Plant and arthropod diversity in prairie restorations around Louisville, KY.

Prairies are important ecological biomes that contain high biodiversity of economic and ecologically important flora and fauna. Unfortunately, despite the vast historic distribution over most of mid-America, remnant prairies are critically threatened due to urbanization and other anthropogenic activities. Therefore, measurements of richness are utilized to assess the stability and condition of remnant and restored prairies-higher richness indicating greater ecosystem stability. Arthropod abundance comprises a significant portion of the species richness found in prairies. Because of this, arthropods are an ideal group of organisms to study due to their relatively limited dispersal range and utilization of microhabitats. In this study, arthropods were collected in the summer of 2012 at four restored prairies located in Jefferson (Iroquois Park and American Synthetic Rubber Company Landfill), Nelson (Jefferson Memorial Forest), and Bullitt (Bernheim Research Forest and Arboretum) Counties of Kentucky. Comparisons of species richness for arthropods and vegetation were made between study locations. Because of low sample sizes and species dominance, no definitive relationships were determined. However, information about plant and arthropod presences were compiled for site management reference

Moving From Me to We: Interpersonal Coordination’s Effects on Self-Construal

We all move in time together throughout our lives, and doing so has been shown to lead to more pro-social attitudes and behaviors towards co-actors. However, little research has investigated how coordinated movement affects how individuals feel about themselves. This mixed-methods study took self-generated qualitative responses of how participants construed their own identities after either coordinated movement or a carefully matched control task. Responses were analysed qualitatively using thematic analyses, and quantitatively using content analysis. Four themes were identified from thematic analysis, and inferential statistical testing showed significant differences in how participants construed their identities post coordination (cf. control). Participants in the coordinated condition generated a higher proportion of interdependent (social) rather than independent (personal) self-construals, driven by differences in broad social structures/constructs rather than close specific social relations. Furthermore, participants in the coordinated condition reported less mental state items, and more sexual/romantic items. These findings may explain how and why coordinated movement leads to prosociality amongst those who take part, by leading individuals to think of themselves and each other in group terms

What factors influence the uptake of vaccinations amongst pregnant women following the Covid-19 pandemic : a qualitative study

Background Pregnant women and their unborn babies are at increased risk from serious complications, hospitalisation and death from infectious diseases. Vaccinations for influenza (flu), pertussis (whooping cough) and Covid-19 vaccination are available free for pregnant women in the UK, but uptake of these repeatedly remains low. This qualitative study aims to explore how pregnant women feel about vaccinations, and what factors influence the uptake of vaccinations amongst pregnant women since the onset of the Covid-19 pandemic. Methods Pregnant women were recruited via two participating hospitals in one geographic area of the UK, and via one community group offering support to pregnant women from ethnic minorities. Interviews were conducted remotely using telephone, were anonymised and transcribed using a University approved transcription service, and analysed using thematic analysis. Findings Semi-structured interviews were conducted remotely with 43 pregnant women. The following themes were identified as influencing uptake of vaccinations amongst pregnant women: internal factors and beliefs, vaccination related factors, external influences and Covid-19 and changing perceptions of the pandemic. Discussion Findings of this study increase awareness of some of the factors influencing vaccination decisions of pregnant women. It informs practice regarding healthcare professionals’ discussions with pregnant women about vaccinations, and future vaccination campaigns and interventions that are targeting an increase in vaccination uptake amongst this population

Dementia and physical activity (DAPA) trial of moderate to high intensity exercise training for people with dementia : randomised controlled trial

Objective: To estimate the effect of a moderate to high intensity aerobic and strength exercise training programme on cognitive impairment and other outcomes in people with mild to moderate dementia. Design: Multicentre, pragmatic, investigator masked, randomised controlled trial. Setting: National Health Service primary care, community and memory services, dementia research registers, and voluntary sector providers in 15 English regions. Participants: 494 people with dementia: 329 were assigned to an aerobic and strength exercise programme and 165 were assigned to usual care. Random allocation was 2:1 in favour of the exercise arm. Interventions: Usual care plus four months of supervised exercise and support for ongoing physical activity, or usual care only. Interventions were delivered in community gym facilities and NHS premises. Main outcome measures: The primary outcome was score on the Alzheimer’s disease assessment scale-cognitive subscale (ADAS-cog) at 12 months. Secondary outcomes included activities of daily living, neuropsychiatric symptoms, health related quality of life, and carer quality of life and burden. Physical fitness (including the six minute walk test) was measured in the exercise arm during the intervention. Results: The average age of participants was 77 (SD 7.9) years and 301/494 (61%) were men. By 12 months the mean ADAS-cog score had increased to 25.2 (SD 12.3) in the exercise arm and 23.8 (SD 10.4) in the usual care arm (adjusted between group difference −1.4, 95% confidence interval −2.6 to −0.2, P=0.03). This indicates greater cognitive impairment in the exercise group, although the average difference is small and clinical relevance uncertain. No differences were found in secondary outcomes or preplanned subgroup analyses by dementia type (Alzheimer’s disease or other), severity of cognitive impairment, sex, and mobility. Compliance with exercise was good. Over 65% of participants (214/329) attended more than three quarters of scheduled sessions. Six minute walking distance improved over six weeks (mean change 18.1 m, 95% confidence interval 11.6 m to 24.6 m). Conclusion: A moderate to high intensity aerobic and strength exercise training programme does not slow cognitive impairment in people with mild to moderate dementia. The exercise training programme improved physical fitness, but there were no noticeable improvements in other clinical outcomes

Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability

New Findings: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit features? What is the main finding and its importance? In the trained limb only, knee extensor force tracking accuracy improved with reduced motor unit firing rate variability in the vastus lateralis, and there was no change to neuromuscular junction transmission instability. Interventional strategies to improve force accuracy may be directed to older/clinical populations where such improvements may aid performance of daily living activities. Abstract: Muscle force output during sustained submaximal isometric contractions fluctuates around an average value and is partly influenced by variation in motor unit (MU) firing rates. MU firing rate (FR) variability seemingly reduces following exercise training interventions; however, much less is known with respect to peripheral MU properties. We therefore investigated whether targeted force accuracy training could lead to improved muscle functional capacity and control, in addition to determining any alterations of individual MU features. Ten healthy participants (seven females, three males, 27±6 years, 170±8cm, 69±16kg) underwent a 4-week supervised, unilateral knee extensor force accuracy training intervention. The coefficient of variation for force (FORCECoV) and sinusoidal wave force tracking accuracy (FORCESinu) were determined at 25% maximal voluntary contraction (MVC) pre- and post-training. Intramuscular electromyography was utilised to record individual MU potentials from the vastus lateralis (VL) muscles at 25% MVC during sustained contractions, pre- and post-training. Knee extensor muscle strength remained unchanged following training, with no improvements in unilateral leg-balance. FORCECoV and FORCESinu significantly improved in only the trained knee extensors by ∼13% (P =0.01) and ∼30% (P <0.0001), respectively. MU FR variability significantly reduced in the trained VL by ∼16% (n =8; P= 0.001), with no further alterations to MU FR or neuromuscular junction transmission instability. Our results suggest muscle force control and tracking accuracy is a trainable characteristic in the knee extensors, which is likely explained by the reduction in MU FR variability which was apparent in the trained limb only

Dementia and Physical Activity (DAPA) - an exercise intervention to improve cognition in people with mild to moderate dementia: Study protocol for a randomized controlled trial

Background: Dementia is more common in older than in younger people, and as a result of the ageing of the population in developed countries, it is becoming more prevalent. Drug treatments for dementia are limited, and the main support offered to people with dementia and their families is generally services to mitigate against loss of function. Physical exercise is a candidate non-pharmacological treatment for dementia. Methods/Design: DAPA is a randomised controlled trial funded by the National Institute for Health Research Health Technology Assessment programme to estimate the effect of a 4-month, moderate- to hard-intensity exercise training programme and subsequent advice to remain active, on cognition (primary outcome) at 12 months in people with mild to moderate dementia. Community-dwelling participants (with their carers where possible), who are able to walk 3 metres without human assistance, able to undertake an exercise programme and do not have any unstable or terminal illness are recruited. Participants are then randomised by an independent statistician using a computerised random number generator to usual care or exercise at a 2:1 ratio in favour of exercise. The exercise intervention comprises 29, 1-hour-long exercise classes, run twice weekly at suitable venues such as leisure centres, which include aerobic exercise (on static bikes) and resistance exercise (using weights). Goals for independent exercise are set while the classes are still running, and supported thereafter with phone calls. The primary outcome is measured using ADAS-cog. Secondary outcome measures include behavioural symptoms, functional ability, quality of life and carer burden. Primary and secondary outcomes will be measured at baseline and at 6 and 12 months after randomisation, by researchers masked to participant randomisation in the participants' own homes. An economic evaluation will be carried out in parallel to the RCT, as will a qualitative study capturing the experiences of participants, carers and staff delivering the intervention. Discussion: The DAPA study will be the first large, randomised trial of the cognitive effects of exercise on people with dementia. The intervention is designed to be capable of being delivered within the constraints of NHS service provision, and the economic evaluation will allow assessment of its cost-effectiveness. Trial registration: DAPA was registered with the ISRCTN database on 29 July 2011, registration number ISRCTN32612072. © 2016 Atherton et al

Social Vulnerabilities Conference 2020: post conference report

The Social Vulnerabilities Research Group represents research carried out across a range of Social Sciences disciplines, in particular members of the Human Geography, Sociology, and Criminology communities. The research group emphasizes the importance and application of interdisciplinary approaches to better understand the challenges facing vulnerable people in different contexts. The 2020 conference, hosted virtually during the pandemic, showcases work from staff and research students working with the Social Vulnerabilities group

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

As shown by analysis of mice and humans bearing DOCK8-inactivating mutations, DOCK8 plays a cell-autonomous role in survival of naive CD8 T cells, LFA-1 polarization toward the immune synapse, and CD8 T cell memory and recall responses following viral infection