23 research outputs found
Accidents and undetermined deaths: re-evaluation of nationwide samples from the Scandinavian countries
Ischaemic heart disease incidence by social class and form of smoking: the Copenhagen Male Study - 17 years' follow-up
Physical fitness or physical activity as a predictor of ischaemic heart disease? A 17-year follow-up in the Copenhagen Male Study
Differences in the Determination of Cause and Manner of 127 Natural Death Cases by Postmortem Inspection and Autopsy
Twoâyear outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study
Background & AimsThe longâterm clinical outcomes in initial survivors with acute liver failure (ALF) are not well known. The aim of this study was to provide an overview of the 2âyear clinical outcomes among initial survivors and liver transplant (LT) recipients that were alive 3 weeks after enrolment in the Acute Liver Failure Study Group (ALFSG).MethodsOutcomes in adult ALFSG patients that were enrolled between 1998 and 2010 were reviewed.ResultsTwoâyear patient survival was significantly higher in the 262 LT recipients (92.4%) compared to the 306 acetaminophen (APAP) spontaneous survivors (SS) (89.5%) and 200 nonâAPAP SS (75.5%) (P < 0.0001). The causes of death were similar in the three groups but the time to death was significantly longer in the LT recipients (P < 0.0001). Independent predictors of 2âyear mortality in the APAP group were a high serum phosphate level and patient age (câstatistic = 0.65 (0.54, 0.76)), patient age and days from jaundice to ALF onset in the nonâAPAP group (câstatistic = 0.69 (0.60, 0.78)), and patient age, days from jaundice, and higher coma grade in the LT recipients (câstatistic = 0.74 (0.61, 0.87)). The LT recipients were significantly more likely to be employed and have a higher educational level (P < 0.05).ConclusionsTwoâyear outcomes in initial survivors of ALF are generally good but nonâAPAP patients have a significantly lower survival which may relate to preâexisting medical comorbidities. Spontaneous survivors with APAP overdose experience substantial morbidity during followâup from ongoing psychiatric and substance abuse issues.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110589/1/liv12632.pd