights Legislation Amendment Act in 1999

Review Article: Rethinking Holder

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68947/2/10.1177_096394709800700104.pd