26 research outputs found

    Jurisprudencia Civil Cubana, 02

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    Case law digest, v. 2. Civil law cases – Actos Propios (cont.)https://ecollections.law.fiu.edu/diaz-cruz-index/1064/thumbnail.jp

    Mesure du champ de déplacement transverse par voie optique appliquée au thermoformage du verre

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    L'objectif de cette étude est de modéliser le comportement thermomécanique du verre au cours d'un procédé complet de thermoformage (montée en température, palier de travail, refroidissement). Le verre étant absorbant, émissif et non-diffusant, la prise en compte du rayonnement dans la modélisation du transfert de chaleur s'avère être indispensable.Après avoir présenté la problématique associée à ce projet, nous décrirons le banc expérimental développé au sein du laboratoire ; il devrait permettre de valider expérimentalement les résultats numériques issus de notre modélisation. Ce banc se compose d'un four de thermoformage adapté et couplé à un système optique de mesures de champ de déplacement et de température de la surface supérieure de la plaque de verre. Le dispositif et la méthode employés pour mesurer le déplacement, basés sur l'utilisation de la lumière structurée, seront au centre de cette présentation

    Age at natural menopause and blood pressure traits: Mendelian randomization study

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    Copyright: © 2021 by the authors. Observational studies suggest that early onset of menopause is associated with increased risk of hypertension. Whether this association is causal or due to residual confounding and/or reverse causation remains undetermined. We aimed to evaluate the observational and causal association between age at natural menopause (ANM) and blood pressure traits in Caucasian women. A cross-sectional and one-sample Mendelian randomization (MR) study was conducted in 4451 postmenopausal women from the CoLaus and Rotterdam studies. Regression models were built with observational data to study the associations of ANM with systolic and diastolic blood pressure (SBP/DBP) and hypertension. One-sample MR analysis was performed by calculating a genetic risk score of 54 ANM-related variants, previously identified in a genome-wide association study (GWAS) on ANM. In the two-sample MR analysis we used the estimates from the ANM-GWAS and association estimates from 168,575 women of the UK Biobank to evaluate ANM-related variants and their causal association with SBP and DBP. Pooled analysis from both cohorts showed that a one-year delay in menopause onset was associated with 2% (95% CI 0; 4) increased odds of having hypertension, and that early menopause was associated with lower DBP (β = −1.31, 95% CI −2.43; −0.18). While one-sample MR did not show a causal association between ANM and blood pressure traits, the two-sample MR showed a positive causal association of ANM with SBP; the last was driven by genes related to DNA damage repair. The present study does not support the hypothesis that early onset of menopause is associated with higher blood pressure. Our results suggest different ANM-related genetic pathways could differently impact blood pressure.The CoLaus study was and is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation (grants 33CSCO-122661, 33CS30-139468, and 33CS30-148401). Zayne M. Roa-Díaz have received fund- ing from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 801076, through the SSPH+Global Ph.D. Fellowship Program in Public Health Sciences (GlobalP3HS) of the Swiss School of Public Health

    Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

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    Correction: Volume53, Issue5 Page 762-762 DOI: 10.1038/s41588-021-00832-z Published MAY 2021Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequencyPeer reviewe

    Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

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