Clustering visitors to a religious island : the case of Tinos

Tourists visiting religious destinations are usually influenced by religious motivations. However, this might not be the case for all tourists, since visitors to religious sites may visit a destination not only for pilgrimage, but also to satisfy various needs interlinked with social, cultural and recreational factors. This paper attempts to investigate the motivations and activities of tourists visiting Tinos, a Greek island known as a religious destination for Christian Orthodox, by undertaking a clustering approach. A self-administrated questionnaire was distributed to 97 visitors of Tinos during the summer of 2007. From the findings it is evident that although the island is considered as one of the main religious sites for Christian Orthodox, tourists are not a homogenous group. Instead, the analytical approach adopted produced three segments, namely the “cultural tourists”, the “vacationers” and the “religious tourists”

Non-parametric comparison of histogrammed two-dimensional data distributions using the Energy Test

When monitoring complex experiments, comparison is often made between regularly acquired histograms of data and reference histograms which represent the ideal state of the equipment. With the larger HEP experiments now ramping up, there is a need for automation of this task since the volume of comparisons could overwhelm human operators. However, the two-dimensional histogram comparison tools available in ROOT have been noted in the past to exhibit shortcomings. We discuss a newer comparison test for two-dimensional histograms, based on the Energy Test of Aslan and Zech, which provides more conclusive discrimination between histograms of data coming from different distributions than methods provided in a recent ROOT release.The Science and Technology Facilities Council, U

Harmonic analysis of precipitation, pressure and temperature over Turkey

Monthly averages of temperature, precipitation and pressure values from ground-based measurements for long-term data observed in different geographical regions in Turkey have been investigated. The main purpose of this study is to define the role of small- and large-scale phenomena (local and synoptic fluctuations) on precipitation, pressure and temperature variations and their periods. Hence, the Fourier transformation analysis of the monthly average value of meteorological parameters has been considered, and phase angles and amplitudes have been calculated. The first-order harmonics of temperature, precipitation and pressure values show large-scale effects, while higher-order harmonics show the effects of small-scale variations. The variations of first–sixth-order harmonic amplitudes and phases provide a useful means of understanding the large- and local-scale effects on meteorological parameters. The phase angle can be used to determine the time of the year when the maximum or minimum of a given harmonic occurs. The analysis helps us distinguish different precipitation, pressure and temperature regimes and transition regions. Local- and large-scale phenomena and some unusual seasonal patterns are also defined. This analysis also shows strong annual variations of precipitation in the Southern and Western part of Anatolia and that strong semi-annual fluctuations are predominant in the eastern part of Turkey. Strong annual influence on pressure variations is mostly observed in the coastal part of Turkey. The dominance of the first three harmonics of pressure is smaller over most of the terrestrial stations. Temperature variations are mostly influenced by the annual fluctuations in eastern and south-eastern Anatolia. The urban heat Island caused by developing metropolitan areas refers to local warming effects and heat islands. The local effects are observed in the western part of Turkey

From building blocks to programming: Investigating how best to integrate computational thinking into early years settings

This study aims to examine the different ways in which early years teachers lay solid foundations for computational thinking in the early years. Moreover, it aims to uncover the materials and activities that tend to run in the classroom background to promote computational thinking skills of children without being noticed as part of a daily routine. Therefore, it is designed to understand more about the attitudes of early childhood teachers towards computational thinking, the linkage between their attitudes and teaching practices, and the potential computational thinking benefits of children reaped from classroom games and activities

The Meaning of Memory Safety

We give a rigorous characterization of what it means for a programming language to be memory safe, capturing the intuition that memory safety supports local reasoning about state. We formalize this principle in two ways. First, we show how a small memory-safe language validates a noninterference property: a program can neither affect nor be affected by unreachable parts of the state. Second, we extend separation logic, a proof system for heap-manipulating programs, with a memory-safe variant of its frame rule. The new rule is stronger because it applies even when parts of the program are buggy or malicious, but also weaker because it demands a stricter form of separation between parts of the program state. We also consider a number of pragmatically motivated variations on memory safety and the reasoning principles they support. As an application of our characterization, we evaluate the security of a previously proposed dynamic monitor for memory safety of heap-allocated data.Comment: POST'18 final versio

Global existence and finite time blow-up in a class of stochastic nonlinear wave equations

We consider a stochastic extension of a class of wave equations with nonlinear viscoelastic damping and nonlinear forcing. We show the global existence of the solution of the stochastic equation and, additionally, when the source term dominates the damping term and when the initial data are large enough, we show that the expected value of the L p norm of the solution, blows up in finite time. In the presence of noise, we extend the previously known range of initial data corresponding to blow-up. Furthermore we use a spectral stochastic Galerkin method to perform numerical simulations that verify certain special cases of our theoretical results

G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes.

Background:Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by which a lipid receptor, G2A, regulates immune responses to a commensal bacterium. Objective:To elucidate the inflammatory properties of G2A in monocytes in response to PA stimulation. Furthermore, our study sought to investigate pathways by which lipids modulate immune responses in response to PA. Methods:Our studies focused on monocytes collected from human peripheral blood mononuclear cells, the monocytic cell line THP-1, and a lab strain of PA. Our studies involved the use of enzyme-linked immunosorbent, Western blot, reverse transcription polymerase chain reaction, small interfering RNA (siRNA), and microarray analysis of human acne lesions in the measurements of inflammatory markers. Results:G2A gene expression is higher in acne lesions compared to normal skin and is inducible by the acne therapeutic, 13-cis-retinoic acid. In vitro, PA induces both the Toll-like receptor 2-dependent expression of G2A as well as the production of the G2A ligand, 9-hydroxyoctadecadienoic acid, from human monocytes. G2A gene knockdown through siRNA enhances PA stimulation of interleukin (IL)-6, IL-8, and IL-1β possibly through increased activation of the ERK1/2 MAP kinase and nuclear factor kappa B p65 pathways. Conclusion:G2A may play a role in quelling inflammatory cytokine response to PA, revealing G2A as a potential attenuator of inflammatory response in a disease associated with a commensal bacterium

Annealed Silver-Island Films for Applications in Metal-Enhanced Fluorescence: Interpretation in Terms of Radiating Plasmons

The effects of thermally annealed silver island films have been studied with regard to their potential applicability in applications of metal-enhanced fluorescence, an emerging tool in nano-biotechnology. Silver island films were thermally annealed between 75 and 250°C for several hours. As a function of both time and annealing temperature, the surface plasmon band at ≈420 nm both diminished and was blue shifted. These changes in plasmon resonance have been characterized using both absorption measurements, as well as topographically using Atomic Force Microscopy. Subsequently, the net changes in plasmon absorption are interpreted as the silver island films becoming spherical and growing in height, as well as an increased spacing between the particles. Interestingly, when the annealed surfaces are coated with a fluorescein-labeled protein, significant enhancements in fluorescence are osbserved, scaling with annealing temperature and time. These observations strongly support our recent hypothesis that the extent of metal-enhanced fluorescence is due to the ability of surface plasmons to radiate coupled fluorophore fluorescence. Given that the extinction spectrum of the silvered films is comprised of both an absorption and scattering component, and that these components are proportional to the diameter cubed and to the sixth power, respectively, then larger structures are expected to have a greater scattering contribution to their extinction spectrum and, therefore, more efficiently radiate coupled fluorophore emission. Subsequently, we have been able to correlate our increases in fluorescence emission with an increased particle size, providing strong experiment evidence for our recently reported metal-enhanced fluorescence, facilitated by radiating plasmons hypothesis