17 research outputs found
Metal Ions and Complexes in Alzheimer's Disease: From Fundamental to Therapeutic Perspectives
No full textInternational audienceIn this article, the author reviews the structural, thermodynamic, and kinetic data on metal ions (copper and zinc) binding to the amyloid‐β peptides of various sequences involved in Alzheimer's disease. Metal ions are indeed regarded as key players in Alzheimer's disease because they may contribute to the oxidative stress and modulate the aggregation propensity of the amyloid‐β peptides, two key processes in the etiology of the disease. An analogy with the influence of the interaction between metal ions and other intrinsically disordered peptides in different pathologies is also drawn. In a second part, several therapeutic and diagnostic approaches based on the role of metal ions are described and discussed. A selection of chelators, metallophores, prodrugs as well as inorganic compounds is proposed that illustrates the various strategies developed by inorganic medicinal chemists to fight Alzheimer's disease
Well-Defined Ruthenium Complex for Acceptorless Alcohol Dehydrogenation in Aqueous Medium
No full textKinetics Are Crucial When Targeting Copper Ions to Fight Alzheimer's Disease: An Illustration with Azamacrocyclic Ligands
No full textSilver complexes of ligands derived from adamantylamines: Water-soluble silver-donating compounds with antibacterial properties
No full textSite directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus
No full textSynthesis, characterization, photoluminescence, anti-tumor activity, DFT calculations and molecular docking with proteins of zinc( ii
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How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study
No full textSynthesis, characterization, antimicrobial, BSA binding, DFT calculation, molecular docking and cytotoxicity of Ni(II) complexes with Schiff base ligands
No full textMembrane insertion exacerbates the α-Synuclein-Cu(II) dopamine oxidase activity: Metallothionein-3 targets and silences all α-synuclein-Cu(II) complexes
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