Osteoarthritis of knee joint - role of quadriceps exercises

Background: Osteoarthritis of knee joint is a common clinical condition among patients attending orthopaedics outpatient department. The role of quadriceps exercises in its management is not effectively stressed. Hence this study was carried out to assess the role of Quadriceps exercises in management of Osteoarthritis of Knee and reduce the morbidity associated with it. Methods: A total of one hundred patients in the age group of 40-65 years and suffering from mild to moderate Osteoarthritis of the knee joint were included in the study. Subjects were divided into two groups, Group I receiving drug therapy only and Group II receiving physiotherapy also, in the form of quadriceps exercises. Data was recorded on a proforma designed to assess symptomatic relief after two weeks. Results: Participants in group II with exercise program had improvements in physical function and symptom relief, decrease in knee pain and increase in range of motion, more than that of participants in group I. It was observed that majority of the study subjects, 39 (78%) had excellent result in group II, whereas 12 (24%) patients from group I had poor result.Conclusions: There is relationship between age, sex and quadriceps exercise with osteoarthritis of knee. Moderate quadriceps exercise is a safe and effective prevention and therapy for Osteoarthritis of knee.

A clinical study of closed reduction and percutaneous Kirschner wire fixation of displaced supracondylar fractures of humerus in children

Background: Supracondylar fractures of the humerus are the most common fracture pattern of the elbow in children. Displaced supracondylar fractures are notorious for difficulty in reduction, maintenance of reduction and frequent involvement of neurovascular structures. The purpose of this study was to evaluate the results of stabilization of these fractures by closed reduction and percutaneous Kirschner wire fixation.Methods: Thirty cases of displaced supracondylar humerus fractures were included in the study. The mean age of the patient was 8.3 years [ranges from 4-14 years]. The male to female ratio was 2:1 and left side was involved in 23 cases whereas 7 had right sided injuries. All fractures were of extension type [Gartland’s type III]. Posteromedial displacement was noted in 22 cases whereas 8 fractures were posterolaterally displaced. In 20 cases, lateral entry wires alone were used whereas in 10 cases one lateral and one medial K-wire were used. K- wires were removed after 3 weeks post-operatively and follow-up was done at 6 weeks,12 weeks, 6 months and 12 months, when they  were evaluated according to Flynn’s criteria.Results: Results were graded using Flynn’s criteria. Excellent results were achieved in 18 [60%], good in 6 [20%] fair in 4 [13.3%], while poor results were seen in 2 [6.7%] patients.Conclusions: Closed reduction and percutaneous fixation using Kirschner wires is a safe and efficient method for fixation of displaced supracondylar fractures of the humerus in children.

Certificates verification on the block chain

All certificates, including those for secondary school graduation, high school diplomas, and college degrees, have been converted to digital form and made accessible to students at higher education institutions. It's essential for learners to keep track of their diplomas. It is a complex and time-consuming process for the institution or organization to verify or authenticate a certificate's validity. This application would aid in the safekeeping of the certificates on the block chain. Digital certificates are created by first digitising the original paper certificates. The certificate's hash code value is generated using the chaotic technique. It is then added to the block chain. The mobile application is used to verify these certifications. We can make digital certificate verification more reliable and safe by implementing block chains

Annexin A2 Limits Neutrophil Transendothelial Migration by Organizing the Spatial Distribution of ICAM-1

ICAM-1 is required for firm adhesion of leukocytes to the endothelium. However, how the spatial organization of endothelial ICAM-1 regulates leukocyte adhesion is not well understood. In this study, we identified the calcium-effector protein annexin A2 as a novel binding partner for ICAM-1. ICAM-1 clustering promotes the ICAM-1-annexin A2 interaction and induces translocation of ICAM-1 into caveolin-1-rich membrane domains. Depletion of endothelial annexin A2 using RNA interference enhances ICAM-1 membrane mobility and prevents the translocation of ICAM-1 into caveolin-1-rich membrane domains. Surprisingly, this results in increased neutrophil adhesion and transendothelial migration under flow conditions and reduced crawling time, velocity, and lateral migration distance of neutrophils on the endothelium. In conclusion, our data show that annexin A2 limits neutrophil transendothelial migration by organizing the spatial distribution of ICAM-1

Study of Antibacterial Properties of Ziziphus mauritiana based Green Synthesized Silver Nanoparticles against Various Bacterial Strains

Due to their low cost and environmentally friendly nature, plant extracts based methods have gained significant popularity among researchers for the synthesis of metallic nanoparticles. Herein, green synthesis of silver nanoparticles was performed using the aqueous solution of Ziziphus mauritiana leaves extract (ZM-LE) as a bio-reducing agent. The as-obtained silver nanoparticles were characterized by using UV-Vis spectroscopy, XRD (X-ray diffraction), TEM (transmission electron microscopy), and FT-IR (Fourier-transform infrared spectroscopy). In addition, the effects of the concentrations of the leaves extract, silver nitrate, and the temperature on the preparation of nanoparticles were also investigated. In order to determine the nature of secondary metabolites present in leaves extract, a preliminary investigation of phytoconstituents was carried out using different methods including Folin-Ciocalteu and AlCl3 methods. The results have indicated the presence of a considerable amount of phenolic and flavonoid contents in the leaves extract, which are believed to be responsible for the reduction of silver ions and stabilization of resulting nanoparticles. Indeed, the FT-IR spectrum of silver nanoparticles also confirmed the presence of residual phytomolecules of leaves extract as stabilizing ligands on the surface of nanoparticles. The antibacterial properties of as-obtained silver nanoparticles were tested against various bacterial strains including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis. The nanoparticles strongly inhibited the growth of S. aureus with a minimum inhibitory concentration (MIC) of 2.5 μg/ml and moderately inhibited the growth of E. coli with a MIC of 5 μg/ml